Article
Genetics & Heredity
Ghada Ajabnoor, Fai Alsubhi, Thoraia Shinawi, Wisam Habhab, Walaa F. F. Albaqami, Hussain S. S. Alqahtani, Hisham Nasief, Nabeel Bondagji, Ramu Elango, Noor Ahmad Shaik, Babajan Banaganapalli
Summary: This study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Irina Gilyazova, Elizaveta Ivanova, Himanshu Gupta, Artur Mustafin, Ruslan Ishemgulov, Adel Izmailov, Gulshat Gilyazova, Elena Pudova, Valentin Pavlov, Elza Khusnutdinova, Bo-Ying Bao, Yung-Hsiang Chen
Summary: This study aimed to investigate the miRNA profile in tissue samples obtained from patients with prostate cancer (PCa) and find potential markers for diagnosis and prognosis. The study found that certain miRNAs were downregulated in early-stage cancer patients, which may be useful for diagnosing and predicting PCa.
Article
Biotechnology & Applied Microbiology
Ying Liu, Changmou Yang, Shisheng Chen, Weihao Liu, Jingyi Liang, Shuhua He, Jialiang Hui
Summary: This study reveals that miR-375 promotes osteoblastic metastasis and tumor progression in prostate cancer by upregulating the Wnt signaling pathway.
CANCER GENE THERAPY
(2022)
Review
Oncology
Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Elena Okina, Mohammad Hossein Gholami, Kiavash Hushmandi, Mehrdad Hashemi, Azuma Kalu, Ali Zarrabi, Noushin Nabavi, Navid Rabiee, Esmaeel Sharifi, Hassan Karimi-Maleh, Milad Ashrafizadeh, Alan Prem Kumar, Yuzhuo Wang
Summary: This review highlights the role of epigenetic alterations in the development of prostate cancer, specifically focusing on lncRNAs. Aberrant expression of lncRNAs in prostate cancer is well-documented, affecting various molecular pathways and regulating tumor progression. Additionally, lncRNAs play a role in radio-resistance, chemo-resistance, and immune evasion of prostate cancer, making them potential targets for therapeutic interventions.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kyung Won Hwang, Jae Won Yun, Hong Sook Kim
Summary: This study aims to unravel the intricate molecular characteristics of FOXA1 mutant prostate cancer through comprehensive in silico analysis. The study identified 1525 differentially expressed genes and discovered KDM1A, MAOA, PDGFB, and HSP90AB1 as potential drug targets. The approved drugs targeting MAOA and KDM1A have the potential to cure FOXA1 mutant primary prostate cancer without lethal side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Can Wang, Wenchao Li, Qiang Hu, Ninghan Feng, Chunhui Liu, Naipeng Shi, Shuqiu Chen, Ming Chen, Han Guan, Zonghao You, Bin Xu
Summary: This study found that overexpression of miR-7 can suppress tumor growth and prolong survival in transgenic mouse models of prostate cancer. miR-7 inhibits glycolysis in prostate cancer cells by regulating multiple key pathways and remodels the acidic tumor microenvironment. These findings provide hope for using miR-7 as a target for treating prostate cancer.
Article
Health Care Sciences & Services
Jongsu Kim, Kyung Won Hwang, Hye Jung Lee, Hong Sook Kim
Summary: This study identified cellular signaling pathways associated with S:E fusion-positive prostate cancer and suggested potential therapeutic targets through gene-drug network analysis. Focal adhesion kinase (FAK)/PI3K-Akt signaling and JAK-STAT signaling were significantly enriched in S:E fusion-positive prostate cancer. PDGFRA and PDGFRB were the most frequently predicted therapeutic targets, with imatinib targeting both genes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Plant Sciences
Abhishek Bohra, Prasad Gandham, Abhishek Rathore, Vivek Thakur, Rachit K. Saxena, S. J. Satheesh Naik, Rajeev K. Varshney, Narendra P. Singh
Summary: The comparative analysis of genome-wide miRNAs and their gene targets between cytoplasmic male sterile (CMS) and fertile lines of pigeonpea suggests a possible role of miRNA-regulated pathways in reproductive development.
