Review
Obstetrics & Gynecology
Hua Yang, Yuan Zhuang
Summary: A systematic review of 32 studies showed that there were no significant deviations of CD4 + T cells in peripheral blood between endometriosis (EMs) and healthy women. However, in peritoneal fluid, EMs patients had significantly lower frequency of CD4 + T cells and CD4 + /CD8 + ratio compared to healthy women.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Oncology
Sarah Brunty, Lauren Clower, Brenda Mitchell, Taylor Fleshman, Nadim Bou Zgheib, Nalini Santanam
Summary: Ovarian cancer ranks as the 4th leading cause of cancer death in women, with a significant proportion of cases linked to endometriosis. Studies suggest that peritoneal fluid from women with endometriosis can induce transformative changes in ovarian cells, promoting the progression from endometriosis to ovarian cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Zhuang Peng, Sha Peng, Kangguang Lin, Bin Zhao, Lai Wei, Qinhui Tuo, Duanfang Liao, Tifei Yuan, Zhe Shi
Summary: This study aimed to investigate the crucial role of CD4(+) Th17 cells in the development of specific subtypes of depression and unravel the underpinnings of their pathogenetic effect.
JOURNAL OF NEUROINFLAMMATION
(2022)
Editorial Material
Obstetrics & Gynecology
Tamara N. Ramirez-Pavez, Francisco Machado-Linde, Pilar Garcia-Penarrubia, Lucia Nieto-Meca, Maria Martinez-Esparza, Pilar Marin-Sanchez
Summary: A standardized protocol for collecting peritoneal free fluid and leukocyte samples in women with endometriosis for biomedical research is proposed. The study found that the presence of free peritoneal fluid was scarce and not significantly related to hormonal treatment. The collected samples had high cell viability, but a certain proportion were contaminated with blood or had low cellularity. The number of leukocytes and macrophages recovered from peritoneal lavages was correlated with lavage volume, body mass index, and independent of patient age.
FERTILITY AND STERILITY
(2023)
Article
Biochemistry & Molecular Biology
Joanna Kacperczyk-Bartnik, Pawel Bartnik, Ksawery Golawski, Janusz Sierdzinski, Grzegorz Manka, Mariusz Kiecka, Michal Lipa, Damian Warzecha, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Krzysztof Czajkowski, Miroslaw Wielgos, Ewa Koc-Zorawska, Marcin Zorawski, Piotr Laudanski
Summary: This study evaluated the levels of PARP in plasma and peritoneal fluid of patients with and without endometriosis. The results showed no significant differences in PARP concentrations between patients with and without endometriosis. However, a higher plasma PARP concentration was associated with a history of infertility.
Article
Obstetrics & Gynecology
Piotr Laudanski, Gabriela Rogalska, Damian Warzecha, Michal Lipa, Grzegorz Manka, Mariusz Kiecka, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Toomas Neuman, Priit Adler, Hedi Peterson, Andres Salumets, Miroslaw Wielgos
Summary: This study found no significant differences in autoantibody expression between patients with endometriosis and the control group, suggesting that specific autoantibodies may not play a pivotal role in the pathogenesis of this disease.
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Pawel Bartnik, Joanna Kacperczyk-Bartnik, Ksawery Golawski, Janusz Sierdzinski, Grzegorz Manka, Mariusz Kiecka, Michal Lipa, Damian Warzecha, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur J. Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Krzysztof Czajkowski, Miroslaw Wielgos, Ewa Koc-Zorawska, Marcin Zorawski, Piotr Laudanski
Summary: ZEB1 and ZEB2, as transcription factors, regulate epithelial-mesenchymal transformation (EMT). However, they do not seem to have significant value in the initial diagnosis of endometriosis as single markers. Elevated plasma ZEB2 levels in infertile patients might indicate a role of EMT dysregulation in the pathogenesis of adverse fertility outcomes.
Article
Biochemistry & Molecular Biology
Damian Warzecha, Julia Zalecka, Grzegorz Manka, Mariusz Kiecka, Michal Lipa, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Miroslaw Wielgos, Lukasz Oldak, Anna Lesniewska, Ewa Gorodkiewicz, Piotr Laudanski
Summary: This study analyzed the concentrations of fibronectin and type IV collagen in peritoneal fluid and plasma, aiming to evaluate their potential as biomarkers for the diagnosis of endometriosis. The findings suggest that elevated levels of fibronectin may indicate abnormalities in cell-ECM signaling during the course of endometriosis, and could be a potential biomarker for early detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Philippe R. Koninckx, Anastasia Ussia, Leila Adamyan, Victor Gomel, Dan C. Martin
Summary: Peritoneal fluid in ovulatory women has higher concentrations of estrogen and progesterone compared to plasma. There is a strong progesterone resistance in superficial endometriosis lesions. Hormone concentrations in the peritoneal fluid play a crucial role in the medical therapy of endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Monika Wrobel, Zielinska Zuzanna, Lukasz Oldak, Aleksandra Kalicka, Grzegorz Manka, Mariusz Kiecka, Robert Z. Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Piotr Pierzynski, Cezary Wojtyla, Michal Lipa, Damian Warzecha, Miroslaw Wielgos, Wlodzimierz Sawicki, Ewa Gorodkiewicz, Piotr Laudanski
Summary: This study evaluated the levels of circulating 20S proteasome and 20S immunoproteasome in plasma and peritoneal fluid of women with and without endometriosis. The results indicate that these markers are not useful in diagnosing the disease but suggest a potential role in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Hirotaka Masuda, Kjiana E. Schwab, C. E. Filby, Charmaine S. C. Tan, Jim Tsaltas, Gareth C. Weston, Caroline E. Gargett
Summary: The study found that endometrial stem/progenitor cells may be present in menstrual blood and peritoneal fluid of women with and without endometriosis during menstruation. Further research on these cells may provide insights into the cellular origins of endometriosis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Endocrinology & Metabolism
Qiaomei Zheng, Ping Wu, Yanjing Zhao, Jinhua Wang, Shaozhan Chen, Lihong Chen
Summary: This study found that there is an increased number of dendritic cells (DCs) in the peritoneal cavity of endometriosis patients, with a decreased proportion of mature DCs and an increased proportion of immature DCs. Similar results were observed in a mouse model of endometriosis. These findings are important for further understanding the pathogenesis of endometriosis and providing new insights into medical treatment.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Cell Biology
Shishi Li, Yier Zhou, Qiongxiao Huang, Xiaohua Fu, Ling Zhang, Fang Gao, Zhen Jin, Limei Wu, Chongyi Shu, Xirong Zhang, Weihai Xu, Jing Shu
Summary: The study found that iron overload in the peritoneal fluid of endometriosis patients can lead to abnormalities in mouse embryo development, mainly through disrupting blastocyst formation, inducing lipid peroxidation, and causing mitochondrial damage to induce embryonic ferroptosis. Furthermore, the ferroptosis inhibitor Fer-1 can alleviate the cytotoxicity caused by iron overload.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Joanna Olkowska-Truchanowicz, Agata Bialoszewska, Aneta Zwierzchowska, Alicja Sztokfisz-Ignasiak, Izabela Janiuk, Filip Dabrowski, Grazyna Korczak-Kowalska, Ewa Barcz, Katarzyna Bocian, Jacek Malejczyk
Summary: Peritoneal fluid from patients with endometriosis exhibits immunoregulatory/immunosuppressive activity, affecting T cell generation and cytokine balance. However, peritoneal milieu from non-patients may also have some immunoregulatory/immunosuppressive properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Pinguang Yang, Hong Tian, Yong-Rui Zou, Pierre Chambon, Hiroshi Ichinose, Gerard Honig, Betty Diamond, Sun Jung Kim
Summary: Epinephrine produced in T(H)17 cells is involved in autoimmune diseases, with PNMT as a key enzyme in epinephrine synthesis. These findings suggest a pathogenic role of epinephrine-producing T(H)17 cells in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Andrzej Wrobel, Izabela Winkler, Tomasz Rechberger, Katarzyna Skorupska, Pawel Miotla
Summary: This study assessed the efficacy of collagen patches in preventing lymphoceles, and found that patients with TachoSil patches had lower drainage volume and a decreased tendency of lymphocele occurrence after completion of adjuvant therapy.
GINEKOLOGIA POLSKA
(2022)
Article
Obstetrics & Gynecology
Wlodzimierz Baranowski, Klaudia Stangel-Wojcikiewicz, Magdalena E. Grzybowska, Andrzej Malinowski, Tomasz Rechberger, Edyta Wlazlak, Tomasz Kluz, Elzbieta Najorczyk-Swiesciak, Artur Rogowski, Grzegorz Surkont
Summary: The Polish Society of Gynecologists and Obstetricians (PSGO) published guidelines for the management of recurrent pelvic organ prolapse, recommending sacrocolpopexy as the method of choice for surgical repair. However, the higher risk of complications associated with sacrocolpopexy compared to vaginal surgeries should be taken into consideration.
GINEKOLOGIA POLSKA
(2022)
Article
Obstetrics & Gynecology
Edyta Wlazlak, Tomasz Kluz, Tomasz Rechberger, Wlodzimierz Baranowski, Artur Rogowski, Magdalena E. Grzybowska, Konrad Futyma, Klaudia Stangel-Wojcikiewicz, Paulina Pajak, Elzbieta Narojczyk-Swiesciak, Bartlomiej Burzynski, Radoslaw Maksym, Grzegorz Surkont
Summary: This translation provides an overview of the Guideline for the diagnostic assessment of pelvic organ prolapse (POP) in women, developed by the Urogynecology Section of the Polish Society of Gynecologists and Obstetricians. It includes the steps and indications for the diagnostic assessment, emphasizing the individualization of the process.
GINEKOLOGIA POLSKA
(2022)
Article
Medicine, General & Internal
Katarzyna Jankiewicz, Michal Bogusiewicz, Lukasz Nowakowski, Tomasz Rechberger, Artur Rogowski, Pawel Miotla
Summary: This study evaluated urinary NGF levels in POP patients involving the anterior vaginal wall and found that it was significantly increased in pure OAB patients. However, NGF cannot serve as a biomarker for OAB in patients with POP, and it is not a predictive factor for the resolution of OAB symptoms after POP surgical treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Michal K. Zarobkiewicz, Agnieszka A. Bojarska-Junak
Summary: CLL is the most common leukemia among adults, and currently there is no cure. Despite the dysfunction of gamma delta T cells in CLL patients, they can still be used for immunotherapy.
Review
Obstetrics & Gynecology
Patrycja A. Pietak, Tomasz Rechberger
Summary: Overactive bladder (OAB) is a common condition with unknown etiology. Its main symptoms include sudden urge to urinate, incontinence, increased daytime frequency, and nocturia. OAB-like symptoms can be caused by various diseases, and ANS dysfunction may contribute to the development of OAB.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wioleta Kowalska, Michal Zarobkiewicz, Waldemar Tomczak, Justyna Wos, Izabela Morawska, Agnieszka Bojarska-Junak
Summary: Monocytes, particularly non-classical subpopulations, may play an important role in chronic lymphocytic leukemia (CLL) pathogenesis. This study assessed monocyte subsets divided based on SLAN and CD16 expression in CLL patients. The findings suggest an increased percentage of non-classical monocytes producing TNF and IL-12, while intermediate monocytes showed a higher percentage of cells synthesizing anti-inflammatory IL-10. The percentage of CD14(dim)CD16(+)SLAN(+) monocytes producing TNF and IL-12 decreased with CLL stage and correlated with prognostic factors. Notably, CLL patients requiring treatment had a lower percentage of CD14(dim)CD16(+)SLAN(+) monocytes producing TNF and IL-12, potentially indicating a beneficial effect of non-classical monocytes on anti-tumor response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Michal K. Zarobkiewicz, Izabela Morawska, Wioleta Kowalska, Pawel Halczuk, Jacek Rolinski, Agnieszka A. Bojarska-Junak
Summary: This study found differential expression of PECAM-1 on γδT cells and a significant downregulation of CD3 expression during relapse in patients with multiple sclerosis, which may indicate overall activation of γδT cells.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sylwia Chocholska, Michal Zarobkiewicz, Agata Szymanska, Natalia Lehman, Justyna Wos, Agnieszka Bojarska-Junak
