Article
Pharmacology & Pharmacy
Sen He, Xin Li, Jie-Zhi Ma, Yuan Yang, Shuang Luo, Xian-De Xie, Bing-Hua Yan, Jian Yang, Lin Luo, Lin-Ying Cao
Summary: This study revealed the potential endocrine disruption mechanism of Niclosamide by activating estrogen receptors (ERs) and estrogen-related receptors (ERRs) at environmentally-related nanomolar levels. By fluorescence competitive binding assays and luciferase reporter gene assays, it was found that NIC showed higher binding affinity with ERR gamma than other receptors. Additionally, molecular docking simulations indicated that NIC could bind to ERR gamma with the highest binding energy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tetsuya Tsujikawa, Akira Makino, Tetsuya Mori, Hideaki Tsuyoshi, Yasushi Kiyono, Yoshio Yoshida, Hidehiko Okazawa
Summary: In recent decades, F-18-FDG PET has been widely used in the diagnosis of gynecological malignancies, showing higher diagnostic accuracy than conventional imaging methods in detecting metastatic lesions, local recurrence, and evaluating treatment response. Moreover, F-18-FES PET provides additional value to F-18-FDG PET in diagnosing and prognosticating estrogen-related gynecological tumors. PET imaging allows for in vivo measurement of tumor behavior, characterization of the entire tumor burden, and capturing the heterogeneity of tumor phenotype.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Environmental Sciences
Jiefeng Liang, Qian S. Liu, Zhihua Ren, Ke Min, Xiaoxi Yang, Fang Hao, Qing Zhang, Qian Liu, Qunfang Zhou, Guibin Jiang
Summary: This study systematically investigated the potential endocrine disrupting activities of four common parabens. The results showed that parabens exhibited typical estrogenic effects and could disrupt the endocrine system by activating estrogen receptors and disturbing steroid hormone synthesis and secretion, posing potential risks to the environment and human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Endocrinology & Metabolism
Caroline S. S. Johnson, Paul E. Micevych, Paul G. G. Mermelstein
Summary: Recent studies have shown that traditional estrogen receptors, alpha and beta, can also act at the cell surface in addition to their nuclear functions. Signaling from these membrane-bound estrogen receptors can rapidly affect cellular excitability and ultimately impact gene expression. The interaction between these membrane receptors and metabotropic glutamate receptors (mGluRs) plays a key role in various female functions such as reproduction and motivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Susanne Schueler-Toprak, Maciej Skrzypczak, Carsten Gruendker, Olaf Ortmann, Oliver Treeck
Summary: Ovarian cancer is the most lethal gynecological cancer mainly diagnosed in advanced stages, while endometrial cancer is often detected in early stages. Treatment options for recurrent or advanced disease are limited. Estrogens and their receptors play a role in both ovarian and endometrial cancers. This article provides an update on the current understanding of the roles of estrogen receptors in these cancers and highlights the need for further research.
Article
Microbiology
Hugo Aguilar-Diaz, Rosa Estela Quiroz-Castaneda, Ixchel Guadalupe Diaz-Esquivel, Raquel Cossio-Bayugar, Estefan Miranda-Miranda
Summary: The search for alternatives to control ticks and tick-borne diseases is an ongoing issue. This study identified an estrogen-related receptor gene in cattle ticks and investigated its interaction with different estrogens, suggesting its potential as a target for tick control strategies.
Article
Fisheries
Shiyan Liu, Haofeng Ouyang, Chong Han, Jingjun Huang, Qiaoying Zhu, Dingrui Liu, Linqiang Han, Shuisheng Li, Guifeng Li, Haoran Lin, Yong Zhang
Summary: The study cloned six estrogen-related receptors (errs) from the gonads of mandarin fish and analyzed their expression patterns and functions.
AQUACULTURE REPORTS
(2022)
Review
Gastroenterology & Hepatology
Xinyu Qi, Chuyu Yun, Yanli Pang, Jie Qiao
Summary: The gut microbiota, considered a full-fledged endocrine organ, plays a major role in women's reproductive endocrine system by interacting with various hormones. Imbalance in microbiota composition can lead to diseases like pregnancy complications and PCOS, highlighting the need for further research and novel therapeutic strategies.
Article
Endocrinology & Metabolism
Anela Blazevic, Anand M. Iyer, Marie-Louise F. Van Velthuysen, Johannes Hofland, Lindsey Oudijk, Wouter W. de Herder, Leo J. Hofland, Richard A. Feelders
Summary: Small-intestinal neuroendocrine tumors (SI-NETs) have a higher prevalence and worse prognosis in male patients. This study found that mesenteric metastasis and fibrosis were more common in men than women. The risk of mesenteric metastasis in women increased around menopause. The expression of estrogen receptor alpha and androgen receptor was observed in primary tumors and mesenteric metastases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Oncology
Darcie D. Seachrist, Lindsey J. Anstine, Ruth A. Keri
Summary: The review discusses the role of FOXA1 in regulating gene activity, cell biology, and the response of breast cancers to hormone therapies. It also highlights the potential for future studies to explore the roles of FOXA1 independent of its regulation of nuclear receptors.
Review
Oncology
Shaimaa Hussein, Pooja Khanna, Neha Yunus, Michael L. Gatza
Summary: Metabolic reprogramming allows cancer cells to adapt to changing environments and provide necessary biological molecules for growth. Hormone receptor positive breast cancer relies on various metabolic processes, with changes influenced by hormone-dependent signaling and other nuclear receptors.
Review
Biochemistry & Molecular Biology
Lea Clusan, Francois Ferriere, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer, the most common and deadliest cancer among women worldwide, is closely associated with estrogen signaling. Hormone therapy using antiestrogens is the standard treatment, but resistance inevitably occurs through various biological mechanisms. Understanding the estrogen pathway is crucial for the development of new therapies for hormone-dependent breast cancer. This mini-review summarizes the current literature on estrogen receptors in breast cancer, including their signalization, mechanisms of action, and clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jan C. Kessel, Ralf Weiskirchen, Sarah K. Schroeder
Summary: Estrogen receptor alpha (ERa) is expressed in reproductive and non-reproductive tissues, and its impact on lipocalin 2 (LCN2) expression varies among tissues. This study found an inverse correlation between ERa and LCN2 expression in reproductive tissues, particularly in Esr1-deficient ovaries. However, no significant differences in LCN2 expression were observed in non-reproductive tissues. These findings provide insight into LCN2 regulation in relation to hormones and health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Zhou Zhu, Nicholas C. Turner, Sherene Loi, Fabrice Andre, Miguel Martin, Veronique Dieras, Karen A. Gelmon, Nadia Harbeck, Cathy Zhang, Joan Q. Cao, Zhengming Yan, Dongrui R. Lu, Ping Wei, Todd L. VanArsdale, Paul A. Rejto, Xin Huang, Hope S. Rugo, Sibylle Loibl, Massimo Cristofanilli, Richard S. Finn, Yuan Liu
Summary: This study conducted a comparative analysis of gene expression and progression-free survival relationships from two phase 3 trials, showing that the addition of palbociclib to endocrine therapy can change biomarker patterns and may recondition endocrine-resistant tumors to respond to ET. This finding may guide the optimal therapeutic sequencing by combining CDK4/6 inhibitors with different ETs.
NPJ PRECISION ONCOLOGY
(2022)
Review
Oncology
Jessica Fernanda Barazetti, Tayana Shultz Jucoski, Tamyres Mingorance Carvalho, Rafaela Nasser Veiga, Ana Flavia Kohler, Jumanah Baig, Hend Al Bizri, Daniela Fiori Gradia, Sylvie Mader, Jaqueline Carvalho de Oliveira
Summary: Breast cancer is a common disease that often recurs due to resistance to tamoxifen. Understanding estrogen receptor-positive breast cancer tumors, which are the most common subtype, is crucial for more effective treatment. Non-coding RNAs play a role in tamoxifen resistance and further exploration of their mechanisms may lead to more personalized and targeted therapies.
Article
Environmental Sciences
Zhixiang Xu, Dimeng Zhao, Xianyao Zheng, Bin Huang, Xuejun Pan, Xueshan Xia
Summary: The study demonstrated that environmental concentrations of E2 can promote cell growth, migration, invasion, apoptosis inhibition, and G1-S progression in tamoxifen-resistant patients. Overexpression of ERα36 and GPR30 can restore tamoxifen sensitivity and partially offset the proliferative effects mediated by E2.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Engineering, Environmental
Chaochao Lai, Huan He, Wenxiao Xie, Sihan Fan, Huang Huang, Yan Wang, Bin Huang, Xuejun Pan
Summary: The presence of Fe was found to greatly enhance the adsorption rate and capacity as well as photodegradation ability of plastic-char for treating persistent organic pollutants in aqueous media. Hydroxyl radical and holes were identified as the predominant reactive species contributing to the photodegradation of target contaminants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Huan He, Tianguo Zhao, Qicheng Ma, Xiaoxia Yang, Qingsong Yue, Bin Huang, Xuejun Pan
Summary: This study constructed an efficient photoelectrocatalytic system using TiO2 nanotube arrays decorated with Ag/SnO2-Sb nanoparticles as the anode and Ti-Pd/SnO2-Sb as the cathode. The system showed high removal efficiency of antibiotics, antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in reclaimed water, while also reducing the ecotoxicity of chloramphenicol (CAP) solution. The study provides a potential alternative method for controlling antibiotic resistance and protecting the quality of reclaimed water.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Xianyao Zheng, Zhixiang Xu, Dimeng Zhao, Yu Luo, Chaochao Lai, Bin Huang, Xuejun Pan
Summary: The study found that humic acid has a dual-dose effect on the growth of Scenedesmus capricornus. At concentrations below 2.0 mgC/L, it slightly promotes growth, but significantly inhibits growth when concentrations exceed 2.0 mgC/L.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Xing Wan, Zhicheng Liao, Huan He, Min Shi, Guoxi Yu, Fenqing Zhao, Chaochao Lai, Yan Wang, Bin Huang, Xuejun Pan
Summary: Sediment dredging is effective in controlling endogenous pollution in lakes, but little attention has been paid to the desorption mechanism of dissolved organic matter (DOM) on pollutants and the change of biodiversity. This study investigated the physicochemical properties of DOM in sediment and its correlation with the desorption behavior of pollutants and aquatic organism biodiversity, using a sediment dredging project in Dianchi Lake as an example.
ENVIRONMENTAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Zhixiang Xu, Xin Long, Yue Jia, Dimeng Zhao, Xuejun Pan
Summary: The recent use of engineered nanomaterials in various industries poses a health risk to organisms and ecosystems. However, there is limited knowledge on the toxicity of nanomaterials in complex soil systems. This review examines the fate of engineered nanomaterials in soils, their toxicity to soil organisms, and the factors that control their toxicity. Factors such as soil properties, organic matter, and coexisting contaminants play a role in determining the toxicity of nanomaterials.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Review
Engineering, Environmental
Zhixiang Xu, Dimeng Zhao, Jichang Lu, Jun Liu, Guohua Dao, Bo Chen, Bin Huang, Xuejun Pan
Summary: Antibiotic resistance has become a global health concern, with antibiotic resistance genes frequently detected in various environmental media. This review focuses on the influence of nanomaterials on the removal and horizontal gene transfer of antibiotic resistance genes. It elaborates on the occurrence, behavior, and potential hazards of antibiotic resistance genes, summarizes nanomaterials-mediated antibiotic resistance removal, discusses the influence of nanomaterials on the horizontal gene transfer of antibiotic resistance genes, and highlights the tradeoff between their elimination and transfer. This review enhances our understanding of nanomaterials-mediated dissemination of antibiotic resistance and alerts us to reconsider the reasons for ARGs spread and the potential detriment of nanomaterials in complex ecological environments.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nutrition & Dietetics
Zhixiang Xu, Yue Jia, Jun Liu, Xiaomin Ren, Xiaoxia Yang, Xueshan Xia, Xuejun Pan
Summary: This study aimed to investigate the synergistic antitumor effects of tamoxifen and naringenin/quercetin on human hepatic carcinoma, and to explore the potential molecular mechanisms involved. The results demonstrated that a combination of tamoxifen and higher concentrations of naringenin or quercetin significantly inhibited cell growth and migration, stimulated apoptosis, and resulted in loss of mitochondrial membrane potential. These effects were regulated by ROS-mediated p53 signaling cascades. On the other hand, lower concentrations of naringenin and quercetin regulated cell migration, invasion, cycle, and apoptosis, thereby inhibiting the tamoxifen-induced antiproliferative effects.
Review
Chemistry, Multidisciplinary
Zhixiang Xu, Yue Jia, Bin Huang, Dimeng Zhao, Xin Long, Siyuan Hu, Caiqing Li, Guohua Dao, Bo Chen, Xuejun Pan
Summary: With the increasing production and use of antibiotics, China has become a major source of antibiotic resistance genes, leading to higher pollution levels and posing a threat to human health. Studies have shown that eastern China has higher levels of antibiotics and resistance genes, with tetracycline and sulfanilamide resistance genes being the most prevalent. These genes can be found in water, soil, atmosphere, and wastewater.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Environmental
Zhixiang Xu, Yue Jia, Xuanhe Zhang, Siyuan Hu, Yu Luo, Huan He, Bo Chen, Bin Huang, Xuejun Pan
Summary: Algae play an important role in the sunlight-driven degradation of environmental contaminants. This study investigated the role of algal organic matter (AOM) from Microcystis aeruginosa in tetracycline photodegradation. The results showed that different types of AOM promoted tetracycline degradation in different ways and efficiencies.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Bo Chen, Fengling Yu, Sha Wang, Yang Liu, Dehong Li, Yuning Chen, Guohua Dao, Zhixiang Xu, Xuejun Pan
Summary: In this study, a novel Fe3+ cross-linked alginate aerogel (SA/DA-Fe3+) was successfully fabricated and applied for highly efficient removal of tetracycline (TC) from water. The Fe3+ and DA in the aerogel enhanced the adsorption of TC, which was effective over a wide pH range. The kinetics process and adsorption isotherm were well-described by chemisorption controlled pseudo-second-order kinetics model and Langmuir equation, respectively. Multiple interactions were involved in the adsorption process. The SA/DA-Fe3+ aerogel showed good stability, reusability, and recyclability, and had great potential for treating TC-containing wastewater.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Environmental
Zhixiang Xu, Dimeng Zhao, Xianyao Zheng, Kemeng Sheng, Yu Luo, Bo Chen, Bin Huang, Xiaoxia Yang, Xuejun Pan
Summary: This study investigated the aquatic toxic effects and mechanisms of MoS2 nanosheets on the freshwater green microalgae Selenastrum capricornutum. The results showed that low concentrations of single-layer MoS2 nanosheets stimulated algal growth, while higher concentrations inhibited growth through oxidative damage and membrane destruction. Additionally, MoS2 nanosheets accelerated the secretion of extracellular polymeric substances and changed their fluorescent components, thus influencing algal growth.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
