Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 138, Issue 23, Pages 7268-7271Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b03899
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Funding
- NIH [GM105766]
- Eli Lilly
- Novartis
- Bristol-Myers Squibb
- Amgen
- Boehringer-Ingelheim
- Sloan Foundation
- Baxter Foundation
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7,20-Diisocyanoadociane, a scarce marine metabolite with potent antimalarial activity, was synthesized as a single enantiomer in 13 steps from simple building blocks (17 linear steps). Chemical synthesis enabled identification of isocyanoterpene antiplasmodial activity against liver-stage parasites, Which suggested that inhibition of heme detoxification does not exclusively underlie the mechanism of action of this class.
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