Letter
Biochemistry & Molecular Biology
Si-Cho Kim, Da-Won Kim, Eun Ju Cho, Jin-Young Lee, Jiwon Kim, Chaesun Kwon, Jeongsil Kim-Ha, Suk Kyun Hong, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Won Kim, Woojin Kim, Hyunsoo Kim, Yoon Jun Kim, Jung-Hwan Yoon, Su Jong Yu, Young-Joon Kim
Summary: To address the limitations of current HCC surveillance tests, this study identifies two HCC-specific methylation markers, RNF135 and LDHB, and develops a highly sensitive PCR method, MS-HRM, to detect them in cfDNA. The combined analysis of RNF135 and LDHB outperforms the AFP test in detecting HCC.
Article
Immunology
Jianzhen Lin, Songhui Zhao, Dongxu Wang, Yang Song, Yue Che, Xu Yang, Jinzhu Mao, Fucun Xie, Junyu Long, Yi Bai, Xiaobo Yang, Lei Zhang, Jin Bian, Xin Lu, Xinting Sang, Jie Pan, Kai Wang, Haitao Zhao
Summary: The study revealed widespread intertumoral heterogeneity in multifocal HCC, with TP53 and TERT being the most common truncal drivers and TSC2 being the most frequently mutated branchy driver. Patients with higher levels of intertumoral heterogeneity had shorter recurrence-free survival after surgical resection. Genomic profiling of cfDNA could effectively capture tumor-derived driver mutations in patients with resected multifocal HCC, serving as a non-invasive strategy to decipher genomic alterations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Hyojin Chae, Pil Soo Sung, Hayoung Choi, Ahlm Kwon, Dain Kang, Yonggoo Kim, Myungshin Kim, Seung Kew Yoon
Summary: The study identified pathogenic variants of TP53 and CTNNB1 genes in cfDNA from HCC patients through deep sequencing, highlighting the utility of cfDNA analysis in identifying genetic variants in HCC patients.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Oncology
Szilvia Lilla Csoma, Judit Bedekovics, Gergo Veres, Anita arokszallasi, Csilla Andras, Gabor Mehes, Attila Mokanszki
Summary: In the era of personalized oncology, next-generation sequencing plays a crucial role in identifying genetic aberrations in biliary tract cancers. Our study demonstrates that liquid biopsy of peripheral blood can effectively monitor the molecular genetic profile and chemotherapy response in BTCs, providing a minimally invasive testing approach for precision oncology treatment.
Article
Medicine, General & Internal
Biyuan Luo, Fang Ma, Hao Liu, Jixiong Hu, Le Rao, Chun Liu, Yongfang Jiang, Shuyu Kuangzeng, Xuan Lin, Chenyang Wang, Yiyu Lei, Zhongzhou Si, Guangshun Chen, Ning Zhou, Chengbai Liang, Fangqing Jiang, Fenge Liu, Weidong Dai, Wei Liu, Yawen Gao, Zhihong Li, Xi Li, Guangyu Zhou, Bingsi Li, Zhihong Zhang, Weiqi Nian, Lihua Luo, Xianling Liu
Summary: This study developed a sensitive blood-based non-invasive screening model for hepatocellular carcinoma (HCC) that can effectively distinguish early-stage HCC patients from high-risk population, and it demonstrated superior performance in an independent validation cohort.
Article
Medical Laboratory Technology
Jie Ren, Ping Lu, Xin Zhou, Yuhan Liao, Xiaomeng Liu, Jingyi Li, Wendong Wang, Jilian Wang, Lu Wen, Wei Fu, Fuchou Tang
Summary: This study conducted genome-scale cfDNA methylation analysis using the MCTA-Seq method in GC patients, and identified 153 cfDNA methylation biomarkers for GC detection in blood. These biomarkers showed high sensitivity and specificity for detecting GC at different stages, and could effectively distinguish CIMP and NON-CIMP tumors. Additionally, this study demonstrated the potential of MCTA-Seq in discriminating early-stage GC, CRC, and HCC in blood with high specificity.
CLINICAL CHEMISTRY
(2022)
Review
Gastroenterology & Hepatology
Xueying Lyu, Yu-Man Tsui, Daniel Wai-Hung Ho, Irene Oi-Lin Ng
Summary: Liver cancer is a fatal cancer that is often detected at an advanced stage. Liquid biopsy, a noninvasive detection method, can detect the presence of liver cancer by analyzing plasma ctDNA. Consistency between plasma ctDNA and tumor tissue genomic DNA mutational profile is crucial in the clinical management of liver cancer. Utilizing genetic information from plasma ctDNA profiling and standardizing clinical practice can lead to more efficient detection, better treatment guidance, and reliable disease monitoring.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Yasutoshi Fujii, Atsushi Ono, C. Nelson Hayes, Hiroshi Aikata, Masami Yamauchi, Shinsuke Uchikawa, Kenichiro Kodama, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Wataru Okamoto, Tomokazu Kawaoka, Masataka Tsuge, Michio Imamura, Kazuaki Chayama
Summary: This study showed that ctDNA profiling can detect somatic alterations in most advanced HCC patients, and monitoring ctDNA kinetics during LEN treatment can serve as a useful marker for disease progression. These findings indicate that ctDNA profiling holds promise for providing valuable information in clinical practice.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Genetics & Heredity
Wenjin Liang, Zhigao Xu, Fangyu Kong, Xiao Huang, Yuxin Xiao, Wei Zhou, Shaojun Ye, Qifa Ye
Summary: This study developed a novel test that combines CTC count and GNB4/Riplet methylation detection for the early diagnosis of HCC. The results showed high sensitivity and specificity for this method.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Shubin Hong, Bo Lin, Minjie Xu, Quan Zhang, Zijun Huo, Mingyang Su, Chengcheng Ma, Jinyu Liang, Shuang Yu, Qiye He, Zhixi Su, Yanbing Li, Rui Liu, Zhuming Guo, Weiming Lv, Haipeng Xiao
Summary: This study aimed to establish a cfDNA-based DNA methylation marker panel for differentiating papillary thyroid carcinoma (PTC) from benign thyroid nodule (BTN). Methylation markers of PTC were identified and combined with PTC markers from literature, and were tested and validated. The ThyMet classifier improved the specificity of differentiating PTC from BTN over ultrasonography, and the combinatorial ThyMet-US classifier may be effective in preoperative diagnosis of PTC.
Review
Biochemistry & Molecular Biology
Sravan Jeepalyam, Ankur Sheel, Aslam Ejaz, Eric Miller, Ashish Manne
Summary: Using cell-free DNA (cfDNA) to revamp the current biomarker landscape of hepatocellular carcinoma (HCC) could improve overall outcomes. However, the commercially available cfDNA testing is limited and lacks predictive value, making it unreliable for perioperative risk stratification in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Ilana Fox-Fisher, Sheina Piyanzin, Bracha Lea Ochana, Agnes Klochendler, Judith Magenheim, Ayelet Peretz, Netanel Loyfer, Joshua Moss, Daniel Cohen, Yaron Drori, Nehemya Friedman, Michal Mandelboim, Marc E. Rothenberg, Julie M. Caldwell, Mark Rochman, Arash Jamshidi, Gordon Cann, David Lavi, Tommy Kaplan, Benjamin Glaser, Ruth Shemer, Yuval Dor
Summary: The immune cell type-specific methylation patterns in circulating cell-free DNA (cfDNA) can be used for studying human immune cell dynamics and provide a novel biomarker for monitoring immune responses to physiological and pathological processes.
