Article
Biochemistry & Molecular Biology
Fuyuan Xie, Longgen Li, Yuting Luo, Rensheng Chen, Jinhong Mei
Summary: This study identified LINC00488 as an oncogenic gene in thyroid cancer, which promoted proliferation, migration, and invasion while inhibiting apoptosis of cancer cells. LINC00488 was found to regulate the miR-376a-3p/PON2 axis, suggesting a potential novel biomarker or target for thyroid cancer treatment.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Yang Liu, Xiaotong Zhao, Bing Wang, Zhijia Liu, Manman Zhang, Jinhan Wang, Chang Xu, Yan Wang, Liqing Du, Feng Wang, Qin Wang, Qiang Liu
Summary: CTC1 is a crucial component of the mammalian CST complex and plays essential roles in resolving replication issues and facilitating DNA replication. The study demonstrated that miR-376a significantly reduced CTC1 expression and induced telomere dysfunction, leading to poor outcomes in rectum adenocarcinoma patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Liguo Zhang, Ping Zhang, Tonggang Liu, Dongmei Li, Xianxian Liu
Summary: circ_0006404 is overexpressed in hepatocellular carcinoma (HCC) and promotes HCC cell growth, cycle, and migration. It functions by regulating the expression of miR-624. These findings suggest that circ_0006404 may serve as a new biomarker for HCC.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Minyong Chen, Huaxiang Wang, Songchang Shi, Hui Zhang, Shaohua Xu, Yi Jiang
Summary: This study found that the expression of miR-6071 was decreased in liver cancer stem cells (LCSCs). Overexpression of miR-6071 inhibited self-renewal and tumorigenesis of LCSCs, as well as proliferation and migration of hepatocellular carcinoma (HCC) cells. The study also revealed that miR-6071 targeted the 3’UTR of PTPN11 mRNA and that upregulation of miR-6071 sensitized HCC cells to lenvatinib treatment. Clinical analysis showed that HCC patients with high miR-6071 expression had better survival outcomes with postoperative lenvatinib treatment.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Bo Feng, Ke Chen, Weiwei Zhang, Qi Zheng, Yong He
Summary: The study revealed the critical role of circPGAM1 in drug resistance of laryngocarcinoma, mediated through miR-376a. Additionally, autophagy-related gene ATG2A was shown to impact drug resistance in laryngocarcinoma cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Hua Li, Bingli Liu, Xin Xu, Shunle Li, Di Zhang, Qingfeng Liu
Summary: This study revealed the regulatory role of circ_SNX27 in hepatocellular carcinoma (HCC) development through the miR-637/FGFR1 axis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Diane Frankel, Valerie Delecourt, Elva-Maria Novoa-Del-Toro, Jerome D. Robin, Coraline Airault, Catherine Bartoli, Aurelie Carabalona, Sophie Perrin, Kilian Mazaleyrat, Annachiara De Sandre-Giovannoli, Frederique Magdinier, Anais Baudot, Nicolas Levy, Elise Kaspi, Patrice Roll
Summary: In this study, miRNA expression profiles were evaluated in HGPS and control fibroblasts, and an enrichment of overexpressed miRNAs belonging to the 14q32.2-14q32.3 miRNA cluster was identified. Using 3D FISH, it was demonstrated that the overexpression of these miRNAs is associated with chromatin remodeling at a specific locus in HGPS fibroblasts. Furthermore, the overexpression of miR-376b-3p and miR-376a-3p in HGPS fibroblasts was found to decrease cell proliferation and increase senescence, while their inhibition rescued these defects and decreased progerin accumulation. These findings suggest that these miRNAs may play a crucial role in the pathophysiology of HGPS.
Article
Oncology
Masamichi Hayashi, Suguru Yamada, Keisuke Kurimoto, Hiroshi Tanabe, Sho Hirabayashi, Fuminori Sonohara, Yoshikuni Inokawa, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera
Summary: miR-23b-3p is found to function as an oncogenic microRNA in HCC cell lines. Overexpression of miR-23b-3p in resected HCC tissues is a significant prognostic factor of overall survival. Both MICU3 and AUH may be candidate gene targets of miR-23b-3p.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zhao Yang, Lei Zhang, Jianwei Liu, Lixue Yang, Hui Xue, Shilei Bai, Kui Wang
Summary: The study showed that PD-L1 expression is upregulated in hepatocellular carcinoma (HCC) and positively correlated with HDAC9 and HDAC2 expression. High levels of PD-L1 combined with increased expression of HDAC9 decreased overall survival in HCC patients. Moreover, HDAC9 overexpression promoted HCC growth and PD-L1 expression.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Thorben Fruendt, Linda Krause, Elaine Hussey, Bettina Steinbach, Daniel Koehler, Johann von Felden, Kornelius Schulze, Ansgar W. Lohse, Henning Wege, Heidi Schwarzenbach
Summary: Exosomes carrying small non-coding RNA, particularly miR-16, miR-146a, miR-192, and miR-221, appear to be promising diagnostic and prognostic markers for hepatocellular carcinoma (HCC) and liver cirrhosis patients. MiR-146a showed potential as a diagnostic marker for distinguishing HCC patients from liver cirrhosis patients, while miR-192 independently correlated with overall survival in HCC patients.
