Review
Pharmacology & Pharmacy
Ubashini Vijakumaran, Muhammad Dain Yazid, Ruszymah Bt Hj Idrus, Mohd Ramzisham Abdul Rahman, Nadiah Sulaiman
Summary: Hydroxytyrosol, a polyphenol of olive plant, shows antioxidant, anti-inflammatory, and anti-atherogenic properties by regulating molecular pathways to promote reendothelization and inhibit VSMCs migration, thereby inhibiting the development of intimal hyperplasia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Shenyu Zhu, Wenbo Yu, Jianfeng Gao, Jianxian Xiong
Summary: A meta-analysis showed that heart transplant recipients on mammalian target of rapamycin inhibitors (MTRIs) had a significantly higher frequency of wound complications (WCs) compared to those on control.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Neurosciences
Henry Querfurth, Han-Kyu Lee
Summary: mTOR is involved in regulating energy metabolism, neuronal growth, insulin signaling, and autophagy, playing both beneficial and pathogenic roles in neurodegenerative diseases. Balanced actions of mTOR complexes may have implications for Alzheimer's disease, Parkinson's disease, Huntington's disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Beyond rapamycin, rapalogs with improved tolerability and delivery modes hold promise in treating age-related conditions.
MOLECULAR NEURODEGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Juan Salazar, Daniela Pirela, Manuel Nava, Ana Castro, Lisse Angarita, Heliana Parra, Samuel Duran-Aguero, Diana Marcela Rojas-Gomez, Nestor Galban, Roberto Anez, Maricarmen Chacin, Andrea Diaz, Nelson Villasmil, Juan Bautista De Sanctis, Valmore Bermudez
Summary: Cardiovascular disease (CVD) is a global public health issue with high morbidity, mortality, and economic impact. Specialized proresolving lipid mediators (SPMs), derived from fatty acids, have shown promise in resolving inflammation associated with the pathogenesis of various diseases, particularly CVD. Preclinical and clinical studies have demonstrated the therapeutic impact of SPMs in CVD, suggesting their potential as a new therapeutic alternative. Further large-scale clinical trials are needed to determine their effects in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Hamdi Nsairat, Alaa A. Aljabali, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala
Summary: The mammalian target of rapamycin (mTOR), a signalling system, is necessary for various cell proliferation activities. It recognizes PI3KAKT stress signals as a serine-threonine kinase. The abnormal regulation of mTOR pathway has been proven to be crucial in cancer growth and advancement. This review primarily discusses the normal functions of mTOR as well as its abnormal roles in cancer development.
Article
Cardiac & Cardiovascular Systems
Allison C. Ostriker, Yi Xie, Raja Chakraborty, Ashley J. Sizer, Yalai Bai, Min Ding, Wen-Liang Song, Anita Huttner, John Hwa, Kathleen A. Martin
Summary: The study found that TET2 is suppressed in CAV and GA, likely mediated by IFN gamma. TET2 helps to protect VSMCs from apoptosis in the context of transplant vasculopathy or IFN gamma stimulation. Enhancing TET2 enzymatic activity with high-dose ascorbic acid reduces VSMC apoptosis and intimal thickening, suggesting that promoting TET2 activity in CAV may be an effective strategy for limiting CAV progression.
Review
Immunology
Jun Zeng, Qiang Zhong, Xiaobing Feng, Linde Li, Shijian Feng, Yu Fan, Turun Song, Zhongli Huang, Xianding Wang, Tao Lin
Summary: Conversion from CNIs to mTORi therapy in kidney transplant recipients can improve renal function and reduce the incidence of malignancy, but is associated with a higher risk of adverse events such as acute rejection, infection, proteinuria, leukopenia, acne, and mouth ulcer, leading to increased drug discontinuation rates. The conversion strategy may be suitable for selected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Mirit Gluck, Emmilia Hodak, Batya Davidovici
Summary: Immunosuppressants are crucial for graft survival in solid-organ transplant recipients, but they can lead to an increased incidence of nonmelanoma skin cancers. A retrospective study showed that mammalian target of rapamycin inhibitors (mTORi) have a sustained effectiveness in reducing the occurrence of nonmelanoma skin cancers.
DERMATOLOGIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Alaa Abou Daher, Sahar Alkhansa, William S. Azar, Rim Rafeh, Hilda E. Ghadieh, Assaad A. Eid
Summary: Understanding the mechanisms behind diabetic nephropathy (DN) is crucial for developing effective treatments. The mTOR pathway has been identified as a key player in diabetes-induced kidney injury, through its involvement in insulin resistance, oxidative stress, and autophagy regulation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Ophthalmology
Nozomi Igarashi, Megumi Honjo, Makoto Aihara
Summary: Glaucoma, the second leading cause of blindness worldwide, is often treated with trabeculectomy, but this surgery can lead to excessive scarring and tissue fibrosis. Studies have shown that mTOR inhibitors may offer a new treatment modality for reducing fibrotic response in human conjunctival fibroblasts and improving bleb scarring after filtration surgery.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Fengjie Guo, Zhipeng Ren, Dongxu Liu, Linghui Wang, Xiaobin Hou, Wen Chen
Summary: Regulatory T cells (Treg cells) inhibit intimal hyperplasia of tissue-engineered blood vessels (TEBVs) in diabetic pigs by promoting endothelial progenitor cells (EPCs) mobilization, anti-inflammatory action, and cellular protection.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Elena Anghileri, Bianca Pollo, Paolo Ferroli, Domenico Aquino, Greta Demichelis, Marco Schiariti, Francesco Ferrau, Luisa Chiapparini, Valeria Cuccarini
Summary: This study describes a case of multiple recurrent intravascular papillary endothelial hyperplasia (IPEH) in the brain and provides details on the diagnostic phase, therapeutic approaches, and related challenges.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
GuiHao Chen, Vincent Phan, Xiang Luo, Dian J. Cao
Summary: mTORC1 plays a crucial role in regulating the functions of cardiac monocytes and macrophages, and its inhibition promotes cardiac repair, reduces inflammatory injury, and decreases mortality from acute ischemia.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Rheumatology
Ecem Sevim, Salma Siddique, Madhavi Latha S. Chalasani, Susan Chyou, William D. Shipman, Orla O'Shea, Joanna Harp, Oral Alpan, Stephane Zuily, Theresa T. Lu, Doruk Erkan
Summary: This study investigated the activation of the mammalian target of rapamycin (mTOR) in the skin of patients with livedo and antiphospholipid antibodies (aPL). The results showed increased mTOR activity in the skin of aPL-positive patients, which may have implications for further research on the mTOR pathway in these patients.
JOURNAL OF RHEUMATOLOGY
(2022)
Letter
Endocrinology & Metabolism
Joseph M. Kim, Deepak L. Bhatt, Samuel Dagogo-Jack, David Z. I. Cherney, Francesco Cosentino, Darren K. McGuire, Richard E. Pratley, Chih-Chin Liu, Nilo B. Cater, Robert Frederich, James P. Mancuso, Christopher P. Cannon
DIABETES OBESITY & METABOLISM
(2023)
Article
Urology & Nephrology
Steven D. Weisbord, Maria K. Mor, Harry Hochheiser, Nadejda Kim, P. Michael Ho, Deepak L. Bhatt, Michael J. Fine, Paul M. Palevsky
Summary: Previous studies have shown that CKD patients are less likely to receive invasive care for ACS, and this study further reveals that the nonuse of clinically indicated invasive care is associated with increased mortality among CKD patients with ACS.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Arjun K. Pandey, Nitish K. Dhingra, Avinash Pandey, Pankaj Puar, Shamon Ahmed, Raj Verma, C. David Mazer, Javed Butler, Mitesh Badiwala, Terrence M. Yau, Bobby Yanagawa, Deepak L. Bhatt, Subodh Verma
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Makoto Hibino, Arjun K. Pandey, Hiromi Hibino, Raj Verma, Dagfinn Aune, Bobby Yanagawa, Yoshiyuki Takami, Deepak L. Bhatt, Guilherme F. Attizzani, Marc P. Pelletier, Subodh Verma
Summary: The objective of this study was to describe recent mortality trends from aortic stenosis (AS) among eight high-income countries. The WHO mortality database was analysed to determine trends in mortality from AS in these countries from 2000 to 2020. Crude and age-standardised mortality rates were calculated, and joinpoint regression was used to analyse the annual percentage change. The findings showed an increase in crude mortality rates in all eight countries, but a decrease in age-standardised mortality rates was observed in Germany, Australia, and the USA.