Article
Infectious Diseases
Amy Oreskovic, Adam Waalkes, Elizabeth A. Holmes, Christopher A. Rosenthal, Douglas P. K. Wilson, Adrienne E. Shapiro, Paul K. Drain, Barry R. Lutz, Stephen J. Salipante
Summary: This study characterized the size and composition of urine cell-free DNA from tuberculosis patients using next-generation sequencing, finding that MTB cfDNA is shorter and increases in abundance with shorter fragment lengths. Additionally, a larger fraction of short human genomic cfDNA was identified in urine samples, along with cfDNA fragments spanning the MTB genome.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Nanoscience & Nanotechnology
Peng Qi, Ya-ling Zeng, Xu Ye, Ya-mei Li, Feng-jiao Wang, Wang-yang Pu, Rong Zhang, Min Li, Li Xiao, Gang Huang, Sirois Pierre, Jun Chuan, Jingjing Luo, Duan-fang Liao, Hongyan Wen, Kai Li
Summary: In this study, several strategies were tested to limit or abolish self-ligation of next generation sequencing adapters. Experimental data showed that these strategies can significantly reduce or completely eliminate self-ligation. Minimizing or eliminating self-ligation is crucial in improving the sensitivity, efficiency, and reproducibility of enzyme-mediated methylation assays. These strategies may also have applications in other nanotechnologies.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Oncology
Ricardo Martins-Ferreira, Barbara Leal, Joao Chaves, Laura Ciudad, Raquel Samoes, Antonio Martins da Silva, Paulo Pinho Costa, Esteban Ballestar
Summary: DNA methylation profiling can be used as a non-invasive and reproducible approach to identify biomarkers for epilepsy.
CLINICAL EPIGENETICS
(2022)
Review
Food Science & Technology
Xiaoxue Zhu, Xin-Huai Zhao, Qiang Zhang, Na Zhang, Olugbenga P. Soladoye, Rotimi E. Aluko, Yuhao Zhang, Yu Fu
Summary: This article reviews the latest research progress on the relationship between celiac disease (CD) and gluten. It emphasizes the structure and function of gluten peptides related to CD, gluten detection methods, the effects of processing on gluten, and gluten-free diets. The limitations in current CD research are also discussed. This study facilitates a comprehensive understanding of CD and gluten, providing a theoretical reference for future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Xilong Wang, Bei Le, Na Zhang, Kathrine H. Bak, Yuhao Zhang, Yu Fu
Summary: Collagen peptides from fish have excellent bioactive and functional properties, making them important functional ingredients in the food industry. However, the off-flavour in fish collagen peptides limits their application. Therefore, researching the removal of off-flavour compounds from fish collagen peptides is of great importance.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Hefei Liu, Yuan Qin, Hung-Yu Chen, Jiangbin Wu, Jiahui Ma, Zhonghao Du, Nan Wang, Jingyi Zou, Sen Lin, Xu Zhang, Yuhao Zhang, Han Wang
Summary: This paper reviews the progress of artificial neuronal devices based on emerging volatile switching materials, focusing on the demonstrated neuron models implemented in these devices and their utilization for computational and sensing applications. Furthermore, it discusses the inspirations from neuroscience and engineering methods to enhance the neuronal dynamics that are yet to be realized in artificial neuronal devices and networks towards achieving the full functionalities of biological neurons.
ADVANCED MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Kunran Xu, Huawei Zhang, Yishi Li, Yuhao Zhang, Rui Lai, Yi Liu
Summary: This article discusses the importance and challenges of tiny machine learning (TinyML), which executes AI workloads on resource and power strictly restricted systems. It introduces an extremely tiny backbone for constructing high efficiency CNN models for various visual tasks. Additionally, a specially designed neural co-processor (NCP) is interconnected with MCU to build an ultra-low power TinyML system, achieving record-breaking ultra-low power consumption of 160mW while implementing object detection and recognition at 30FPS.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Engineering, Electrical & Electronic
Boyan Wang, Ming Xiao, Zichen Zhang, Yifan Wang, Yuan Qin, Qihao Song, Guo-Quan Lu, Khai Ngo, Yuhao Zhang
Summary: Size optimization of Achip is crucial for accurate cost analysis and design of multichip modules, especially for high-cost WBG and UWBG power devices. This study presents a new electrothermal approach to optimize Achip for a given set of specifications, considering breakdown voltage, conduction current, and switching frequency. The approach takes into account conduction and switching losses, as well as heat dissipation in the chip and package. It provides guidelines for power module design and offers more accurate cost analysis.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Joseph P. Kozak, Qihao Song, Ruizhe Zhang, Yunwei Ma, Jingcun Liu, Qiang Li, Wataru Saito, Yuhao Zhang
Summary: This article presents a comparative study of the parametric shift and recovery of three mainstream GaN HEMTs in repetitive overvoltage switching. The study shows that the devices exhibit shifts in threshold voltage and saturation current during the switching process, and these shifts saturate in a short period of time. The recovery process is dominated by hole detrapping and through-gate removal, with the gate stack playing a significant role. The article also suggests effective methods for poststress recovery.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Congyue Zhang, Xiaobo Dou, Lin Wang, Yunfei Dong, Yu Ji
Summary: This paper presents a unified distributed cooperative voltage control approach for grid-following (GFL) and grid-forming (GFM) distributed generators (DGs) in island microgrids. The approach employs a unified modeling method and a novel range-consensus-based distributed control algorithm. The proposed method improves the voltage regulation and anti-interference ability of the system, and its effectiveness is validated through simulation results and a hardware-in-the-loop test.
