Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Mechanism behind Polysorbates’ Inhibitory Effect on P-Glycoprotein

(2022) Laust Moesgaard et al.   MOLECULAR PHARMACEUTICS

Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein

(2022) Chenmala Karthika et al.   Life-Basel

Oral paclitaxel with encequidar compared to intravenous paclitaxel in patients with advanced cancer: a randomised crossover pharmacokinetic study

(2021) Christopher G. C. A. Jackson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor

(2021) Michael P. Smolinski et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-dose etoposide formulations do not saturate intestinal P-glycoprotein: Development, stability, and pharmacokinetics in Sprague-Dawley rats

(2020) Ahmed A. Abdulhussein Al-Ali et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

(2020) Kamil Nosol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC): Relevance to oral drug absorption

(2019) Ahmed A. Abdulhussein Al-Ali et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats

(2018) Ahmed A. Abdulhussein Al-Ali et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells: Impact on P-glycoprotein inhibition, barrier function, and repeated cellular exposure

(2018) Ahmed A. Abdulhussein Al-Ali et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of Sample Diluents on the Quantitation of Basic Compounds by High Performance Liquid Chromaography

(2018) Jinjian Zheng et al.   CHROMATOGRAPHIA

Concomitant solubility-permeability increase: Vitamin E TPGS vs. amorphous solid dispersion as oral delivery systems for etoposide

(2017) Avital Beig et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development of an Improved Three-Dimensional In Vitro Intestinal Mucosa Model for Drug Absorption Evaluation

(2013) Na Li et al.   TISSUE ENGINEERING PART C-METHODS

Development and validation of a GC-EI-MS method with reduced adsorption loss for the quantification of olanzapine in human plasma

(2012) Kayo Ikeda et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

Effect of Temperature on the Critical Micelle Concentration and Micellization Thermodynamic of Nonionic Surfactants: Polyoxyethylene Sorbitan Fatty Acid Esters

(2012) Ehsan Mohajeri et al.   E-Journal of Chemistry

Mechanism of inhibition of P-glycoprotein mediated efflux by Pluronic P123/F127 block copolymers: Relationship between copolymer concentration and inhibitory activity

(2012) Zhang Wei et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments

(2007) Emma L. McConnell et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY