Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 16, Pages 5234-5237Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b02153
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Funding
- NIH-NIGMS [R01GM080269]
- Gordon and Betty Moore Foundation
- Caltech
- Shanghai Institute of Organic Chemistry (SIOC)
- Hiroshima International University
- National Science Foundation
- California HIV/AIDS Research Program [F08-CT-201]
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A catalytic, enantioselective gamma-alkylation of alpha,beta-unsaturated malonates and ketoesters is reported. This strategy entails a highly regio- and enantioselective iridium-catalyzed alpha-alkylation of an extended enolate, and a subsequent translocation of chirality to the gamma-position via a Cope rearrangement.
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