IEEE TRANSACTIONS ON POWER SYSTEMS
(2023)
Review
Physics, Applied
Ruizhe Zhang, Yuhao Zhang
Summary: This paper investigates avalanche and non-avalanche breakdown mechanisms in wide bandgap and ultra-wide bandgap devices and comparatively introduces various breakdown voltage characterization methods. Additionally, it discusses the device physics behind time- and frequency-dependent breakdown voltage and enabling device structures for avalanche breakdown, while identifying research gaps for understanding breakdown in wide bandgap and ultra-wide bandgap power devices.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Jing Sun, Xiongkai Tang, Jiaqi Tang, Yuhao Zhang, Zilin Li, Hui Chaolumen, Shuo Guo, Hui Shen
Summary: Little progress has been made in developing alternative bottom-up synthetic strategies for N-heterocyclic carbene (NHC)-stabilized gold nanoclusters, but this study presents a simple and straightforward approach using imidazolium salts instead of free carbenes or NHC-coordinated gold complexes as precursors. The researchers successfully synthesized an NHC-stabilized Au13Br4 cluster using a one-pot and one-step process involving chemical reduction. This work not only expands the Au13 library with a new NHC-ligated superatom, but also provides a facile and reasonable method to explore similar analogues.
INORGANIC CHEMISTRY
(2023)
Article
Nuclear Science & Technology
Haiqi Zhao, Daogang Lu, Yuhao Zhang, Xueyuan Zhang
Summary: This paper investigates the influence of different heat exchanger (DHX) layout schemes on the performance of a pool-type sodium-cooled fast reactor (SFR) through numerical simulations. The results show that installing DHXs in both cold and hot pools can achieve the long-term cooling stage of natural convection earlier and result in a more uniform temperature distribution in the hot pool. However, a local asymmetrical temperature distribution is observed in the cold pool.
