Article
Rehabilitation
Ryo ONUMA, Tadashi MASUDA, Fumihiko HOSHI, Tadamitsu MATSUDA, Tomoko SAKAI, Atsushi OKAWA, Tetsuya JINNO
Summary: This study aimed to investigate reduced anticipatory postural adjustments during gait initiation in post-stroke hemiplegic patients through measuring the center of pressure. The results showed that the latency and magnitude of center of pressure displacement peak for the paretic leg were significantly different compared to controls, and correlated with clinical measures of motor dysfunction and postural balance.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Neurosciences
Vicenta Martinez-Corcoles, Pilar Nieto-Gil, Laura Ramos-Petersen, Javier Ferrer-Torregrosa
Summary: This study examined the balance performance of children after the COVID-19 quarantine and found a significant reduction in balance performance after the quarantine period. The findings also suggest that regular physical activity benefits postural control, and physically active children are more affected in terms of balance.
Article
Nutrition & Dietetics
Debora Melo van Lent, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Birgit Stoffel-Wagner, Horst Bickel, Birgitt Wiese, Siegfried Weyerer, Michael Pentzek, Frank Jessen, Matthias Schmid, Wolfgang Maier, Martin Scherer, Steffi G. G. Riedel-Heller, Alfredo Ramirez, Michael Wagner
Summary: Deficiency of vitamin D increases the risk of developing Alzheimer's dementia. It is recommended to monitor vitamin D levels in the elderly and provide supplementation in cases of deficiency.
Article
Clinical Neurology
Lotte van de Venis, Vivian Weerdesteyn, Aletta Konijnenburg, Bart P. C. van de Warrenburg, Alexander C. H. Geurts, Jorik Nonnekes
Summary: This study found an association between increased trunk movements and reduced balance capacity in patients with HSP. The increased trunk movements may partly reflect balance correcting strategies, as ankle strategies and foot placement strategies become impaired and insufficient to restore balance after intrinsic perturbations.
JOURNAL OF NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Debora Melo van Lent, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Wolfgang Maier, Frank Jessen, Alfredo Ramirez, Matthias Schmid, Martin Scherer, Steffi G. Riedel-Heller, Michael Wagner
Summary: This study found that higher concentrations of eicosapentaenoic acid (EPA) were associated with a lower incidence of Alzheimer's disease (AD) in older individuals, and also with a decreased risk for all-cause dementia and AD, especially among apolipoprotein E epsilon 4 non-carriers.
Article
Orthopedics
Jaclyn Megan Sions, Maureen Donohoe, Emma Haldane Beisheim-Ryan, Ryan Todd Pohlig, Tracy Michele Shank, Louise Reid Nichols
Summary: This study aimed to assess the reliability of gait and balance measures in individuals with arthrogryposis multiplex congenita. The results showed that gait speed, non-linear walking, and dynamic balance assessment had adequate test-retest reliability in this population.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Rehabilitation
Paula T. Bezerra, Lorenna M. Santiago, Isaira A. Silva, Aline A. Souza, Camila L. Pegado, Clecia M. Damascena, Tatiana S. Ribeiro, Ana R. Lindquist
Summary: Combining action observation, motor imagery, and gait training did not show greater effectiveness than isolated gait training for balance and freezing of gait in individuals with Parkinson's disease. However, motor imagery training can moderate the effects of action observation and enhance motor learning when used together.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Review
Rehabilitation
Silvia Marazzi, Pawel Kiper, Katie Palmer, Michela Agostini, Andrea Turolla
Summary: This review suggests that whole body vibration treatment can significantly improve gait performance in patients with Parkinson's disease compared to standard treatment, but not significantly better for other outcomes. Studies on localized vibration were not suitable for quantitative meta-analysis due to high heterogeneity.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Review
Cell Biology
Thanwarat Chantanachai, Daina L. Sturnieks, Stephen R. Lord, Narelle Payne, Lyndell Webster, Morag E. Taylor
Summary: This systematic review identified risk factors for prospectively ascertained falls in older people with cognitive impairment living in the community. Balance deficits, poor mobility, slow gait speed, and depressive symptoms were found to be associated with fallers. Global cognition was not significantly associated with falls, suggesting interventions should focus on improving balance impairment. More high-quality research is needed to support these findings.
