Article
Medicine, Research & Experimental
Nasrullah Jan, Asadullah Madni, Muhammad Abdur Rahim, Naveed Ullah Khan, Talha Jamshaid, Arshad Khan, Abdul Jabar, Safiullah Khan, Hassan Shah
Summary: The study aimed to develop and evaluate PCL nanoparticles loaded with cytarabine for sustained release behavior and anti-leukemic influence. The developed nanoparticles showed efficient toxicity against leukemic and breast cancer cell lines, with sustained release pattern enhancing the anti-cancer effects.
Article
Medicine, Research & Experimental
Safiullah Khan, Muhammad Naeem Aamir, Asadullah Madni, Nasrullah Jan, Arshad Khan, Abdul Jabar, Hassan Shah, Muhammad Abdur Rahim, Ahsan Ali
Summary: The study successfully developed lipid polymer hybrid nanoparticles for delivering 5-fluorouracil, demonstrating sustained release and enhanced anti-cancer efficacy. The system shows potential for targeted chemotherapy delivery and minimizing toxic side effects.
Article
Nanoscience & Nanotechnology
SungGyu Chun, Jie Feng
Summary: The study introduces the formulation of abamectin nanopesticides using Flash NanoPrecipitation (FNP) technology for extended photostability and sustained release. The use of cost-effective stabilizers led to optimized nanoparticles while achieving improved performance of abamectin. The results demonstrate the potential of FNP for mass production of low-cost abamectin nanopesticides, essential for large-scale application in food and agriculture.
ACS APPLIED NANO MATERIALS
(2021)
Article
Polymer Science
Yahya Alhamhoom, Sandip. M. M. Honmane, Umme Hani, Riyaz Ali M. Osmani, Geetha Kandasamy, Rajalakshimi Vasudevan, Sharanya Paramshetti, Ravindra. R. Dudhal, Namrata. K. Kengar, Manoj. S. S. Charde
Summary: The present research aimed to develop a Piroxicam nanosuspension to enhance the solubility and in vitro bioavailability of the drug. Piroxicam nanosuspension was prepared using PVP K30 and Poloxamer 188 as stabilizers. The results showed that the nanosuspension significantly improved the particle size and solubility. Therefore, the Piroxicam nanosuspension can improve the solubility and in vitro dissolution behavior of the drug, leading to enhanced bioavailability.
Article
Engineering, Chemical
Jungsuk Kim, Joachim Ulrich
Summary: The kinetics of the formation and transformation of disodium guanosine 5'-monophosphate were studied using in situ Raman and focused beam reflectance measurement. Various operating conditions, including supersaturation, solvent composition, feed concentration, addition rate, and viscosity, were found to affect the rate determining steps of the transformation. The study suggests that in situ Raman spectroscopy and FBRM can be used to determine the rate-limiting processes during the phase transformation and develop a control strategy for producing the desired form in the final product.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Physical
Chen Li, Kun Fang, Wei He, Kai Li, Yi Jiang, Jianbin Li
Summary: In this study, bovine serum albumin was loaded onto chitosan-ferulic acid conjugants as a model protein drug carrier. The conjugates exhibited high thermal stability and superior in vitro sustained release property, making them suitable for oral carrier in functional foods and drug delivery systems.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Polymer Science
Muhammad Suhail, An Xie, Jia-Yu Liu, Wan-Chu Hsieh, Yu-Wen Lin, Muhammad Usman Minhas, Pao-Chu Wu
Summary: The main objective of this study was to sustain the releasing behavior of theophylline using fabricated polymeric microgels. Different combinations of aspartic acid, 2-acrylamido-2-methylpropanesulfonic acid, and N',N'-methylene bisacrylamide were used to develop the microgels. Characterizations such as DSC, TGA, SEM, FTIR, and PXRD were performed to assess their thermal stability, surface morphology, and the formation of a new polymeric system. Various studies including dynamic swelling, drug loading, sol-gel analysis, in vitro drug release, and kinetic modeling were conducted. The results indicated that the prepared carrier system has the potential to sustain the release of theophylline for an extended period of time.
Article
Pharmacology & Pharmacy
Changzhi Shi, Kewei Guo, Li Zhang, Yi Guo, Yu Feng, Sandra Cvijic, Dongmei Cun, Mingshi Yang, Jyrki Heinaemaeki, Ain Raal
Summary: This study investigated lung exposure to various inhalable ciprofloxacin (CIP) formulations with different drug release rates in a rat model. The results showed that drug release rate plays an important role in lung exposure to inhaled antibiotics, implying that lung exposure can be improved by using sustained-release formulations.