Article
Oncology
Tingting Lu, Tao Han, Mingfang Zhao
Summary: miR-3168 is increased in liver cancer stem cells (CSCs) and inhibits CSC expansion by targeting p53 directly. Additionally, miR-3168 may be a predictor of survival benefits from transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. The study uncovers a novel mechanism of liver CSC regulation and provides a potential therapeutic target for liver CSCs.
Article
Oncology
Yuan Wei, Lai Wei, Tao Han, Shuang Ding
Summary: This study reveals the elevated expression of miR-3154 in hepatocellular carcinoma (HCC) and its association with patient survival. Inhibiting miR-3154 suppresses self-renewal, proliferation, metastasis, and tumorigenesis of HCC cells. The mechanism involves the direct targeting of HNF4 alpha by miR-3154. Furthermore, miR-3154 may predict the clinical benefit of lenvatinib treatment in HCC patients.
Article
Genetics & Heredity
Shuying Chen, Zile Fu, Shuzhan Wen, Xiaoyi Yang, Chengxuan Yu, Wenhan Zhou, Yong Lin, Yuan Lv
Summary: miR-497 and miR-1246 may serve as biomarkers in HCC by regulating target genes involved in the progression of the disease. Their expression levels are significantly associated with prognosis and diagnosis of HCC.
FRONTIERS IN GENETICS
(2021)
Article
Engineering, Chemical
Khawlah W. Al-Bakr, Abdullah M. Alzahrani, Emad A. Ahmed
Summary: This study investigated the biochemical and immunological changes in the blood and brain of diabetic mothers and their offspring, as well as the expression levels of miRNAs. The results showed that newborn pups suffered from oxidative stress conditions similar to their mothers, while 5-week-old offspring exhibited increased levels of proinflammatory cytokines. The expression levels of miRNAs were mostly similar between diabetic mothers and newborn pups, but differed in offspring at puberty age.
Article
Biochemistry & Molecular Biology
Marta Gil-Martinez, Clara Lorente-Sorolla, Jose M. Rodrigo-Munoz, Sara Naharro, Zahara Garcia-de Castro, Joaquin Sastre, Marcela Valverde-Monge, Santiago Quirce, Maria L. Caballero, Jose M. Olaguibel, Victoria del Pozo
Summary: Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Mengjiao Cai, Xin Liang, Xiao Sun, Huan Chen, Yiping Dong, Lingzhi Wu, Suxi Gu, Suxia Han
FRONTIERS IN ONCOLOGY
(2019)
Article
Medicine, Research & Experimental
Shoujian Ji, Huan Chen, Keyan Yang, Guanxiong Zhang, Beibei Mao, Ying Hu, Henghui Zhang, Jianming Xu
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Oncology
Yong Wang, Dandan Liang, Jimin Chen, Huan Chen, Rui Fan, Ye Gao, Yongsheng Gao, Rongjie Tao, Henghui Zhang
Summary: This case study suggests that FGFR3-TACC3 fusion could be a new indication for treating recurrent glioblastoma with anlotinib. The patient showed an exceptional response (maintained partial response >17 months) after a 2-month combined therapy of anlotinib and oral temozolomide chemotherapy. The importance of molecular diagnosis for clinically complex cases is highlighted in this case.
Article
Oncology
Zhihao Lu, Huan Chen, Xi Jiao, Wei Zhou, Wenbo Han, Shuang Li, Chang Liu, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yanyan Li, Jie Li, Yan Li, Malcolm Brock, Henghui Zhang, Lin Shen
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Zhihao Lu, Huan Chen, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Lihong Wu, Jianing Yu, Wenbo Han, Huaibo Sun, Xi Jiao, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, Lin Shen
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Gastroenterology & Hepatology
Haibei Xin, Dandan Liang, Minfeng Zhang, Dandan Ren, Huan Chen, Hao Zhang, Shanshan Li, Guanghui Ding, Cunzhen Zhang, Zhiwen Ding, Lihong Wu, Wenbo Han, Wei Zhou, Yanhui Chen, Hongli Luo, Yating Wang, Henghui Zhang, Shupeng Liu, Nan Li
Summary: The distribution pattern of TILs in HCC patients is associated with prognosis, with higher CD68/CD8 ratio correlating with poorer outcomes. CD68+ macrophages and CD8+ T-cells are important immunological determinants for HCC prognosis.
