Article
Endocrinology & Metabolism
Jun Kou, Chunyang He, Lin Cui, Zhengping Zhang, Wei Wang, Li Tan, Da Liu, Wei Zheng, Wei Gu, Ning Xia
Summary: The study on Chinese postmenopausal women with osteoporosis identified potential biomarkers related to metabolic pathway disorders, providing new insights for early diagnosis. The findings suggest that metabonomic analysis has great potential for application in postmenopausal women with osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Stefano Angioni, Francesca Congiu, Salvatore Giovanni Vitale, Maurizio Nicola D'Alterio, Antonio Noto, Giovanni Monni, Maria Laura Santoru, Vassilios Fanos, Federica Murgia, Luigi Atzori
Summary: This study used gas chromatography-mass spectrometer (GC-MS) to analyze serum samples of patients with symptomatic endometriosis and found metabolic alterations and potential biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhanxuan E. Wu, Marlena C. Kruger, Garth J. S. Cooper, Ivana R. Sequeira, Anne-Thea McGill, Sally D. Poppitt, Karl Fraser
Summary: Untargeted metabolomics of blood samples has been widely used to study metabolic alterations in diseases and identify biomarkers. This study found that the concentration of metabolites in plasma was more reflective of the liver profile than muscle or adipose tissue, highlighting the importance of considering the metabolomic relationship between different tissues and plasma.
Article
Biochemical Research Methods
Jia-You Lin, Bao-Rong Juo, Yu-Hsuan Yeh, Shu-Hsuan Fu, Yi-Ting Chen, Chien-Lun Chen, Kun-Pin Wu
Summary: The study identified potential metabolite markers for early-stage bladder cancer detection through comparative urine metabolomics. The association between early-stage bladder cancer and sugars and polyols metabolism may improve opportunities for detection of bladder cancer.
BMC BIOINFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Manendra Singh Mohit, Manendra Singh Tomar, Fabrizio Araniti, Ankit Pateriya, Ram Awadh Singh Kushwaha, Bhanu Pratap Singh, Sunit Kumar Jurel, Raghuwar Dayal Singh, Ashutosh Shrivastava, Pooran Chand
Summary: This study identified metabolic biomarkers and pathways associated with severe obstructive sleep apnea (OSA). The results showed significant alterations in metabolites and their related pathways in OSA patients compared to controls. The upregulation of specific metabolites related to chronic kidney disease, cardiovascular risk, and oxidative stress suggests their potential as biomarkers for disease management in OSA patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Beata A. Raczkowska, Patrycja Mojsak, David Rojo, Beata Telejko, Magdalena Paczkowska-Abdulsalam, Justyna Hryniewicka, Anna Zielinska-Maciulewska, Malgorzata Szelachowska, Maria Gorska, Coral Barbas, Adam Kretowski, Michal Ciborowski
Summary: The study identified specific serum metabolites associated with gestational diabetes mellitus (GDM), with a combination of alpha-HB, beta-HB, and myristic acid showing high specificity and sensitivity for the diagnosis of GDM, as well as predicting the risk of GDM in early pregnancy. These findings suggest potential new markers for the early diagnosis of GDM.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qing-Qing Yu, Heng Zhang, Shiyuan Zhao, Dadi Xie, Haibo Zhao, Weidong Chen, Min Pang, Baoqin Han, Pei Jiang
Summary: This study comprehensively analyzed the metabolite changes in a mouse model of irinotecan-induced intestinal mucositis, identifying 46 metabolites with significant changes in tissues and serum. The study highlighted key pathways related to these metabolites, offering insights into new biomarkers for diagnosis and treatment of intestinal mucositis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Analytical
A. Fernez Asensio, E. Alvarez-Gonzalez, A. Rodriguez, L. M. Sierra, E. Blanco-Gonzalez
Summary: Dysregulation of TCA cycle enzymes leads to abnormal accumulation of oncometabolites, which contribute to cancer formation and progression. GC-MS and LC-MS are powerful analytical tools for accurate identification and determination of these metabolites.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biotechnology & Applied Microbiology
Hao Yang, Zhenfei Wang, Shujun Shi, Qin Yu, Meiling Liu, Zhelin Zhang
Summary: This study demonstrated that CSF metabolomics based on LC-MS can differentiate neurobrucellosis patients from normal controls, offering new perspectives for diagnosis and treatment of neurobrucellosis.
