Article
Nutrition & Dietetics
Yiqing Peng, Malinda Wu, Jessica A. Alvarez, Vin Tangpricha
Summary: Cystic fibrosis-related diabetes (CFRD) affects up to half of CF patients by adulthood, primarily caused by pancreatic dysfunction. This study found that vitamin D deficiency increases the risk of developing CFRD in adults with CF, and maintaining a serum 25(OH)D concentration above 20 ng/mL may decrease this risk.
Article
Nutrition & Dietetics
Carmen Mangas-Sanchez, Maria Garriga-Garcia, Maria Juliana Serrano-Nieto, Ruth Garcia-Romero, Marina alvarez-Beltran, Elena Crehua-Gaudiza, Rosana Munoz-Codoceo, Lucrecia Suarez-Cortina, Saioa Vicente-Santamaria, Cecilia Martinez-Costa, Juan Jose Diaz-Martin, Carlos Bousono-Garcia, David Gonzalez-Jimenez
Summary: In patients with CF, higher doses of vitamin D were associated with a decreased risk of deficiency and higher serum calcidiol levels. However, nearly one-third of CF patients still do not reach sufficient levels of vitamin D despite the new guidelines.
Article
Nutrition & Dietetics
Xiaoning Cui, Ke Wang, Jinghua Zhang, Zhen-Bo Cao
Summary: Myocardial fibrosis is a crucial factor in the development of heart diseases associated with cardiovascular disease. Vitamin D deficiency promotes the development of cardiovascular disease, while exercise plays a role in its treatment. This study aimed to investigate the effects of 12-week aerobic exercise training on myocardial fibrosis in vitamin D-deficient mice.
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Medicine, General & Internal
Michele Santiago dos Santos, Daniele Canale, Desiree Rita Denelle Bernardo, Maria Heloisa Massola Shimizu, Antonio Carlos Seguro, Rildo Aparecido Volpini, Ana Carolina de Braganca
Summary: Maintaining adequate levels of vitamin D can improve renal function, reduce inflammation and fibrotic lesions, and may serve as a therapeutic alternative in mitigating renal disease progression.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. R. Delanghe, Marijn M. M. Speeckaert
Summary: Vitamin D is an immune modulator that affects infection susceptibility. The relationship between vitamin D deficiency and mortality in sepsis patients remains unclear. Adequate vitamin D concentration may reduce mortality in sepsis patients with severe deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jose Luis Perez-Castrillon, Antonio Duenas-Laita, Carlos Gomez-Alonso, Esteban Jodar, Javier del Pino-Montes, Maria Luisa Brandi, Fernando Cereto Castro, Jose Manuel Quesada-Gomez, Laura Gallego Lopez, Jose Manuel Olmos Martinez, Maria Rosa Alhambra Exposito, Bernat Galarraga, Jesus Gonzalez-Macias, Jose Luis Neyro, Roger Bouillon, Gonzalo Hernandez-Herrero, Nieves Fernandez-Hernando, Sandra P. Chinchilla
Summary: This report presents the results of a 1-year clinical trial comparing the efficacy and safety of monthly calcifediol and cholecalciferol in postmenopausal women with vitamin D deficiency. The study found that monthly calcifediol is an effective and safe treatment, maintaining stable vitamin D levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Takashi Ogasawara, Yasuhisa Tajima, Naoto Nakamura, Hiroki Kanasaki, Wataru Matsuyama, Mitsuru Niwa, Yuichi Ozawa, Masayuki Sugiura, Masahito Ogiku, Jun Sato
Summary: This study aimed to evaluate the efficacy of 1-hydroxy-vitamin D in COVID-19 patients. The results showed that patients treated with 1-hydroxy-vitamin D had a significantly lower proportion of needing respiratory support and in-hospital mortality compared to the control group.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Jose-Luis Perez-Castrillon, Ricardo Usategui-Martin, Pawel Pludowski
Summary: Calcifediol is the prohormone of the vitamin D endocrine system, used to prevent and treat vitamin D deficiency. It is more efficient and safe than cholecalciferol, with a rapid onset of action and greater potency. The increase in 25-OH vitamin D depends on the dose and frequency of calcifediol administration, while cholecalciferol administration is influenced by additional factors such as obesity and malabsorption.
Article
Nutrition & Dietetics
Zaleha Md Isa, Nor Rumaizah Mohd Nordin, Muhammad Hilmi Mahmud, Syahirah Hashim
Summary: Vitamin D deficiency is prevalent worldwide, including in Malaysia, particularly among females, Indians, and those of Malay ethnicity. It can be managed through pharmacological or non-pharmacological approaches, and prevention methods include adequate intake, sun exposure, or supplementation. Special attention should be given to high-risk groups such as infants, obese patients, and the elderly.
