Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 45, Pages 14848-14851Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b09736
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Funding
- NIH-NIGMS [R01-GM43214]
- NSF
- Alexander von Humboldt Foundation
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An enantioselective, catalytic aza-Sakurai cyclization of chlorolactams has been developed as an efficient entry into indolizidine and quinolizidine frameworks. Structure-enantioselectivity relationship studies and mechanistic analysis point to a dual role of the catalyst wherein the thiourea moiety of the catalyst is engaged in both anion binding and Lewis base activation of a substrate.
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