Article
Pharmacology & Pharmacy
Samaa Abdullah, Ahmad Bani-Jaber, Nabil A. Alhakamy, Yahya F. Jamous, Alaa A. Al-Masud, Meshal Marzoog Al-Sharafa
Summary: The study investigated the drug-polyelectrolyte complexation between ciprofloxacin and λ-carrageenan, and the complex was used as a sustained-release matrix. Various characterization techniques were employed to examine the complex and its properties compared to physical mixing. Cipro-CRG matrices showed improved swelling, erosion, and drug release properties, and exhibited slow-prolonged oral drug absorption in vivo.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Yun-Hong Wang, Tong Qu, Xue-Lian Wang, Rong-Ping Yang
Summary: This study investigated the preparation of sustained-release microcapsules of salvianolic acid using chitosan as the carrier. The optimal conditions for the preparation process were identified, resulting in smooth-surfaced microcapsules with high drug loading and sustained release characteristics. The properties of salvianolic acid were maintained in the microcapsules, demonstrating the successful preparation of sustained-release microcapsules of salvianolic acid using marine polysaccharide as a carrier.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Ahmed Hassen Elshafeey, Rania Moataz El-Dahmy
Summary: The study aimed to develop and optimize palatable oral fast-dissolving films (OFDFs) loaded with a paroxetine nanosuspension to increase the bioavailability of paroxetine. OFDFs offer convenience for patients with mental illness and are suitable for pediatric, elderly, and developmentally disabled patients.
Article
Chemistry, Multidisciplinary
Nazanin Mokhtari, Mohammad Dinari, Fatemeh Khosravi Esmaeiltarkhani
Summary: Among novel drug delivery systems, covalent organic frameworks (COFs) are promising for pharmaceutical science. In this study, an imine-linked COF was synthesized and used as a pH-dependent carrier for the release of doxorubicin (DOX). The COF exhibited excellent drug encapsulation efficiency, and DOX release showed pH-dependent behavior. The cytotoxicity tests demonstrated that the COF did not affect normal breast cells, while DOX@APB-COF limited the proliferation of breast cancer cells. This research highlights the potential of COFs as innovative drug delivery systems.
Article
Polymer Science
Yu-Shuai Yang, Ze Li, Kai-Jie Zhang, Sheng Yang
Summary: This study prepared water-soluble inclusion complexes of Altrenogest using the freeze-drying method, in order to improve its solubility in water and broaden its clinical applications. The inclusion complexes were characterized by various analytical techniques, and the solubility of Altrenogest in the complexes was significantly increased. In addition, the sustained-release silica gel suppositories of the inclusion complexes demonstrated better sustained-release effects. Overall, the inclusion complexes showed good stability and can be easily produced through an industrialized process.
Article
Engineering, Environmental
Chenju Liang, Chen -Yuan Weng
Summary: This study developed an alkaline activated sodium persulfate sustained release oxidation rod for long-term in situ chemical oxidation accelerated treatment of TCE dissolved from TCE DNAPL, by creating a greater concentration gradient at the TCE DNPL boundary.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Biagio Todaro, Aldo Moscardini, Stefano Luin
Summary: Recent findings have shown the benefits of using Pioglitazone (PGZ) encapsulated in nanoparticles for the treatment of atherosclerosis and type 2 diabetes. This study optimized the formulation parameters for the production of PGZ-loaded PLGA nanoparticles, and found that the nanoprecipitation method was the simplest, fastest, and most reliable synthetic pathway. The nanoparticles produced by this method had high drug encapsulation efficiency and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Pauline Legrand, Oumar Dembele, Helena Alamil, Catherine Lamoureux, Nathalie Mignet, Pascal Houze, Rabah Gahoual
Summary: The translation text describes an analytical strategy that enables the structural identification and quantification of monoclonal antibodies in potentially counterfeit drugs. By using capillary zone electrophoresis analysis, size exclusion chromatography coupled to multi-angle light scattering, and liquid chromatography tandem mass spectrometry, information on the nature and structure of mAbs is obtained.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Thomas Lecuyer, Nicolas Bia, Pierre Burckel, Cedric Loubat, Alain Graillot, Johanne Seguin, Yohann Corvis, Jianhua Liu, Lucie Valero, Daniel Scherman, Nathalie Mignet, Cyrille Richard
Summary: Optical in vivo imaging using inorganic nanoparticles as imaging probes is a promising technique for clinical diagnostics and treatment applications. In this study, ZGO nanoparticles were developed for their unique properties of bright persistent luminescence signal and activation in vivo. To avoid opsonization by the mononuclear phagocyte system, the NPs were coated with hydrophilic polymers using a new functionalization method involving two different polyethylene glycol phosphonic acid polymers. The newly functionalized NPs exhibited long circulation time and low protein adsorption, showing potential for in vivo imaging.
Article
Pharmacology & Pharmacy
Morgane Renault-Mahieux, Nathalie Mignet, Johanne Seguin, Khair Alhareth, Muriel Paul, Karine Andrieux
Summary: Flavonoids are promising molecules for cancer treatment due to their various properties, but vectorization is necessary due to their lipophilic properties and chemical instability. Co-encapsulation with other anti-cancer agents can achieve synergistic effects, delay drug resistance, or reduce toxicity. However, co-encapsulation may affect the properties and stability of nanoparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemical Research Methods
Pauline Legrand, Sophie Dufay, Nathalie Mignet, Pascal Houze, Rabah Gahoual
Summary: This study implemented the accelerated stability assessment program (ASAP) to model the long-term stability of monoclonal antibodies (mAbs). Using LC-MS/MS and SEC-MALS-UV/RI analysis, post-translational modifications and degradation pathways of mAbs were characterized. Comparison of ASAP models and long-term stability data indicated the stability of mAbs. The study demonstrated the particularities of ASAP modeling for mAbs and its ability to accurately predict long-term stability.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Anesthesiology
Raquel Tonello, Wayne B. Anderson, Steve Davidson, Virginie Escriou, Lei Yang, Brian L. Schmidt, Wendy L. Imlach, Nigel W. Bunnett
Summary: This study suggests that endocytosis plays a key role in sensitization of nociceptors and synaptic transmission, and inhibiting endocytosis could be a potential therapeutic approach for pain treatment.
