Bulk pancreatic cancer cells can convert into cancer stem cells(CSCs) in vitro and 2 compounds can target these CSCs

Microenvironment, tumor cell plasticity, and cancer

(2015) Eva Faurobert et al.   CURRENT OPINION IN ONCOLOGY

Response of Breast Cancer Cells and Cancer Stem Cells to Metformin and Hyperthermia Alone or Combined

(2014) Hyemi Lee et al.   PLoS One

Survival improvement in patients with pancreatic cancer by decade: A period analysis of the SEER database, 1981–2010

(2014) Huanhuan Sun et al.   Scientific Reports

Cancer stem cells: A shifting subpopulation of cells with stemness?

(2013) Yijun Hu et al.   MEDICAL HYPOTHESES

Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action

(2013) Shanmiao Gou et al.   PLoS One

Effects of Metformin on CD133+ Colorectal Cancer Cells in Diabetic Patients

(2013) Yanfei Zhang et al.   PLoS One

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Metformin targets ovarian cancer stem cells in vitro and in vivo

(2012) Jessica J. Shank et al.   GYNECOLOGIC ONCOLOGY

Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030

(2011) L Lin et al.   BRITISH JOURNAL OF CANCER

Cancer stem cells: Models, mechanisms and implications for improved treatment

(2011) Jiangbing Zhou et al.   CELL CYCLE

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colorectal Cancer Stem Cells and Cell Death

(2011) Veronica Catalano et al.   Cancers

Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells

(2010) Margherita Gaviraghi et al.   BIOSCIENCE REPORTS

Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: Towards targeting of cancer stem cells with phytochemicals

(2010) Dunne Fong et al.   CANCER LETTERS

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

(2009) Madhuri Kakarala et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma

(2009) Jennifer L. Dembinski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Are Cancer Stem Cells Real? After Four Decades, Debate Still Simmers

(2009) K. Rowan   JNCI-Journal of the National Cancer Institute

Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma

(2008) Peng Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY