Article
Substance Abuse
Elizabeth E. Krans, Joo Yeon Kim, Qingwen Chen, Scott D. Rothenberger, Alton Everette James, David Kelley, Marian P. Jarlenski
Summary: This study analyzed 13,320 pregnancies among women with opioid use disorder in Pennsylvania, USA. The findings suggest that longer duration of medication for opioid use disorder during pregnancy is associated with decreased overdose and preterm birth rates, increased postpartum medication continuation rate, and higher neonatal abstinence syndrome rate, indicating improved maternal and perinatal outcomes with continued medication use.
Article
Environmental Sciences
Boya Lin, Yi Zheng, Dikea Roussos-Ross, Kelly K. Gurka, Matthew J. Gurka, Hui Hu
Summary: The prevalence of opioid use disorder (OUD) during pregnancy has increased fourfold in recent years and varies across different regions in the US. To explore the environmental factors associated with OUD during pregnancy, a study was conducted using an external exposome-wide association analysis. The study found that measures of walkability, vacant land, and food access were associated with the diagnosis of OUD during pregnancy. This study provides valuable insights for developing screening tools for substance use and guiding future research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Kathryn Miele, Shin Y. Kim, Rachelle Jones, Juneka H. Rembert, Elisha M. Wachman, Hira Shrestha, Michelle L. Henninger, Teresa M. Kimes, Patrick D. Schneider, Vaseekaran Sivaloganathan, Katherine A. Sward, Vikrant G. Deshmukh, Pilar M. Sanjuan, Jessie R. Maxwell, Neil S. Seligman, Sarah Caveglia, Judette M. Louis, Tanner Wright, Carolyne Cody Bennett, Caitlin Green, Nisha George, Lucas Gosdin, Emmy L. Tran, Dana Meaney-Delman, Suzanne M. Gilboa
Summary: MAT-LINK is a surveillance network that collects population and clinical information about pregnant women with OUD to understand the impact of MOUD on outcomes and provide information for clinical care and public health interventions. The network gathered data on 5,541 pregnancies from 2014 to 2021, with initial clinical sites not being representative but the addition of three sites in 2021 improved representation. This report provides detailed information on the system and initial findings, showing that pregnant women receiving MOUD tend to be older, White, and have public insurance.
MMWR SURVEILLANCE SUMMARIES
(2023)
Article
Psychiatry
Reza Ghanbari, Yuanyuan Li, Wimal Pathmasiri, Susan McRitchie, Arash Etemadi, Jonathan D. Pollock, Hossein Poustchi, Afarin Rahimi-Movaghar, Masoumeh Amin-Esmaeili, Gholamreza Roshandel, Amaneh Shayanrad, Behrouz Abaei, Reza Malekzadeh, Susan C. J. Sumner
Summary: The study focused on developing biological markers to differentiate between chronic opiate users with OUD and without OUD, with metabolomics analysis revealing a metabolic profile that can predict a positive diagnosis of OUD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Kathryn Miele, Shin Y. Kim, Rachelle Jones, Juneka H. Rembert, Elisha M. Wachman, Hira Shrestha, Michelle L. Henninger, Teresa M. Kimes, Patrick D. Schneider, Vaseekaran Sivaloganathan, Katherine A. Sward, Vikrant G. Deshmukh, Pilar M. Sanjuan, Jessie R. Maxwell, Neil S. Seligman, Sarah Caveglia, Judette M. Louis, Tanner Wright, Carolyne Cody Bennett, Caitlin Green, Nisha George, Lucas Gosdin, Emmy L. Tran, Dana Meaney-Delman, Suzanne M. Gilboa
Summary: This article introduces the surveillance network MAT-LINK established in the United States, which collects clinical and demographic information about persons with opioid use disorder (OUD) during pregnancy. The goal is to understand the effects of medication for OUD on outcomes and provide information for clinical care and public health interventions. MAT-LINK is the first surveillance system to collect comprehensive and longitudinal data on pregnant persons receiving medication for OUD.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Substance Abuse
Chung Jung Mun, Patrick H. Finan, David H. Epstein, William J. Kowalczyk, Daniel Agage, Janelle E. Letzen, Karran A. Phillips, Kenzie L. Preston
Summary: In individuals receiving opioid agonist treatment, momentary pain appears to indirectly influence illicit opioid use through momentary opioid craving.
Article
Multidisciplinary Sciences
Lexis R. Galarneau, Jesse Hilburt, Zoe R. O'Neill, Jane A. Buxton, Frank X. Scheuermeyer, Kathryn Dong, Janusz Kaczorowski, Aaron M. Orkin, Skye Pamela Barbic, Misty Bath, Jessica Moe, Isabelle Miles, Dianne Tobin, Sherry Grier, Emma Garrod, Andrew Kestler
Summary: The aim of the study was to understand the pandemic experiences of people with opioid use disorder through semi-structured qualitative interviews. Participants showed a good understanding of COVID-19 and its impacts on their community. The pandemic had profound effects on the social lives, access to services, and risk-taking behavior of individuals with opioid use disorder.
Editorial Material
Substance Abuse
Alexa DeLisle, Hendree E. Jones, Lauren M. Jansson
Summary: Gabapentin, commonly used to treat epilepsy and neuropathic pain, has been historically considered safe. However, recent research suggests potential risks associated with its use in pregnancy and individuals with substance misuse tendencies. Concerns have been raised regarding in utero exposure and neonatal exposure via breastmilk. Therefore, caution should be exercised when using gabapentin during pregnancy and the postpartum period.
JOURNAL OF ADDICTION MEDICINE
(2023)
Letter
Pediatrics
Mir M. Ali, Kristina D. West, Rachel Mosher Henke, Michael A. Head, Stephen W. Patrick
Summary: This study examines the relationship between mothers receiving treatment for opioid use disorder during pregnancy and their infants' utilization of health services in the first year of life.
Article
Substance Abuse
Lauren Riedel, Lori Uscher-Pines, Ateev Mehrotra, Alisa B. Busch, Michael L. Barnett, Pushpa Raja, Haiden A. Huskamp
Summary: Most clinicians found telemedicine effective for OUD patients and were comfortable using video for clinically stable patients. While many preferred in-person care, they believed telemedicine should still be offered in the future.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Clinical Neurology
Yu Kyung Lee, Mark S. Gold, Brian S. Fuehrlein
Summary: This paper reviews novel treatments being investigated for opioid use disorder (OUD), including neuromodulatory interventions, psychedelic drugs, and other novel approaches. These proposed treatments offer hope for a more durable and effective OUD treatment beyond the traditional opioid agonist therapy. However, more clinical data are needed to support their efficacy and safety.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Obstetrics & Gynecology
Vanessa L. Short, Diane J. Abatemarco, Meghan Gannon
Summary: The study aimed to describe breastfeeding intention, knowledge, and attitude among pregnant women in treatment for opioid use disorder (OUD). While most participants expressed some intention to breastfeed, less than half were aware of recommendations and benefits of breastfeeding. Prenatal programs for women with OUD should address gaps in knowledge and concerns regarding breastfeeding.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Substance Abuse
Canyon Foot, Philip T. Korthuis, Judith I. Tsui, Sean X. Luo, Brian Chan, Ryan R. Cook
Summary: The aim of this study was to investigate the impact of ongoing stimulant use on the return to illicit opioid use after medication for opioid use disorder (MOUD) initiation. The findings suggest that individuals who use stimulants are more likely to relapse to ongoing non-prescribed opioid use, especially among those who initiate buprenorphine.
Article
Psychiatry
Gayatri Bhatia, Ragul Ganesh, Alok Kulkarni
Summary: Opioid use disorders (OUDs) are linked to cognitive impairments and increased risk of relapse. Current treatments do not effectively address these cognitive deficits, so exploring other options, such as cognition enhancing drugs, is important. Certain prescription drugs used for dementia have shown promise in reversing opioid-induced cognitive impairments, and the potential role of nootropics in improving OUD-related cognitive decline is worth investigating.
PSYCHIATRY RESEARCH
(2023)
Article
Obstetrics & Gynecology
Katherine R. Standish, Tierney M. Morrison, Amita Wanar, Lisa Crowell, Cara B. Safon, Eve Colson, Mari-Lynn Drainoni, Bryanne N. Colvin, Hayley Friedman, Davida M. Schiff, Sara Stulac, Eileen Costello, Margaret Parker
Summary: This study aimed to understand the barriers and facilitators to breastfeeding initiation and continuation among mothers with opioid use disorder (OUD). Through in-depth, semi-structured interviews with 23 mothers with OUD who cared for their infants at home, factors influencing breastfeeding decisions were identified, including infant withdrawal, maternal health and recovery, and social context. Overcoming these barriers may serve as future intervention targets for promoting breastfeeding among this high-risk population.
BREASTFEEDING MEDICINE
(2023)