Article
Pharmacology & Pharmacy
He Li, Linling Liu, Hong-ying Chen, Ru-li Li, Jie Lan, Kun-yue Xue, Xue Li, Cai-li Zhuo, Lan Lin, Ling-yu Li, Zhuang Wu, Die Zhang, Xue-mei Wang, Wen-jing Huang, Yingling Wang, Wei Jiang, Liming Zhou
Summary: Mogrol, a chemotherapy drug, effectively suppresses lung cancer cells by inducing excessive autophagy and autophagic cell death via activating the AMPK signaling pathway, as well as cell cycle arrest and apoptosis via activating the p53 pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Jeong-Geon Mun, Yo-Han Han, Hee-Dong Jeon, Dae Hwan Yoon, Yeong Gyeong Lee, Seung-Heon Hong, Ji-Ye Kee
Summary: The study demonstrated that gallotannin (GT) can inhibit lung metastasis of metastatic colorectal cancer cells by inducing apoptosis, cell cycle arrest, and autophagic cell death, as well as regulating PI3K/AKT/mTOR and AMPK signaling pathways. GT also suppresses migration and invasion of CRC cells by inhibiting the expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9, and downregulating mesenchymal markers including snail, twist, and vimentin.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Plant Sciences
Hee Dong Jeon, Yo-Han Han, Jeong-Geon Mun, Dae Hwan Yoon, Yeong Gyeong Lee, Ji-Ye Kee, Seung-Heon Hong
Summary: The study found that dehydroevodiamine (DHE) has potential therapeutic effects on lung metastasis of colorectal cancer (CRC) and proliferation of CRC cells. DHE suppresses cell viability, induces apoptosis and autophagy, and regulates cell migration and invasion.
Article
Medicine, Research & Experimental
Linhai Zhu, Ying Wang, Wang Lv, Xiao Wu, Hongxu Sheng, Cheng He, Jian Hu
Summary: This study demonstrates that Schizandrin A (SchA) can inhibit the viability and proliferation of non-small cell lung cancer (NSCLC) cells by inducing cell cycle arrest and apoptosis. Additionally, SchA partially induces autophagy, although it does not result in cytoprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Plant Sciences
Matheus Scherer Bastos, Rafaela Mallmann Saalfeld, Bruna Pasqualotto Costa, Maria Claudia Garcia, Krist Helen Antunes, Ketlin Fernanda Rodrigues, Denizar Melo, Eliane Romanato Santarem, Jarbas Rodrigues de Oliveira
Summary: This study aimed to use the ethanolic extract and fractions of Moquiniastrum polymorphum subsp. polymorphum in the treatment of hepatic fibrosis, and the results suggest a potential therapeutic effect against liver fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Junkui Li, Peili Zhu, Yifei Chen, Shiqing Zhang, Zhu Zhang, Zhang Zhang, Ying Wang, Xiaoli Jiang, Kaili Lin, Wei Wu, Zhixian Mo, Stephen Cho Wing Sze, Ken Kin Lam Yung
Summary: Colorectal cancer (CRC) can be effectively inhibited by Isoalantolactone (IATL) through regulating cell cycle, apoptosis, and autophagy in vitro and in vivo. Mechanistic studies revealed that IATL induces cytoprotective autophagy in CRC cells by inhibiting the AKT/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Haini Wang, Junli Zuo
Summary: Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. Result showed that shikonin inhibited the NSCLC H1299 cell proliferation in a dose-dependent manner. Moreover, shikonin fits well with survivin by molecular docking. Shikonin also inhibited the mRNA expression and protein level of survivin in H1299 cells. Shikonin arrested H1299 cell cycle at the G0/G1 phase by regulating CDK/cyclin family members. In addition, shikonin regulated the expression of X-linked inhibitor of apoptosis- (XIAP-) mediated caspases 3 and 9, thus leading to the damage of mitochondrial membrane potential and induction of H1299 cell apoptosis. Overall, shikonin inhibited H1299 cell growth by inducing apoptosis and blocking the cell cycle. The underlying mechanism involves targeting survivin, which subsequently regulates the protein expression of XIAP/caspase 3/9, CDK2/4, and cyclin E/D1. Thus, shikonin, a survivin inhibitor, is a promising therapeutic strategy in NSCLC treatment.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Rebecca Caeser, Christopher Hulton, Emily Costa, Vidushi Durani, Megan Little, Xiaoping Chen, Sam E. Tischfield, Marina Asher, Faruk Erdem Kombak, Shweta S. Chavan, Nisargbhai S. Shah, Metamia Ciampricotti, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen
Summary: Activation of the mitogenic signaling pathway plays a significant role in lung cancer, particularly in small cell lung cancer. Research suggests that the most common subtype of SCLC, SCLC-A, is selectively sensitive to MAPK activation, potentially inhibiting proliferation through inducing cell cycle arrest and senescence.
