Article
Biochemical Research Methods
Grit Preusse, Vincenz Porstmann, Thomas Bartels, Christian Schnabel, Roberta Galli, Edmund Koch, Martin Oelschlaegel, Ortrud Uckermann, Gerald Steiner
Summary: A novel method of in ovo sex determination using two-wavelength fluorescence excitation is described. The accuracy of sex determination is 96% with no reduction in hatching rate.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Giovanni Batignani, Emanuele Mai, Giuseppe Fumero, Shaul Mukamel, Tullio Scopigno
Summary: This article introduces a nonlinear Raman experiment to access an elusive aspect of the excited-state displacements: their sensed directions relative to the ground-state.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
David Reichert, Mikael T. Erkkilae, Johanna Gesperger, Lisa I. Wadiura, Alexandra Lang, Thomas Roetzer-Pejrimovsky, Adelheid Woehrer, Marco Wilzbach, Christoph Hauger, Wolfgang Drexler, Barbara Kiesel, Georg Widhalm, Rainer A. Leitgeb, Angelika Unterhuber, Marco Andreana
Summary: Precise intraoperative brain tumor visualization is crucial for surgeons to achieve maximal safe resection. Recent studies have shown that protoporphyrin IX fluorescence-guided surgery can improve prognosis in patients with high-grade gliomas. This work demonstrates further optimization of the technique by minimizing the crosstalk of autofluorescence signal contributions, resulting in a clearer distinction between tumor fluorescence and autofluorescence background.
APPLIED SCIENCES-BASEL
(2022)
Article
Optics
Jingyue Pan, Qingquan Liu, Hao Sun, Weibo Zheng, Peiru Wang, Long Wen, Junli Duan, Zhiyi Xuan, Xiang Yu, Shaowei Wang, Xiuli Wang, Tao Zhang, Wei Lu
Summary: A miniature portable fluorescence imaging device has been introduced for diagnosing skin cancer, with a coaxial design combining the excitation light source and fluorescence receiver to reduce size and ensure illumination homogeneity. The device was successfully demonstrated to easily distinguish cancer lesions in squamous cell carcinoma mice, showing potential for noninvasive detection of early skin tumors and integration with other diagnostic methods for multiple diagnose of skin tumors.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chen Yu, Bing Zhao, Yan Li, Hengchang Zang, Lian Li
Summary: This review discusses the current research status of osteoarthritis (OA), the importance of early diagnosis, the potential application of vibrational spectroscopy in OA diagnosis, comparison of various diagnostic methods, and the promising role of vibrational spectroscopy as a tool for early OA diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
David Reichert, Mikael T. Erkkilae, Johanna Gesperger, Lisa Wadiura, Alexandra Lang, Thomas Roetzer, Adelheid Woehrer, Marco Andreana, Angelika Unterhuber, Marco Wilzbach, Christoph Hauger, Wolfgang Drexler, Barbara Kiesel, Georg Widhalm, Rainer A. Leitgeb
Summary: Maximal safe resection is crucial for brain tumor management. Intraoperative fluorescence guidance using 5-aminolevulinic acid can improve tumor-specific accumulation of protoporphyrin IX. Integration of fluorescence lifetime imaging with fluorescence spectroscopy shows promise in distinguishing different tumor types for potential clinical translation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kanamat Efendiev, Polina Alekseeva, Artem Shiryaev, Arina Voitova, Kirill Linkov, Tatiana Pisareva, Igor Reshetov, Victor Loschenov
Summary: This study aims to develop a method for phototheranostics of tumors in the near-infrared range using PpIX and Ce6 photosensitizers. The results show that NIR spectral fluorescence diagnostics of PpIX and Ce6 can be achieved using red lasers. The fluorescence intensity of PpIX and Ce6 in the NIR range was measured, and the photobleaching of PSs during PDT was determined. This method allows personalized adjustment of light exposure duration and monitoring of PS distribution in deeper tumors.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Analytical
Ziying Zhan, Xiaoli Qin, Kenneth Chu, Xuhui Sun, Zhifeng Ding
Summary: Novel determination methods are reported for absolute electrochemiluminescence (ECL) and chemiluminescence (CL) efficiencies of Protoporphyrin IX dimethyl ester (Pro-IX) with values of 0.0018% and 0.0020%, respectively. The new strategies have significantly reduced the error caused by traditional methods, providing valuable information on Pro-IX's molecular structure and reaction mechanisms. Pro-IX exhibits quasi-reversible reductions and irreversible oxidation at specific potentials, indicating the stability of its radical anion and instability of its radical cation. ECL and CL effects are observed in Pro-IX, and it is anticipated that these properties could be useful for photodynamic diagnosis of live cells.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Spectroscopy
