Article
Engineering, Biomedical
Nagendra Kumar Kaushik, Pradeep Bhartiya, Neha Kaushik, Yungoh Shin, Linh Nhat Nguyen, Jang Sick Park, Doyoung Kim, Eun Ha Choi
Summary: This study demonstrates that nitric oxide enriched plasma-activated water (NO-PAW), generated by a microwave plasma system, effectively inhibits coronavirus infection in host lung cells and improves host antiviral responses.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Craig J. Neal, Candace R. Fox, Tamil Selvan Sakthivel, Udit Kumar, Yifei Fu, Christina Drake, Griffith D. Parks, Sudipta Seal
Summary: The COVID19 pandemic has raised global awareness of emerging viruses and antiviral therapies, particularly the transmissibility and infectivity of respiratory viruses. This study developed two silver-modified formulations of cerium oxide with specific antiviral activities, demonstrating potential for highly effective antiviral materials.
Review
Biochemistry & Molecular Biology
Xue Wang, Yi Liu, Kaiyuan Li, Zhihui Hao
Summary: The SARS-CoV-2 coronavirus has attracted global attention due to its highly pathogenic nature and the resulting health crisis and economic burden. Developing effective anti-coronavirus drugs is challenging due to the virus's high mutation rate and unique exonuclease enzymes. The p53 tumor suppressor molecule represents a potential target for antiviral drugs due to its critical role in cell signaling pathways and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Maimoona S. Bhutta, Daniel G. Sausen, Elisa S. Gallo, Harel Dahari, Gustavo F. Doncel, Ronen Borenstein
Summary: Ginkgolic Acid (GA) has shown promising potential as an effective antiviral treatment for Human Coronavirus strain 229E (HCoV-229E) infection, significantly reducing progeny virus production, viral protein expression, and cytopathic effects in human epithelial lung cells (MRC-5).
Article
Biotechnology & Applied Microbiology
S. Butot, L. Baert, S. Zuber
Summary: A novel approach was developed to evaluate the antiviral activity of coatings, testing three commercially available products against human coronaviruses. Results showed that a copper compound-based coating performed best, while coatings based on other compounds did not meet efficacy criteria. These findings provide valuable insights for future development of antiviral coatings.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Khaled AbouAitah, Abdou K. Allayh, Jacek Wojnarowicz, Yasser M. Shaker, Anna Swiderska-Sroda, Witold Lojkowski
Summary: The study introduces a novel nanoformulation against DNA and RNA viruses, with potential antiviral activity against COVID-19. The formulation shows high therapeutic indexes against various viruses and direct inactivation of HCoV-229E. It is a potentially safe and cost-effective agent for exploring new therapeutic strategies.
Article
Chemistry, Medicinal
Rui Wang, Annelies Stevaert, Tien Nguyen Truong, Qifei Li, Besir Krasniqi, Benjamin Van Loy, Arnout Voet, Lieve Naesens, Wim Dehaen
Summary: The study investigates the structure-activity relationship of novel coronavirus inhibitors and identifies a class of 1,2,3-triazolo fused triterpenoid compounds with strong antiviral activity against HCoV-229E.
ARCHIV DER PHARMAZIE
(2023)
Article
Engineering, Environmental
Ahmed O. Rashed, Chi Huynh, Andrea Merenda, Julio Rodriguez-Andres, Lingxue Kong, Takeshi Kondo, Joselito M. Razal, Ludovic F. Dumee
Summary: By engineering dry-spun ultrafiltration carbon nanotube (CNT) membranes coated with anti-viral SnO2 thin films, an efficient approach for simultaneous filtration and disinfection of waterborne Human Coronavirus 229E (HCoV-229E) is proposed.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
John E. Mamatis, Carla E. Gallardo-Flores, Ujjwal Sangwan, Trinity H. Tooley, Taylor Walsh, Che C. Colpitts
Summary: This study evaluated the antiviral mechanisms of the immunosuppressive drug CsA against HCoV-229E infection. The results showed that CsA's antiviral activity is independent of classical target proteins, but inhibits HCoV-229E infection by inducing the expression of antiviral genes in a manner dependent on interferon regulatory factor 1.
ANTIVIRAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
William A. Rutala, Luisa A. Ikner, Curtis J. Donskey, David J. Weber, Charles P. Gerba
Summary: The surface environment in rooms of COVID-19 patients may remain contaminated despite disinfection. A continuously active disinfectant has demonstrated excellent and sustained antiviral activity against SARS-CoV-2 and human coronavirus 229E within a certain time frame.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marion Chambon, Charline Herrscher, Dana Al Halabi, Nathan Francois, Sandrine Belouzard, Stephanie Boutet, Van Cuong Pham, Thi Mai Huong Doan, Karin Seron, Patrick Mavingui, Marc Litaudon, Chaker El Kalamouni, Cecile Apel
Summary: The COVID-19 pandemic has highlighted the need for antivirals against coronaviruses. A study found that an ethyl acetate extract from the leaves of Clausena harmandiana showed significant activity against SARS-CoV-2, with two phenolic lipids inhibiting the virus. This suggests that phenolic lipids from Clausena harmandiana could be a potential source of new antiviral agents against coronaviruses.
Article
Microbiology
Kexin Yan, Simeng Feng, Jiahao Cheng, Fan Zheng, Zhiqiang Li, Zhibang Deng, Xiaomin Yuan
Summary: In this study, it was demonstrated that IFITM3 plays a crucial role in the innate immune response against TGEV. IFITM3 inhibits TGEV replication by interfering with its binding to PK15 cells and preventing the upregulation of inflammatory cytokines. Mutations in IFITM3 were found to affect its antiviral activity against TGEV, with the M22A mutant losing some of its antiviral effect and the K24A mutant enhancing it. Furthermore, a synergistic effect between IFITM3 and CQ was observed, resulting in increased antiviral activity against TGEV.
VETERINARY MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Silvia Santopolo, Anna Riccio, M. Gabriella Santoro
Summary: SARS-CoV-2 is a more serious threat to public health compared to SARS and MERS due to its efficient spread. There is currently no approved treatment for COVID-19, prompting the need for urgent development of antiviral drugs. Targeting host factors essential for the virus life cycle is receiving increasing attention as a potential strategy for developing effective therapeutics.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Brian F. Niemeyer, Kambez H. Benam
Summary: It is crucial to respond quickly to emerging respiratory viruses, such as SARS-CoV-2, in order to control their spread and minimize their impact. Drug repurposing offers a solution to the time and resource-consuming processes of traditional drug discovery and development. This review examines various therapeutic and prophylactic approaches for the treatment of SARS-CoV-2 infection, focusing on the use of host serine protease-inhibiting anticoagulants.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Virology
Yanmei Hu, Hyunil Jo, William F. DeGrado, Jun Wang
Summary: This study discovered the antiviral mechanism of Brilacidin, which inhibits the entry of multiple human coronaviruses by targeting HSPGs on the host cell surface. The study also found a strong synergistic effect of Brilacidin in combination with remdesivir against a specific coronavirus.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
