The Noncompetitive AMPAR Antagonist Perampanel Abrogates Brain Endothelial Cell Permeability in Response to Ischemia: Involvement of Claudin-5

Endocannabinoids modulate human blood-brain barrier permeabilityin vitro

(2015) William H Hind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dabigatran Abrogates Brain Endothelial Cell Permeability in Response to Thrombin

(2015) Brian Thomas Hawkins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transmembrane proteins of the tight junctions at the blood–brain barrier: Structural and functional aspects

(2015) Reiner F. Haseloff et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Adverse effects and safety profile of perampanel: A review of pooled data

(2014) Fergus Rugg-Gunn   EPILEPSIA

The discovery and development of perampanel for the treatment of epilepsy

(2014) Takahisa Hanada   Expert Opinion on Drug Discovery

Homer1 knockdown protects dopamine neurons through regulating calcium homeostasis in an in vitro model of Parkinson's disease

(2013) Tao Chen et al.   CELLULAR SIGNALLING

Heart Disease and Stroke Statistics—2014 Update

(2013) Alan S. Go et al.   CIRCULATION

Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex

(2013) S.A. Neale et al.   NEUROCHEMISTRY INTERNATIONAL

Influence of GluN2 subunit identity on NMDA receptor function

(2013) D.J.A. Wyllie et al.   NEUROPHARMACOLOGY

Activation of AMP-activated protein kinase alleviates High-glucose-induced dysfunction of brain microvascular endothelial cell tight-junction dynamics

(2012) Chao Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

(2012) Shigeki Hibi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus

(2012) Laura Ceolin et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury

(2012) Silvia Manzanero et al.   NEUROCHEMISTRY INTERNATIONAL

Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

(2011) Takahisa Hanada et al.   EPILEPSIA

Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons

(2011) Tao Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium

(2010) Weiyong Shen et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma

(2009) J D Bell et al.   CELL DEATH AND DIFFERENTIATION

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

(2009) R. I. Stanika et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Blood-Brain Barrier Permeability by Transient Receptor Potential Type C and Type V Calcium-Permeable Channels

(2008) Rachel C. Brown et al.   MICROCIRCULATION

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE