Article
Engineering, Marine
Naomasa Oshiro, Takumi Tomikawa, Kyoko Kuniyoshi, Akira Ishikawa, Hajime Toyofuku, Takashi Kojima, Hiroshi Asakura
Summary: Ciguatera fish poisoning is a common seafood poisoning disease in tropical regions, caused by ciguatoxins. Research shows that the levels and profiles of ciguatoxins in fish vary among different regions, reflecting potential impacts on marine ecological environments.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Chemistry, Medicinal
Pablo Estevez, David Castro, Jose Manuel Leao-Martins, Manoella Sibat, Angels Tudo, Robert Dickey, Jorge Diogene, Philipp Hess, Ana Gago-Martinez
Summary: This study focused on the identification of toxic compounds produced by a G. australes strain from the Mediterranean Sea, revealing the presence of a novel MTX analogue named MTX5 and the absence of CTX precursors, highlighting the complexity of identifying CTX precursors in these regions.
Article
Environmental Sciences
Christopher R. Loeffler, Ann Abraham, Justin E. Stopa, Harold A. Flores Quintana, Edward L. E. Jester, Joshua La Pinta, Jonathan Deeds, Ronald A. Benner, Jason Adolf
Summary: Invasive species like the Cephalopholis argus in the Hawaiian Archipelago can have far-reaching environmental and economic consequences. A study on the risk of Ciguatera seafood poisoning (CP) in two regions found that CTX levels were higher in fish from the Leeward location compared to the Windward location, confirming the accuracy of local fishers and environmental understandings regarding harvest locations. This study provides additional evidence supporting the severe CP risk posed by C. argus in the coastal food web of Hawaii.
ENVIRONMENTAL RESEARCH
(2022)
Article
Food Science & Technology
Naomasa Oshiro, Hiroya Nagasawa, Kyoko Kuniyoshi, Naoki Kobayashi, Yoshiko Sugita-Konishi, Hiroshi Asakura, Takeshi Yasumoto
Summary: Ciguatera fish poisoning is a common seafood poisoning syndrome caused by consuming marine finfish contaminated with ciguatoxins, with traditional beliefs about the toxicity of fish heads and viscera lacking scientific support. Analyzing tissue samples from yellow-edged lyretail individuals, the study found ciguatoxins distributed evenly in flesh, supporting the conclusion that samples for analysis can be taken from any part of the body. Interestingly, the study also demonstrated significantly higher levels of toxins in the tissue surrounding the eyeball, providing scientific evidence of their high toxicity.
Article
Chemistry, Medicinal
Angels Tudo, Maria Rambla-Alegre, Cintia Flores, Nuria Sagrista, Paloma Aguayo, Laia Reverte, Monica Campas, Neide Gouveia, Carolina Santos, Karl B. Andree, Antonio Marques, Josep Caixach, Jorge Diogene
Summary: Ciguatera Poisoning (CP) is a public concern in some temperate regions, and this study identified the presence of CTX-like toxicity in fish specimens from Macaronesia. The liver of Muraena augusti had the highest CTX-like toxicity, and CTX analogues were detected in this species as well as Gymnothorax unicolor.
Article
Engineering, Marine
Naomasa Oshiro, Hiroya Nagasawa, Miharu Watanabe, Mio Nishimura, Kyoko Kuniyoshi, Naoki Kobayashi, Yoshiko Sugita-Konishi, Hiroshi Asakura, Katsunori Tachihara, Takeshi Yasumoto
Summary: This study analyzed the ciguatoxin levels in fish using liquid chromatography-tandem mass spectrometry and found that 64% of the specimens contained ciguatoxins, with 43% exceeding the FDA guidance level. The study also revealed a correlation between fish size and toxin levels, with skinnier fish having higher toxin levels. This research highlights the importance of monitoring ciguatoxin contamination in fish and its potential health risks.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Food Science & Technology
Ha Viet Dao, Aya Uesugi, Hajime Uchida, Ryuichi Watanabe, Ryoji Matsushima, Zhen Fei Lim, Steffiana J. Jipanin, Ky Xuan Pham, Minh-Thu Phan, Chui Pin Leaw, Po Teen Lim, Toshiyuki Suzuki
Summary: In coastal countries of Southeast Asia, fish is a staple diet but limited information on ciguatoxins diagnosis makes it difficult to diagnose food-borne diseases. A study in Malaysia identified ciguatoxin-1B in toxic red snapper, suggesting continuous consumption of the toxic fish may lead to CFP.