Article
Multidisciplinary Sciences
Adventina Padmyastuti, Marina Garcia Sarmiento, Maria Dib, Jens Ehrhardt, Janosch Schoon, Maryna Somova, Martin Burchardt, Cindy Roennau, Pedro Caetano Pinto
Summary: In this study, a microphysiological system (MPS) model was developed to replicate prostate cancer microenvironments and induce cellular phenotypic changes. The results showed that androgen-sensitive (LNCaP) and androgen-insensitive (PC3) prostate cancer cells exhibited different morphologies and expression profiles in 3D and MPS cultures under dynamic culture conditions.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Valentina Doldi, Rihan El Bezawy, Nadia Zaffaroni
Summary: Prostate cancer is a common and deadly tumor in men, with high heterogeneity making individual patient management challenging. microRNAs are crucial in determining prostate cancer response to radiation and drug therapy, potentially serving as novel therapeutic targets or tools for improving treatment response.
Article
Biochemistry & Molecular Biology
Rahaba Marima, Flavia Zita Francies, Rodney Hull, Thulo Molefi, Meryl Oyomno, Richard Khanyile, Sikhumbuzo Mbatha, Mzubanzi Mabongo, David Owen Bates, Zodwa Dlamini
Summary: Cancer is a complex disease involving alterations in gene expression, with key roles played by miRNA dysregulation and alternative splicing events. Dysregulation of miRNA and splicing events can promote carcinogenesis and drug resistance in various cancers. The interplay between miRNA and alternative splicing, particularly in altering target mRNA binding sites, can impact protein production and drug resistance mechanisms. Understanding these molecular alterations is crucial for developing effective strategies to combat drug resistance in cancer treatment.
Article
Cell Biology
Shidong Lv, Zeyu Wu, Mayao Luo, Yifan Zhang, Jianqiang Zhang, Laura E. Pascal, Zhou Wang, Qiang Wei
Summary: This study investigated the pharmacological effects and targets of ivermectin in prostate cancer. Ivermectin was found to inhibit the proliferation of prostate cancer cells and interact with FOXA1 and Ku70/Ku80, leading to changes in gene expression and repair ability, ultimately resulting in cell death.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Ganghua Yang, Zhengyang Lu, Fandi Meng, Yong Wan, Lei Zhang, Qinhong Xu, Zheng Wang
Summary: This study aimed to investigate the biological function and diagnostic and prognostic value of miR-141 in gallbladder cancer (GBC). The results showed that miR-141 was highly expressed in GBC cells but lowly expressed in normal tissues. Elevated plasma miR-141 expression was also detected in GBC patients and could serve as a more valuable diagnostic biomarker for GBC. Moreover, high plasma miR-141 expression was closely associated with tumor invasion, lymph node metastasis, and advanced pathological TNM stage, and it was also an independent prognostic factor for predicting poorer survival in GBC patients. These findings suggest that miR-141 may be a potential biomarker for diagnosis, prognosis, and treatment of GBC.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Biochemistry & Molecular Biology
Jakob Haldrup, Siri H. Strand, Clara Cieza-Borrella, Magnus E. Jakobsson, Maria Riedel, Maibritt Norgaard, Stine Hedensted, Frederik Dagnaes-Hansen, Benedicte Parm Ulhoi, Rosalind Eeles, Michael Borre, Jesper Olsen, Martin Thomsen, Zsofia Kote-Jarai, Karina D. Sorensen
Summary: FRMD6 has been identified as a novel tumor suppressor gene and prognostic biomarker candidate in prostate cancer, with its low expression associated with postoperative biochemical recurrence. It inhibits functions and growth of PC cells, leading to enrichment of Hippo/YAP and c-MYC signaling pathways upon knockout, ultimately causing prostatic intraepithelial neoplasia and hyperproliferation.
