The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload

Inhaled Iloprost Improves Right Ventricular Load-Independent Contractility in Pulmonary Hypertension

(2022) Khodr Tello et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure

(2022) Olivier Boucherat et al.   CIRCULATION RESEARCH

The right ventricular involvement in dilated cardiomyopathy: prevalence and prognostic implications of the often-neglected child

(2022) Paolo Manca et al.   HEART FAILURE REVIEWS

Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial

(2022) Theresa-Marie Dachs et al.   EUROPEAN HEART JOURNAL

NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension

(2020) Eamon P. Mulvaney et al.   BMC Pulmonary Medicine

Ca2+ release via IP3 receptors shapes the cytosolic Ca2+ transient for hypertrophic signalling in ventricular cardiomyocytes

(2020) Hilary Hunt et al.   BIOPHYSICAL JOURNAL

Pulmonary artery banding is a relevant model to study the right ventricular remodeling and dysfunction that occurs in pulmonary arterial hypertension

(2020) Yohei Akazawa et al.   JOURNAL OF APPLIED PHYSIOLOGY

In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes

(2020) Patrícia Gonçalves-Rodrigues et al.   Jove-Journal of Visualized Experiments

Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension

(2020) Eamon P. Mulvaney et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanism of thromboxane receptor-induced vasoconstriction in human saphenous vein

(2020) Gulsev Ozen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Anatomy, Function, and Dysfunction of the Right Ventricle

(2019) Javier Sanz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Efficacy and Safety of the Use of Pulmonary Arterial Hypertension Pharmacotherapy in Patients with Pulmonary Hypertension Secondary to Left Heart Disease: A Systematic Review

(2019) Kazuhiko Kido et al.   PHARMACOTHERAPY

Right heart failure in pulmonary hypertension: Diagnosis and new perspectives on vascular and direct right ventricular treatment

(2019) Khodr Tello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia–reperfusion injury

(2019) Andrej Roczkowsky et al.   CARDIOVASCULAR RESEARCH

Abstract 824: Thromboxane/Prostanoid Receptor Activation Increases Calpain-Mediated Proteolysis and Alters Calcium Handling and Fibrosis Following Right Ventricular Pressure Overload

(2019) James D West et al.   CIRCULATION RESEARCH

Antagonism of the Thromboxane‐Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy

(2019) James D. West et al.   Journal of the American Heart Association

Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension

(2018) Andrea L. Frump et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HAX-1 regulates SERCA2a oxidation and degradation

(2018) Philip A. Bidwell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding

(2018) Nabham Rai et al.   Biomed Research International

Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement

(2018) Tim Lahm et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis

(2018) Charles-Antoine Guay et al.   PLoS One

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

(2017) Markus Follmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms Involved in Thromboxane A2-induced Vasoconstriction of Rat Intracavernous Small Penile Arteries

(2016) Martin Grann et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial HypertensionClinical Perspective

(2016) Silvia Rain et al.   Circulation-Heart Failure

Expression of the TPα and TPβ isoforms of the thromboxane prostanoid receptor (TP) in prostate cancer: clinical significance and diagnostic potential

(2016) Eamon P. Mulvaney et al.   Oncotarget

Antagonism of the Thromboxane-Prostanoid Receptor is Cardioprotective against Right Ventricular Pressure Overload

(2016) James D. West et al.   Pulmonary Circulation

The Right Ventricle in Pulmonary Arterial Hypertension

(2014) John J. Ryan et al.   CIRCULATION RESEARCH

Molecular Basis of Calpain Cleavage and Inactivation of the Sodium-Calcium Exchanger 1 in Heart Failure

(2014) Pimthanya Wanichawan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension

(2014) Silvia Rain et al.   Journal of the American Heart Association

Riociguat for Patients With Pulmonary Hypertension Caused by Systolic Left Ventricular Dysfunction

(2013) Diana Bonderman et al.   CIRCULATION

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Right Heart Adaptation to Pulmonary Arterial Hypertension

(2013) Anton Vonk-Noordegraaf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cooperation between proteolytic systems in cardiomyocyte recycling

(2012) O. Yamaguchi et al.   CARDIOVASCULAR RESEARCH

Endothelin Axis Is Upregulated in Human and Rat Right Ventricular Hypertrophy

(2012) Jayan Nagendran et al.   CIRCULATION RESEARCH

Differential calcium handling in two canine models of right ventricular pressure overload

(2012) Marc R. Moon et al.   JOURNAL OF SURGICAL RESEARCH

The monocrotaline model of pulmonary hypertension in perspective

(2011) Jose G. Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis

(2011) Prasanna Ekambaram et al.   CANCER AND METASTASIS REVIEWS

Hyperphosphorylation of Mouse Cardiac Titin Contributes to Transverse Aortic Constriction-Induced Diastolic Dysfunction

(2011) Bryan Hudson et al.   CIRCULATION RESEARCH

Progressive Right Ventricular Dysfunction in Patients With Pulmonary Arterial Hypertension Responding to Therapy

(2011) Mariëlle C. van de Veerdonk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Activation of NFATc1 is directly mediated by IP3 in adult cardiac myocytes

(2010) Andreas Rinne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The IP 3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli

(2010) Hiroyuki Nakayama et al.   CIRCULATION RESEARCH

PKC Phosphorylation of Titin’s PEVK Element

(2009) Carlos Hidalgo et al.   CIRCULATION RESEARCH

Inhibition of Thromboxane A2-Induced Arrhythmias and Intracellular Calcium Changes in Cardiac Myocytes by Blockade of the Inositol Trisphosphate Pathway

(2009) M. J. Wacker et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endothelin-1-Stimulated InsP3-Induced Ca2+ Release Is a Nexus for Hypertrophic Signaling in Cardiac Myocytes

(2009) Daniel R. Higazi et al.   MOLECULAR CELL

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

(2008) M. Iglarz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS