Article
Biochemistry & Molecular Biology
Michelle. T. T. Sun, Matthew Tran, Kuldev Singh, Robert Chang, Huaizhou Wang, Yang Sun
Summary: The rising prevalence of myopia worldwide is raising concerns among clinicians due to its association with severe ocular diseases like glaucoma. Managing glaucoma in patients with high myopia can be challenging, as clinical features and imaging technology may not accurately diagnose the condition, especially in those with normal intraocular pressures. Long-term follow-up and monitoring are crucial in detecting early glaucomatous changes in high-risk myopic patients. This review discusses the complex relationship between myopia and glaucoma, as well as the limitations of current diagnostic protocols.
Article
Ophthalmology
Marta Ibarz Barbera, Laura Morales Fernandez, Pedro Tana Rivero, Rosario Gomez de Liano, Miguel A. Teus
Summary: This study used AS-OCT to analyze the morphological evolution of filtering blebs and their correlation with intraocular pressure after ab externo SIBS microshunt implantation. The results showed significant horizontal and vertical expansion of the blebs, with no significant correlation with the decrease in IOP.
ACTA OPHTHALMOLOGICA
(2022)
Article
Medicine, General & Internal
Jens Julian Storp, Friederike Elisabeth Vietmeier, Ralph-Laurent Merte, Raphael Koch, Julian Alexander Zimmermann, Nicole Eter, Viktoria Constanze Bruecher
Summary: The aim of this study is to report real-world data of a heterogeneous glaucoma cohort who received Preserflo MicroShunt implantation at a specialized glaucoma clinic. The study found that the Preserflo MicroShunt achieved a noticeable reduction in intraocular pressure (IOP) over the course of 12 months in glaucoma patients, irrespective of disease severity or subtype. The frequency of postoperative adverse events and revision surgeries was low over the follow-up period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Noriko Katayama, Naoki Tojo, Mitsuya Otsuka, Atsushi Hayashi
Summary: This study compared the surgical outcomes of Ex-PRESS surgery for primary open-angle glaucoma (POAG) between low preoperative intraocular pressure (IOP) and high preoperative IOP. The results showed that EXP surgery significantly reduced IOP and was particularly effective for patients with low preoperative IOP.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Biology
Muhammad Yaqoob Shahani, Samreen Memon, Shakeel Ahmed Sheikh, Umbreen Bano, Pashmina Shaikh, Samina Gul Memon, Shazia Begum Shahani, Ikram Din Ujjan, Ashok Kumar Narsani, Ali Muhammad Waryah
Summary: This study conducted genetic association analysis on 25 families with primary open-angle glaucoma (POAG) and found a new POAG associated with a variant in the CYP1B1 gene, as well as a POAG associated with a variant in the Myoc gene. This indicates a high genetic heterogeneity among POAG patients in the southern province of Pakistan.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Ophthalmology
Sebastiao Cronemberger, Artur W. Veloso, Christy Veiga, Gustavo Scarpelli, Yara C. Sasso, Rafael Merola
Summary: There were negative correlations between IOP at 6 AM and increment IOP with RNFLT quadrants in POAG patients, while in GS patients, only IOP at 6 AM was negatively correlated with the inferior quadrant. These findings suggest potential risk factors for glaucoma progression.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Yuta Nakaniida, Kana Tokumo, Hiromitsu Onoe, Naoki Okada, Shunsuke Nakakura, Ryo Asaoka, Yoshiaki Kiuchi
Summary: This study compared corneal visualization Scheimpflug technology (CST) parameters between eyes with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). The results showed that the biomechanical properties of the cornea differed between POAG and PACG. In some parts, the axial length differences between the POAG and PACG groups might contribute to the variation in CST parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Xiaobin Xu, Zixuan Liu, Liqiang Wang, Yifei Huang, He Yang
Summary: In this paper, a thin-film integrated optical IOP sensor based on the interferometry principle was designed to read out the IOP value by interference patterns and monitor the value changes real-time. The results showed that our sensor exhibited a sensitivity of 0.19 mu m/mmHg and an average accuracy of 0.84 mmHg over the pressure range of 0-45 mmHg, with the advantage of easier fabrication process and low-cost compared to other optical systems. Our sensor device implies great potential in the application of human physiological index measurement and other chip-integrated medical sensing instruments.
