Article
Chemistry, Analytical
Duygu Cimen, Nilay Bereli, Serdar Gunaydin, Adil Denizli
Summary: In this study, a molecularly imprinted surface plasmon resonance (SPR) biosensor was developed for the detection of low concentrations of thrombin. The biosensor showed high selectivity towards thrombin and exhibited good performance in both thrombin solutions and patient serum samples.
Article
Biochemical Research Methods
Duygu Cimen, Sevgi Asliyuce, Tugce Deniz Tanalp, Adil Denizli
Summary: A simple, fast, sensitive and selective surface plasmon resonance (SPR) sensor was prepared for endotoxin detection using molecular imprinting method. The sensor showed a limit of detection and quantification of 0.023 and 0.078 ng/mL, respectively, with a response time of approximately 14 minutes. Selectivity studies with cholesterol and hemoglobin, as well as validation studies using limulus amebocyte lysate (LAL), demonstrated the applicability of the SPR sensor for endotoxin detection.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Instruments & Instrumentation
Duygu Cimen, Nilay Bereli, Adil Denizli
Summary: In this study, patulin imprinted and non-imprinted nanoparticles were synthesized and attached to the surface of surface plasmon resonance (SPR) chips, allowing for detection and characterization of patulin. Kinetic studies revealed the limit of detection and quantification values, as well as the response time. Selectivity studies were conducted in the presence of other toxins, demonstrating the applicability of the patulin imprinted SPR nanosensor.
Article
Chemistry, Analytical
Onur Celik, Yeseren Saylan, Ilgim Gokturk, Fatma Yilmaz, Adil Denizli
Summary: Detection of antibiotic residues is crucial for protecting human health. This study successfully detected benzylpenicillin antibiotic using a surface plasmon resonance sensor and a molecularly imprinted polymer, with high selectivity and a low detection limit.
Article
Chemistry, Analytical
Duygu Cimen, Nilay Bereli, Adil Denizli
Summary: The study designed a surface plasmon resonance sensor for detecting L-phenylalaine using molecular imprinting technology, achieving rapid, sensitive, and selective detection. Characterization and kinetic studies were conducted, revealing good detection limits and response time in various experiments.
Article
Chemistry, Multidisciplinary
Timothy J. J. Palinski, Bin Guan, Bronwyn H. H. Bradshaw-Hajek, Michael A. A. Lienhard, Craig Priest, Felix A. Miranda
Summary: This paper presents a colorimetric sensing system for rapid detection of gas-phase analytes from flowing micro-volume fluid samples. The sensor platform combines an analyte-responsive metal-insulator-metal (MIM) thin-film structure with a large area quartz micropillar array, allowing precise alignment and separation of optical and fluidic structures. The sensor's response time is reduced from minutes to seconds, making it suitable for portable/wearable devices. The platform shows potential for continuous, compact, and quantitative colorimetric analysis of volatile analytes in low-volume samples.
Article
Optics
I Vitoria, C. R. Zamarreno, A. Ozcariz, J. J. Imas, I. R. Matias
Summary: This study explores the lossy mode resonance (LMR) phenomenon in the short wave infrared region (SWIR) and medium wave infrared region (MWIR) using fluoride glass optical fiber. Devices fabricated with nanometric thin-film of titanium dioxide show extraordinary sensitivities to external refractive index (RI) variations, demonstrating great potential for detecting minute concentrations of gaseous or biological compounds in different media. The research also reveals the utilization of LMRs in these regions for the first time.
Article
Chemistry, Multidisciplinary
Kivilcim Caktu, Erdogan Ozgur, Nilay Bereli, Adil Denizli
Summary: The study focuses on the design of a diclofenac (DFC) imprinted SPR sensor for DFC detection. The DFC imprinted SPR sensor was successfully prepared by forming a pre-complex and copolymerizing it on the functionalized SPR chip. The surface of the DFC imprinted SPR sensor was characterized using various methods. The results showed that the Langmuir adsorption model was the most suitable for describing the DFC adsorption kinetics, and the selectivity and imprinting effect of the sensor were also demonstrated.
Article
Engineering, Electrical & Electronic
Nilay Bereli, Duygu Cimen, Adil Denizli
Summary: A selective, rapid, and sensitive surface plasmon resonance (SPR) sensor was developed for real-time detection of tartrazine in fruit juice, with promising results in terms of detection limits, validation through liquid chromatography-tandem mass spectrometry, and characterization studies.
