Journal
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
Volume 25, Issue 3, Pages 679-687Publisher
ELSEVIER
DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.041
Keywords
Ischemic stroke; meta-analysis; MTHFR; polymorphism
Categories
Funding
- National Natural Science Foundation of China [81200914]
- Ministry of Science and Technology
- Ministry of Health of the People's Republic of China [2011BAI08B01]
- Beijing Biobank of Cerebral Vascular Disease [D131100005313003]
- Program of Talents by Beijing Municipal [2010D003034000012]
- Beijing Municipal Science and Technology Project [D131100002313003]
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Background: Hyperhomocysteinemia, a condition that is strongly determined by dietary intake of B vitamins, has been suggested to be an independent risk factor for ischemic stroke (IS). To test this hypothesis, we performed a meta-analysis to investigate the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which plays a critical role in modulating plasma homocysteine concentrations, and IS risk. Materials and Methods: We searched case-control studies on the association between MTHFR C677T genetic polymorphism and susceptibility to IS through PubMed, Embase, and Medline databases from January 2000 up to October 2014. The random-effects model was employed because moderate heterogeneity across studies was observed, as assessed by I-2 statistic. Publication bias was estimated using funnel plot and Egger's regression test. Results: A total of 22 case-control studies were included in the current meta-analysis. Significant associations between MTHFR C677T genetic polymorphism and IS were found under the dominant model (pooled odds ratio [OR] = 1.40, 95% confidence interval [CI]: 1.24-1.57), the recessive model (pooled OR = 1.37, 95% CI: 1.16-1.61), and the allele model (pooled OR = 1.29, 95% CI: 1.18-1.42). Conclusions: The meta-analysis suggests that MTHFR C677T genetic polymorphism is significantly associated with susceptibility to IS, which provides evidence supporting hyperhomocysteinemia as a risk factor for stroke.
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