Article
Biology
Abdulhadi Ibrahim Hussain Bima, Ayman Zaky Elsamanoudy, Kawthar Saad Alghamdi, Thoraia Shinawi, Abdulrahman Mujalli, Prabhakar Rao Kaipa, Deema Aljeaid, Zuhier Awan, Noor Ahmad Shaik, Babajan Banaganapalli
Summary: This study explores how the MC4R genotype influences protein phenotype, stability, and ligand binding characteristics and finds that computational methods can effectively distinguish pathogenic and neutral missense variants of MC4R. These findings expand our understanding of MC4R genotype-protein phenotype and may pave the way for personalized medicine for morbid obesity.
Article
Pediatrics
Huda Husain Al-Numan, Rana Mohammed Jan, Najla bint Saud Al-Saud, Omran M. Rashidi, Nuha Mohammad Alrayes, Hadeel A. Alsufyani, Abdulrahman Mujalli, Noor Ahmad Shaik, Mahmoud Hisham Mosli, Ramu Elango, Omar I. Saadah, Babajan Banaganapalli
Summary: This study identified the molecular basis of early onset inflammatory bowel disease (IBD) in Arab patients through whole exome sequencing. The ITGAV and FN1 genes were found to be associated with IBD, with abundant expression in the gastrointestinal tract and immune organs. The dysregulation of these genes disrupts immune homeostasis and may induce intestinal inflammation. These findings provide new insights into the molecular etiology of pediatric onset IBD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Genetics & Heredity
Nuha Alrayes, Bayan A. Mallah, Noha M. Issa, Babajan Banaganapalli, Noor Ahmad Shaik, Khalidah K. Nasser, Bandar Ali Alshehri, Zahurul A. Bhuiyan, Amnah Y. Bdier, Jumana Y. Al-Aama
Summary: The study identified a novel heterozygous de novo mutation in the LRP1 gene in TOF patients in Saudi Arabia. This mutation was predicted to be pathogenic and affects the structure and function of the protein. Functional biology data from knock out mouse models confirmed the association of this gene mutation with cardiac defects and lethality. The findings contribute to accurate diagnosis and understanding of the molecular mechanisms and pathophysiology of TOF.
Article
Genetics & Heredity
Ghada Ajabnoor, Fai Alsubhi, Thoraia Shinawi, Wisam Habhab, Walaa F. F. Albaqami, Hussain S. S. Alqahtani, Hisham Nasief, Nabeel Bondagji, Ramu Elango, Noor Ahmad Shaik, Babajan Banaganapalli
Summary: This study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Noor Ahmad Shaik, Najla Bint Saud Al-Saud, Thamer Abdulhamid Aljuhani, Kaiser Jamil, Huda Alnuman, Deema Aljeaid, Nasreen Sultana, Ashraf AbdulRahman El-Harouni, Zuhier Ahmed Awan, Ramu Elango, Babajan Banaganapalli
Summary: This study investigates the impact of SERPINA1 missense variants on the structural and functional characteristics of A1AT protein in Alpha-1 antitrypsin deficiency. The results suggest that these variants alter the structure, stability, and function of A1AT protein, and negatively affect its binding with NE ligand molecule.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Endocrinology & Metabolism
Bassem Refaat, Akhmed Aslam, Shakir Idris, Ahmed H. Almalki, Mofareh Y. Alkhaldi, Hassan A. Asiri, Riyad A. Almaimani, Abdulrahman Mujalli, Faisal Minshawi, Sara A. Alamri, Mona I. AlHussain, Badee A. Baltow, Mansour H. Alqasmi, Ghaiyda T. Basfar, Ohoud M. Alosaimi, Ibrahim A. Muhayya
Summary: This study reveals that the expression of estrogen and androgen receptors in colorectal cancer tissues is correlated with tumor characteristics, and hormonal therapy may serve as an alternative treatment strategy for colorectal cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abdulrahman Mujalli, Julien Viaud, Sonia Severin, Marie-Pierre Gratacap, Gaetan Chicanne, Karim Hnia, Bernard Payrastre, Anne-Dominique Terrisse
Summary: Phosphoinositides (PIs) are important for regulating intracellular signaling and membrane trafficking. This study reveals a previously unknown pool of phosphatidylinositol 3-monophosphate (PI3P) in the outer leaflet of resting platelet plasma membrane. The presence of external PI3P is influenced by certain kinases and can bind to PI3P-binding proteins, suggesting a potential role in platelet communication and protein elimination.
Article
Biochemistry & Molecular Biology
Ahmad A. Obaid, Hussain Almasmoum, Riyad A. Almaimani, Mohamed El-Boshy, Akhmed Aslam, Shakir Idris, Mazen M. Ghaith, Mahmoud Z. El-Readi, Jawwad Ahmad, Wesam F. Farrash, Abdulrahman Mujalli, Safaa Y. Eid, Mohamed E. Elzubier, Bassem Refaat
Summary: This study showed that co-supplementing vitamin D and calcium can effectively alleviate Cd-induced nephropathy, possibly by better regulation of Ca-dependent anti-oxidative and anti-inflammatory actions.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abdulrahman Mujalli, Wesam F. Farrash, Kawthar S. Alghamdi, Ahmad A. Obaid
Summary: Autoimmune diseases lack definitive diagnostic tests, and this systematic review identified amino acid metabolism as a potential diagnostic biomarker. The review also revealed that autoimmune disorders might cause multiple metabolic changes, indicating a complex interaction. Further studies are needed to validate the metabolomics findings associated with autoimmune diseases.
Article
Biochemical Research Methods
Ramu Elango, Babajan Banaganapalli, Abdulrahman Mujalli, Nuha AlRayes, Sarah Almaghrabi, Majid Almansouri, Ahmed Sahly, Gada Ali Jadkarim, Md Zubbair Malik, Hussam Ibrahim Kutbi, Noor Ahmad Shaik, Eman Alefishat
Summary: This study compared gene expression between blood and substantia nigra tissue to identify key genes associated with Parkinson's disease. The analysis revealed significant differences in gene expression and identified pathways related to the disease. Network analysis and gene regulatory networks further revealed additional genes connected to PD molecular mechanisms, as well as potential drug molecules.
BIOINFORMATICS AND BIOLOGY INSIGHTS
(2023)
Review
Pharmacology & Pharmacy
Meshari A. Alaifan, Ohood Abusharifah, Rana Yagoub Bokhary, Babajan Banaganapalli, Noor Ahmad Shaik, Naglaa M. Kamal, Omar Saadah
Summary: Interleukin-2 receptor alpha (IL2RA) defect is an immune disease characterized by recurrent infections. A patient from Saudi Arabia with IL2RA defect was found to have a novel pathogenic mutation and showed signs of granulomatous hepatitis.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Bayan Abdullah Mallah, Babajan Banaganapalli, Noor Ahmad Shaik, Ramu Elango, Jumana Al-Aama
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Mathematical & Computational Biology
Abdulhadi Ibrahim H. Bima, Ayman Zaky Elsamanoudy, Walaa F. Albaqami, Zeenath Khan, Snijesh Valiya Parambath, Nuha Al-Rayes, Prabhakar Rao Kaipa, Ramu Elango, Babajan Banaganapalli, Noor A. Shaik
Summary: This study aimed to discover key genes, molecular mechanisms, and new drug targets for obesity and type 2 diabetes mellitus (T2D) by analyzing genome-wide gene expression data. The researchers found 1932 unique differentially expressed genes (DEGs) between the diabetes group and the obese group, and identified 190 high centrality network (HCN) genes through protein interaction network analysis. By applying additional topological parameters, they mapped 25 high confidence genes connected to diabetes and obesity traits. Some of these genes, such as ERBB2, FN1, FYN, HSPA1A, HBA1, and ITGB1, were found to be tractable by small chemicals, antibodies, and/or enzyme molecules.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