IEEE SENSORS JOURNAL
(2021)
Review
Optics
Siqi Zhang, Bo Han, Ya-nan Zhang, Yingxuan Liu, Wanlu Zheng, Yong Zhao
Summary: Fiber optic sensors based on surface plasmon resonance (SPR) have shown excellent performance in various fields such as biomedical, environmental monitoring, and public safety, providing a powerful platform for qualitative detection and quantitative analysis of molecular interactions. Multichannel fiber optic SPR sensors have become a core tool in parallel detection scenarios due to their ability to compensate for nonspecific binding and environmental fluctuations, and to enable multi-analyte determination. This review analyzes and compares the structure, excitation effect, sensing performance, advantages and disadvantages of different types of multichannel fiber optic SPR sensors. Despite some challenges, efforts in multidisciplinary research, including developing high-performance sensitive films and innovative micro-nano fabrication processes, will overcome these obstacles. Finally, the future development directions of multichannel fiber optic SPR sensors from principle, structure, and material aspects are discussed.
LASER & PHOTONICS REVIEWS
(2022)
Article
Chemistry, Analytical
Yeseren Saylan
Summary: This study develops a biomimetic optic sensor for detecting Enterococcus faecalis in drinking water. The sensor utilizes a molecularly imprinted nanofilm made of gold nanoparticles. Extensive characterization shows that the sensor has remarkable detection capabilities with a low detection limit of 6.6x103 cfu/mL and a high determination coefficient within the Enterococcus faecalis concentration range of 5x104 - 1x108 cfu/mL. Importantly, the sensor is effective not only in buffer solutions but also in water sample solutions, making it practical for real-world applications.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hongli Fan, Liping Huang, Rui Li, Mingqian Chen, Junjie Huang, Hao Xu, Wenjun Hu, Gang L. Liu
Summary: This study aims to develop a high-throughput portable nanoplasmonic platform for fast and reliable detection of molecular interactions, which is necessary for drug screening and control of infections or diseases. The integration of nanocup array-enhanced surface plasmon resonance (NanoSPR) sensor with a standard 96-well plate or a simple eight-pillar device provides rapid and label-free interaction analysis and highly sensitive binding kinetics for drug screening.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Nesrin Capar, Bahar Bankoglu Yola, Ilknur Polat, Sena Bekerecioglu, Necip Atar, Mehmet Lutfi Yola
Summary: In this study, a selective detection method for zearalenone (ZEA) in rice grain samples was developed using a molecularly imprinted surface plasmon resonance (SPR) sensor with sulfur-doped g-C3N4/Bi2S3 (S-g-C3N4/Bi2S3) nanocomposite. The S-g-C3N4/Bi2S3 nanocomposite was synthesized with high purity and green chemistry principles, followed by the preparation of the ZEA-imprinted SPR chip using UV polymerization. The developed SPR sensor exhibited linearity towards ZEA in the range of 1.0 - 10.0 ng/L with a detection limit of 0.33 ng/L. This sensor allows for reliable determination of ZEA in rice grain samples, ensuring food safety.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Monireh Bakhshpour-Yucel
Summary: The combination of nanotechnology and sensor enables easy detection of diagnostic biomarkers with high sensitivity. The use of a surface plasmon resonance sensor system and graphene oxide-based molecular imprinting technology enables label-free and real-time detection of target molecules. The SPR sensor system, composed of a gold nanofilm and a graphene oxide-imprinted composite nanofilm, shows high selectivity and sensitivity in detecting lysozyme, serving as a model protein.
Article
Biochemical Research Methods
Youjun Zeng, Zhaogang Nie, Dongyun Kai, Jiajie Chen, Yonghong Shao, Weifu Kong, Zhengqiang Yuan, Ho-Pui Ho, Fangteng Zhang
Summary: This paper presents a novel WSPRi sensing system with a high anti-interference capability and low cost. By introducing devices such as an acousto-optic tunable filter and a halogen lamp, real-time recording of brine concentration and formation of the coffee ring effect were successfully achieved, and the performance of the biosensor was improved. The high anti-interference capability and accuracy of this system will greatly contribute to the exploration of biomolecule behaviors in biological and biochemistry studies.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)