Article
Biochemistry & Molecular Biology
Hanif Haidari, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: The development of highly potent ultrasmall AgNPs combined with a biocompatible hydrogel has shown promising results in eliminating mature biofilm infections in vivo and promoting wound healing. The treatment exhibited superior antibacterial efficacy and improved wound closure, re-epithelization, and collagen deposition compared to conventional silver-based treatments.
Article
Chemistry, Inorganic & Nuclear
Hamed Barabadi, Faraz Mojab, Hossein Vahidi, Boshra Marashi, Niloufar Talank, Omid Hosseini, Muthupandian Saravanan
Summary: This study aimed to fabricate Zataria multiflora-derived silver nanoparticles (AgNPs) and compare their antibacterial and biofilm inhibitory activities against Staphylococcus aureus ATCC 25923 with commercial AgNPs. The plant-mediated fabricated AgNPs (P-AgNPs) exhibited significant antibacterial activity and biofilm inhibition at lower concentrations, showing stronger effects compared to commercial AgNPs.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Yizhen Wang, Qijun Lv, You Chen, Langtao Xu, Miao Feng, Zhiyong Xiong, Jiajun Li, Jie Ren, Jie Liu, Bo Liu
Summary: Biofilms are closely related to the difficult healing and dysfunctional inflammation in chronic wounds. Photothermal therapy (PTT) can destroy biofilm structures using physical heat, but it is limited due to the potential tissue damage. We propose a GelMA-EGF/Gelatin-MPDA-LZM hydrogel dressing that combines lysozyme-enhanced PTT and wound healing promotion. The bilayer hydrogel can release photothermal agents and has shown promising results in biofilm eradication and wound repair.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Multidisciplinary
John Jackson, Helen Burt, Dirk Lange, In Whang, Robin Evans, David Plackett
Summary: The study successfully developed a silver nitrate-loaded/poly(vinyl alcohol) film that forms a water-compatible hydrogel with sustained release of antibacterial silver nanoparticles. An optimal formulation was achieved with 5% silver nitrate in PVA membrane films heated at 140 degrees C for 90 minutes.
Article
Biochemistry & Molecular Biology
Hang Jia, Xuejun Zeng, Shiqi Fan, Rui Cai, Zhouli Wang, Yahong Yuan, Tianli Yue
Summary: By anchoring silver nanoparticles on magnetic carboxymethyl cellulose-e-polylysine hybrids, an efficient antibacterial strategy was developed to accelerate wound healing in bacteria-infected wounds. In vitro and in vivo experiments demonstrated the effective antibacterial activity and biocompatibility of the hybrids. This synergistic antibacterial strategy shows great potential for the therapy of bacterial-infected wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Taghi Kilani, Frank Ko, Aziz Ghahary, Dirk Lange
Summary: A silver nanoparticle-based hydrogel composite has been created to prevent infection, promote tissue repair, and fill cavities in wounds that are difficult to reach with other dressings.
Article
Nanoscience & Nanotechnology
Pai Sun, Lingyue Ye, Xinyi Tan, Juanjuan Peng, Lingzhi Zhao, Yunyun Zhou
Summary: This study combined silver nanoparticles with photodynamic therapy to effectively treat bacterial biofilm infections, showing advanced antibacterial activity against both Gram-positive and Gram-negative bacteria.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yun Zhu, Li Liu, Shaoqing Chen, Dan Han, Cheng Wang
Summary: Wound infection, especially chronic ones, can lead to the emergence of antibiotic-resistant bacteria and cause physical and mental burden on patients. This study developed an agarose-hyaluronic acid hydrogel that could potentially serve as an antibacterial wound dressing, promoting healing while maintaining antibacterial efficacy.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Dengyan Wu, Dong Wei, Maotao Du, Song Ming, Qian Ding, Ranjing Tan
Summary: In this study, novel chitosan and poly (D,L-lactide-co-glycolide) nanoparticles loaded with benzalkonium bromide (BZK) were developed for wound healing after MRSA infection. These nanoparticles exhibited significant antibacterial activity, anti-biofilm properties, and the ability to damage bacterial cell walls, indicating their potential in promoting skin wound healing. These findings suggest a new avenue for nanomedicine development in wound treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yalei Liu, Jie Mao, Zhiyong Guo, Yufang Hu, Sui Wang
Summary: The authors prepared a bifunctional hydrogel with antibacterial and self-healing properties by cross-linking polyvinyl alcohol and carboxymethyl chitosan through hydrogen bonds and borate ester bonds. The hydrogel showed improved mechanical properties and the addition of silver nanoparticles effectively inhibited bacterial growth, providing potential applications in biological wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Gandhimathi Chinnasamy, Smitha Chandrasekharan, Tong Wey Koh, Somika Bhatnagar
Summary: The study presented a green synthesis route to produce AI-AgNPs with enhanced antibacterial and free-radical scavenging efficacy. The biocompatibility and antibacterial properties of AI-AgNPs were confirmed through various experiments, highlighting their potential use in wound healing applications.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Hanif Haidari, Zlatko Kopecki, Adam T. Sutton, Sanjay Garg, Allison J. Cowin, Krasimir Vasilev
Summary: A sensitive pH-responsive hydrogel has been developed for on-demand release of silver nanoparticles to effectively eliminate both Gram-negative and positive bacteria in infected wounds. The hydrogel shows potential as a promising new material for wound treatment with no toxicity towards mammalian skin cells.