Article
Chemistry, Analytical
Chiara Maria Vitale, Arjen Lommen, Carolin Huber, Kevin Wagner, Borja Garlito Molina, Rosalie Nijssen, Elliott James Price, Marco Blokland, Frederike van Tricht, Hans G. J. Mol, Martin Krauss, Laurent Debrauwer, Olga Pardo, Nuria Leon, Jana Klanova, Jean-Philippe Antignac
Summary: A set of QA/QC criteria for nontargeted measurement of pesticide exposure markers in human urine has been proposed and applied in the HBM4EU project. The criteria include monitoring signal intensities, mass accuracy, and retention times of selected markers. The results show high repeatability and accuracy of the data. This is the first time that harmonized QA/QC criteria have been used to assess the quality of nontargeted analysis of human samples across multiple laboratories.
ANALYTICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Yuyang Hou, Yuanping He, Jingjie Wang, Yanfen Zhou, Bo Ma, Xin Li, Liang Shi, Qi Zhang
Summary: By analyzing the metabolic profiles of four different types of asthenozoospermia, this study revealed abnormal changes in metabolites and metabolic pathways associated with the disease. The findings provide new clues and evidence for the etiology, diagnosis, and treatment of asthenozoospermia.
CLINICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Teresa S. McMillen, Andrew Leslie, Kenneth Chisholm, Susanne Penny, Jeffrey Gallant, Alejandro Cohen, Arik Drucker, James P. Fawcett, Devanand M. Pinto
Summary: This study presents a comprehensive and quantitatively robust method for metabolomic analysis, using HILIC and RP stationary phases combined with positive and negative electrospray ionization. The method allows for complete analysis of a single sample in as little as 40 minutes and has been validated with clinical samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Shiyuan Zhao, Haitao Zhong, Chunmei Geng, Hongjia Xue, Changshui Wang, Wenxue Sun, Ruili Dang, Wenxiu Han, Pei Jiang
Summary: In this study, gas chromatography-mass spectrometry was used to investigate the toxic mechanisms of ACR in the main target tissues of rats, revealing 14 metabolic pathways related to amino acid, fatty acid, purine, and energy metabolism. The study suggests that the toxic mechanism of ACR may involve oxidative stress, inflammation, amino acid metabolism, and energy disorders.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Parker Ladd Bremer, Gert Wohlgemuth, Oliver Fiehn
Summary: Metabolomics by GC/MS is a standardized and reliable platform for understanding small molecule biology. The West Coast Metabolomics Center at UC Davis has collated over 156,000 samples and 2000 studies into the BinBase database, which provides meaningful insight to biologists and helps standardize metabolomics studies. They have developed an easy-to-use query interface, BinDiscover, for intuitive hypothesis generation based on these metabolomic samples.
