Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 1, Pages 381-388Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b11077
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Funding
- Irish Research Council (IRC)
- School of Chemistry TCD
- Science Foundation Ireland (SFI) [10/IN.1/B2999, 13/IA/1865]
- Science Foundation Ireland (SFI) [10/IN.1/B2999] Funding Source: Science Foundation Ireland (SFI)
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Herein we present a supramolecular (delayed luminescent) Eu(III)-based pH-responsive probe/sensor with the ability to detect the urease-mediated hydrolysis of urea in aqueous solution. A series of photophysical titrations show this Eu(III) chelate behaves as an on-off luminescent switching probe, with its luminescence being quenched upon urea being enzymatically converted into ammonia and carbon dioxide. Calculation of the rate constant (k) and activation energy (Ea) for this hydrolysis reaction are detailed; the results demonstrate a direct observation of enzymatic activity in solution by the sensor. The potential application of this probe in detecting the onset of catheter-associated urinary tract infections (CAUTIs) is also demonstrated by incorporating 1.Eu into water-permeable hydrogels that can be utilized as an alternative coating for catheters.
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