Article
Pharmacology & Pharmacy
Zongzhi Yin, Jingjing Su, Jiajia Fei, Tengteng Li, Dan Li, Yunxia Cao, Raouf A. Khalil
Summary: Women undergoing diagnostic hysteroscopy may experience thermal injury to the uterus, causing potential harm to uterine functions and fertility. This study explored the effects of uterine thermal insult on myometrium function and various factors related to contraction. The findings suggest that the uterus undergoes a recovery and adaptation process after inflammation caused by thermal insult, with preserved contraction, hormone inhibition, and specific cellular processes.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Z. B. Turner, F. S. Lima, A. J. Conley, B. R. McNabb, J. D. Rowe, A. Garzon, T. M. Urbano, C. M. Morris, R. V. Pereira
Summary: The most frequent definition for cystic ovarian disease in cattle is an abnormally persistent follicle (>7 to 10 d) with a diameter >25 mm. Discriminating between luteal and follicular ovarian cystic structures has traditionally been done by measuring the rim width of luteal tissue. The most common practice for diagnosing cystic ovarian disease is rectal palpation with or without the use of a B-mode ultrasound.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Damien Hunter, Kee Heng, Navdeep Mann, Ravinder Anand-Ivell, Richard Ivell
Summary: This study found that maternal exposure to xenobiotics DBP or DES may cause long-term changes in hypothalamic gene expression and reproductive behavior in offspring, particularly leading to significant impact on gene expression and sexual behavior with DES treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Leonie Dopavogui, Florence Cadoret, Gaspard Loison, Sara El Fouikar, Francois-Xavier Frenois, Frank Giton, Sandrine Ellero-Simatos, Frederic Lasserre, Arnaud Polizzi, Clemence Rives, Nicolas Loiseau, Roger D. Leandri, Nicolas Gatimel, Laurence Gamet-Payrastre
Summary: Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, is considered to be involved in this reproductive disorder. This study found that exposure to a common pesticide mixture can disrupt folliculogenesis in mice, leading to abnormal ovarian structure and changes in hormone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Zhuo Li, Hongrui Wei, Siyan Li, Pei Wu, Xiaoyun Mao
Summary: The progesterone receptor modulates estrogen receptor action in breast cancer and is a valuable prognostic biomarker in the disease.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Carolin Jungmann, Caroline Gauguin Houghton, Frederik Goth Nielsen, Eva-Maria Packeiser, Hanna Koerber, Iris M. Reichler, Orsolya Balogh, Sandra Goericke-Pesch
Summary: Alterations in OXTR and PGR expression were found in canine uterine inertia, with higher expression observed in primary uterine inertia compared to obstructive dystocia. The study also suggested the involvement of counterregulatory mechanisms to overcome myometrial quiescence and the need for further research on the differences in OXTR expression between myometrial layers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lucie Kolatorova, Jana Vitku, Josef Suchopar, Martin Hill, Antonin Parizek
Summary: Progesterone, traditionally associated with female fertility and pregnancy, has various novel actions, particularly neuro- and immunoprotective activities. It is widely used in reproductive medicine and has the potential for application in other medical fields. Its physiological and pharmacological actions, as well as its impact on the environment, have been researched and documented.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hidenori Yamasue, Masaki Kojima, Hitoshi Kuwabara, Miho Kuroda, Kaori Matsumoto, Chieko Kanai, Naoko Inada, Keiho Owada, Keiko Ochi, Nobutaka Ono, Seico Benner, Tomoyasu Wakuda, Yosuke Kameno, Jun Inoue, Taeko Harada, Kenji Tsuchiya, Kazuo Umemura, Aya Yamauchi, Nanayo Ogawa, Itaru Kushima, Norio Ozaki, Satoshi Suyama, Takuya Saito, Yukari Uemura, Junko Hamada, Yukiko Kano, Nami Honda, Saya Kikuchi, Moe Seto, Hiroaki Tomita, Noriko Miyoshi, Megumi Matsumoto, Yuko Kawaguchi, Koji Kanai, Manabu Ikeda, Itta Nakamura, Shuichi Isomura, Yoji Hirano, Toshiaki Onitsuka, Hirotaka Kosaka, Takashi Okada
Summary: Intranasal oxytocin has the potential to be a novel therapy for autism spectrum disorder, but the efficacy of repeated administrations is inconsistent. This study tested the effect of TTA-121, a new formulation of intranasal oxytocin with improved bioavailability, on the core symptoms of autism spectrum disorder and determined the dose-response relationship. The findings showed that TTA-121 at a dose of 6 U per day significantly improved the reciprocity score, indicating potential benefits for individuals with autism spectrum disorder.