Article
Medicine, General & Internal
Anirudh Bhimavarapu, Qiao Deng, Marta Bean, Nick Lee, Thomas R. Ziegler, Jessica Alvarez, Vin Tangpricha
Summary: This study aimed to assess factors impacting vitamin D status in patients with cystic fibrosis before experiencing pulmonary exacerbation. Sunlight exposure was found to be the most predictive determinant of vitamin D status, while reported vitamin D intake was generally below recommended levels. Further investigation is needed to optimize vitamin D status prior to a pulmonary exacerbation.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Jae-Hun Jung, Eun-Ah Kim, Sang-Yoon Lee, Jung-Eun Moon, Eun-Joo Lee, Sook-Hyun Park
Summary: This study aimed to investigate changes in vitamin D levels and factors associated with vitamin D deficiency (VDD) in Korean preterm infants during the first year of life. The study found a high incidence of VDD in these infants, with vitamin D levels at birth being the strongest predictor of VDD during follow-up. Vitamin D supplementation at 400 IU/day did not affect vitamin D levels during the first year of life. Further research is needed to determine the optimal vitamin D supplementation dose for Korean preterm infants.
Article
Endocrinology & Metabolism
John D. Sluyter, Yoshihiko Raita, Kohei Hasegawa, Ian R. Reid, Robert Scragg, Carlos A. Camargo
Summary: Using machine learning models to predict vitamin D deficiency showed higher accuracy in predicting 25(OH)D <25 nmol/L compared to traditional models, suggesting a potential role for machine learning models in participant selection for vitamin D supplement trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Sandra Alvear-Vega, Rodrigo Benavente-Contreras, Hector Vargas-Garrido
Summary: The social determinants associated with Serum 25-hydroxyvitamin D concentrations deficiency in older adults include gender, native origin, urban residence, sunlight exposure, and geographical latitude. Health promotion and prevention programs should be targeted towards older adults in urban areas, with a special focus on women, especially in the southernmost regions.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Hyeri Seok, Jooyun Kim, Won Suk Choi, Dae Won Park
Summary: A prospective cohort study found that severe vitamin D deficiency significantly increased mortality in sepsis patients. Evaluating vitamin D levels in sepsis patients may become necessary in an aging society.
Article
Urology & Nephrology
Alayne D. Markland, Camille P. Vaughan, Alison J. Huang, Eunjung Kim, Vadim Y. Bubes, Vin Tangpricha, Julie R. Buring, I-Min Lee, Nancy R. Cook, JoAnn E. Manson, Francine Grodstein
Summary: The purpose of this study was to evaluate the effectiveness of vitamin D supplementation in preventing or treating overactive bladder and urinary incontinence in men. The results showed that overall, vitamin D supplementation did not improve overactive bladder or urinary incontinence compared to placebo. However, there were inconsistent findings when vitamin D supplements were used in men with lower levels of 25-hydroxyvitamin D.
JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Eric Walton, Sina Abhari, Vin Tangpricha, Cameron Futral, Akanksha Mehta
Summary: This study investigated family planning and fertility counseling perspectives of reproductive-age gender diverse adults and youth pursuing gender affirming hormone therapy. The results showed that individuals interested in or uncertain about future parenthood were more likely to consider cryopreservation and report inadequate family planning counseling. Therefore, current counseling practices may be insufficient and referral to a fertility specialist should be considered.
Review
Endocrinology & Metabolism
Renata Arrington-Sanders, Nathan T. Connell, Devin Coon, Nadia Dowshen, Anna L. Goldman, Zil Goldstein, Frances Grimstad, Noelle Marie Javier, Ellie Kim, Martina Murphy, Tonia Poteat, Asa Radix, Aviva Schwartz, Colt St Amand, Carl G. Streed Jr, Vin Tangpricha, Mabel Toribio, Robert H. Goldstein
Summary: Gender affirming hormone therapy (GAHT) improves mental health outcomes in transgender persons, but the risk of venous thromboembolism (VTE) should be considered, especially during long-term therapy and perioperative period. Hormone formulation, dosing, route, and duration of therapy can impact thromboembolic risk, and individualized risk assessment is necessary to avoid stopping GAHT due to concerns about VTE risk.
ENDOCRINE PRACTICE
(2023)
Editorial Material
Endocrinology & Metabolism
Vin Tangpricha
ENDOCRINE PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Sanjana Pampati, W. Dana Flanders, Qi Zhang, Brian K. Ahmedani, Shalender Bhasin, Darios Getahun, Timothy L. Lash, Courtney McCracken, David E. Sandberg, Michael J. Silverberg, Vin Tangpricha, Suma Vupputuri, Michael Goodman
Summary: Comparison between self-inflicted injuries among transgender and gender diverse (TGD) youth and their cisgender peers reveals that TGD individuals are more likely to engage in self-harm and have multiple mental health diagnoses. Universal suicide prevention efforts are necessary for all youth, including those without mental health issues, with intensified efforts for TGD youth and those with mental health diagnoses.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Lena Chu, Sarah Gold, Carlyn Harris, Leslie Lawley, Pranav Gupta, Vin Tangpricha, Michael Goodman, Howa Yeung
Summary: This retrospective cohort study aimed to assess the incidence and predictors of acne among transgender adolescents receiving testosterone. It found that 54% of the patients who did not have baseline acne developed acne within 1 year of testosterone initiation. Patients who used progestin prior to or during follow-up were more likely to develop acne. Therefore, transgender adolescents starting testosterone, particularly those taking progestin, should be monitored for acne development and treated proactively.