Article
Ophthalmology
Ronnie George, Rashima Asokan, Lingam Vijaya
Summary: This study did not find any association between the effects of metformin on the incidence of POAG after analyzing 4302 participants.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Health Care Sciences & Services
Gabriel Zeno Munteanu, Zeno Virgiliu Ioan Munteanu, Cristian Marius Daina, Lucia Georgeta Daina, Mihaela Cristina Coroi, Carmen Domnariu, Dana Badau, George Roiu
Summary: The aim of this study is to develop a predictive model with several explanatory variables that can guide ophthalmologists to make a more objective assessment of the evolution of open-angle glaucoma (OAG) during tertiary prevention. The study identified possible predictors of OAG using a dichotomous questionnaire tool with a complementary role in tertiary prophylactic activities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Ophthalmology
Elena Bastia, Carol B. Toris, Stefania Brambilla, Corinna Galli, Nicoletta Almirante, Michael V. W. Bergamini, Emanuela Masini, Silvia Sgambellone, Andrea M. Unser, Feryan Ahmed, Karen Y. Torrejon, Tomas Navratil, Francesco Impagnatiello
Summary: NCX 667 demonstrates robust and dose-dependent IOP-lowering effects in multiple animal models, likely resulting from NO-mediated increase of the conventional outflow pathway. Other mechanisms such as changes in AH production and episcleral vein pressure may also contribute to the observed effects.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Peter Szurman, Kevin Gillmann, Anna -Maria Seuthe, H. Burkhard Dick, Esther M. Hoffmann, Andre Mermoud, Marc J. Mackert, Robert N. Weinreb, Harsha L. Rao, Kaweh Mansouri
Summary: The EYEMATE-SC sensor was found to be safe and well tolerated throughout a 12-month period in patients undergoing nonpenetrating glaucoma surgery. It provided accurate and continuous monitoring of intraocular pressure.
Article
Ophthalmology
Maximilian Schultheiss, Bogomil Voykov, Maren Klemm, Ulrich Gross, Heinz-Peter Schultheiss, Martin S. Spitzer, Maria Casagrande
Summary: The study revealed the existence of cellular infiltration inflammation in the distal outflow system posterior of the Schlemm's canal in primary open-angle glaucoma (POAG), which is limited to the area around the collector channels. 92% of biopsies showed positive results, indicating significant diagnostic and therapeutic implications for the treatment of POAG.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Chemistry, Medicinal
Cristina Minnelli, Francesco Piva, Monia Cecati, Tatiana Armeni, Giovanna Mobbili, Roberta Galeazzi, Alberto Melecchi, Martina Cristaldi, Roberta Corsaro, Dario Rusciano
Summary: MID is a synthetic drug that decreases the availability of L-carnitine, which is important for mitochondria energy generation, thus modulating energy metabolism pathways. It has shown protective effects on blood vessels in models of endothelial dysfunction induced by high glucose or hypertension.
