Article
Cell Biology
Lina Wang, Bin Xiao, Ting Yu, Li Gong, Yu Wang, Xiaokai Zhang, Quanming Zou, Qianfei Zuo
Summary: This study revealed that high expression of PVT1 is associated with poor prognosis in GC patients and can promote EMT process and metastasis of GC cells. PVT1 binds with miR-30a to increase Snail expression, affecting the migration of GC cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Surgery
Xiaojie Wang, Ying Zhang, Wei Li, Xiaolei Liu
Summary: The study demonstrates that circPVT1 can modulate chemoresistance and malignancy of gastric cancer by regulating HDGF expression via sponging miR-152-3p.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
K. O. J. TAKAO, H. I. R. O. T. A. K. A. KONISHI, D. A. I. K. I. MATSUBARA, K. A. T. S. U. T. O. S. H. SHODA, T. O. M. O. H. I. R. O. ARITA, H. I. R. O. K. I. SHIMIZU, S. H. U. H. E. KOMATSU, A. T. S. U. S. H. I. SHIOZAKI, Y. U. S. U. K. E. YAMAMOTO, T. A. K. E. S. H. KUBOTA, H. I. T. O. S. H. I. FUJIWARA, K. A. Z. U. M. A. OKAMOTO, E. I. G. O. OTSUJI
Summary: miR-3663-3p is significantly downregulated in gastric cancer and is associated with lower recurrence-free survival in patients. Overexpression of miR-3663-3p suppresses cell proliferation, migration/invasion, and induces cell cycle arrest through downregulating Cyclin D1 and reducing Rb phosphorylation.
ANTICANCER RESEARCH
(2021)
Article
Cell Biology
Jiying Wang, Zhiyi Dong, Zhaoying Sheng, Yong Cai
Summary: Lung cancer chemoresistance during chemotherapy is a challenge, with hypoxia being one of the contributing factors. This study aimed to analyze the regulatory relationship between hypoxia and PVT1 and the mechanism of PVT1 in hypoxia-induced chemoresistance in lung cancer. The results showed that the expression of PVT1 is regulated by HIF-1 alpha and participates in hypoxia-induced chemoresistance.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Qing Li, Fanfei Kong, Rong Cong, Jian Ma, Cuicui Wang, Xiaoxin Ma
Summary: PVT1 is highly expressed in endometrial cancer and cancer stem cells (CSCs) and correlates with poor prognosis. It promotes the malignant behavior and stemness of endometrial cancer cells (ECCs) and CSCs. In contrast, miR-136, which is lowly expressed, has the opposite effect. PVT1 competitively sponges miR-136 to activate Sox2, which promotes the malignant behavior and stemness of ECCs and CSCs. Simultaneously downregulating PVT1 and upregulating miR-136 has the strongest anti-tumor effect in endometrial cancer.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Medicinal
Guan-Nan He, Na-Ren Bao, Shuang Wang, Man Xi, Tian-Hao Zhang, Feng-Shou Chen
Summary: Ketamine was found to suppress liver cancer cell proliferation and induce ferroptosis, potentially through regulating the lncPVT1/miR-214-3p/GPX4 axis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Chunxian Huang, Jinxiao Liang, Shaodan Lin, Dongyan Wang, Qingsheng Xie, Zhongqiu Lin, Tingting Yao
Summary: The study found that lower miR-193b expressions in cervical cancer are associated with more advanced stages of the disease and deeper stromal invasion. miR-193b functions as a tumor suppressor in cervical tumors, regulated by m(6)A methylation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Caiping Chen, Jianju Lu, Wang Li, Xiang Lu
Summary: The study found that circATP2C1 is upregulated in breast cancer cells and tissues and is significantly associated with poor overall survival in patients. CircATP2C1 promotes the oncogenesis and metastasis of breast cancer by sponging miR-432/miR-335 to abolish the inhibition of the target gene CCND1. This study has implications for the diagnosis and treatment of breast cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wei Yuan, Shuang Li, Ya-Nan Yang, Hui Gao, Chang Liu
Summary: EGCG can effectively reduce the levels of sepsis-induced inflammatory cytokines by targeting the PVT1/miR-16-5p/TLR4 axis.
Article
Oncology
Rong Cong, Fanfei Kong, Jian Ma, Qing Li, Hui Yang, Xiaoxin Ma
Summary: By constructing a PVT1-centered ceRNA network, this study revealed that the PVT1/miR-612/CENP-H/CDK1 axis plays a crucial role in promoting the malignant progression of advanced endometrial cancer, providing a potential therapeutic target.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Pathology
Elahe Abdollahi, Hossein Mozdarani
Summary: Assessing the radiosensitivity of cells can help select appropriate treatment regimens and minimize adverse effects in breast cancer patients. The study found that circ-HIPK3 and circ-PVT1 may serve as promising biomarkers for predicting breast cancer and cellular radiosensitivity.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2023)
Article
Oncology
Jing Feng, Fang-yuan Gao, Yan-ying Li, Xi-yun Xiao, Jie Xi
Summary: Mounting evidence suggests that LINC01503 plays a crucial role in the progression of cervical cancer by modulating the miR-615-3p/CCND1 axis, leading to enhanced invasion and proliferation of tumor cells.
Article
Medicine, Research & Experimental
Tebo Hua, Yong Luo
Summary: The study demonstrated that circPVT1 was significantly upregulated in thyroid cancer and was associated with clinical stage and lymph node metastasis. Silencing circPVT1 inhibited proliferation, migration, and invasion of thyroid cancer cells. Additionally, circPVT1 directly interacted with miR-384, and inhibition of miR-384 partially reversed the inhibitory effects of circPVT1 knockdown.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, Research & Experimental
Linfeng Zhang, Diandian Sun, Junjie Zhang, Yanyan Tian
Summary: Our study revealed that circ-UBR1 is upregulated in breast cancer (BC), and its silencing can inhibit BC cell proliferation, metastasis, and promote apoptosis in vitro, as well as restrain BC tumor growth in vivo. Furthermore, circ-UBR1 can sponge miR-1299, and miR-1299 inhibitor can reverse the effect of circ-UBR1 knockdown on BC cell progression, affecting CCND1 expression.
Article
Oncology
Min Li, Chi Chi, Liqin Zhou, Youguo Chen, Xiuwu Tang
Summary: PVT1 is a dysregulated gene in various cancers and is associated with shorter survival time in ovarian cancer patients, especially those in advanced stages. Circular PVT1 plays an important role in ovarian cancer progression by regulating multiple biological processes and affecting cell proliferation and migration.