Article
Cardiac & Cardiovascular Systems
David D. Berg, Filipe A. Moura, Andrea Bellavia, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Itamar Raz, Erin A. Bohula, Robert P. Giugliano, Jeong-Gun Park, Mark W. Feinberg, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
Summary: A risk model for atherothrombosis in patients with type 2 diabetes mellitus (T2DM) was developed and validated using data from 42,181 patients. The model identified 16 independent predictors of myocardial infarction (MI) or ischemic stroke (IS). The model performed well in validation and has the potential to improve risk assessment and clinical decision-making.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Deepak L. Bhatt
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Patricia Irizar, Daniel Pan, Dharmi Kapadia, Laia Becares, Shirley Sze, Harry Taylor, Sarah Amele, Eliud Kibuchi, Pip Divall, Laura J. Gray, Laura B. Nellums, Srinivasa Vittal Katikireddi, Manish Pareek
Summary: This study analyzed global data on COVID-19 clinical outcomes and found systematic ethnic inequalities in health outcomes. Minoritised ethnic groups have a higher risk of infection, hospitalization, ICU admission, and mortality compared to the ethnic majority group. The study highlights the importance of addressing the drivers of ethnic inequalities, such as structural racism and racial discrimination.
Article
Medicine, General & Internal
Christopher A. Martin, Joshua Nazareth, Amar Jarkhi, Daniel Pan, Mrinal Das, Nicola Logan, Sam Scott, Luke Bryant, Neha Abeywickrama, Oluwatobi Adeoye, Aleem Ahmed, Aqua Asif, Srini Bandi, Nisha George, Marjan Gohar, Laura J. Gray, Ross Kaszuba, Jitendra Mangwani, Marianne Martin, Arumugam Moorthy, Valerie Renals, Lucy Teece, Denny Vail, Kamlesh Khunti, Paul Moss, Andrea Tattersall, Bassam Hallis, Ashley D. Otter, Cathy Rowe, Brian J. Willett, Pranab Haldar, Andrea Cooper, Manish Pareek
Summary: This study compares the cellular and humoral immune responses to SARS-CoV-2 vaccination among different ethnic groups of healthcare workers in the UK. The results show that South Asian healthcare workers have higher levels of neutralizing antibodies and T cell responses compared to White healthcare workers, with these differences being most pronounced in the early period following vaccination.
Article
Cardiac & Cardiovascular Systems
Hyeok-Hee Lee, Hokyou Lee, Deepak L. Bhatt, Danbee Kang, Jong-Chan Youn, Dong Wook Shin, Juhee Cho, Hyeon Chang Kim
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Arjun K. Pandey, Deepak L. Bhatt, Avinash Pandey, Nikolaus Marx, Francesco Cosentino, Ambarish Pandey, Subodh Verma
Summary: For decades, heart failure with preserved ejection fraction (HFpEF) has been difficult to treat. Recently, SGLT2 inhibitors have shown to reduce the risk of heart failure hospitalization or cardiovascular death in patients with HFpEF. These agents have multiple mechanisms of action and have established themselves as disease-modifying therapies.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Francesco Perone, Marco Bernardi, Alban Redheuil, Dario Mafrica, Edoardo Conte, Luigi Spadafora, Fiona Ecarnot, Lale Tokgozoglu, Carlos G. Santos-Gallego, Sergio Emanuel Kaiser, Federica Fogacci, Annabelle Sabouret, Deepak L. Bhatt, Francesco Paneni, Maciej Banach, Raul Santos, Giuseppe Biondi Zoccai, Kausik K. Ray, Pierre Sabouret
Summary: Optimal risk assessment for primary prevention is challenging and there are major discrepancies between guidelines and practice. Cardiovascular imaging plays a crucial role in categorizing individuals and enabling precise therapeutic strategies. Further research is needed to define individual residual risk and intensify treatment in high-risk subgroups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Toshiki Kuno, Atsuyuki Watanabe, Yoshihisa Miyamoto, Leandro Slipczuk, Deepak L. Bhatt
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Roxana Mehran, Davis B. Jones, Alessandro Spirito, Samantha Sartori, Dominick J. Angiolillo, Sripal Bangalore, Junbo Ge, Yihan Feng, James Bernard Hermiller, Raj R. Makkar, F. J. Neumann, Shigeru Saito, Birgit Vogel, Deepak L. Bhatt, Marco Valgimigli
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Samuel C. R. R. Sherratt, Peter Libby, Deepak L. Bhatt, R. Preston Mason
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Samuel C. R. R. Sherratt, Peter Libby, Deepak L. Bhatt, R. Preston Mason
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)