PROGRESS IN NUCLEAR ENERGY
(2023)
Review
Biology
Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen, Xiao Chen, Yanhao Chen, Yu Chen, Yutian Chen, Zhiyang Chen, Jagadish K. Chhetri, Yingjie Ding, Junlin Feng, Jun Guo, Mengmeng Guo, Chuting He, Yujuan Jia, Haiping Jiang, Ying Jing, Dingfeng Li, Jiaming Li, Jingyi Li, Qinhao Liang, Rui Liang, Feng Liu, Xiaoqian Liu, Zuojun Liu, Oscar Junhong Luo, Jianwei Lv, Jingyi Ma, Kehang Mao, Jiawei Nie, Xinhua Qiao, Xinpei Sun, Xiaoqiang Tang, Jianfang Wang, Qiaoran Wang, Siyuan Wang, Xuan Wang, Yaning Wang, Yuhan Wang, Rimo Wu, Kai Xia, Fu-Hui Xiao, Lingyan Xu, Yingying Xu, Haoteng Yan, Liang Yang, Ruici Yang, Yuanxin Yang, Yilin Ying, Le Zhang, Weiwei Zhang, Wenwan Zhang, Xing Zhang, Zhuo Zhang, Min Zhou, Rui Zhou, Qingchen Zhu, Zhengmao Zhu, Feng Cao, Zhongwei Cao, Piu Chan, Chang Chen, Guobing Chen, Hou-Zao Chen, Jun Chen, Weimin Ci, Bi-Sen Ding, Qiurong Ding, Feng Gao, Jing-Dong J. Han, Kai Huang, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jian Li, Xin Li, Baohua Liu, Feng Liu, Lin Liu, Qiang Liu, Qiang Liu, Xingguo Liu, Yong Liu, Xianghang Luo, Shuai Ma, Xinran Ma, Zhiyong Mao, Jing Nie, Yaojin Peng, Jing Qu, Jie Ren, Ruibao Ren, Moshi Song, Zhou Songyang, Yi Eve Sun, Yu Sun, Mei Tian, Shusen Wang, Si Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wang, Catherine C. L. Wong, Andy Peng Xiang, Yichuan Xiao, Zhengwei Xie, Daichao Xu, Jing Ye, Rui Yue, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Weiqi Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhang, Tongbiao Zhao, Yuzheng Zhao, Dahai Zhu, Weiguo Zou, Gang Pei, Guang-Hui Liu
Summary: Aging biomarkers are a combination of biological parameters used to assess age-related changes, track the physiological aging process, and predict the transition into a pathological status. This review summarizes the current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, and proposes that aging biomarkers should be specific, systemic, and clinically relevant.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Review
Multidisciplinary Sciences
Mengyu Guo, Muya Xiong, Jinying Peng, Tong Guan, Haixia Su, Yanyi Huang, Cai-Guang Yang, Yang Li, Diana Boraschi, Thanigaimalai Pillaiyar, Guanbo Wang, Chengqi Yi, Yechun Xu, Chunying Chen
Summary: The ongoing COVID-19 pandemic has caused global concerns in public health and economy, leading to continuous development in therapeutics and vaccines. The use of multi-omics approaches has been instrumental in understanding the virus and its molecular features, aiding in the design of potential treatments and expediting vaccine development. This overview highlights the latest applications of multi-omics technologies in addressing COVID-19, providing suggestions for the development of effective therapeutics and vaccines based on comprehensive knowledge.
NATIONAL SCIENCE REVIEW
(2023)
Article
Nuclear Science & Technology
Yuhao Zhang, Xueyuan Zhang, Haiqi Zhao, Daogang Lu
Summary: The China Experimental Fast Reactor (CEFR) has a pool-type primary circuit. The sticking of the main circulating pump shaft in the secondary circuit is an important accident. To investigate this accident, the three-dimensional thermal-hydraulic phenomena in the sodium pool were simulated using a modular modeling and integrated coupling calculation method. The simulation results provided numerical reference for the safety design and assessment of CEFR.
PROGRESS IN NUCLEAR ENERGY
(2023)
Article
Optics
Peiyu Fang, Peihao Huo, Liding Wang, Zifeng Zhao, Gang Yu, Yanyi Huang, Zuqiang Bian, Zhiwei Liu
Summary: Efficient single-emitting-layer white organic light-emitting diodes (WOLEDs) with a maximum external quantum efficiency of 15.9% and CIE coordinates of (0.33, 0.39) were demonstrated using a cerium complex and an europium complex as emitters. The electroluminescence mechanism involving direct hole capture and hindered energy transfer between the two emitters enabled a manageable doping concentration of the low-energy emitter, avoiding the limitation of low concentration in typical SEL-WOLEDs. The results suggest that d-f transition emitters have the potential to simplify energy level regulation and enhance the development of SEL-WOLEDs.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Physical
Mengting Jin, Yanhao Wang, Mengyue Gu, Xuewen Zhao, Rongzheng Zhao, Yuhao Zhang, Yonghong Cheng, Jinying Zhang
Summary: This study successfully controlled the growth of layered violet phosphorus along a specific direction with the assistance of tin, resulting in needle-shaped phosphorus with enhanced photocatalytic degradation ability.