Article
Materials Science, Multidisciplinary
Luidgi Giordano, Guanyu Cai, Johanne Seguin, Jianhua Liu, Cyrille Richard, Lucas Carvalho Veloso Rodrigues, Bruno Viana
Summary: The use of an infrared laser as a power source and an upconversion process for charging persistent luminescence has gained attention in the field. In this study, a novel approach using energy transfer on associated materials is proposed. The hybrid material, composed of beta-NaGd0.8Yb0.17Er0.03F4 and Zn1.33Ga1.335Sn0.33Cr0.005O4 nanoparticles, demonstrates persistent luminescence at 700 nm after being charged with a 980 nm laser. This material shows potential as a rechargeable persistent nanoprobe for in vivo applications.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Analytical
Tessa Reinert, Pascal Houze, Nathalie Mignet, Yannis-Nicolas Francois, Rabah Gahoual
Summary: Despite the challenges in predicting and monitoring post-administration effects of post-translational modifications, this study identified and evaluated the modification kinetics of infliximab and its biosimilars in vitro. The methodology used mass spectrometry analysis to determine modified and unmodified forms, and the results showed the potential for studying structural stability after administration.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Aurelien Lemercier, Nicolas Couvrat, Yohann Cartigny, Morgane Sanselme, Yohann Corvis, Philippe Espeau, Gerard Coquerel
Summary: The dehydration of prednisolone sesquihydrate was investigated using various physico-chemical analysis methods, leading to the discovery of a new metastable solid form (form 3) that had not been identified before. The rehydration of anhydrous forms 1 and 2 of prednisolone was studied, and it was found that neither form was sensitive to humidity. The sesquihydrate could only be obtained from the isomorphic anhydrous form through solid-gas equilibria. The classification of the sesquihydrate was based on the activation energy determined during dehydration.
Review
Chemistry, Multidisciplinary
Feras Oyoun, Antoniya Toncheva, Luis Castillo Henriquez, Raphael Grougnet, Fouad Laoutid, Nathalie Mignet, Khair Alhareth, Yohann Corvis
Summary: In the field of pharmacy, the use of environmentally friendly chemical products is a hot topic, especially in the context of circular economy and sustainable chemistry. Organic solvents, which have harmful effects on the environment and human health, are being restricted, leading to the emergence of deep eutectic solvents (DESs) as greener alternatives. DESs offer environmental benefits, low cost, and biocompatibility, and can solubilize active pharmaceutical ingredients (APIs) to form therapeutic DESs (TheDESs). This review article provides a precise definition, classification, preparation methods, and characterization of DESs, and discusses the selection of DES constituents to minimize experimental efforts. The role of DESs in the biomedical and pharmaceutical sectors and their impact on successful therapies are also explored.
Article
Chemistry, Inorganic & Nuclear
Robin Vinck, Orsolya Domotor, Johannes Karges, Marta Jakubaszek, Johanne Seguin, Mickael Tharaud, Vincent Guerineau, Kevin Cariou, Nathalie Mignet, Eva A. Enyedy, Gilles Gasser
Summary: Maleimide-containing prodrugs can selectively react with circulating serum albumin, leading to longer blood circulation times and improved tumor accumulation. This study synthesized maleimide-functionalized complexes and investigated their interaction with albumin. The complexes showed lower cytotoxicity in noncancerous cells under dark conditions but did not result in a significant increase in tumor accumulation.
INORGANIC CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Sarah Boumati, Angelique Sour, Valerie Heitz, Johanne Seguin, Gautier Beitz, Yusuke Kaga, Marta Jakubaszek, Johannes Karges, Gilles Gasser, Nathalie Mignet, Bich-thuy Doan
Summary: Researchers have successfully used a theranostic agent with combined diagnostic and therapeutic capabilities for photodynamic therapy, fluorescence imaging, and magnetic resonance imaging. The experimental results show that this theranostic agent has a significant impact on tumor growth and has the potential to become a drug candidate for cancer.
ACS APPLIED BIO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Delphine Dassonville, Thomas Lecuyer, Johanne Seguin, Yohann Corvis, Jianhua Liu, Guanyu Cai, Julia Mouton, Daniel Scherman, Nathalie Mignet, Cyrille Richard
Summary: This study proposes the use of zwitterion coatings to delay the liver uptake of chromium-doped zinc gallate nanoparticles and compares it with PEG coatings. The results show that zwitterion coatings have similar protein repulsion effects and smaller particle size compared to PEG coatings, allowing for similar circulation times in mice.