Article
Oncology
Wei Wang, Lina Xiao, Deng Pan, Lingzhi Hu
Summary: ASF1B is highly expressed in lung cancer and is associated with tumor stage, lymph node metastasis, and poor prognosis. ASF1B promotes cell proliferation, migration, and invasion in lung cancer through the P53-mediated EMT signaling pathway.
Article
Oncology
Natalia Glatzel-Plucinska, Aleksandra Piotrowska, Adam Rzechonek, Marzenna Podhorska-Okolow, Piotr Dziegiel
Summary: SATB1, a nuclear matrix protein, has been identified as a factor promoting tumor invasion in lung cancer. Its expression is positively correlated with EMT-associated proteins and significantly increases after EMT induction in NSCLC cell lines. The results suggest that SATB1 may act as a regulator of EMT in NSCLC.
Review
Immunology
Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang
Summary: As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes can be used as a potential tool for non-invasive liquid biopsy due to their presence in various body fluids. This study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). It also discusses the occurrence of EGFR+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kaitlin McLaughlin, Kay See Tan, Joe Dycoco, Monica F. Chen, Jamie E. Chaft, Nikhil P. Mankuzhy, Andreas Rimner, Rania G. Aly, Rachel E. Fanaroff, William D. Travis, Mark Bilsky, Manjit Bains, Robert Downey, James Huang, James M. Isbell, Daniela Molena, Bernard J. Park, David R. Jones, Valerie W. Rusch
Summary: A multidisciplinary care paradigm, involving medical and radiation oncology, as well as spine neurosurgery, can improve surgical outcomes for Pancoast tumors. Spine neurosurgery allows for the resection of transverse processes and vertebral bodies. This treatment approach is associated with a high rate of R0 resection, complete response, and major pathologic response. The prognosis of cT3 and cT4 tumors is similar.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Yoshihisa Shimada, Jun Matsubayashi, Akira Saito, Tatsuo Ohira, Masahiko Kuroda, Norihiko Ikeda
Summary: This study investigated the utility of miRNA profiling in distinguishing LSQCC and MSQCC from HNSQCC. Thirteen miRNAs were identified as significant in differentiating the expression patterns of these cancer types. Further analysis revealed that miR-10a, miR-28, and miR-3120 levels in serum extracellular vesicles were promising noninvasive tools for differential diagnosis between LSQCC and MSQCC.
Article
Oncology
Sandra Ortiz-Cuaran, Aurelie Swalduz, Jean-Philippe Foy, Solene Marteau, Anne-Pierre Morel, Frederique Fauvet, Genevieve De Souza, Lucas Michon, Maxime Boussageon, Nicolas Gadot, Marion Godefroy, Sophie Leon, Antonin Tortereau, Nour-El-Houda Mourksi, Camille Leonce, Marie Alexandra Albaret, Anushka Dongre, Beatrice Vanbervliet, Marie Robert, Laurie Tonon, Roxane M. Pommier, Veronique Hofman, Valery Attignonf, Sandrine Boyaulta, Carole Audoynaud, Jessie Auclairf, Fanny Bouquetg, Qing Wang, Christine Menetrier-Cauxa, Maurice Perolb, Christophe Cauxa, Paul Hofmand, Sylvie Lantuejoulb, Alain Puisieuxa, Pierre Saintigny
Summary: Epithelial-to-mesenchymal transition (EMT) is associated with tumor aggressiveness, drug resistance, and poor survival in non-small cell lung cancer (NSCLC) and other cancers. Researchers have found that CD70 and ZEB1 play a key role in immune escape in NSCLC, providing new insights for treating NSCLC through immunotherapy strategies.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Sarah M. Groves, Nicholas Panchy, Darren R. Tyson, Leonard A. Harris, Vito Quaranta, Tian Hong
Summary: This study analyzed the relationship between SCLC subtypes and epithelial to mesenchymal transition (EMT), and found a correspondence between SCLC subtypes and the EMT program. This study provides a basis for further understanding the gene regulatory mechanisms of SCLC tumor plasticity and its applicability to other cancer types.
Article
Biology
Fumie Nakasuka, Sho Tabata, Takeharu Sakamoto, Akiyoshi Hirayama, Hiromichi Ebi, Tadaaki Yamada, Ko Umetsu, Maki Ohishi, Ayano Ueno, Hisatsugu Goto, Masahiro Sugimoto, Yasuhiko Nishioka, Yasuhiro Yamada, Masaru Tomita, Atsuo T. Sasaki, Seiji Yano, Tomoyoshi Soga
Summary: Through metabolome and transcriptome analyses, Nakasuka et al find that TGF-beta-induced epithelial-mesenchymal transition (EMT) in non-small cell lung cancer cells is associated with reprogramming of amino acid metabolism. They also identify P4HA3 as a key enzyme involved in these changes altogether providing insights into potential mechanisms of metastasis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Mengmeng Fan, Makoto Arai, Akinobu Tawada, Tetsuhiro Chiba, Reo Fukushima, Katsuhiro Uzawa, Masashi Shiiba, Naoya Kato, Hideki Tanzawa, Yuichi Takiguchi
Summary: The study revealed the roles of EPSTI1 in conferring malignant characteristics to oral squamous cell carcinoma (OSCC) and lung squamous cell carcinoma (LSCC), with the gene showing oncogenic roles in OSCC and tumor-suppressive roles in LSCC. Additionally, PCR array analyses identified some genes with altered expression levels along with modified EPSTI1 expression in both OSCC and LSCC cell lines, suggesting EPSTI1 may be a therapeutic target for both types of cancer.
