Review
Biochemistry & Molecular Biology
Weronika Frak, Joanna Hajdys, Ewa Radzioch, Magdalena Szlagor, Ewelina Mlynarska, Jacek Rysz, Beata Franczyk
Summary: Cardiovascular diseases (CVD) are a major global health concern, and sodium/glucose cotransporter 2 (SGLT2) inhibitors have emerged as a promising class of medications for managing CVD. In this paper, we discuss the role of various SGLT-2 inhibitors as potential therapeutic targets for cardiovascular diseases, highlighting their significant cardiovascular benefits and renal protection. These novel therapeutic approaches aim to improve patient outcomes and reduce the burden of these conditions, but further studies are needed to explore the scientific advancements and mechanisms.
Article
Biochemistry & Molecular Biology
Cheng-Yang Hsieh, Sheng-Feng Sung
Summary: Chronic kidney disease (CKD) is a significant risk factor for stroke and cerebrovascular disease, yet the interaction between the brain and kidneys has received less attention compared to the interaction between the heart and kidneys. This article focuses on the potential of SGLT2 inhibitors, a class of oral anti-diabetic drugs, in preventing strokes and improving the cerebro-renal interaction, regardless of diabetes status. The authors propose the roles of baseline renal functions and dual inhibition of SGLT1/2 in stroke prevention, as well as the additional benefits of reducing atrial fibrillation and hemorrhagic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Lucia Scisciola, Vittoria Cataldo, Fatemeh Taktaz, Rosaria Anna Fontanella, Ada Pesapane, Puja Ghosh, Martina Franzese, Armando Puocci, Antonella De Angelis, Liberata Sportiello, Raffaele Marfella, Michelangela Barbieri
Summary: Atherosclerosis is an inflammatory disease that leads to cardiovascular mortality and morbidity. Type 2 diabetes mellitus is a known risk factor for atherosclerosis. Sodium-glucose co-transporter 2 inhibitors have been found to have anti-inflammatory effects and can potentially slow down the progression of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Oncology
Can Huang, Lanlan Dong, Baohua Zhao, Yifei Lu, Shurun Huang, Zhiqiang Yuan, Gaoxing Luo, Yong Xu, Wei Qian
Summary: Hydrogel dressings have shown promising potential in the biomedical field, particularly in promoting wound healing. In recent years, significant progress has been made in addressing excessive inflammation and promoting wound healing with hydrogel dressings. Excessive inflammation is a common issue in chronic wounds, hindering the repair process. Therefore, resolving excessive inflammation is crucial for effective wound healing.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Endocrinology & Metabolism
Richard Ofori-Asenso, Berhe W. Sahle, Ken Lee Chin, Mohsen Mazidi, Zanfina Ademi, Marie Louise De Bruin, Danny Liew
Summary: The study found that real-world adherence and persistence to SGLT2 inhibitors is poor, with approximately 60% of patients adherent at six months and 50% at one year, while persistence data showed even lower proportions. Targets for improving treatment adherence and persistence need to be identified and appropriate interventions implemented.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen
Summary: Emodin can improve diabetic wound healing by promoting extracellular matrix synthesis and granulation tissue formation, and promote the conversion of M1-like macrophages to M2-like macrophages by down-regulating the NF-xB signaling pathway. This study identified potential targets of emodin and revealed its role in fibroblast proliferation and ECM formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Mehmet Evren Okur, Ayse Esra Karadag, Yagmur Ozhan, Hande Sipahi, Sule Ayla, Benay Daylan, Suekran Kultur, Betuel Demirci, Fatih Demirci
Summary: The study demonstrates the antioxidant and anti-inflammatory properties of Phlomis rigida, as well as its positive effects on wound healing through both in vitro and in vivo experiments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biology
Tomoaki Tatsumi, Toshiyuki Oshitari, Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Yuki Shiko, Takayuki Baba, Koutaro Yokote, Shuichi Yamamoto
Summary: This study found that systemic SGLT2i can reduce DMEs, suggesting that SGLT2i may be an additional treatment option to anti-VEGF treatments for eyes with DMEs.
Article
Biochemistry & Molecular Biology
Rui Hu, Anita Layton
Summary: The study investigates how kidney function is altered in patients with diabetes and the renal effects of an anti-hyperglyceamic therapy that inhibits SGLT2. Results indicate that SGLT2 inhibition may attenuate glomerular hyperfiltration and reduce single-nephron glomerular filtration rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Asmaa Elrakaybi, Katharina Laubner, Qian Zhou, Martin J. Hug, Jochen Seufert
Summary: SGLT2 inhibitors may exert anti-inflammatory effects either indirectly by improving metabolism and reducing stress conditions or by directly modulating inflammatory signaling pathways. Their clinical use in heart failure patients with and without diabetes has been established, regardless of glucose levels.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Miodrag Janic, Matej Cankar, Jan Smid, Alenka France Stiglic, Ales Jerin, Miso Sabovic, Andrej Janez, Mojca Lunder
Summary: In this study, the empagliflozin-metformin combination demonstrated strong antioxidative and anti-inflammatory properties in patients with type 1 diabetes. The antioxidative activity of the combination therapy partially explains the improvement in arterial function.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Plant Sciences
Esra Kuepeli Akkol, Gulin Renda, Mert Ilhan, Nurdan Yazici Bektas
Summary: The study revealed that Prunella vulgaris has significant wound healing and anti-inflammatory activities, and the compounds ursolic acid, chlorogenic acid, and rosmarinic acid are responsible for these effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cell Biology
Lucia Scisciola, Fabiola Olivieri, Concetta Ambrosino, Michelangela Barbieri, Maria Rosaria Rizzo, Giuseppe Paolisso
Summary: SGLT2 inhibitors, commonly used to treat type 2 diabetes, have the potential to be used as anti-aging drugs. They can modulate pathways associated with the aging process and mitigate the harmful effects of inflammaging, the main risk factor for accelerated aging and age-related diseases. Though promising, further cellular and clinical investigations are needed to validate the anti-aging effects of SGLT2 inhibitors.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Xiaolong Lin, Tao Fu, Yuqing Lei, Jiajia Xu, Sa Wang, Fuming He, Zhijian Xie, Ling Zhang
Summary: This study developed a new antibacterial hydrogel with excellent antimicrobial activity, histocompatibility, and wound healing potential. The hydrogel released antibacterial peptides to inhibit bacterial biofilm formation and regulate inflammatory responses, as well as promote angiogenesis, thereby aiding in the rapid healing of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