Article
Environmental Sciences
Luciana Tartaglione, Christopher R. Loeffler, Valentina Miele, Fabio Varriale, Michela Varra, Marcello Monti, Alessia Varone, Dorina Bodi, Astrid Spielmeyer, Samuela Capellacci, Antonella Penna, Carmela Dell'Aversanoa
Summary: Marine toxins have a significant impact on seafood resources and human health. This study focused on screening and identifying bioactive compounds produced by Gambierdiscus balechii, a toxic microalgae species, using liquid chromatography-high resolution mass spectrometry and in vitro cell-based bioassays. The study identified CTX-like and MTX-like toxicity in fractions of the algal extract, and confirmed the presence of a putative I/C-CTX congener. This research has important implications for understanding ciguatera poisoning and developing analytical methods for its detection.
Article
Food Science & Technology
Fedor Kryuchkov, Alison Robertson, Elizabeth M. Mudge, Christopher O. Miles, Soetkien Van Gothem, Silvio Uhlig
Summary: This study presents a new chemical derivatization approach to improve the detection sensitivity and chromatographic peak shapes of C-CTX-1. The approach involves using Girard's reagent T to tag the C-56-ketone intermediate of C-CTX-1, resulting in a significant increase in instrument response.
Article
Food Science & Technology
Clayton T. Bennett, Alison Robertson
Summary: This study aimed to investigate the bioaccumulation and depuration kinetics of C-CTX-1 in the marine omnivore Lagodon rhomboides. Results showed an increase in CTX levels in fish tissues during the exposure period, with a decline in CTX-specific toxicity observed in viscera extracts during depuration. Modeling analysis revealed a total concentration decline to 56% with an approximate half-life of 97 days, while growth dilution correction models indicated a pseudo-elimination and a half-life of 143-148 days due to the major factor of growth reducing C-CTX concentrations in the fish body. These findings have important implications for food web CTX models and management of ciguatera poisoning in endemic regions.
Article
Food Science & Technology
Dabor Resiere, Jonathan Florentin, Hossein Mehdaoui, Zakaria Mahi, Papa Gueye, Didier Hommel, Jean Pujo, Flaubert NKontcho, Patrick Portecop, Remi Neviere, Hatem Kallel, Bruno Megarbane
Summary: Ciguatera poisoning is a common cause of marine poisoning associated with fish consumption in tropical areas. This study provides a description of the clinical characteristics, management, and outcome of CP in Martinique. The findings show that CP is mainly caused by the ingestion of certain fish, such as trevallies, and that supportive management is effective in most cases.
Article
Environmental Sciences
Astrid Spielmeyer, Christopher R. Loeffler, Oliver Kappenstein
Summary: This study conducted an in-depth investigation using a semi-targeted LC-MS/MS approach to analyze tissue samples of Lutjanus bohar from the Indian Ocean and Pacific Ocean. The samples revealed a complex CTX contaminant profile, with the presence of several congeners of the CTX3C-group, which have a strong association with ciguatera poisoning. Furthermore, there were no distinguishable differences in toxin profile among individual samples or among the different oceanic capture regions, suggesting either a species-specific CTX metabolism or the emergence of an interoceanic CTX toxin profile.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Food Science & Technology
Hiroya Nagasawa, Kyoko Kuniyoshi, Toshiaki Tanigawa, Naoki Kobayashi, Yoshiko Sugita-Konishi, Hiroshi Asakura, Naomasa Oshiro
Summary: Ciguatera poisoning is one of the most common seafood poisonings worldwide, mainly occurring in tropical and subtropical regions. In Japan, CP cases are reported in subtropical areas such as Okinawa, Amami Islands, and Kagoshima. Analysis of grouper specimens from these islands indicated undetectable levels of ciguatoxins in the waters.