Article
Biochemistry & Molecular Biology
Masashi Kawami, Shinnosuke Takenaka, Mizuki Akai, Ryoko Yumoto, Mikihisa Takano
Summary: The study revealed that in p53-wild type NSCLC cells, miR-34a led to an upregulation of α-SMA, enhanced p53 activity, and promoted cell migration. However, these effects were not significant in p53-deficient cells. Under p53-knockdown condition, miR-34a only upregulated α-SMA, illustrating a close relationship between p53 and miR-34a-induced EMT in p53-wild type NSCLC cells.
Article
Biochemistry & Molecular Biology
Ewa Katnik, Agnieszka Gomulkiewicz, Aleksandra Piotrowska, Jedrzej Grzegrzolka, Alicja Kmiecik, Katarzyna Ratajczak-Wielgomas, Anna Urbaniak, Natalia Glatzel-Plucinska, Piotr Blasiak, Piotr Dziegiel
Summary: BCL11A may be a potential biomarker for NSCLC, with its protein expression significantly higher in NSCLC cases compared to non-malignant lung tissue. Nuclear expression of BCL11A decreases with increasing malignancy grade and correlates positively with Ki-67, Slug, and Twist expression, while the opposite relationships were found for cytoplasmic expression. The nuclear expression of BCL11A in NSCLC cells may affect tumor cell proliferation and change their phenotype, thus promoting tumor progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Giuseppe Giaccone, Yongfeng He
Summary: Lung cancer is the leading cause of cancer related death, with two major histological subtypes, NSCLC and SCLC. Transformation from NSCLC to SCLC can cause treatment resistance, potentially due to therapy-induced changes or clonal selection. This article discusses the potential mechanisms, cell of origin, and genomic alterations in both de novo and transformed SCLC, as well as treatment options including chemotherapy, radiotherapy, TKIs, immunotherapy, and antiangiogenic agents.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Cell Biology
William L. Harryman, Kendra D. Marr, Ray B. Nagle, Anne E. Cress
Summary: This article discusses the diffusion and invasion mechanisms of muscle-invasive cancers in specialized biophysical and growth factor enriched microenvironments. The study proposes that the heterogeneity of cell-cell and cell-ECM adhesion receptors is a key factor in driving aggressive tumor networks, while the tumor's phenotype heterogeneity allows it to traverse through muscle and survive. The study also identifies the existence of epithelial-mesenchymal cooperation (EMC) within the tumor invasive network, facilitating tumor escape, muscle invasion, and metastasis. Additionally, the study highlights the special characteristics of the smooth muscle microenvironment and its alteration by primary tumors that contribute to tumor escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal-Egana, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Faergeman, Ole N. Jensen, Rasmus Siersbaek, Kumar Somyajit, Paolo Ceppi
Summary: This study found an inverse association between short-chain fatty acids and EMT in non-small cell lung cancer patients. In vitro experiments showed that propionate treatment enhanced the epithelial transcriptional program and reduced the EMT phenotype in lung cancer cell lines. Animal experiments also confirmed that propionate can reduce lung cancer metastasis and lymph node spread. Further mechanistic investigation revealed that propionate treatment caused chromatin remodeling through p300-mediated histone acetylation.
EMBO MOLECULAR MEDICINE
(2023)
Article
Polymer Science
Anna Ulldemolins, Alicia Jurado, Carolina Herranz-Diez, Nuria Gavara, Jorge Otero, Ramon Farre, Isaac Almendros
Summary: Physiomimetic decellularized extracellular matrix-derived hydrogels are an important source of bioactive vesicles that can modulate lung repair. EVs and ECM-vesicles derived from MSCs and L-HG have similar therapeutic capacity in lung repair, but MSCs-derived EVs show higher therapeutic potential.
Editorial Material
Dermatology
Su Jung Park, Jae Wan Park, Soon Auck Hong, Kui Young Park, Seong Jun Seo
ANNALS OF DERMATOLOGY
(2022)
Article
Surgery
Jesung Park, Hyun Kang, Yoo Shin Choi, Suk-Won Suh, Soon Auck Hong, Geun Joo Choi, Woo Jung Sim
Summary: The intraperitoneal application of Mediclore and the combination of Mediclore and rosuvastatin effectively reduced postoperative adhesions in a rat model, demonstrating a strong antiadhesive effect.
EUROPEAN SURGICAL RESEARCH
(2022)
Article
Oncology
Heejin Lee, Sang Hoon Chun, Seo Yun Moon, Jung-Sook Yoon, Hye Sung Won, Soon Auck Hong, Seo Ree Kim, Kwang-Jae Cho, Keunsoo Kang, Sieun Lee, Young-Ho Ahn, Ji Hyung Hong, Yoon Ho Ko
Summary: This study found that miR-769-3p is overexpressed in the stromal cells of oral squamous cell carcinoma and inhibits the proliferation, migration, and invasion of cancer cells. miR-769-3p may serve as a potential biomarker of the miRNA phenotype in oral squamous cell carcinoma.