AGEING RESEARCH REVIEWS
(2021)
Article
Engineering, Biomedical
Desiderio Cano Porras, Jesse V. Jacobs, Rivka Inzelberg, Yotam Bahat, Gabriel Zeilig, Meir Plotnik
Summary: This study investigates the impact of vertical and horizontal perturbations on muscle activation patterns, finding that vertical perturbations result in longer onset latencies, shorter durations of activation, and lower activation magnitudes compared to horizontal perturbations. The availability of visual input appears to affect response efficiency, with incongruent visual input potentially adversely affecting response triggering.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Medicine, General & Internal
Michal Elboim-Gabyzon, Michal Pitluk, Einat Shuper Engelhard
Summary: Postural stability and gait are influenced by an individual's emotional state. Physical therapy practice often overlooks the assessment of emotional status, while complementary movement therapies commonly assess grounding quality, which includes both physical and emotional stabilities. This study found a correlation between postural stability and grounding quality, suggesting that they measure different aspects of movement stability.
ANNALS OF MEDICINE
(2022)
Article
Engineering, Biomedical
Luo Yi, Lin Houwei, Wang Lin, Zhao Lihua, Chen Mengjie, Wang Sun, Rao Zejiang, Ma Qichao
Summary: The study found that lumbar lordosis was positively correlated with pelvic tilt and sacral slope; on the major curve side, pelvic tilt showed positive correlation with all baropodometric parameters; while thoracic kyphosis showed negative correlations with contact surface and weight percentage of the forefoot.
CLINICAL BIOMECHANICS
(2021)
Review
Physiology
Yunzhi Wu, Yuqi Dong, Yunqi Tang, Weiran Wang, Yulong Bo, Cui Zhang
Summary: This study aims to review the relationship between motor performance and cortical activity of older patients with neurological disorders during walking and balance tasks. The results showed that motor performance and cortical activation were affected under difficult task conditions, with poor performance and increased activation observed in Parkinson's disease, stroke, and multiple sclerosis patients. More comprehensive and profound analysis is needed to further understand the relationship between motor performance and activation of the motor-related cortex.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Chemistry, Analytical
Tanapon Keatsamarn, Sarinporn Visitsattapongse, Hisayuki Aoyama, Chuchart Pintavirooj
Summary: This research proposes an optical-based foot plantar pressure measurement system for personal identification and postural control. The system generates color-coded plantar pressure images of the subject standing on the platform by extracting features from the images. Experimental results show promising outcomes in both posture balance evaluation and person identification.
Article
Neurosciences
Patrick G. Monaghan, Sarah A. Brinkerhoff, Jaimie A. Roper
Summary: The study found that physical activity status did not affect frontal plane dynamic balance in healthy young adults. Conditions that constrain step width, such as tandem and beam walking, are adequate for challenging frontal plane dynamic balance, indicating possible adjustments in trunk kinematics when step width is constrained.
Article
Clinical Neurology
Seyed Ahmad Sajjadi, Syed Bukhari, Kiana A. Scambray, Rui Yan, Claudia Kawas, Thomas J. Montine, Maria M. Corrada
Summary: LATE-NC is a prevalent degenerative pathology in the oldest-old, with significant associations with dementia and cognitive impairment. Past medical histories of hypertension and osteoarthritis are associated with a lower likelihood of LATE-NC.
Article
Clinical Neurology
Zarui. A. Melikyan, Claudia. H. Kawas, Annlia Paganini-Hill, Luohua Jiang, Bryce. A. Mander, Maria M. Corrada
Summary: Sleep duration and napping are associated with sex-specific risks of dementia in old age. Short sleep duration and no napping are associated with higher risk of dementia after age 90 in women, while short to moderate napping is associated with lower risk of dementia after age 90 in men.
BEHAVIORAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Annlia Paganini-Hill, Thomas J. Montine, Syed A. Bukhari, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi
Summary: This study investigated the neuropathological construct of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and its associations with estrogen-related risk factors. The study found that there was no association between menstrual and reproductive variables with LATE-NC. However, the long-term and recent use of estrogen replacement therapy (ERT) were associated with a reduced risk of LATE-NC.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Steven J. Granger, Luis Colon-Perez, Myra Sarai Larson, Ilana J. Bennett, Michael Phelan, David B. Keator, John T. Janecek, Mithra T. Sathishkumar, Anna P. Smith, Liv McMillan, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Summary: The perforant path, connecting the entorhinal cortex with the hippocampal formation, deteriorates with age-related cognitive decline. Diffusion-weighted MRI has limitations in quantifying the perforant path integrity, so this study used ultra-high resolution diffusion imaging to investigate its structural connectivity and found that older age and poorer delayed recall are associated with reduced connectivity of the path. The findings suggest that intra-MTL connectivity may serve as new candidate biomarkers for age-related cognitive decline.
