Therapeutic Bacteriophages for Gram-Negative Bacterial Infections in Animals and Humans

Direct Lytic Agents: Novel, Rapidly Acting Potential Antimicrobial Treatment Modalities for Systemic Use in the Era of Rising Antibiotic Resistance

(2022) Raymond Schuch et al.   Frontiers in Microbiology

Cefiderocol: Systematic Review of Mechanisms of Resistance, Heteroresistance and In Vivo Emergence of Resistance

(2022) Stamatis Karakonstantis et al.   Antibiotics-Basel

The Many Applications of Engineered Bacteriophages—An Overview

(2021) Bryan Gibb et al.   Pharmaceuticals

European regulatory aspects of phage therapy: magistral phage preparations

(2021) Gilbert Verbeken et al.   Current Opinion in Virology

Assessing Animal Models of Bacterial Pneumonia Used in Investigational New Drug Applications for the Treatment of Bacterial Pneumonia

(2020) Ursula Waack et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RLP, a bacteriophage of the family Podoviridae, rescues mice from bacteremia caused by multi-drug-resistant Pseudomonas aeruginosa

(2020) Iqbal Ahmad Alvi et al.   ARCHIVES OF VIROLOGY

Pharmacokinetics/pharmacodynamics of antipseudomonal bacteriophage therapy in rats: A Proof-of-Concept study

(2020) Yu-Wei Lin et al.   CLINICAL MICROBIOLOGY AND INFECTION

Potential of a Bacteriophage Isolated from Wastewater in Treatment of Lobar Pneumonia Infection Induced by Klebsiella pneumoniae in Mice

(2020) Mahboubeh Soleimani Sasani et al.   CURRENT MICROBIOLOGY

Identification of a newly isolated lytic bacteriophage against K24 capsular type, carbapenem resistant Klebsiella pneumoniae isolates

(2020) Marianna Horváth et al.   Scientific Reports

Impact of Frequent Administration of Bacteriophage on Therapeutic Efficacy in an A. baumannii Mouse Wound Infection Model

(2020) Michael D. Rouse et al.   Frontiers in Microbiology

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis

(2020) Vance G. Fowler et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective and therapeutic application of the depolymerase derived from a novel KN1 genotype of Klebsiella pneumoniae bacteriophage in mice

(2019) Can Wang et al.   RESEARCH IN MICROBIOLOGY

Successful treatment of antibiotic resistant poly-microbial bone infection with bacteriophages and antibiotics combination

(2019) Ran Nir-Paz et al.   CLINICAL INFECTIOUS DISEASES

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

(2019) Kaitlyn E. Kortright et al.   Cell Host & Microbe

Two Novel Bacteriophages Improve Survival in Galleria mellonella Infection and Mouse Acute Pneumonia Models Infected with Extensively-drug-resistant Pseudomonas aeruginosa

(2019) Jongsoo Jeon et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Isolation of phage lysins that effectively kill Pseudomonas aeruginosa in mouse models of lung and skin infection

(2019) Assaf Raz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria

(2019) Ryan D. Heselpoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

(2019) Nancy Law et al.   INFECTION

Early clinical experience of bacteriophage therapy in 3 lung transplant recipients

(2019) Saima Aslam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema caused by Pseudomonas aeruginosa

(2019) Susan Maddocks et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

(2019) Kevin Yehl et al.   CELL

Antibiotic development — economic, regulatory and societal challenges

(2019) Christine Årdal et al.   NATURE REVIEWS MICROBIOLOGY

Steering Phages to Combat Bacterial Pathogens

(2019) James Gurney et al.   TRENDS IN MICROBIOLOGY

An experimental mouse model for phage therapy of bacterial pathogens causing bacteremia

(2019) Sadeq Abdulridha Gatea Kaabi et al.   MICROBIAL PATHOGENESIS

Kinetics of Targeted Phage Rescue in a Mouse Model of Systemic Escherichia coli K1

(2018) György Schneider et al.   Biomed Research International

Enzymes and Mechanisms Employed by Tailed Bacteriophages to Breach the Bacterial Cell Barriers

(2018) Sofia Fernandes et al.   Viruses-Basel

Adapted Bacteriophages for Treating Urinary Tract Infections

(2018) Aleksandre Ujmajuridze et al.   Frontiers in Microbiology

Extensively drug-resistant and pan-drug resistant Gram-negative bacteria in a tertiary-care hospital in Eastern India: a 4 year retrospective study

(2018) Debi Prasad Mohapatra et al.   Journal of Global Antimicrobial Resistance

A Systematic and Critical Review of Bacteriophage Therapy against Multi-Drug Resistant ESKAPE Organisms in Humans

(2018) Lynn El Haddad et al.   CLINICAL INFECTIOUS DISEASES

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

Ex vivo and in vivo evaluation of microemulsion based transdermal delivery of E . coli specific T4 bacteriophage: A rationale approach to treat bacterial infection

