Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Acoustics
Yunhao Luo, Jie Chen, Liting Feng, Wenbin Cao, Hao Wu, Miao Ma, Fangting He, Jing Luo, Chihua Wu, Jinping Liu, Qin Chen, Jun Luo
Summary: This study investigated the sentinel lymph node and lymphatic drainage pattern of breast cancer using contrast-enhanced ultrasound. The most common lymphatic drainage pattern observed was one lymphatic channel originating from the upper quadrant of the areola and one sentinel lymph node. Contrast-enhanced ultrasound can identify the lymphatic drainage pattern before surgery, reducing the false negative rate of sentinel lymph node biopsy.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Medicine, General & Internal
Piotr Kedzierawski, Artur Bocian, Agnieszka Radowicz-Chil, Anna Huruk-Kuchinka, Ryszard Mezyk
Summary: The purpose of this study was to determine the correlation between the biological subtype of breast cancer and the risk of metastasis to a sentinel lymph node. In the analyzed group of 1018 women with breast cancer, 57% were classified as Luminal A subtype. A positive sentinel lymph node was found in 26.5% of the women.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Surgery
Y. Andersson, L. Bergkvist, J. Frisell, J. de Boniface
Summary: The SENOMIC trial found that omitting axillary lymph node dissection in patients with breast cancer and sentinel node micrometastases had excellent 3-year event-free survival rates. However, patients who underwent mastectomy had worse tumor characteristics and higher risk of recurrence, especially without adjuvant radiotherapy. Long-term follow-up and enrollment of mastectomy patients are crucial.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Miaomiao Zhao, Yan Zheng, Jian Chu, Zhenhua Liu, Fenglin Dong
Summary: This study developed a novel non-invasive method to predict sentinel lymph node metastasis in breast cancer by analyzing ultrasound imaging characteristics and peripheral blood T-cell subsets. The constructed combined model showed good performance and can be used to guide clinical decisions in breast surgery.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Anastasia Bothou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Georgia Margioula-Siarkou, Stefanos Zervoudis, Alexandros Sotiriadis, Frederic Amant, Konstantinos Dinas
Summary: Sentinel lymph node biopsy (SLNB) appears to be a safe and effective technique for breast cancer during pregnancy, according to this systematic review. A total of 63 articles were included, with 47 strongly in favor of SLNB in pregnancy-related breast cancer (PABC), 4 partially in favor, 10 strongly against, and 2 partially against. Sub-categorization based on study type showed that the majority of studies in favor had higher levels of evidence. In total, 382 women with PABC underwent SLNB, and full data were reported for 237 cases. The overall live birth rate was 95.8%, while the overall neonatal complication rate was 3.4%. No cases of maternal side effects or anaphylactic reaction, maternal death, stillbirth, or neonatal death were reported (0%).
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Roberto Cirocchi, Giulio Metaj, Michela Cicoletti, Fabrizio Arcangeli, Angelo De Sol, Giulia Poli, Paolo Bruzzone, Sara Gioia, Christos Anagnostou, Fabio Loreti, Simona Francesconi, Linda Ricci, Maria Elena Laurenti, Andrea Capotorti, Marco Artico, Vito D'Andrea, Brandon Michael Henry, Piergiorgio Fedeli, Luigi Carlini
Summary: Studies have shown significant heterogeneity in lymphatic drainage patterns of different cutaneous melanomas, emphasizing the need for multiple imaging evaluations in critical skin areas. The use of fluorescence lymphography with indocyanine green has greatly improved visualization at a microscopic level. It is crucial to combine SPET-CT scans with lymphoscintigraphy preoperatively and perform additional evaluations with indocyanine green intraoperatively to accurately identify sentinel nodes and reduce false negative rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Article
Oncology
Swadha D. Guru, Tanya L. Hoskin, Dana H. Whaley, Mark A. Nathan, James W. Jakub
Summary: There are limited data on the optimal injection technique for repeat sentinel lymph node (rSLN) surgery. Preoperative lymphoscintigraphy is beneficial in patients with recurrent breast cancer. Periareolar and peritumoral injections had similar incidence of sentinel lymph node identification and aberrant drainage.
CLINICAL BREAST CANCER
(2021)
Article
Oncology
R. Haarsma, A. A. van Loevezijn, M. L. Donswijk, A. N. Scholten, M. T. F. D. Vrancken Peeters, F. H. van Duijnhoven
Summary: The added value of repeat sentinel lymph node biopsy (rSLNB) in clinically node-negative (cN0) patients with ipsilateral breast tumor recurrence (IBTR) who underwent optimal clinical staging with FDG-PET/CT was assessed. The study found that the incidence of a tumor-positive rSLNB in patients with a negative FDG-PET/CT is low and does not change survival. Therefore, rSLNB can be omitted in these cN0 patients.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Chaobin Wang, Fuzhong Tong, Yingming Cao, Peng Liu, Bo Zhou, Hongjun Liu, Lin Cheng, Miao Liu, Jiajia Guo, Fei Xie, Houpu Yang, Siyuan Wang, Yuan Peng, Shu Wang
Summary: The combination of ICG and MB showed a high detection rate and accuracy in SLNB for early breast cancer patients, with low rates of recurrence and lymphedema.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Francesco Giammarile, Sergi Vidal-Sicart, Diana Paez, Olivier Pellet, Estrada-Lobato Enrique, Miriam Mikhail-Lette, Olga Morozova, Navarro Marulanda Maria Camila, Rodriguez Sanchez Diana Ivonne, Roberto C. Delgado Bolton, Renato A. Valdes Olmos, Giuliano Mariani
Summary: Breast cancer is the most common cancer in women worldwide, and sentinel lymph node biopsy is a highly reliable method for detecting lymph node metastasis. Despite some variations and differences, improved accuracy can be achieved with the accumulation of experience.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Ilker Ozgur, Hadley M. Wood, Emre Gorgun
COLORECTAL DISEASE
(2023)
Article
Surgery
Ilker Ozgur, Sumeyye Yilmaz, Amit Bhatt, Stefan D. Holubar, Scott R. Steele, Emre Gorgun
Summary: This study presents the authors' experience in managing iatrogenic colonic perforations through endoscopic closure. Among 964 advanced endoscopic resections, 22 cases (2.3%) experienced colonic perforation, with 18 cases treated with endoscopic clipping. No complications were observed postoperatively, and there was no recurrence during the follow-up period.