Article
Engineering, Biomedical
Jingjing Hu, Sijia Chen, Yongxin Yang, Lin Li, Xuejing Cheng, Yiyun Cheng, Quan Huang
Summary: A smart hydrogel, formed by acid-labile imine linkage, is able to release drugs to inhibit biofilm formation and kill bacteria. The gel shows great potential in inhibiting biofilm formation on medical devices, reducing bacteria pathogenicity, and treating implantation-associated and chronic wound infections.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Jiang Ouyang, Qingyue Bu, Na Tao, Mingkai Chen, Haijun Liu, Jun Zhou, Jinggong Liu, Bo Deng, Na Kong, Xingcai Zhang, Tianfeng Chen, Yihai Cao, Wei Tao
Summary: This study developed a simple and universal method to construct antibiotic-free protein hydrogels that can overcome drug-resistant bacteria and biofilm infections, promoting wound healing.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Physical
Hang Jia, Xiao Zhang, Xuejun Zeng, Rui Cai, Zhouli Wang, Yahong Yuan, Tianli Yue
Summary: The study reported the application of flower-like silver nanoparticles anchored hybrids in controlling pathogenic bacteria and promoting wound healing. Experimental results showed that the material exhibited high inhibitory effects against Escherichia coli and Staphylococcus aureus.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Karnpimon Krorakai, Supannika Klangphukhiew, Sirinan Kulchat, Rina Patramanon
Summary: The study introduces an NFC potentiostat for electrochemical analysis which can connect with smartphones, offering features like low cost, portability, and user-friendliness.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Oranee Srichaiyapol, Saengrawee Thammawithan, Pawinee Siritongsuk, Sawinee Nasompag, Sakda Daduang, Sompong Klaynongsruang, Sirinan Kulchat, Rina Patramanon
Summary: The study demonstrates that silver nanoparticles have strong antibacterial activity against Burkholderia pseudomallei, including ceftazidime-resistant strains, with a fast-killing mode. Additionally, the nanoparticles are effective in killing both planktonic bacteria in solution and bacteria in established biofilm. Furthermore, there was no resistance development observed in the bacteria after prolonged exposure to sublethal concentrations of silver nanoparticles, indicating their potential as a potent antimicrobial agent to combat antibiotic resistance.
Article
Chemistry, Multidisciplinary
Chanon Talodthaisong, Kittiya Plaeyao, Chatariga Mongseetong, Wissuta Boonta, Oranee Srichaiyapol, Rina Patramanon, Navaphun Kayunkid, Sirinan Kulchat
Summary: ZnO nanoparticles decorated with GABA, CurBF(2), and AgNPs were prepared and characterized in this study. The ZnO NPs-GABA/CurBF(2)-AgNPs showed excellent antibacterial activity against both Gram-negative and Gram-positive bacteria, indicating their potential use in future antibacterial technologies.