Article
Medicine, General & Internal
Justin T. Bradshaw, Telyn Peterson, Lawsen M. Parker, Zeke Richards, Chad J. Skidmore, Kevin Brighton, Maxton W. Muir, Alexandra Moody, Andrew Collyer, Isain Zapata, Amanda E. Brooks, Marcos Reyes
Summary: Glaucoma is a leading cause of irreversible blindness worldwide. This study suggests that allowing medical students to perform community-based glaucoma screening events in medically underserved areas can decrease the cost burden associated with late diagnosis and raise awareness about glaucoma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Sidra Zafar, Kristen A. Staggers, Jie Gao, Yao Liu, Praveen J. Patel, Paul J. Foster, Benjamin J. Frankfort, Michael Abramoff, Charles G. Minard, Alasdair Warwick, Anthony P. Khawaja, Roomasa Channa
Summary: This study examined the relationship between diabetes, glycemic control, and retinal nerve fiber layer thickness. The results showed that higher HbA1c levels and diabetes were associated with thinner superior and inferior pRNFL, indicating the areas most affected by diabetes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Dolly Shuo-Teh Chang, Yuzhen Jiang, Julia Anne Kim, Shengsong Huang, Beatriz Munoz, Tin Aung, Mingguang He, Paul J. Foster, David Friedman
Summary: This study assessed the long-term impact of laser peripheral iridotomy (LPI) on cataract formation in Chinese primary angle-closure suspect (PACS) patients. The results showed that LPI treatment did not cause significant cataract progression and did not increase the risk of developing clinically meaningful cataract worsening over time.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Alasdair N. Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Summary: This study describes the grading methods and baseline characteristics for UK Biobank participants who underwent retinal imaging, and characterizes individuals with retinal features suggestive of age-related macular degeneration, glaucoma, and retinopathy. The results provide important insights into both ocular and systemic health.
Article
Ophthalmology
Akiko Hanyuda, Bernard A. Rosner, Janey L. Wiggs, Kazuno Negishi, Louis R. Pasquale, Jae H. Kang
Summary: This prospective cohort study assessed the association between total alcohol intake and individual alcoholic beverage intake and the incidence of exfoliation glaucoma/glaucoma suspect (XFG/XFGS) status. The results showed that long-term alcohol consumption was associated with an increased risk of XFG/XFGS.
Correction
Ophthalmology
Alasdair Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Article
Ophthalmology
Kelsey V. Stuart, Robert N. Luben, Alasdair N. Warwick, Kian M. Madjedi, Praveen J. Patel, Mahantesh I. Biradar, Zihan Sun, Mark A. Chia, Louis R. Pasquale, Janey L. Wiggs, Jae H. Kang, Jihye Kim, Hugues Aschard, Jessica H. Tran, Marleen A. H. Lentjes, Paul J. Foster, Anthony P. Khawaja
Summary: The purpose of this study was to examine the associations between alcohol consumption and glaucoma and related traits, assess whether genetic predisposition to glaucoma modified these associations, and perform MR experiments to investigate causal effects. The findings showed consistent and adverse associations between alcohol intake and glaucoma and related traits, even at levels below the current guidelines in the UK and the US.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Chimei Liao, Harry Quigley, Yuzhen Jiang, Shengsong Huang, Wenyong Huang, David Friedman, Paul J. Foster, Mingguang He
Summary: The aim of this study is to evaluate the dynamic changes of iris area and volume with physiologic pupil dilation for the progress of primary angle closure suspects. The results showed that progressors had smaller iris area and volume, and older age, narrower horizontal angle opening distance, flatter iris curvature, and lower loss of iris volume were significantly associated with progression. The change in iris volume is an additional risk factor for identifying eyes more likely to develop angle closure disease.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Joelle E. Vergroesen, Alexander K. Schuster, Kelsey V. Stuart, Nigus G. Asefa, Audrey Cougnard-Gregoire, Cecile Delcourt, Cedric Schweitzer, Patricia Barreto, Rita Coimbra, Paul J. Foster, Robert N. Luben, Norbert Pfeiffer, Julia V. Stingl, Toralf Kirsten, Franziska G. Rauscher, Kerstin Wirkner, Nomdo M. Jansonius, Louis Arnould, Catherine P. Creuzot-Garcher, Bruno H. Stricker, Christina Keskini, Fotis Topouzis, Geir Bertelsen, Anne E. Eggen, Mukharram M. Bikbov, Jost B. Jonas, Caroline C. W. Klaver, Wishal D. Ramdas, Anthony P. Khawaja
Summary: This study investigated the association between commonly used systemic medications and glaucoma and intraocular pressure (IOP) in the European population. The use of calcium channel blockers (CCBs) was found to be associated with a higher prevalence of glaucoma, while the use of β-blockers was associated with lower IOP.
Article
Ophthalmology
Kian M. Madjedi, Kelsey V. Stuart, Sharon Y. L. Chua, Pradeep Y. Ramulu, Alasdair Warwick, Robert N. Luben, Zihan Sun, Mark A. Chia, Hugues Aschard, Janey L. Wiggs, Jae H. Kang, Louis R. Pasquale, Paul J. Foster, Anthony P. Khawaja
Summary: The purpose of this study was to examine the association between physical activity and glaucoma. The study found that higher levels of overall physical activity and more time spent in moderate and vigorous physical activity were associated with thicker macular ganglion cell-inner plexiform layer (mGCIPL). However, there was no association between physical activity and glaucoma status or intraocular pressure (IOP).
Article
Multidisciplinary Sciences
Oana A. Zeleznik, Jae H. Kang, Jessica Lasky-Su, A. Heather Eliassen, Lisa Frueh, Clary B. Clish, Bernard A. Rosner, Tobias Elze, Pirro Hysi, Anthony Khawaja, Janey L. Wiggs, Louis R. Pasquale
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, but its etiology is poorly understood. This study aimed to identify plasma metabolites associated with the risk of primary open-angle glaucoma (POAG) using case-control studies and cross-sectional studies. The results showed that higher levels of diglycerides and triglycerides were adversely associated with glaucoma, indicating their important role in glaucoma pathogenesis.
NATURE COMMUNICATIONS
(2023)
Article
Psychiatry
Siegfried K. Wagner, Mario Cortina-Borja, Steven M. Silverstein, Yukun Zhou, David Romero-Bascones, Robbert R. Struyven, Emanuele Trucco, Muthu R. K. Mookiah, Tom MacGillivray, Stephen Hogg, Timing Liu, Dominic J. Williamson, Nikolas Pontikos, Praveen J. Patel, Konstantinos Balaskas, Daniel C. Alexander, Kelsey V. Stuart, Anthony P. Khawaja, Alastair K. Denniston, Jugnoo S. Rahi, Axel Petzold, Pearse A. Keane
Summary: This study found measurable differences in neural and vascular integrity of the retina in patients with schizophrenia, which were mostly secondary to the higher prevalence of diabetes and hypertension in these patients.
Review
Biochemistry & Molecular Biology
Kelsey Stuart, Louis R. Pasquale, Jae H. Kang, Paul J. Foster, Anthony P. Khawaja
Summary: Glaucoma is a complex human disease with genetic and environmental determinants. Population-based cohorts and biobanks have accelerated research on the disease's etiology. Genome-wide association studies have enhanced our understanding of the genetic architecture, while epidemiological studies have identified environmental risk factors. Gene-environment interactions play a significant role in glaucoma and have implications for diagnostics and therapeutics in the future.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Nutrition & Dietetics
Soshiro Ogata, JoAnn E. Manson, Jae H. Kang, Julie E. Buring, I-Min Lee, Kunihiro Nishimura, Yasuhiko Sakata, Jacqueline Suk Danik, Denise D'Agostino, Samia Mora, Christine M. Albert, Nancy R. Cook
Summary: This study aimed to investigate whether n-3 fatty acid supplementation reduced cardiovascular disease (CVD) events based on win ratio. The results showed that n-3 fatty acid supplementation did not have a significant benefit for the primary CVD outcome, but it reduced myocardial infarction. Participants with low fish consumption at baseline benefited more from the supplementation.
Article
Ophthalmology
William G. Mitchell, Augusto Azuara-Blanco, Paul J. Foster, Omar Halawa, Jennifer Burr, Craig R. Ramsay, David Cooper, Claire Cochran, John Norrie, David Friedman, Dolly Chang
Summary: This study assessed the baseline ocular parameters predicting long-term intraocular pressure (IOP) control in patients with primary angle closure (PAC) disease after clear lens extraction (CLE) or laser peripheral iridotomy (LPI). The results showed that CLE was more effective in maintaining good IOP control compared to LPI. Non-Chinese ethnicity, higher baseline IOP, and no prior use of glaucoma drops were associated with worse long-term IOP response.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)