Gerard Dumancas, Indra Adrianto
Summary: This study developed a stacked regression ensemble approach using near infrared spectroscopic method for accurate determination of biomass compositional analyses. The performance of various machine learning techniques was compared, and the stacked regression outperformed other methods, providing a more accurate prediction of biomass compositions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Gauthier Croizat, Aurelien Gregor, Jaroslava Joniova, Emmanuel Gerelli, Georges Wagnieres
Summary: The study reveals the different fluorescence characteristics of PpIX at different concentrations, and the linear correlation between fluorescence characteristics and local concentration. The observation of PpIX excimer fluorescence allows for more accurate measurement of PpIX concentration in tissues, which is significant for applications such as photodynamic therapy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Environmental Sciences
Khawla Chouchene, Tommaso Nacci, Francesca Modugno, Valter Castelvetro, Mohamed Ksibi
Summary: Plastic film mulching and use of wastewaters for irrigation are common agricultural practices in Tunisia, which have led to the contamination of farmland soil by microplastics. A study in the Moknine province found that the predominant type of microplastics in the soil is polypropylene, and these microplastics also carry a wide range of heavy metals, indicating soil contamination.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemical Research Methods
Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei
Summary: This study proposes an analytical model considering the opto-thermo-mechanical properties of multi-layered samples in 3-D space, which eliminates several assumptions that have been limiting previous PT-OCT models. Comparative analysis between model results and experimental signals is conducted to explore the influence of sample and system parameters on the acquired signals. The proposed model and findings offer insights into the effects of system parameters and tissue properties on experimental signals, optimize experimentation strategies based on parameters, and guide downstream signal processing for predicting tissue composition.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Optics
Fabrizio R. Giorgetta, Jeff Peischl, Daniel I. Herman, Gabriel Ycas, Ian Coddington, Nathan R. Newbury, Kevin C. Cossel
Summary: Open-path dual-comb spectroscopy has been extended to the mid-infrared 5 µm atmospheric window, enabling high precision measurements of multispecies atmospheric gas concentrations, including primary greenhouse gases and criteria air pollutants. The retrieved ratios of excess CO versus CO2 and N2O versus CO2 show variations and discrepancies with previous studies and emission inventories.
LASER & PHOTONICS REVIEWS
(2021)
Article
Spectroscopy
Yafei Li, Ling Yu, Chuantao Zheng, Zhuo Ma, Shuo Yang, Fang Song, Kaiyuan Zheng, Weilin Ye, Yu Zhang, Yiding Wang, Frank K. Tittel
Summary: In this study, a mid-infrared carbon monoxide (CO) and carbon dioxide (CO2) dual-gas sensor system was developed for early fire detection and location. The performance of the sensor system was evaluated through experiments, and a method of early fire detection using the concentration ratio between CO and CO2 as the key alarm parameter was proposed. Additionally, a mobile early fire location method was presented based on gas turbulent diffusion combined with particle swarm optimization.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Acoustics
Erika Toneth Ponce Ayala, Fernanda Alves Dias de Sousa, Jose Dirceu Vollet-Filho, Marlon Rodrigues Garcia, Leonardo de Boni, Vanderlei Salvador Bagnato, Sebastiao Pratavieira
Summary: Sono-photodynamic therapy combines sonodynamic and photodynamic therapy to enhance cancer treatment effectiveness. The results suggest that SPD activity can improve the decay rate of PpIX and induce greater necrosis depth. Further research is needed to fully understand the potential of this protocol.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemical Research Methods
Carla Kirschbaum, Kim Greis, Sandy Gewinner, Wieland Schoellkopf, Gerard Meijer, Gert von Helden, Kevin Pagel