Article
Biochemistry & Molecular Biology
Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin, Liangcheng Zheng
Summary: ZNF674-AS1 expression is decreased in NSCLC compared to normal tissues, and its downregulation is significantly correlated with advanced TNM stage and decreased overall survival of NSCLC patients. ZNF674-AS1 inhibits NSCLC cell proliferation, colony formation, and tumorigenesis, accompanied by G0/G1 cell cycle arrest, through upregulation of p21 and downregulation of miR-423-3p. This study suggests the therapeutic potential of ZNF674-AS1 in NSCLC treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Infectious Diseases
Anchalee Rawangkan, Pattama Wongsirisin, Grissana Pook-In, Achiraya Siriphap, Atchariya Yosboonruang, Anong Kiddee, Jureeporn Chuerduangphui, Nanthawan Reukngam, Acharaporn Duangjai, Surasak Saokaew, Ratsada Praphasawat
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), is a complex disease. The study aimed to evaluate the new function of dinactin in anti-NSCLC proliferation. The results showed that dinactin suppressed cell growth and reduced cancer stemness properties in NSCLC cells, suggesting its potential as a promising strategy for NSCLC therapy targeting cancer stem cells.
Article
Pharmacology & Pharmacy
Bingjie Fu, Xiaojing Dou, Miao Zou, Hao Lu, Kaixuan Wang, Qingxia Liu, Yao Liu, Wei Wang, Meihua Jin, Dexin Kong
Summary: Amlodipine can suppress lung cancer cell proliferation by modulating multiple signaling pathways and protein expression, and it shows a good therapeutic effect when used alone or in combination with gefitinib.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Wenfeng Gou, Xiaojun Yu, Shaohua Wu, Hongying Wu, Huajie Chang, Leyuan Chen, Huiqiang Wei, Changfen Bi, Hongxin Ning, Yingliang Wu, Wenbin Hou, Daiying Zuo, Yiliang Li
Summary: This study investigated the impact of AND-1 on the radiosensitivity of non-small cell lung cancer (NSCLC) and found that AND-1 inhibition significantly increased the radiosensitivity of NSCLC cells, likely by regulating the cell cycle and enhancing DNA damage.
Article
Biochemistry & Molecular Biology
Reihaneh Fatehi, Marzieh Rashedinia, Amin Reza Akbarizadeh, Mozhdeh Zamani, Negar Firouzabadi
Summary: This study investigated the effect of metformin in combination with resveratrol and cisplatin on MCF-7 cells. The results showed that metformin inhibited cell proliferation, while resveratrol suppressed proliferation through induction of apoptosis and cell cycle arrest. The triple combination of metformin, resveratrol, and cisplatin exhibited a significant inhibitory effect through the induction of autophagy-mediated cell death, apoptosis, and cell cycle arrest. These findings support the anti-cancer properties of metformin and resveratrol, and suggest their potential synergistic effects in combination therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Senlin Qin, Huijun Geng, Guoyan Wang, Lei Chen, Chao Xia, Junhu Yao, Zhangzhen Bai, Lu Deng
Summary: Suffruticosol C from peony seeds induces autophagy and cell cycle arrest, possibly regulating cancer cell viability by inhibiting mTORC1 signaling.
Article
Oncology
Fuyan Xu, Huizhi Xi, Mengya Liao, Yiqian Zhang, Hongbo Ma, Mengling Wu, Qiang Xue, Hongbao Sun, Yiwen Zhang, Yong Xia
Summary: Chlorpromazine effectively suppresses colorectal cancer by inducing cell cycle arrest and apoptosis. It also inhibits autophagic flux and induces cytotoxic autophagy in cancer cells. Furthermore, it suppresses tumor growth in mouse models and has no effect on the proportions of immune cells.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)