NEUROBIOLOGY OF AGING
(2023)
Article
Neuroimaging
Batool Rizvi, Mithra Sathishkumar, Soyun Kim, Freddie Marquez, Steven J. Granger, Myra S. Larson, Blake A. Miranda, Martina K. Hollearn, Liv McMillan, Bin Nan, Nicholas J. Tustison, Patrick J. Lao, Adam M. Brickman, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. . Yassa
Summary: This study examined the relationship between white matter hyperintensities, medial temporal lobe subregional volumes, and hippocampal memory in older adults. The results suggest that white matter hyperintensities may be associated with memory decline through their impact on medial temporal lobe atrophy. These findings provide new insights into the role of vascular pathologies in memory loss in older adults.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Raumin S. Neuville, Roshni Biswas, Chu-Ching Ho, Syed Bukhari, Seyed Ahmad Sajjadi, Annlia Paganini-Hill, Thomas J. Montine, Maria M. Corrada, Claudia H. Kawas
Summary: This study investigated the relationship between neuropathological changes and dementia in centenarians and nonagenarians. The results showed that the prevalence of at least four neuropathological changes was 59% for centenarians and 47% for nonagenarians. In centenarians, neuropathological changes were strongly associated with dementia and this association was not attenuated with age compared to nonagenarians. Each additional neuropathological change was associated with a 2-point decrease in the Mini-Mental State Examination score for both groups. This highlights the importance of slowing or preventing the development of multiple neuropathological changes in the aging brain to maintain cognitive health.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Ruijia Chen, Camilla Calmasini, Kaitlin Swinnerton, Jingxuan Wang, Sebastien Haneuse, Sarah F. Ackley, Andrew K. Hirst, Eleanor Hayes-Larson, Kristen M. George, Rachel Peterson, Yenee Soh, Lisa L. Barnes, Elizabeth Rose Mayeda, Paola Gilsanz, Dan M. Mungas, Rachel A. Whitmer, Maria M. Corrada, M. Maria Glymour
Summary: The challenge of accounting for practice effects (PEs) in modeling cognitive change was amplified by the COVID-19 pandemic. Comparing three approaches, we found that correcting for PEs based on a preliminary model produced more accurate estimations of cognitive trajectories, and the association between grip strength and cognitive decline was not sensitive to the approach used.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Roshni Biswas, Claudia Kawas, Thomas J. Montine, Syed A. Bukhari, Luohua Jiang, Maria M. Corrada
Summary: A study explores the neuropathological changes in the brains of oldest-old individuals with superior cognitive performance. It found that Alzheimer's disease and low levels of vascular pathologic change were not associated with superior cognition, but Lewy body disease and hippocampal sclerosis were more likely to be non-superior cognitive performers. Multiple comorbid neuropathologic features were also associated with a lower likelihood of being superior cognitive performers.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Anne-Marie C. Leiby, Kiana A. Scambray, Hannah L. Nguyen, Farheen Basith, Shahrzad Fakhraee, Zarui A. Melikyan, Syed A. Bukhari, Thomas J. Montine, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi
Summary: This study describes the clinical and cognitive characteristics of LATE-NC without ADNC and LB, and compares it with other neurodegenerative diseases. It found that this type of pathology is rare in the oldest old cohort, but is associated with significant cognitive decline and other symptoms.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Annlia Paganini-Hill, Syed Bukhari, Thomas J. J. Montine, Maria M. M. Corrada, Claudia H. H. Kawas
Summary: Alzheimer's disease (AD) is the leading cause of dementia. AD neuropathologic change (ADNC) may start decades before clinical symptoms. Oxidative stress is one mechanism implicated in AD. This study investigates the potential association between ADNC and antioxidant vitamin supplements taken about 30 years prior to death.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2023)