Article
Biotechnology & Applied Microbiology
Andreea-Gabriela Nedelea, Rebecca L. Plant, Lori I. Robins, Sarah E. Maddocks
Summary: The study aimed to test the effectiveness of commercially available wound dressings and a HOCl gel formulation against two- and five-species biofilms in an in vitro chronic wound infection model. Results showed that HOCl gel was most effective against 24-hour established biofilms, particularly in inhibiting P. aeruginosa, and multiple doses indicated no tolerance to treatment from bacteria.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Infectious Diseases
Sathit Malawong, Saengrawee Thammawithan, Pawinee Sirithongsuk, Sakda Daduang, Sompong Klaynongsruang, Pamela T. Wong, Rina Patramanon
Summary: The study demonstrated that combining antibiotics with silver nanoparticles can effectively enhance the antibacterial effects against Burkholderia pseudomallei, showing a synergistic antimicrobial effect, especially the combination of gentamicin sulfate with AgNPs exhibited the most significant enhancing effect.
Article
Biochemistry & Molecular Biology
Sawinee Nasompag, Pawinee Siritongsuk, Saengrawee Thammawithan, Oranee Srichaiyapol, Panchika Prangkio, Terri A. Camesano, Chomdao Sinthuvanich, Rina Patramanon
Summary: The study focused on the membrane perturbation mechanism of live E. coli treated with KYR and C-14-KYR peptides using AFM imaging. Results showed that C-14-KYR caused severe surface disruption, including membrane shrinkage, periplasmic membrane separation, and cytosolic leakage. Additional evidence from SR-FTIR revealed marked structural changes in the membrane component after lipopeptide attack. AFM demonstrated that the mechanistic effect of the lipopeptide against bacterial cells can be quantified through surface imaging and adhesion force measurements.
Article
Agriculture, Dairy & Animal Science
Saengrawee Thammawithan, Oranee Srichaiyapol, Pawinee Siritongsuk, Sakda Daduang, Sompong Klaynongsruang, Nuvee Prapasarakul, Rina Patramanon
Summary: The study demonstrates that anisotropic AgNPs gel is effective in eliminating bacteria, preventing pus formation, and supporting wound healing. The gel also improves collagen fiber alignment, aiding in scar disappearance.
Review
Surgery
Nicola Reeves, Samuel Phillips, Aron Hughes, Sarah Maddocks, Matthew Bates, Jared Torkington, Lori Robins, Julie Cornish
Summary: This systematic review evaluates the potential use of volatile organic compounds (VOCs) released by surgical wounds as a non-invasive method for identifying bacterial species and predicting the progression to chronic non-healing wounds. The analysis of seven studies shows that VOC profiles are associated with causative bacterial species, indicating anatomical specificity and the ability to monitor treatment effects.
WORLD JOURNAL OF SURGERY
(2022)
Article
Materials Science, Multidisciplinary
Pawinee Siritongsuk, Saengrawee Thammawithan, Oranee Srichaiyapol, Sawinee Nasompag, Sarawut Pongha, Sakda Daduang, Sompong Klaynongsruang, Rina Patramanon
Summary: This research proposes a self-disinfection coating containing AgNPs-chitosan composite, which has a strong antibacterial effect. The physical and chemical properties of AgNPs-chitosan nanocomposite were studied, confirming its inhibitory effect on bacteria. Short- and long-term antibacterial activity studies showed that the coating has a high effectiveness against E. coli and S. aureus.
Article
Microbiology
Ammara Khalid, Alan R. R. Cookson, David E. E. Whitworth, Michael L. L. Beeton, Lori I. I. Robins, Sarah E. E. Maddocks
Summary: Understanding chronic wound infection is crucial for successful treatment, and accurate laboratory models are necessary. A modified biofilm flow device was developed to simulate the chronic wound environment, with simulated wound fluid, a collagen-based biofilm matrix, and a mixture of clinically relevant bacteria. The biofilms cultured in this model exhibited characteristics consistent with real-world wound biofilms, making it a versatile and inexpensive in vitro tool for studying chronic wound infection.
Article
Veterinary Sciences
Saengrawee Thammawithan, Pawinee Siritongsuk, Sawinee Nasompag, Sakda Daduang, Sompong Klaynongsruang, Nuvee Prapasarakul, Rina Patramanon
Summary: This study demonstrates that anisotropic silver nanoparticles exhibit effective antibacterial activity against bacterial pathogens with low cytotoxicity to skin cells, and can be formulated into a gel for treating wound infections. The anisotropic AgNPs show long-term antibacterial protection compared to povidone iodine, suggesting their potential as an alternative antimicrobial agent for treating bacterial skin infections and promoting wound healing.
VETERINARY SCIENCES
(2021)