Summary: Tandem mass spectrometry plays a crucial role in elucidating lipid structures, with the coordination of silver ions enabling differentiation of glycerophospholipid isomers. Gas-phase infrared spectroscopy confirms the generation of dioxolane-type fragments from silver-adducted glycerophospholipids, providing qualitative explanations for the fragmentation behaviors of different isomers. This study demonstrates the significant contribution of gas-phase IR spectroscopy to understanding lipid dissociation mechanisms and the effects of coordinating cations.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kim Greis, Carla Kirschbaum, Martin I. Taccone, Michael Goetze, Sandy Gewinner, Wieland Schoellkopf, Gerard Meijer, Gert von Helden, Kevin Pagel
Summary: mRNA-based vaccines have become crucial during the COVID-19 pandemic. This study investigates the mechanism of backbone cleavage of RNA strands and the tautomerization of cytosine in the gas phase using experimental and theoretical approaches. The findings have important implications for the development and analysis of mRNA vaccines.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Physics, Applied
Richarda Niemann, Soeren Wasserroth, Guanyu Lu, Sandy Gewinner, Marco De Pas, Wieland Schoellkopf, Joshua D. Caldwell, Martin Wolf, Alexander Paarmann
Summary: In this work, super-resolution microscopy in the long-wave infrared range is demonstrated using IR-visible sum-frequency generation. Enhanced spatial resolution and differentiation of different polariton modes within nanostructures are achieved.
APPLIED PHYSICS LETTERS
(2022)
Article
Multidisciplinary Sciences
Jinhyeong Jang, Chan Beum Park
Summary: This study discovered the dissociation function of magnetoelectric nanomaterials for Aβ aggregates under low-frequency magnetic field and confirmed their alleviating effect on Aβ-associated toxicity. The high efficacy of BCFO nanoparticles for the clearance of Aβ plaques in an AD mouse model was also demonstrated, indicating the potential of magnetoelectric materials for future AD treatment using magnetic fields.
Article
Nanoscience & Nanotechnology
Jinhyeong Jang, Chan Beum Park
Summary: A study has found that linnaeite mineral can dissociate Alzheimer's beta-amyloid oligomers under near-infrared light irradiation, suggesting its potential as a drug for reducing AD pathology.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jinhyeong Jang, Yonghan Jo, Chan Beum Park
Summary: In this study, the photoacoustic dissociation of beta-amyloid (Afl) aggregates, a hallmark of Alzheimer's disease, by metal-organic framework derived carbon (MOFC) was reported. MOFC exhibited near-infrared (NIR) light-responsive photoacoustic characteristic and successfully transformed toxic Afl aggregates into nontoxic debris.
Article
Chemistry, Physical
Jeehoon Shin, Calvin Andreas Hutomo, Jinhyun Kim, Jinhyeong Jang, Chan Beum Park
Summary: This research presents an eco-friendly approach to synthesize highly photocatalytic metal oxides using sporopollenin exine capsules as a template. The metal oxides synthesized on the surface of pollen maintain their unique morphology and show excellent performance in organic pollutants degradation under visible light.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Li Zi-Yu, Francine Horn, Li Yao, Mou Li-Hui, Wieland Schoellkopf, Chen Hui, He Sheng-Gui, Knut R. Asmis
Summary: In this study, we investigated cluster-mediated C-N bond formation in the gas phase using N-2 as a nitrogen source. The V3C++N-2 reaction was studied using ion-trap mass spectrometry and infrared photodissociation spectroscopy, and the proposed reaction mechanism was validated by identifying the structures of the reactant and product ions. The resulting metal nitride product exhibited characteristic C=N double bond and V-N single bond stretching bands.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Carla Kirschbaum, Reuben S. E. Young, Kim Greis, Jan Philipp Menzel, Sandy Gewinner, Wieland Schoellkopf, Gerard Meijer, Gert von Helden, Tim Causon, Venkateswara R. Narreddula, Berwyck L. J. Poad, Stephen J. Blanksby, Kevin Pagel
Summary: 3-pyridylcarbinol ester derivatization allows for the acquisition of gas-phase infrared spectra of individual lipids, enabling discrimination between isomers and structural assignment of fatty acids. This technique is compatible with conventional chromatography-mass spectrometry and has the potential to uncover new pathways in lipid metabolism.