Summary: The aim of this study was to investigate the expression of miR-17 similar to 92 cluster members in CLL patients. The study provides new evidence regarding the heterogeneity of miR-17 similar to 92 cluster members' expression in CLL patients. High miR-20a expression can be considered an independent favorable prognostic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pathology
Marta Monist, Dorota Lewkowicz, Patrycja Pietak, Anna Pilewska-Kozak, Yan-Gao Man, Andrzej Semczuk
Summary: The occurrence of synchronous carcinomas originating from the uterine corpus and uterine cervix, of the same histological subtype, is extremely rare. This case study presents a synchronous early stage G1 adenocarcinoma of the uterine corpus with cervical G2 endometrioid adenocarcinoma. The tumors differ in histological grading and clinical stage, and are preceded by different precancerous lesions, atypical endometrial hyperplasia and foci of endometriosis localized within the uterine cervix.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Andrea Romano, Tea Lanisnik Rizner, Henrica Maria Johanna Werner, Andrzej Semczuk, Camille Lowy, Christoph Schroeder, Anne Griesbeck, Jerzy Adamski, Dmytro Fishman, Janina Tokarz
Summary: Endometrial cancer, the most common gynaecological malignancy, has a high incidence and mortality rate in developed countries. There is a need for non/minimally invasive tools for diagnosis and prognosis to manage the increasing number of women at risk. Biomarkers from proteomics and metabolomics can be used to develop such tools, and this review explores the current research in this field. A systematic review of published studies using proteomics and/or metabolomics for biomarker discovery in endometrial cancer is provided, along with recommendations for future studies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Plant Sciences
Marek Gogacz, Jerzy Peszke, Dorota Natorska-Chomicka, Monika Ruszala, Katarzyna Dos Santos Szewczyk
Summary: Propolis and its extracts have a wide range of biological activities. A new cold separation method was used to obtain qualitatively better propolis extracts, containing chemical compounds that are absent in extracts obtained using high-temperature methods. The biological activity of these extracts against breast cancer cell lines was evaluated, and the results showed cytotoxicity against the cancer cells and potential application as health-promoting supplements.
Article
Oncology
Agnieszka Bojarska-Junak, Wioleta Kowalska, Sylwia Chocholska, Agata Szymanska, Waldemar Tomczak, Michal Konrad Zarobkiewicz, Jacek Rolinski, Daniela De Totero, Paolo Giannoni
Summary: This study explores the potential role of Galectin-9 (Gal-9) as a novel prognostic biomarker in chronic lymphocytic leukemia (CLL). Through quantification of Gal-9 mRNA expression in purified B-lymphocytes of 100 CLL patients, the study reveals the upregulation of Gal-9 mRNA in malignant B-cells, which is closely associated with unfavorable prognostic markers and a shorter time to treatment. Furthermore, the study suggests that EBV coinfection may worsen prognosis in CLL by inducing upregulation of Gal-9 expression.
Review
Medicine, General & Internal
Danuta Vasilevska, Andrzej Semczuk, Dominika Vasilevska, Artiomas Sirvys, Vilius Rudaitis
Summary: The management of early-stage cervical cancer in young women poses challenges in preserving fertility and achieving optimal oncological outcomes. Insufficient data hinder proper counseling for this vulnerable patient group. This report presents a case of successful treatment outcome in a young woman with early-stage cervical cancer who desired fertility preservation, using neoadjuvant chemotherapy followed by laparoscopic radical trachelectomy. Ongoing prospective trials are expected to provide stronger evidence in this area.
MEDICINA-LITHUANIA
(2022)
