Article
Materials Science, Multidisciplinary
Xiaotian Hao, Sheng Miao, Zhiquan Li, Taoran Wang, Baobao Xue, Jingdi Chen, Chunxing Xian, Long Bi
Summary: Porous hydrogel scaffolds with medium pore sizes were prepared using 3D printing technology to study the effect of the 3D printed porous structures on the osteogenic differentiation of BMSCs in hydrogel scaffolds. The results showed that the osteogenic differentiation of BMSCs in the structured porous hydrogels was more prominent compared to the non-porous groups, and the mineralization of the hydrogel scaffolds was also enhanced. The 3D printing-based approach provides a facile strategy for the preparation of hydrogels with intermediate pore structures, promoting the viability and osteogenic differentiation of BMSCs in hydrogel scaffolds.
MATERIALS & DESIGN
(2023)
Article
Oncology
Jing-Jin Yang, Wei-Xia Peng, Mei-Biao Zhang
Summary: This study investigated the role of lncRNA KCNQ1OT1 in osteogenic differentiation of bone marrow mesenchymal stem cells. The results showed that KCNQ1OT1 can upregulate the expression of RICTOR by inhibiting miR-205-5p, thus promoting osteogenesis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yuan Zhou, Zhuo Xu, Yuanyi Wang, Qiang Song, Ruofeng Yin
Summary: This study investigates the role of MALAT1 in osteogenic differentiation and cell apoptosis in osteoporosis. MALAT1 upregulates the expression of Bmp4, Col1a1, and Spp1, enhances ALP activity, and inhibits apoptosis. MALAT1 promotes osteogenic differentiation and inhibits cell apoptosis through the miR-485-5p/WNT7B axis, suggesting its potential as a target for alleviating osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Orthopedics
Xiao-Mei Yang, Ya-Qi Song, Liang Li, Dong-Ming Liu, Guang-Dong Chen
Summary: This study found that miR-1249-5p promotes osteogenic differentiation of ADSCs by targeting PDX1 through the PI3K/Akt signaling pathway, which was confirmed through bioinformatic analyses and experimental validations.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Immunology
Misun Kim, Hyein Jo, Yoojung Kwon, Myeong Seon Jeong, Hyun Suk Jung, Youngmi Kim, Dooil Jeoung
Summary: The study demonstrates the pivotal role of the miR-154-5p-MCP1 axis in allergic inflammation, indicating that miR-154-5p can mediate allergic reactions in vitro and in vivo by regulating the expression of MCP1.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yutong Wu, Hongbo Ai, Qiankun Yang, Ce Dou, Jianzhong Xu
Summary: In this study, it was found that osteoclast-derived small extracellular vesicles (OC-sEVs) inhibited Fam134a through miR-106a-5p and significantly promoted bone mesenchymal stem cell (BMSC) osteogenic mineralization in vitro. Additionally, demineralized bone matrix (DBM) scaffolds modified with miR-106a-5p-sEVs showed enhanced capacity for bone regeneration in a calvarial defect mouse model. This important finding emphasizes the critical role of sEV-mediated miR-106a-5p transfer in osteogenesis and reveals a novel communication mode between osteoclasts and BMSCs.
CELLULAR SIGNALLING
(2023)
Article
Medicine, General & Internal
Xiang Gao, Guanhao Hong, Weiqiang Zhan, Tianfeng Liu, Shouquan Yan, Mingzhu Deng, Chenlin Tu, Peng Li
Summary: This study found that DPA can promote the osteogenic differentiation of hBMSCs through the miR-9-5p/ERK/ALP signaling pathway. This provides a potential therapeutic strategy for patients with bone loss.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kangrui Zeng, Weiping Li, Qiongyi Kang, Yutong Li, Qing Cheng, Wenwei Xia
Summary: This study revealed that miR-342-5p inhibits the odonto/osteogenic differentiation of hDPSCs by interfering with Wnt/beta-catenin signaling via targeting Wnt7b.
Article
Biochemistry & Molecular Biology
Carmen Ciavarella, Ilenia Motta, Francesco Vasuri, Silvia Fittipaldi, Sabrina Valente, Daniela Pollutri, Francesca Ricci, Mauro Gargiulo, Gianandrea Pasquinelli
Summary: The study reveals that End-MT serves as a crucial link between inflammation and vascular calcification. Moreover, miR-30a-5p and miR-30d can regulate both the End-MT and osteogenic processes, with an impact on key genes like SLUG, VIMENTIN, and RUNX-2.
Article
Multidisciplinary Sciences
Junhao Yin, Zhanglong Zheng, Xiaoli Zeng, Yijie Zhao, Zexin Ai, Miao Yu, Yang'ou Wu, Jirui Jiang, Jia Li, Shengjiao Li
Summary: The study revealed that lncRNA Malat1 plays a critical role in maintaining the osteogenic potential of aging BMSCs by sponging miR-129-5p. This suggests that Malat1 and miR-129-5p play important roles in regulating the osteogenic ability of BMSCs.
Article
Cell & Tissue Engineering
Changming Zhao, Yulin Gu, Yan Wang, Qiaozhen Qin, Ting Wang, Meng Huang, Heyang Zhang, Yannv Qu, Jingwen Zhang, Zhangzhen Du, Xiao-Xia Jiang, Lulu Xu
Summary: This study aimed to explore the role of miR-129-5p in regulating bone marrow mesenchymal stem cell (BMSC) differentiation and bone regeneration. The results showed that miR-129-5p promotes osteogenic differentiation of BMSCs and bone regeneration, and the miR-129-5p/Dkk3 axis may be new potential targets for the treatment of bone defect and bone loss.
STEM CELLS INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Ning Han, Fei Qian, Xianping Niu, Guoting Chen
Summary: This study reveals the regulatory roles of circ_0058792 and miR-181a-5p in steroid-induced osteonecrosis of the femoral head (ONFH), demonstrating that circ_0058792 acts as a sponge for miR-181a-5p and influences osteogenic differentiation via the TGF-beta/Smad7 pathway.
Article
Biotechnology & Applied Microbiology
Chuxi Zhang, Zhongwei Zhou, Nian Liu, Jiangping Chen, Jinyang Wu, Yong Zhang, Kaili Lin, Shilei Zhang
Summary: This study investigates the potential application of 3D-printed nano-topographic surface modified porous tantalum in the repair of oral and cranio-maxillofacial bone defects. The results show that the modified porous tantalum can promote the proliferation and osteogenic differentiation of BMSCs and accelerate the formation of new bone in the mandible bone defect of rabbits.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Ladislav Cvrcek, Jan Krcil, Jana Musilkova, Veronika Musilkova, Lucie Bacakova, Vaclav Nehasil, Frantisek Denk, Zdenek Cejka
Summary: In this study, a PEEK material with a gradient surface topography and suitable chemical composition was prepared by 3D printing and coating with a nanostructured TiNb layer. The surface properties and biological activity were analyzed, and the results showed that the nanostructured TiNb layer significantly improved the biological activity of PEEK.
MATERIALS & DESIGN
(2022)
Article
Environmental Sciences
Dingyi Wang, Tingting Zhi, Lihong Liu, Li Yan, Wei Yan, Yinyin Tang, Bin He, Ligang Hu, Chuanyong Jing, Guibin Jiang
Summary: This article introduces the use of 3D printing technology to load nanoparticles onto macrostructures, which are then used for the removal of arsenic in water. The results of the study demonstrate that 3D printing provides a promising method for designing and fabricating customized macrostructures with specific properties of nanomaterials.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)