Article
Materials Science, Multidisciplinary
Injun Lee, Cheolmin Park, Tae Soo Kim, Minsoo Kang, Hyeongyeol Oh, Jinhyeong Jang, Jungjae Park, Jong Min Yuk, Hohjai Lee, Chan Beum Park, Sung-Yool Choi, Kibum Kang, Wonryung Lee, Byeong-Soo Bae
Summary: Upconversion nanoparticles (UCNPs) are encapsulated with a siloxane polymer (UCNP@SiOx) through a sol-gel process, enabling water stability and photo-patternability. The UCNP@SiOx demonstrates no significant decrease in upconversion photoluminescence (PL) intensities and PL decay time after immersion in water, and is found to be non-toxic. Integration of UCNP@SiOx with MoS2 phototransistors results in enhanced responsivity and specific detectivity, as well as excellent mechanical durability. This work introduces a facile synthesis method for water-stable and photo-patternable siloxane-encapsulated UCNPs and a strategy for fabricating high-performance flexible NIR phototransistors through wavelength conversion.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Seungwan Kim, Joohyuk Kang, Injun Lee, Jinhyeong Jang, Chan Beum Park, Wonryung Lee, Byeong-soo Bae
Summary: Ecoflex is widely used in bioelectronics due to its low modulus and large stretchability. Conventional patterning strategies for Ecoflex lack sufficient quality and process compatibility, so we propose a method of patterning Ecoflex by developing Photo-patternable Ecoflex (PPE). The PPE layer effectively dissipates strain energy, resulting in increased electrical conductance under strain. We fabricated intrinsically stretchable multi-sensors using PPE, which can monitor bio-signals in sweat and maintain durability under strain.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Chemistry, Inorganic & Nuclear
David Yubero Valdivielso, Christian Kerpal, Wieland Schoellkopf, Gerard Meijer, Andre Fielicke
Summary: A series of saturated ruthenium cluster carbonyls have been synthesized and characterized by infrared spectroscopy. Their size-specific IR spectra in the regions of carbonyl stretch vibration and Ru-C-O bending modes are obtained. The structures of these cluster carbonyls are assigned based on density functional calculations. Different activated CO ligands are identified in these cationic cluster carbonyls, ranging from terminal ligands to symmetrically bridging CO ligands with varying degrees of interaction with additional Ru atoms.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Martin I. Taccone, Daniel A. Thomas, Katja Ober, Sandy Gewinner, Wieland Schoellkopf, Gerard Meijer, Gert von Helden
Summary: Hydrogen bonding interactions play a crucial role in the stability and properties of complex molecular systems, with carboxylic acid groups being common participants. This study focuses on the deprotonated formic acid trimer and investigates its gas-phase conformer and vibrational features through experimental and computational analysis. The results suggest that the prevalent conformer exhibits a planar structure resembling the crystalline structure of formic acid under the experimental conditions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Lee Yeong Kim, Sanghwan Park, Chang Young Lee, Wieland Schollkopf, Bum Suk Zhao
Summary: We report a method to enhance the elastic and coherent reflection of helium clusters from a solid surface under grazing incidence conditions. The use of multiple-edge diffraction enables a higher reflection probability and provides evidence of the coherent and elastic nature of scattering.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Chang Heon Lee, Seuk Young Song, You Jung Chung, Eun Kyoung Choi, Jinhyeong Jang, Dai Heon Lee, Hae Dong Kim, Dong-Uk Kim, Chan Beum Park
Summary: Researchers have developed a photoactivated antimicrobial therapy using a light-responsive carbon dot-embedding hydrogel. The hydrogel releases carbon dots, which possess photodynamic capabilities, to inhibit the growth of infectious bacteria in vitro and accelerate the healing of infected wounds in vivo.
ACS APPLIED BIO MATERIALS
(2022)