Article
Oncology
Xiaoli Liu, Jilin Lu, Guanxiong Zhang, Junyan Han, Wei Zhou, Huan Chen, Henghui Zhang, Zhiyun Yang
Summary: A machine learning algorithm incorporating clinical characteristics, laboratory parameters, and peripheral immune signatures has been developed to predict the risk of HCC-related death. The model showed high concordance indexes in the training and validation sets and successfully categorized patients into high, medium, and low-risk subgroups.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Chuanhua Zhao, Lihong Wu, Dandan Liang, Huan Chen, Shoujian Ji, Guanxiong Zhang, Keyan Yang, Ying Hu, Beibei Mao, Tianshu Liu, Yiyi Yu, Henghui Zhang, Jianming Xu
Summary: This study identified a refined checkpoint signature as a potential biomarker for anti-PD-1/PD-L1 monotherapy in gastrointestinal cancers by analyzing plasma samples from ICB-treated patients. The checkpoint signature and T-cell trafficking signature were associated with therapeutic efficacy, and higher levels of these signatures correlated with improved overall survival and progression-free survival in both cohorts.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Yipeng Song, Jian Huang, Dandan Liang, Ying Hu, Beibei Mao, Qiujing Li, Huaibo Sun, Ying Yang, Jiao Zhang, Henghui Zhang, Huan Chen, Hao Liu, Shukun Zhang
Summary: Research suggests that mutations in DDR genes are common in CRC patients and are associated with improved overall survival. DDR mutations are also linked to higher tumor mutational burden, increased immune cell infiltration, and immune checkpoint molecule expression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xi Jiao, Xin Wei, Shuang Li, Chang Liu, Huan Chen, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yujiao Wang, Yanni Wang, Na Zhuo, Henghui Zhang, Zhihao Lu, Lin Shen
Summary: The study analyzed the genomic profile of gastrointestinal cancer patients treated with immunotherapy and constructed a gastrointestinal immune prognostic signature. These findings demonstrated that GIPS was a powerful predictor of immunotherapeutic survival and may serve as a potential biomarker guiding immunotherapy treatment decisions.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Yanni Wang, Huan Chen, Xi Jiao, Lihong Wu, Ying Yang, Jiao Zhang, Lijia Wu, Chang Liu, Na Zhuo, Shuang Li, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Jie Li, Yan Li, Zhihao Lu, Henghui Zhang, Lin Shen
Summary: The study found that mutations in the PTCH1 gene are associated with the response of colorectal cancer (CRC) patients to immunotherapy, with PTCH1 mutation subgroup patients having better prognosis and clinical benefit rate. PTCH1-mutated tumors have more diverse anti-tumor immune signatures and higher proportions of immune cell infiltration compared to PTCH1 wild-type tumors.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Yuan Zhou, Xinying Shi, Huan Chen, Beibei Mao, Xue Song, Lingling Gao, Jiao Zhang, Ying Yang, Henghui Zhang, Guo Wang, Wei Zhuang
Summary: In LUAD patients, late recurrence may be associated with antigen presentation, MHC protein complex, and IFN-gamma signaling, while immune cell infiltration could serve as prognostic indicators. Transcriptome data analysis revealed the potential value of two DEGs in prognostic assessment.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Genetics & Heredity
Zhihao Lu, Huan Chen, Xi Jiao, Yujiao Wang, Lijia Wu, Huaibo Sun, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Keyan Yang, Ying Hu, Beibei Mao, Lei Zhang, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, Lin Shen
Summary: The study retrospectively analyzed genomic profiling data from metastatic GI cancer patients and found that HLA-B evolutionary divergence was associated with overall survival. High HLA-B evolutionary divergence was linked to better overall survival, with a potential utility as a combinatorial biomarker together with tumor mutational burden (TMB) for patient stratification.
Article
Oncology
Yujiao Wang, Xi Jiao, Shuang Li, Huan Chen, Xin Wei, Chang Liu, Jifang Gong, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yanni Wang, Na Zhuo, Jianling Zou, Henghui Zhang, Jian Li, Lin Shen, Zhihao Lu
Summary: The study found that DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICI treatment, which could serve as a potential biomarker to guide patient selection for immunotherapy.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Yue Fan, Haifeng Ying, Xueying Wu, Huan Chen, Ying Hu, Henghui Zhang, Lijia Wu, Ying Yang, Beibei Mao, Lan Zheng
CANCER BIOLOGY & MEDICINE
(2020)