FOOD HYGIENE AND SAFETY SCIENCE
(2021)
Article
Food Science & Technology
Christopher R. Loeffler, Astrid Spielmeyer, Vincent Blaschke, Dorina Bodi, Oliver Kappenstein
Summary: Consuming seafood contaminated with ciguatoxins (CTXs) can cause ciguatera poisoning (CP), a common seafood-related illness worldwide. The southwestern coast of India has been identified as a major source of seafood responsible for isolated and widespread CP outbreaks since 2015, affecting both local and global populations. This study investigates and describes a CP outbreak in the Netherlands linked to frozen snapper (Lutjanus bohar) imported from southwest India, providing detailed information on the production chain, catch region, toxin-group, and subsequent actions taken in response to the outbreak. This in-depth traceback investigation sheds light on the CP outbreak in a region of coastal India with a significant seafood industry and limited CP data available.
Article
Food Science & Technology
Michael J. Holmes, Richard J. Lewis
Summary: By modeling a marine food chain in Platypus Bay, Australia, we aimed to understand the impact of food chain dynamics on ciguatera risk. Due to limited data, the estimates from this simulation were rough, but it highlighted the need for better quantitative estimates to improve our understanding and management of ciguatera risk.
Article
Food Science & Technology
Tsuyoshi Ikehara, Kyoko Kuniyoshi, Naomasa Oshiro, Takeshi Yasumoto
Article
Chemistry, Analytical
Kentaro Yogi, Satsuki Sakugawa, Naomasa Oshiro, Tsuyoshi Ikehara, Kiminori Sugiyama, Takeshi Yasumoto
JOURNAL OF AOAC INTERNATIONAL
(2014)
Article
Food Science & Technology
Shigeto Taniyama, Tomohiro Takatani, Taiki Sorimachi, Takefumi Sagara, Hirofumi Kubo, Naomasa Oshiro, Kaname Ono, Ning Xiao, Katsuyasu Tachibana, Osamu Arakawa
FOOD HYGIENE AND SAFETY SCIENCE
(2013)
Article
Food Science & Technology
Kentaro Yogi, Naomasa Oshiro, Seiko Matsuda, Satsuki Sakugawa, Toshiaki Matsuo, Takeshi Yasumoto
FOOD HYGIENE AND SAFETY SCIENCE
(2013)
Article
Food Science & Technology
Ryohei Tatsuno, Taiki Sorimachi, Shigeto Taniyama, Naomasa Oshiro, Hirofumi Kubo, Tomohiro Takatani, Osamu Arakawa
FOOD HYGIENE AND SAFETY SCIENCE
(2014)
Article
Food Science & Technology
Tsuyoshi Ikehara, Kyoko Kuniyoshi, Haruyo Yamaguchi, Yuuhiko Tanabe, Tomoharu Sano, Masahiro Yoshimoto, Naomasa Oshiro, Shihoko Nakashima, Mina Yasumoto-Hirose
Article
Engineering, Marine
Naomasa Oshiro, Takumi Tomikawa, Kyoko Kuniyoshi, Akira Ishikawa, Hajime Toyofuku, Takashi Kojima, Hiroshi Asakura
Summary: Ciguatera fish poisoning is a common seafood poisoning disease in tropical regions, caused by ciguatoxins. Research shows that the levels and profiles of ciguatoxins in fish vary among different regions, reflecting potential impacts on marine ecological environments.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Chemistry, Analytical
Mika Nagae, Tomoji Igarashi, Kazushi Mizukoshi, Kyoko Kuniyoshi, Naomasa Oshiro, Takeshi Yasumoto
Summary: This study aimed to develop and validate an LC-MS/MS method for quantifying major toxins in fish from the Pacific Ocean, providing an efficient means of toxin determination.