ENDOCRINE PRACTICE
(2023)
Correction
Nutrition & Dietetics
M. D. Kearns, J. N. G. Binongo, D. Watson, J. A. Alvarez, D. Lodin, T. R. Ziegler, V. Tangpricha
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Pranav Gupta, Briana C. Patterson, Lena Chu, Sarah Gold, Seth Amos, Howa Yeung, Michael Goodman, Vin Tangpricha
Summary: This study investigated the proportion and reasons for discontinuation of gender-affirming hormone therapy (GAHT) in transgender and gender diverse (TGD) individuals. The results showed that only a small percentage of participants discontinued GAHT, and the main reason was achieving desired treatment effects. This suggests that GAHT discontinuation is low when therapy follows the guidelines of the Endocrine Society.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Urology & Nephrology
Meron Siira, Darios Getahun, Michael J. Silverberg, Vin Tangpricha, Michael Goodman, Howa Yeung
Summary: This study examined patient satisfaction with current gender-affirming hormone therapy and their goals for additional hormone therapy. The majority of participants were satisfied with their current therapy, but transfeminine individuals and older participants were less likely to report satisfaction. Transfeminine individuals were more likely to plan for additional treatment to achieve goals such as breast size growth and feminine body fat distribution, while transmasculine individuals aimed for reducing dysphoria and masculine body fat distribution.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Computer Science, Information Systems
Carl G. Streed Jr, Dana King, Chris Grasso, Sari L. Reisner, Kenneth H. Mayer, Guneet K. Jasuja, Tonia Poteat, Monica Mukherjee, Ayelet Shapira-Daniels, Howard Cabral, Vin Tangpricha, Michael K. Paasche-Orlow, Emelia J. Benjamin
Summary: The study aims to validate an algorithm for identifying transgender and gender diverse (TGD) patients within electronic health record (EHR) data and evaluate its accuracy. The algorithm was validated in an EHR data set with self-reported gender identity using TGD-related diagnosis and procedure codes, and hormone therapy prescription data. The results showed that the algorithm had good sensitivity, specificity, positive predictive value, and negative predictive value in identifying TGD patients in administrative data. Further categorization based on prescription data also had high accuracy.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Malinda Wu, Anirudh Bhimavarapu, Jessica A. Alvarez, William R. Hunt, Vin Tangpricha
Summary: People with cystic fibrosis have increased risk for low bone mineral density and CF-related bone disease due to chronic inflammation and infection. This study suggests that vitamin D supplementation during acute pulmonary exacerbation may help reduce the risk for CF-related bone disease by decreasing markers of bone turnover.
Correction
Multidisciplinary Sciences
Pichatorn Suppakitjanusant, Nittaya Kasemkosin, Alisa K. Sivapiromrat, Samuel Weinstein, Boonsong Ongphiphadhanakul, William R. Hunt, Viranuj Sueblinvong, Vin Tangpricha
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Supavit Chesdachai, Zachary A. Yetmar, Nischal Ranganath, Jenna J. Everson, Nancy L. Wengenack, Omar M. Abu Saleh
Summary: The prevalence of invasive candidiasis caused by non-Candida albicans has increased rapidly, with Candida glabrata being an important pathogen associated with high mortality. This study examined the susceptibility of C. glabrata to antifungal drugs and its patterns of resistance to azoles and echinocandins. It was found that the proportion of fluconazole-resistant C. glabrata is relatively high, and itraconazole may be an effective treatment option for fluconazole resistance.
Article
Psychology, Clinical
Hayley Braun, Elaine C. Thompson, Qi Zhang, Vin Tangpricha, Michael Goodman, Howa Yeung
Summary: The prevalence of psoriasis among transgender individuals is similar to that in the general population, but further longitudinal research is needed to explore the potential association between psoriasis and gender-affirming hormone therapy.
TRANSGENDER HEALTH
(2023)
Review
Infectious Diseases
Isin Yagmur Comba, Supavit Chesdachai, Hussam Tabaja, Maryam Mahmood, Sharon Deml, Nancy L. Wengenack, John W. Wilson
Summary: Cardiovascular device infection due to rapidly growing mycobacteria (RGM) is becoming increasingly important. We report seven cases of RGM cardiovascular device infection and found that all patients had comorbidities, resulting in different treatment approaches.
JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)