JOURNAL OF CHEMINFORMATICS
(2023)
Article
Oncology
Xin Chen, Bo-lun Shi, Run-zhi Qi, Xing Chang, Hong-gang Zheng
Summary: This study investigated the therapeutic effects and molecular mechanisms of Honokiol (HNK) on colorectal cancer through metabolomics analysis. Results showed potential urine biomarkers related to purines, tyrosines, tryptophans metabolism, and indicated that HNK modulated the citrate cycle to exert its efficacy against intestinal tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Belen Callejon-Leblic, Marta Selma-Royo, Maria Carmen Collado, Jose Luis Gomez-Ariza, Nieves Abril, Tamara Garcia-Barrera
Summary: In this study, the interaction between selenium intake, gut microbiota, and metabolites was investigated. Significant differences in gut metabolites were observed in mice after selenium supplementation, indicating the important effect of selenium on microbiota metabolism. The correlation analysis revealed associations between metabolites and gut bacterial profiles, with a higher abundance of Lactobacillus spp. associated with specific metabolite levels.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Environmental Sciences
G. Rodriguez-Moro, C. Roman-Hidalgo, S. Ramirez-Acosta, N. Aranda-Merino, J. L. Gomez-Ariza, N. Abril, M. A. Bello-Lopez, R. Fernandez-Torres, T. Garcia-Barrera
Summary: This study investigated the bioaccumulation of cadmium, arsenic, and diclofenac in different tissues of Procambarus clarkii over 21 days of exposure and 28 days of depuration. Results showed that arsenic and cadmium accumulated mainly in the hepatopancreas, while diclofenac increased in the abdominal muscle during the depuration phase. The metabolomic analysis revealed a significant impact on metabolic pathways in the hepatopancreas.
Article
Chemistry, Applied
A. Arias-Borrego, I Velasco, J. L. Gomez-Ariza, T. Garcia-Barrera
Summary: The study found that several metabolites in the breast milk of iodine-deficient women were altered, affecting metabolic pathways such as lipid metabolism, amino acid cycle, the tricarboxylic acid cycle, and glycolysis. Additionally, the concentrations of selenium, zinc, and copper were significantly lower in the breast milk of iodine-deficient women.
Article
Nutrition & Dietetics
Marianne Lonnebotn, Lucia Calciano, Ane Johannessen, Deborah L. Jarvis, Michael J. Abramson, Bryndis Benediktsdottir, Lennart Braback, Karl A. Franklin, Raul Godoy, Mathias Holm, Christer Janson, Nils O. Jogi, Jorunn Kirkeleit, Andrei Malinovschi, Antonio Pereira-Vega, Vivi Schlunssen, Shyamali C. Dharmage, Simone Accordini, Francisco Gomez Real, Cecilie Svanes
Summary: In a recent study, it was found that fathers' overweight during puberty is associated with asthma in their adult offspring. However, the potential impact on the adult lung function of the offspring, which is an important marker of overall and respiratory health, has not been studied. The study investigated the causal effects of parents' overweight on the lung function of adult offspring, specifically within the paternal and maternal lines. The findings suggest that fathers' overweight before puberty can lead to lower FEV1 and FVC in their future sons, partially mediated through the sons' adult height.
Article
Multidisciplinary Sciences
Sara Ramirez-Acosta, Marta Selma-Royo, Maria Carmen Collado, Francisco Navarro-Roldan, Nieves Abril, Tamara Garcia-Barrera
Summary: This study investigates the potential role of selenoproteins on gut microbiota and male reproductive health. A new assay for the quantification of selenoproteins in testicular tissue has been developed and applied. The study finds associations between testicular selenoproteins and gut microbiota, and demonstrates the significant impact of Se-supplementation on gut microbiota and male reproductive health.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Rocio Capelo, Diane S. Rohlman, Rocio Jara, Tamara Garcia, Jesus Vinas, Jose A. Lorca, Manuel Contreras Llanes, Juan Alguacil
Summary: This study explored the association between residence in a metal-polluted area and neurobehavioral performance in children aged 9 to 11, finding that children living near industrial areas had deficits in neurobehavioral performance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Francisco Sanchez-Saez, Arce Domingo-Relloso, Zulema Rodriguez-Hernandez, Sonia Tarazona, Vannina Gonzalez-Marrachelli, Maria Grau-Perez, Jose M. Morales-Tatay, Nuria Amigo, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, F. Javier Chaves, Ana Barbara Garcia-Garcia, Rebeca Melero, Maria Tellez-Plaza, Juan C. Martin-Escudero, Josep Redon, Daniel Monleon
Summary: This study evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. The results showed that exposures to Co, Cu, Se, Zn, As, Cd and Sb were associated with several metabolic patterns involved in chronic disease. Carriers of redox-related variants may have differential susceptibility to metabolic alterations associated with excessive exposure to metals.
Article
Chemistry, Multidisciplinary
S. Ramirez-Acosta, R. Uhlirova, F. Navarro, J. L. Gomez-Ariza, T. Garcia-Barrera
Summary: Selenomethionine can protect HepG2 cells against cadmium toxicity by modulating selenoprotein synthesis and reducing cadmium accumulation.
FRONTIERS IN CHEMISTRY
(2022)
Article
Food Science & Technology
Ana Arias-Borrego, Francisco J. Soto Cruz, Marta Selma-Royo, Christine Bauerl, Elia Garcia Verdevio, Francisco J. Perez-Cano, Carles Lerin, Ines Velasco Lopez, Cecilia Martinez-Costa, M. Carmen Collado, Tamara Garcia-Barrera
Summary: This study investigates the impact of maternal SARS-CoV-2 infection on the elemental and metabolomic profiles of human milk (HM). It finds that COVID-19 significantly alters the composition of HM, with decreases in certain elements and significant changes in various metabolites.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Engineering, Environmental
C. Parra-Martinez, M. Selma-Royo, B. Callejon-Leblic, M. C. Collado, N. Abril, T. Garcia-Barrera
Summary: Several environmental pollutants have been shown to damage the brain and affect gut microbiota. This study found that chemical cocktails (CC) of pollutants can have an impact on the brain metabolome, but this can be mitigated by the antioxidant selenium (Se). Furthermore, the study identified associations between brain metabolites and gut microbes, which were influenced by Se supplementation.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
A. Arias-Borrego, M. Selma-Royo, M. C. Collado, N. Abril, T. Garcia-Barrera
Summary: Biological systems are exposed to a complex environment where pollutants can interact through synergistic or antagonistic mechanisms. This study investigates the effects of selenium supplementation on gut microbiota, plasma selenoproteome, metabolome, and arsenic metabolization using different models and methods. The results show that selenium reduces the concentration of the antioxidant glutathione peroxidase in plasma and increases the arsenic methylation rate. Furthermore, synergistic deleterious effects were observed between pollutants, antibiotics, and selenium.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Food Science & Technology
Barbara O. Guimaraes, Belen Villarreal-Toribio, Tamara Garcia-Barrera, Ana Arias-Borrego, Pieter Gremmen, Rene H. Wijffels, Maria J. Barbosa, Sarah D'Adamo
Summary: This study investigated the effect of sulphur on selenite accumulation in the microalga Nannochloropsis oceanica. The results showed that low concentrations of sulphur significantly increased selenium accumulation, while high concentrations of sulphur reduced selenium accumulation. Additionally, sulphur had no significant effect on total fatty acid content.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Environmental Sciences
Carlos Ruiz Canovas, Dino Quispe, Francisco Macias, Belen Callejon-Leblic, Ana Arias-Borrego, Tamara Garcia-Barrera, Jose Miguel Nieto
Summary: This study investigates the release of metal/loids from sulfide mine wastes during weathering and the associated health risks. The researchers conducted a comprehensive characterization of the mine wastes and determined the bioaccessibility of the metal/loids through digestion and inhalation simulation tests. They found that most wastes with high concentrations of soluble compounds are considered hazardous according to European regulations.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Barbara O. Guimaraes, Belen Villarreal-Toribio, Tamara Garcia-Barrera, Ana Arias-Borrego, Pieter Gremmen, Rene H. Wijffels, Maria J. Barbosa, Sarah D'Adamo
Summary: This study investigated the effect of sulphur on selenite accumulation in Nannochloropsis oceanica and found that lower sulphur concentrations increased selenium accumulation, while higher concentrations decreased it. The main organic selenium species identified was selenomethionine.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)