Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 68, Issue 19, Pages 2107-2117Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2016.08.036
Keywords
outcome; pathogenesis; signaling; treatment
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Funding
- NHLBI NIH HHS [R01 HL117913, P01 HL129941] Funding Source: Medline
- NIAID NIH HHS [R01 AI108906] Funding Source: Medline
- NIAMS NIH HHS [R01 AR042527] Funding Source: Medline
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Although the early outcome of acute coronary syndrome (ACS) has considerably improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly because recurrence of ACS eventually leads to the pandemics of heart failure and sudden cardiac death, thus calling for a reappraisal of the mechanisms responsible for coronary instability. This review discusses recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS and the clinical implications that arise from these new pathogenic concepts. (C) 2016 by the American College of Cardiology Foundation.
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