Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

Versatile signaling mechanisms of inositol pyrophosphates

(2022) Minh Nguyen Trung et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Nucleolus and Nucleolar Stress: From Cell Fate Decision to Disease Development

(2022) Lu Hua et al.   Cells

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

(2021) Chunfang Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Straightforward Method for 3D Visualization of B Cell Clusters and High Endothelial Venules in Lymph Nodes Highlights Differential Roles of TNFRI and -II

(2021) Kim C. M. Jeucken et al.   Frontiers in Immunology

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

(2021) Prasath Paramasivam et al.   JOURNAL OF CELL BIOLOGY

IP6K1 upregulates the formation of processing bodies by influencing protein-protein interactions on the mRNA cap

(2021) Akruti Shah et al.   JOURNAL OF CELL SCIENCE

Mechanism of phosphate sensing and signaling revealed by rice SPX1-PHR2 complex structure

(2021) Jia Zhou et al.   Nature Communications

Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling

(2020) Xingyao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties

(2020) Gregory L. Dignon et al.   Annual Review of Physical Chemistry

It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly

(2020) Monica C. Pillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between PFBC-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis

(2020) Uriel López-Sánchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals

(2020) Seulgi Lee et al.   MOLECULES

InsP7is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics

(2020) Soumyadip Sahu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity‐based proteomics reveals novel targets of inositol pyrophosphate (5‐IP 7 )‐dependent phosphorylation and binding in Trypanosoma cruzi replicative stages

(2020) Brian S. Mantilla et al.   MOLECULAR MICROBIOLOGY

Phase-to-Phase With Nucleoli – Stress Responses, Protein Aggregation and Novel Roles of RNA

(2019) Leena Latonen   Frontiers in Cellular Neuroscience

Nol9 Is a Spatial Regulator for the Human ITS2 Pre-rRNA Endonuclease–Kinase Complex

(2019) Jacob Gordon et al.   JOURNAL OF MOLECULAR BIOLOGY

The nucleolus functions as a phase-separated protein quality control compartment

(2019) F. Frottin et al.   SCIENCE

Identity and functions of inorganic and inositol polyphosphates in plants

(2019) Laura Lorenzo‐Orts et al.   NEW PHYTOLOGIST

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

(2019) Jinsheng Zhu et al.   eLife

Nucleolar Function in Lifespan Regulation

(2018) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis

(2017) Chunfang Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KO of 5-InsP7kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype

(2017) Chunfang Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization

(2017) Mohammad Tauqeer Alam et al.   Nature Communications

Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

(2017) Qingzhang Zhu et al.   Molecular Metabolism

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels

(2016) Chunfang Gu et al.   PLoS One

Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms

(2016) Mingxuan Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains

(2016) R. Wild et al.   SCIENCE

Small nucleoli are a cellular hallmark of longevity

(2016) Varnesh Tiku et al.   Nature Communications

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo

(2016) Igor Pavlovic et al.   Nature Communications

Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription inSaccharomyces cerevisiae

(2015) Swarna Gowri Thota et al.   BIOCHEMICAL JOURNAL

Elucidating Diphosphoinositol Polyphosphate Function with Nonhydrolyzable Analogues

(2014) Mingxuan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family

(2014) Huanchen Wang et al.   Nature Communications

PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3for polyphosphoinositide-binding domains

(2013) Nikhil A. Gokhale et al.   BIOCHEMICAL JOURNAL

Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs

(2013) Rajagopal S. Kilari et al.   FEBS LETTERS

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin

(2011) D. Avitabile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

(2010) Anutosh Chakraborty et al.   CELL

Characterization and prediction of protein nucleolar localization sequences

(2010) Michelle S. Scott et al.   NUCLEIC ACIDS RESEARCH