Article
Pathology
Soon Auck Hong, Haeyoen Jung, Sung Sun Kim, Min-Sun Jin, Jung-Soo Pyo, Ji Yun Jeong, Younghee Choi, Gyungyub Gong, Yosep Chong
Summary: This study reports the results of the Continuous Quality Improvement program for cytopathology in 2020, highlighting the impact of the coronavirus pandemic on cytologic examinations, particularly in respiratory-related specimens. The program conducted proficiency tests and evaluations to assess the current status of cytopathology practice in Korea, serving as a gold standard.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Daeun Ryu, Tae-Min Kim, Yun-Hee Lee, U-Syn Ha
Summary: Longitudinal tumor sequencing of recurrent bladder cancer (BC) was performed using whole-exome and transcriptome sequencing. The study revealed the genetic makeup associated with APOBEC deaminase activity was accomplished early in cancer evolution and that chemotherapy often led to clonal sweeps. Transcriptome sequencing also showed frequent subtype switching during tumor progression. This research provides insights into BC heterogeneity in terms of somatic mutations, cell clones, and transcriptome-based tumor subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Seungyeon Joe, Miseon Lee, Jun Kang, Joori Kim, Sook-Hee Hong, Sung Jong Lee, Keun Ho Lee, Ahwon Lee
Summary: The study utilized POLE ddPCR and L1CAM IHC as alternative methods for molecular classification in early-stage endometrial cancer, enhancing risk stratification and providing valuable information for treatment decisions and patient outcomes.
Article
Health Care Sciences & Services
Tae Young Park, Jae Hyuk Do, Hyoung-Chul Oh, Yoo Shin Choi, Seung Eun Lee, Hyun Kang, Soon Auck Hong
Summary: The severity of acute cholecystitis (AC) does not correlate with the extent of gallbladder (GB) inflammation on histopathological and laboratory findings. However, there is a correlation between the severity of AC and the rate of microbiological isolation in blood and bile.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pathology
Yosep Chong, Soon Auck Hong, Hoon Kyu Oh, Soo Jin Jung, Bo-Sung Kim, Ji Yun Jeong, Ho-Chang Lee, Gyungyub Gong
Summary: This study assessed the feasibility of digitally scanned images in cytological proficiency testing (PT) and found that digital PT showed comparable results to conventional PT in terms of image quality, feature presentation, and error rates. The number of discordant cases was slightly higher in the digital PT group. However, careful selection of scanners and optimal conditions are necessary for the successful establishment of digital quality assurance programs in cytology.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Article
Anesthesiology
Kwon Hui Seo, Ji Hyung Hong, Mi Hyoung Moon, Wonjung Hwang, Sea-Won Lee, Jin Young Chon, Hyejin Kwon, Sook Hee Hong, Sukil Kim
Summary: This study aimed to compare the oncological outcomes of total intravenous anesthesia (TIVA) and inhalation anesthesia in patients with non-small cell lung cancer (NSCLC) who underwent curative resection. The results showed that TIVA was associated with significantly improved recurrence-free survival (RFS) and overall survival (OS) compared with inhalation anesthesia. Multivariable Cox regression analysis also revealed that TIVA was an independent prognostic factor for recurrence and OS.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Oncology
Sook-hee Hong, Nahyeon Kang, Okran Kim, Soon Auck Hong, Juyeon Park, Joori Kim, Myung-Ah Lee, Jinhyoung Kang
Summary: This article reports the impact of the CXCL10/CXCR3 pathway on EGFR-TKI resistance in EGFR-mutant lung cancer. It was found that in the co-culture of EGFR-mutant tumor cells and activated PBMCs treated with EGFR-TKI, CXCL10 increased in the supernatant, activating CXCR3 in tumor cells and leading to phosphorylation of Src and NF-KB subunit p65 as well as the expression of HIF-1a. Furthermore, treatment with CXCL10 siRNA decreased CXCL10 levels in the supernatant, suggesting that CXCL10 acts through autocrine and paracrine pathways. Importantly, the elevated CXCL10/CXCR3 signaling was also observed in a transgenic lung cancer mouse model. Overall, the results indicate that increased CXCL10 levels during early EGFR-TKI treatment stimulate persistent tumor cell signaling and contribute to EGFR-TKI resistance via autocrine and paracrine pathways.
Article
Medicine, General & Internal
Hana Song, Jae Yong Park, Ju-Hee Kim, Tae-Seop Shin, Soon Auck Hong, Md Nazmul Huda, Beom Jin Kim, Jae Gyu Kim
Summary: This study successfully established and cultured gastric cancer patient-derived organoids (PDOs) and verified their origin and tumor characteristics through histopathological examination and staining methods. The results of this study demonstrate that gastric cancer PDO models exhibit the characteristics of primary tumors and have potential applications in drug screening and development.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)