(2017) Vaibhav Rastogi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Apitherapeutics and phage-loaded nanofibers as wound dressings with enhanced wound healing and antibacterial activity

(2017) Wessam A Sarhan et al.   Nanomedicine

Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa

(2017) Elaine M Waters et al.   THORAX

Therapeutic Application of Phage Capsule Depolymerases against K1, K5, and K30 Capsulated E. coli in Mice

(2017) Han Lin et al.   Frontiers in Microbiology

Personalized Therapeutic Cocktail of Wild Environmental Phages Rescues Mice from Acinetobacter baumannii Wound Infections

(2016) James M. Regeimbal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intranasal treatment with bacteriophage rescues mice fromAcinetobacter baumannii-mediated pneumonia

(2016) Yong Wang et al.   Future Microbiology

Bacteriophage LM33_P1, a fast-acting weapon against the pandemic ST131-O25b:H4Escherichia coliclonal complex

(2016) Nicolas Dufour et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vivo efficacy of single phage versus phage cocktail in resolving burn wound infection in BALB/c mice

(2016) Parul Chadha et al.   MICROBIAL PATHOGENESIS

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

Novel Phage Lysin Capable of Killing the Multidrug-Resistant Gram-Negative Bacterium Acinetobacter baumannii in a Mouse Bacteremia Model

(2015) Rolf Lood et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment of Highly Virulent Extraintestinal Pathogenic Escherichia coli Pneumonia With Bacteriophages*

(2015) Nicolas Dufour et al.   CRITICAL CARE MEDICINE

Bacteriophage-Loaded Nanostructured Lipid Carrier: Improved Pharmacokinetics Mediates Effective Resolution ofKlebsiella pneumoniae–Induced Lobar Pneumonia

(2015) Saloni Singla et al.   JOURNAL OF INFECTIOUS DISEASES

Isolation and Characterization of a “phiKMV-Like” Bacteriophage and Its Therapeutic Effect on Mink Hemorrhagic Pneumonia

(2015) Zhenhui Cao et al.   PLoS One

A century of phage research: Bacteriophages and the shaping of modern biology

(2014) Eric C. Keen   BIOESSAYS

Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial

(2014) D.D. Rhoads et al.   Journal of Wound Care

PredictingIn VivoEfficacy of Therapeutic Bacteriophages Used To Treat Pulmonary Infections

(2013) Marine Henry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

wksl3, a New Biocontrol Agent for Salmonella enterica Serovars Enteritidis and Typhimurium in Foods: Characterization, Application, Sequence Analysis, and Oral Acute Toxicity Study

(2013) Hyun-Wol Kang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Safety analysis of a Russian phage cocktail: From MetaGenomic analysis to oral application in healthy human subjects

(2013) Shawna McCallin et al.   VIROLOGY

The complex pathogenesis of bacteremia

(2013) Eirini Christaki et al.   Virulence

Antibacterial Efficacy of Temperate Phage-Mediated Inhibition of Bacterial Group Motilities

(2012) In-Young Chung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pseudomonas aeruginosa Keratitis in Mice: Effects of Topical Bacteriophage KPP12 Administration

(2012) Ken Fukuda et al.   PLoS One

Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh

(2012) Shafiqul Alam Sarker et al.   VIROLOGY

Bacteriophages  MR299-2 and  NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells

(2012) D. Alemayehu et al.   mBio

In VivoGrowth Rates Are Poorly Correlated with Phage Therapy Success in a Mouse Infection Model

(2011) J. J. Bull et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Experimental Phage Therapy in TreatingKlebsiella pneumoniae-Mediated Liver Abscesses and Bacteremia in Mice

(2011) Chih-Hsin Hung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Local bacteriophage isolates showed anti-Escherichia coli O157:H7 potency in an experimental ligated rabbit ileal loop model

(2011) Muntasir Alam et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

(2011) A.-P. Magiorakos et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antibacterial efficacy of lytic Pseudomonas bacteriophage in normal and neutropenic mice models

(2011) Birendra R. Tiwari et al.   JOURNAL OF MICROBIOLOGY

Phage Choice, Isolation, and Preparation for Phage Therapy

(2010) Jason Gill et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Bacteriophage versus antimicrobial agents for the treatment of murine burn wound infection caused by Klebsiella pneumoniae B5055

(2010) S. Kumari et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Phage Therapy Paradigm: Prêt-à-Porter or Sur-mesure?

(2010) Jean-Paul Pirnay et al.   PHARMACEUTICAL RESEARCH

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

T-even-related bacteriophages as candidates for treatment of Escherichia coli urinary tract infections

(2008) H. Nishikawa et al.   ARCHIVES OF VIROLOGY

Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli O149 infection of pigs

(2008) Nidham Jamalludeen et al.   VETERINARY MICROBIOLOGY