Article
Biochemistry & Molecular Biology
Thanh-Hoa Vo, Chia-Ching Liaw, Yu-Chi Lin, Duc Hanh Nguyen, Thi Tuyet Nhung Nguyen, Ching-Kuo Lee, Yao-Haur Kuo
Summary: This study isolated major flavonoid derivatives from Millettia pulchra radix, developed and validated a HPLC-PDA method for content determination, and optimized the extraction process. The research suggests an effective method for quality control in pharmaceutical development of this species.
Article
Medicine, General & Internal
Alexandra Stroda, Carina Jaekel, Rene M'Pembele, Alexander Guenther, Theresa Tenge, Carl Maximilian Thielmann, Simon Thelen, Erik Schiffner, Dan Bieler, Michael Bernhard, Ragnar Huhn, Giovanna Lurati Buse, Sebastian Roth
Summary: This study investigated the association between myocardial injury at presentation in severe trauma patients and the incidence of in-hospital major adverse cardiac events (MACE) and acute kidney injury (AKI). The results showed that myocardial injury was independently associated with the incidence of MACE and AKI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yan Li, Qing Meng, Ling Wang, Yongjian Cui
Summary: The study revealed that TRIM27 plays a critical role in myocardial ischemia/reperfusion, and its deletion accelerates infarction size and cardiac dysfunction while exacerbating apoptosis and inflammatory response. The interaction between TRIM27 and p53 may be involved in regulating the physiological state of cardiomyocytes in response to ischemic injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongbin Liang, Qiuxia Zhang, Yiting Gao, Guojun Chen, Yujia Bai, Yanan Zhang, Kai Cui, Qiancheng Wang, Shiping Cao, Yuqing Hou, Heye Zhang, Dhijnoo N. Ghista, Xiujian Liu, Jiancheng Xiu
Summary: This study aims to evaluate the diagnostic accuracy of a novel Angio-FFR analysis that considers the side branch flow based on the bifurcation fractal law. The results showed that our method had comparable diagnostic accuracy to FFR_s and provided significantly higher diagnostic accuracy than that of FFR_n. Our Angio-FFR analysis demonstrated good diagnostic performance by compensating for side branch flow using the bifurcation fractal law.
EUROPEAN RADIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Meihua Ji, Jing Cheng, Daimin Zhang
Summary: This study investigated the effects of Oxycodone on myocardial ischemia-reperfusion (I/R) injury and its mechanisms related to SIGMAR1. The results showed that Oxycodone alleviated myocardial I/R injury in vivo and in vitro by binding to SIGMAR1, resulting in decreased ischemic area, improved myocardial function, and enhanced endothelial integrity.
Article
Plant Sciences
Qian Zhang, Yuan-Ye Dang, Xiu Luo, Ji-Jun Fu, Zhi-Cong Zou, Xue-Jing Jia, Guo-Dong Zheng, Chu-Wen Li
Summary: Kazinol B (KB), an isoprenylated flavan derived from Broussonetia kazinoki Sieb. (Moraceae) root, has protective effects on hypoxia and reoxygenation-induced cardiac injury in H9c2 rat cardiac myoblasts, and its mechanism involves modulating the AKT and AMPK-mediated Nrf2 induction.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Pathology
Juthipong Benjanuwattra, Nattayaporn Apaijai, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Kannaporn Intachai, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: In a model of myocardial ischemia/reperfusion injury, the timing of erythropoietin (EPO) administration was found to have varying effects on cardioprotection. EPO given during ischemia or reperfusion was shown to attenuate arrhythmia, improve cardiac function, reduce infarct size and apoptosis.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Bradley R. Lewis, Ramila A. Mehta, Olatunde Ola, Jonathan D. Knott, Laura De Michieli, Ashok Akula, Ronstan Lobo, Eric H. Yang, S. Michael Gharacholou, Marshall Dworak, Erika Crockford, Nicholas Rastas, Eric Grube, Swetha Karturi, Scott Wohlrab, David O. Hodge, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe
Summary: Using a single hs-cTnT below the limit of quantitation of 6 ng/L is a safe and rapid method to identify a substantial number of patients at very low risk for acute myocardial injury and infarction.