Article
Environmental Sciences
Nolwenn Adam, Marie-Amelie Lachayze, Caroline Parmentier, Helene Hardin-Pouzet, Sakina Mhaouty-Kodja
Summary: This study examined the effects of exposure to DEHP, an organic pollutant, on maternal behavior in mice. The findings suggest that exposure to DEHP can alter maternal behavior, possibly through neuroendocrine pathways involving oxytocin and estrogen.
ENVIRONMENTAL POLLUTION
(2022)
Article
Pharmacology & Pharmacy
Rafael Chitolina, Patricia Nicola, Adrieli Sachett, Fernanda Bevilaqua, Lemen Cunico, Alissara Reginatto, Kanandra Bertoncello, Katiuska Marins, Ana Paula Zanatta, Marta Medeiros, Acauane S. Lima, Cristiane Parisotto, Jean Carlo O. Menegatt, Andre F. Goetten, Francielli C. Zimermann, Adriano T. Ramos, Valerio M. Portela, Marcos H. Barreta, Greicy Michelle M. Conterato, Leila Zanatta
Summary: Studies have shown that glyphosate can disrupt the endocrine system and have negative effects on male reproductive system. However, its effects on ovarian function are not well understood, calling for further studies on the toxicity of glyphosate in the female reproductive system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Sagi Enicole A. Gillera, William P. Marinello, Kevin T. Cao, Brian M. Horman, Heather M. Stapleton, Heather B. Patisaul
Summary: The study found that developmental exposure to the common FR mixture Firemaster 550 has gender-specific effects on social behaviors and neuronal populations in prairie voles. Exposed females showed changes in AVP neurons while exposed males had alterations in dopaminergic neurons, indicating potential endocrine disruption on OT/AVP pathways and coordination of behaviors.
Article
Endocrinology & Metabolism
John Flanagan, Andreas Chatzittofis, Adrian Desai E. Bostrom, Jonas Hallberg, Katarina Gorts Oberg, Stefan Arver, Jussi Jokinen
Summary: Hypersexual men exhibit significantly higher plasma oxytocin levels, while completion of cognitive-behavioral therapy treatment leads to a significant reduction in oxytocin levels. These results suggest that the hyperactive oxytocinergic system in hypersexual men may serve as a compensatory mechanism to attenuate hyperactive stress.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Masatoshi Nagano, Fumihito Saitow, Shinpei Higo, Makoto Uzuki, Yasunori Mikahara, Toshio Akimoto, Hitoshi Ozawa, Katsuhiko Nishimori, Hidenori Suzuki
Summary: This study experimentally demonstrated that cesarean section may induce autism-like traits in offspring mice, and some of these changes were ameliorated by oxytocin treatment. Blocking oxytocin receptors before natural delivery also induced autism-related behaviors. Insufficient oxytocin exposure from dams to offspring during delivery may be a trigger for autism-related behaviors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Katrin Elisabeth Giel, Kathrin Schag, Elisabeth Johanna Leehr, Isabelle Mack, Lea-Sarah Schuster, Ariane Wiegand, Stephan Zipfel, Manfred Hallschmid, Vanessa Nieratschker
Summary: This study found that clinically significant binge eating pathology might be associated with lower DNA methylation of OXTR in obese males. This supports the idea that BED represents a specific vulnerability within the obesity spectrum. A better understanding of the epigenetic mechanisms of the OXT system could contribute to the development of interventions for eating and weight disorders.
CLINICAL EPIGENETICS
(2022)
Article
Pharmacology & Pharmacy
Rene Garduno-Gutierrez, Gabriela Rodriguez-Manzo, Alejandro Velazquez-Alvarado, Carolina Miller-Perez, Martha Leon-Olea
Summary: Repeated exposure to DE-79 alters the oxytocin-oxytocin receptor system in the brain and modifies male rat sexual behavior.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Obstetrics & Gynecology
F. Sultana, S. R. Davis, R. J. Bell, S. Taylor, R. M. Islam
Summary: The association between endogenous testosterone blood concentrations and cognitive performance among postmenopausal women remains inconclusive due to the imprecision of testosterone measurement and the methodological heterogeneity of the included studies.
Article
Obstetrics & Gynecology
Z. N. Azene, S. R. Davis, J. J. McNeil, A. M. Tonkin, D. J. Handelsman, R. M. Islam
Summary: This study investigated the association between estrone and sex hormone binding globulin (SHBG) concentrations with lipid concentrations in older postmenopausal women. The results showed that estrone and SHBG are associated with lipid concentrations in older women, with SHBG providing additional clinical predictive utility for the assessment of cardiometabolic disease risk.
Review
Obstetrics & Gynecology
S. R. Davis
Summary: This article summarizes some of the known information about testosterone in women, including its actions, consequences of depletion and replacement. It is not a comprehensive review of the literature in this field, but provides some informative insights.
