Article
Chemistry, Analytical
Leicheng Zhang, Tengfei Xu, Jingtao Zhang, Stephen Choong Chee Wong, Mark Ritchie, Han Wei Hou, Yulan Wang
Summary: The study proposes a novel strategy integrating spiral inertial microfluidics and ion mobility mass spectrometry for single-cell metabolite detection and identification. The technology successfully screened the metabolic profiles of different types of cancer cells, improving confidence in metabolite identification. This approach offers a simple and efficient method for single-cell lipid profiling, with additional ion mobility separation significantly enhancing the confidence toward identification of metabolites.
ANALYTICAL CHEMISTRY
(2021)
Article
Fisheries
Ramasamy Harikrishnan, Gunapathy Devi, Hien Van Doan, S. Vijay, Chellam Balasundaram, Einar Ringo, Seyed Hossein Hoseinifar, Sanchai Jaturasithaf
Summary: The study found that feeding spotted snakehead with 200 mg of lycopene (LYC) significantly enhanced blood physiology, digestive-antioxidant enzyme activity, specific-nonspecific immune response, and regulation of cytokines, heat shock proteins, and vitellogenins against Pseudomonas aeruginosa.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marcela Konjevod, Jorge Saiz, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Lucija Tudor, Suzana Uzun, Oliver Kozumplik, Coral Barbas, Neven Zarkovic, Nela Pivac, Dubravka Svob Strac
Summary: Posttraumatic stress disorder (PTSD) is a complex neuropsychiatric disorder triggered by a traumatic event. This study used lipidomic analysis to identify altered lipid compounds in PTSD patients. The identified lipids are associated with biological processes such as membrane integrity and function, mitochondrial dysfunction, inflammation, and oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biology
Francisca Marques, Diana Lopes, Tiago Conde, Tania Melo, Joana Silva, Maria Helena Abreu, Pedro Domingues, Maria Rosario Domingues
Summary: Macro- and microalgae are rich sources of lipids with nutritional quality and bioactivities for human health. This study characterized the lipidome of a blend of macro- and microalgae and evaluated its antioxidant capacity. The results show promising potential for food, nutraceutical, and biotechnological applications.
Article
Food Science & Technology
Tatiana Mauricio, Daniela Couto, Diana Lopes, Tiago Conde, Rita Pais, Joana Batista, Tania Melo, Marisa Pinho, Ana S. P. Moreira, Mafalda Trovao, Ana Barros, Helena Cardoso, Joana Silva, Pedro Domingues, M. Rosario Domingues
Summary: This study compared the fatty acid and lipid profile of four commercialized strains of Chlorella vulgaris and assessed their antioxidant and anti-inflammatory properties. Results showed differences in lipid composition and fatty acid profile among the strains, with C-Auto having higher lipid content and omega-3 polyunsaturated fatty acid levels, while C-Hetero, C-Honey, and C-White had higher omega-6 polyunsaturated fatty acid levels. All extracts exhibited antioxidant and anti-inflammatory activity, with C-Auto showing the greatest potential. These findings suggest that different strains of C. vulgaris can be selectively utilized as a source of value-added lipids for various food and nutraceutical applications.
Article
Chemistry, Analytical
Tian Xia, Ming Yuan, Yongwei Xu, Feng Zhou, Kate Yu, Yu Xia
Summary: Glycerolipids are crucial for cellular lipid homeostasis, with dysregulation in their metabolism linked to metabolic diseases. A new workflow utilizing charge-tagging PB derivatization, SFC, and MS/MS has been developed to accurately analyze GL structures and composition, potentially enabling lipid marker discovery for disease monitoring or diagnosis.
ANALYTICAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Qingwei Meng, Yiming Zhang, Jibo Li, Baoming Shi, Qingquan Ma, Anshan Shan
Summary: Supplementation of lycopene can improve intestinal barrier function, regulate intestinal antioxidant signaling, and improve gut microbiota in weaned piglets.
JOURNAL OF NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Lili Zhao, Jinxuan Zhang, Wupeng Ge, Jun Wang
Summary: The lipidomes of human milk and ruminant milk were compared in this study. The results showed that human milk was closer to camel milk in terms of lipid composition, with similar digestion and bioactivity properties. Camel milk could be considered as a new resource for lipid base in infant formula.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Satoshi Morozumi, Masahiro Ueda, Nobuyuki Okahashi, Makoto Arita
Summary: Microbial lipids play a crucial role in maintaining host health and controlling disease. Variations in the structures of microbial lipids impact receptor selectivity and agonist/antagonist activity. Advanced lipidomics technologies help uncover the complex diversity of bacterial lipids and discover new functional metabolites involved in host homeostasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Multidisciplinary Sciences
Isaac Asante, Stan Louie, Hussein N. Yassine
Summary: This review examines the impact of the APOE4 allele on brain lipid remodeling and chronic inflammation in Alzheimer's disease. The authors focus on the activation of cPLA2 by APOE4 and its effects on brain signaling pathways involving arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Nutrition & Dietetics
Moganatharsa Ganeshalingam, Samantha Enstad, Sarbattama Sen, Sukhinder Cheema, Flavia Esposito, Raymond Thomas
Summary: Breast milk is the best source of nutrition for infants, with functional lipids playing a crucial role. Lipidomics, an emerging field, helps to determine the physiological mechanisms of lipids and discover biomarkers for early disease diagnosis.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Lipidomics refers to the analysis of the structure, functions, and interactions of lipids. It is important in understanding inflammatory skin diseases and lipid disturbances. This review focuses on lipidomics in psoriasis, lichen planus, atopic dermatitis, hidradenitis suppurativa, rosacea, and acne vulgaris. Future studies on skin lipidome are needed for better insight into this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Gian Luigi Russo, Stefania Moccia, Maria Russo, Carmela Spagnuolo
Summary: Carotenoids, a class of compounds with important roles in foods, have been widely studied for their potential anticancer activity, but research results in this area vary; the dual nature of carotenoids acting as both antioxidants and pro-oxidants complicates mechanistic studies.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Clemens Wittenbecher, Fabian Eichelmann, Estefania Toledo, Marta Guasch-Ferre, Miguel Ruiz-Canela, Jun Li, Fernando Aros, Chih-Hao Lee, Liming Liang, Jordi Salas-Salvado, Clary B. Clish, Matthias B. Schulze, Miguel Angel Martinez-Gonzalez, Frank B. Hu
Summary: This study identified and validated two lipid metabolites and several lipidomics patterns as potential novel biomarkers of HF risk. Lipid profiling may capture preclinical molecular alterations that predispose to incident HF.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mikaila Ann Bantugan, Haotian Xian, Victoria Solomon, Mitchell Lee, Zhiheng Cai, Shaowei Wang, Marlon Duro, Bilal E. Kerman, Alfred Fonteh, Cristiana Meuret, Meitong Li, Meredith N. Braskie, Laura Beth J. McIntire, Lucia Jurin, Sarah Oberlin, James Evans, Roderick Davis, Wendy J. Mack, Laila Abdullah, Hussein N. Yassine
Summary: The study aimed to investigate the effects of APOE4 and DHA lipid species on the entorhinal cortex (EC) in the brain. The results showed that DHA supplementation increased DHA levels in cerebrospinal fluid (CSF), with lower increase in APOE4 carriers. The thickness of the EC was strongly correlated with plasma DHA levels.
JOURNAL OF LIPID RESEARCH
(2023)