Article
Surgery
Doua Elamin, Ilker Ozgur, Scott R. Steele, Alok A. Khorana, Xue Jia, Emre Gorgun
Summary: During the COVID pandemic, there was a significant decrease in the number and rate of colorectal cancer diagnoses. However, there were no differences in staging at diagnosis or time to treatment initiation.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Sumeyye Yilmaz, Ilker Ozgur, Adina Feinberg, Brogan Catalano, Scott R. Steele, Emre Gorgun
Summary: A retrospective chart review was conducted to explore the impact of advanced endoscopic resections on early oncological outcomes of malignant colorectal lesions. The study found that even in the presence of perforation, advanced endoscopic procedures did not have a negative impact on the early oncological outcomes of these patients.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Ilker Ozgur, David Liska, Michael A. Valente, Nicholas Smith, Xue Jia, Brogan Catalano, Scott R. Steele, Emre Gorgun
Summary: A retrospective review found no significant difference in surgical and oncologic outcomes between segmental colon resections and extended colectomies for splenic flexure colon cancer.
AMERICAN JOURNAL OF SURGERY
(2023)
Editorial Material
Gastroenterology & Hepatology
Ilker Ozgur, Grace C. C. Lee, Emre Gorgun
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
Ilker Ozgur, Carla F. F. Justiniano, Hadley M. M. Wood, Emre Gorgun
Summary: This study presents the first cases of single-port endorobotic rectal mucosa harvesting for urethral reconstruction. The technique provides precise submucosal dissection with meticulous control of traction and delivered energy, showing promising potential for future applications.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Surgery
Ilker Ozgur, Ipek Sapci, Berke Sengun, Michael A. Valente, Scott R. Steele, David Liska, Conor P. Delaney, Emre Gorgun
Summary: The study investigated the associations between the Paris classification, surface morphology, and Kudo pit pattern to submucosal invasion in advanced endoscopic resection techniques. The results showed that surface morphology and pit pattern can predict submucosal invasion in the North American patient population. Thus, polyp morphology may aid polyp selection for advanced endoscopic interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Ilker Ozgur, Carla F. F. Justiniano, Michael A. A. Valente, Stefan D. D. Holubar, Scott R. R. Steele, Emre Gorgun
Summary: This study evaluated the management and outcomes of endoscopic treatment for ileocecal valve lesions. The results showed low complications and acceptable recurrence rates in patients treated with advanced endoscopy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Emre Gorgun, Elif Ozcimen, Sumeyye Yilmaz, Xue Jia, Ilker Ozgur
Summary: This study aimed to describe the surgical technique and outcomes of single-incision laparoscopic clockwise continuous total abdominal colectomy with end ileostomy in patients with ulcerative colitis. The study included 52 patients, with a median operation time of 100 minutes and a postoperative complication rate of 25%. There were no intraoperative complications or conversions to open surgery. The results showed that single-incision laparoscopic surgery is a safe and effective treatment option.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Nynke G. Greijdanus, Kiedo Wienholts, Sander Ubels, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Francisco B. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Yves Panis, Martin Rutegard, Roel Hompes, Camiel Rosman, Frans van Workum, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: The study developed a prediction model for 1-year stoma-free survival in rectal cancer patients with anastomotic leakage. The model, consisting of 18 clinically relevant factors, showed good discrimination and calibration, providing guidance for patient counseling and future treatment strategies analysis.
Article
Gastroenterology & Hepatology
Ilker Ozgur, Emre Gorgun
Summary: The role of lateral pelvic lymph node dissection in the treatment of locally advanced rectal cancer is controversial. While it is widely used in Korea and Japan, it is not routinely practiced in Western countries. This review aims to examine the role of lateral pelvic lymph node dissection.
CLINICS IN COLON AND RECTAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Danica N. Giugliano, Adina E. Feinberg, Ipek Sapci, Ilker Ozgur, Michael A. Valente, Scott R. Steele, Emre Gorgun
Summary: This study retrospectively analyzed the number of procedures required to achieve proficiency in advanced endoscopy and found that at least 100 cases were needed to achieve a polyp removal rate of 30 mm/h, with low complication rate, low polyp recurrence rate, and high en bloc resection rate.
DISEASES OF THE COLON & RECTUM
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Sumeyye Yilmaz, Naz Tursun, Madison Conces, Doua Elamin, Ilker Ozgur, Marianna Maspero, David R. Rosen, Smitha Krishnamurthi, Alok Khorana, Ehsan H. Balagamwala, Sudha Amarnath, David Liska, Michael Valente, Scott Steele, Emre Gorgun
Meeting Abstract
Gastroenterology & Hepatology
E. Ozcimen, I. Ozgur, I. Hameed, E. Gorgun
DISEASES OF THE COLON & RECTUM
(2022)