Article
Obstetrics & Gynecology
F. Sultana, S. R. Davis, A. M. Murray, R. L. Woods, J. J. McNeil, R. M. Islam
Summary: This study aimed to explore the associations between sex hormones and cognitive performance in older women. The results showed no associations between sex hormones and cognitive performance, but a correlation was found between low sex hormone binding globulin concentrations and better processing speed.
Letter
Obstetrics & Gynecology
S. R. Davis
Review
Endocrinology & Metabolism
Sasha Taylor, Rakibul M. Islam, Robin J. Bell, Chandima Hemachandra, Susan R. Davis
Summary: This study aims to investigate the associations between endogenous testosterone blood concentrations and muscle mass, strength, and performance in community dwelling women. The review found that there is no association between total testosterone and muscle mass, strength, or performance in women. Although calculated free or bioavailable testosterone showed a positive association with lean muscle mass, no association was found for muscle strength or performance.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Scott M. Nelson, Susan R. Davis, Sophia Kalantaridou, Mary Ann Lumsden, Nick Panay, Richard A. Anderson
Summary: This systematic review aimed to determine the usefulness of serum anti-Mullerian hormone (AMH) in diagnosing menopause, predicting menopause, or predicting/diagnosing premature ovarian insufficiency (POI). The review found that lower age-specific AMH concentrations were associated with earlier menopause, but AMH alone could not accurately predict the age at menopause. However, undetectable or extremely low AMH levels may assist in the early diagnosis of POI in young women.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Geriatrics & Gerontology
Chandima Hemachandra, Rakibul M. Islam, Robin J. Bell, Farhana Sultana, Susan R. Davis
Summary: This review examines the association between endogenous testosterone blood concentrations and depression in postmenopausal women. The results suggest no significant association between total testosterone or free testosterone and depression, except for one study which found a relationship between bioavailable testosterone and incident depressive symptoms in women at least 21 years postmenopause. However, due to methodological limitations in the included studies, further research using community-based samples and validated depression assessment tools is necessary to address this knowledge gap.
Review
Obstetrics & Gynecology
Chandima Hemachandra, Susan R. Davis, Robin J. Bell, Farhana Sultana, Rakibul M. Islam
Summary: This systematic review examines the association between endogenous DHEA/DHEAS and depression in postmenopausal women. The review concludes that there is no evidence to support a link between these hormones and depression in this population.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Obstetrics & Gynecology
Robin J. Bell, Penelope J. Robinson, Marina A. Skiba, Rakibul M. Islam, Chandima Hemachandra, Susan R. Davis
Summary: A large-scale study found that endometriosis has a significant impact on sick leave and work ability in women, including those without severe symptoms.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
M. Jahangirifar, E. Fooladi, S. R. Davis, R. M. Islam
Summary: Refugee and asylum seeker women at midlife and beyond face various health challenges, including menopausal symptoms, sexual dysfunctions, and pelvic floor disorders. However, there is limited global knowledge about the prevalence and risk factors of these neglected health issues in this population.
Article
Endocrinology & Metabolism
Jo Wrigglesworth, Ian H. Harding, Rakibul M. Islam, Phillip G. D. Ward, Robyn L. Woods, Robin J. Bell, John J. McNeil, Elsdon Storey, Gary Egan, Anne M. Murray, Ruth E. Trevaks, Stephanie A. Ward, Susan R. Davis, Joanne Ryan
Summary: This study investigated the relationship between circulating sex hormones and structural brain ageing in older women. The findings showed that women with higher levels of DHEA had higher baseline brain ageing, but this association was not significant after controlling for age and other potential confounding factors. Estrone, testosterone, and sex-hormone binding globulin were not associated with brain ageing. Further studies on circulating sex hormones and brain health in postmenopausal women are needed.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Susan R. Davis, Karen Magraith
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Review
Obstetrics & Gynecology
S. R. Davis
Summary: Cardiovascular disease (CVD) is the leading cause of death in older women, and sex hormones, especially estrogens in women, play a crucial role in its development. Low testosterone levels in women may also have detrimental effects on cardiovascular function. Testosterone has been shown to have favorable effects on blood vessel function and blood pressure in postmenopausal women. Animal studies have demonstrated advantageous effects of testosterone on myocardial function and cardiac electrical signaling. However, there is limited human data, mainly consisting of observational and mechanistic studies, on the cardiovascular effects of testosterone in women.
Review
Obstetrics & Gynecology
S. R. Davis, S. Taylor, C. Hemachandra, K. Magraith, P. R. Ebeling, F. Jane, R. M. Islam
Summary: The Practitioner's Toolkit for Managing the Menopause has been revised to ensure that it reflects current best practice, with updated algorithms and supporting information.