Article
Cardiac & Cardiovascular Systems
Luyan Yao, Funan He, Quanyi Zhao, Dandan Li, Shufang Fu, Mingzhi Zhang, Xingzhong Zhang, Bingying Zhou, Li Wang
Summary: Imaging mass cytometry was used to characterize the spatial distribution and dynamics of cell phenotypes and communities in the mouse left ventricle following myocardial infarction. H3K9me3 in endothelial cells was identified as a potential therapeutic target for alleviating pathological remodeling of the heart after ischemia-reperfusion injury.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Philipp Schuette, Mailin-Christin Manke, Katherina Hemmen, Patrick Muenzer, Barbara F. Schoerg, Gustavo Campos Ramos, Michaela Pogoda, Valerie Dicenta, Sabrina H. L. Hoffmann, Juergen Pinnecker, Ferdinand Kollotzek, Monika Zdanyte, Karin A. L. Mueller, Yogesh Singh, Andreas F. Mack, Bernd Pichler, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Katrin G. Heinze, Nicolas Casadei, Oliver Borst
Summary: Platelet-derived miRNAs play a critical role in myocardial inflammation and structural remodeling in response to myocardial ischemia/reperfusion (I/R). In a mouse model with a Dicer gene deletion, disrupted miRNA processing machinery in platelets led to increased myocardial inflammation, impaired angiogenesis, accelerated cardiac fibrosis, and larger infarct size. These findings highlight the importance of platelet-derived miRNA in regulating cellular processes following myocardial I/R.
CIRCULATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Virayu Suthiphasilp, Narawadee Rujanapun, Pakit Kumboonma, Boonyanoot Chaiyosang, Sarawut Tontapha, Tharakorn Maneerat, Brian O. Patrick, Raymond J. Andersen, Thidarat Duangyod, Rawiwan Charoensup, Surat Laphookhieo
Summary: A phytochemical investigation of the root and leaf extracts of Millettia pachycarpa Benth led to the isolation and identification of 16 compounds. These compounds were evaluated for their antidiabetic and cytotoxic activities, and some of them showed promising results.
Article
Pathology
Wichida Kaorop, Chayodom Maneechote, Sirinart Kumfu, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Obesity is a common health problem worldwide, and mitochondrial dysfunction is suggested to be a potential mechanism for its progression. Recent studies have shown that mitochondrial-derived peptides (MDPs) have the potential to improve metabolic function and treat obesity-associated diabetes and heart pathologies. This review comprehensively summarizes the roles of MDPs in metabolic pathways and their use in treating adverse effects of obesity based on evidence from in vitro, in vivo, and clinical studies.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiuli Cheng, Jin Hu, Xiaofeng Liu, Jonnea Japhet Tibenda, Xiaobo Wang, Qipeng Zhao
Summary: Traditional Chinese medicine plays a significant role in treating ischemic cardiovascular and cerebrovascular diseases by inhibiting apoptosis. More research is needed on the pharmacodynamic ingredients of TCM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Peng Yu, Shuai Song, Xiaokai Zhang, Shujun Cui, Gang Wei, Zihang Huang, Linqi Zeng, Ting Ni, Aijun Sun
Summary: This study revealed the regulatory mechanism of APA in post-MI HF and identified the potential therapeutic effect of the APA-regulated gene AVEN in treating HF.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Sureshbabu Mangali, Audesh Bhat, Deepika Dasari, Dharmarajan Sriram, Arti Dhar
Summary: Protein kinase R (PKR) inhibition attenuated myocardial dysfunction, cardiac fibrosis, oxidative/nitrosative stress, inflammation, cell death, and interrelated signalling pathways in a myocardial ischemia model. Inhibition of PKR improved ischemia-mediated inflammation, apoptosis, cardiac hypertrophy, and fibrosis, suggesting it as a potential intervention therapy for myocardial ischemia.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)