JOURNAL OF AOAC INTERNATIONAL
(2021)
Article
Food Science & Technology
Naomasa Oshiro, Hiroya Nagasawa, Kyoko Kuniyoshi, Naoki Kobayashi, Yoshiko Sugita-Konishi, Hiroshi Asakura, Takeshi Yasumoto
Summary: Ciguatera fish poisoning is a common seafood poisoning syndrome caused by consuming marine finfish contaminated with ciguatoxins, with traditional beliefs about the toxicity of fish heads and viscera lacking scientific support. Analyzing tissue samples from yellow-edged lyretail individuals, the study found ciguatoxins distributed evenly in flesh, supporting the conclusion that samples for analysis can be taken from any part of the body. Interestingly, the study also demonstrated significantly higher levels of toxins in the tissue surrounding the eyeball, providing scientific evidence of their high toxicity.
Article
Engineering, Marine
Naomasa Oshiro, Kyoko Kuniyoshi, Shigeyoshi Yamamoto, Ayano Hotta, Takuma Yamada, Takafumi Suzuki, Noriko Sugita, Keiichi Matsuura, Akie Nakashima, Yoichi Anzai, Hiroshi Asakura
Summary: Consumption of the pufferfish T. flavipterus is popular in Japan, but it can lead to tetrodotoxin poisoning. A study found that some specimens of T. flavipterus had toxic flesh due to migration of TTX from highly toxic skin. It is recommended to remove toxic portions of the fish immediately after catching and avoid consuming fish from known highly toxic areas.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Engineering, Marine
Tsuyoshi Ikehara, Kazuya Chikanishi, Naomasa Oshiro
Summary: Diarrhetic shellfish poisoning (DSP) is a global disease affecting public health and trade. The toxins causing DSP, including okadaic acid (OA) and dinophysistoxins (DTX1 and DTX2), are collectively referred to as OAs. By determining OA equivalents for different toxins in PP2A inhibition and cytotoxicity assays, the study found that these values matched better with oral toxicity data in mice.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Engineering, Marine
Naomasa Oshiro, Hiroya Nagasawa, Miharu Watanabe, Mio Nishimura, Kyoko Kuniyoshi, Naoki Kobayashi, Yoshiko Sugita-Konishi, Hiroshi Asakura, Katsunori Tachihara, Takeshi Yasumoto
Summary: This study analyzed the ciguatoxin levels in fish using liquid chromatography-tandem mass spectrometry and found that 64% of the specimens contained ciguatoxins, with 43% exceeding the FDA guidance level. The study also revealed a correlation between fish size and toxin levels, with skinnier fish having higher toxin levels. This research highlights the importance of monitoring ciguatoxin contamination in fish and its potential health risks.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Food Science & Technology
Naomasa Oshiro, Takumi Tomikawa, Kyoko Kuniyoshi, Keisuke Kimura, Takashi Kojima, Takeshi Yasumoto, Hiroshi Asakura
Summary: Ciguatera fish poisoning (CFP) mainly affects the tropical and subtropical Indo-Pacific region and the Caribbean Sea. The Japanese government has prohibited the import of certain fish species and local governments recommend rejecting certain fish species caught in Japan to prevent CFP. A study found CTXs in fish specimens brought to a wholesale market that were disapproved for sale, showing that the local government's regulations contribute to the prevention of CFP.
FOOD HYGIENE AND SAFETY SCIENCE
(2021)
Article
Food Science & Technology
Naomasa Oshiro
FOOD HYGIENE AND SAFETY SCIENCE
(2016)