Article
Genetics & Heredity
Wanjin Chen, Haibo Wang, Yuanlong Shen, Shouwen Wang, Deng Liu, Hongchuan Zhao, Guobin Wang, Fan Huang, Wei Wang, Ruolin Wu, Liujin Hou, Zhenghui Ye, Xinghua Zhang, Xiaoping Geng, Xiaojun Yu
Summary: The aim of this study was to investigate the effect of let-7c-5p on hepatocellular carcinoma (HCC) and its molecular pathway. The expression level of let-7c-5p was reduced in HCC and was associated with shorter survival time of HCC patients. Let-7c-5p inhibited HCC cell proliferation, invasion, and migration, and promoted apoptosis. CDCA8 was identified as a downstream mRNA of let-7c-5p that was negatively regulated by it. CDCA8 was found to be related to immune cells and immune pathways. Let-7c-5p suppresses HCC by down-regulating CDCA8, contributing to the understanding of HCC pathogenesis and drug development.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Xiang Liu, Wei Zeng, Dayang Zheng, Min Tang, Wangyan Zhou
Summary: This study found that ESPL1 is upregulated in LUAD and promotes invasion, proliferation, and migration of LUAD cells. Furthermore, ESPL1 is a target gene of let-7c-5p. Let-7c-5p is downregulated in LUAD cells and plays a suppressive role, which is reversed by ESPL1. Therefore, let-7c-5p/ESPL1 may be potential therapeutic targets for LUAD.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yun Liu, Chao-Yue Su, Yan-Yan Yan, Jian Wang, Jia-Jun Li, Ji-Jun Fu, Yu-Qing Wang, Jian-Ye Zhang
Summary: This research uncovers that exosomal let-7c-5p and miR-181b-5p derived from A549 cells can induce migration, invasion, and EMT in BEAS-2B cells, potentially through the regulation of focal adhesion and MAPK signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Toxicology
Keke Luo, Yu Qin, Ting Ouyang, Xilan Wang, Aihua Zhang, Peng Luo, Xueli Pan
Summary: Endemic fluorosis is caused by high environmental fluoride intake and affects the teeth and bones. miRNAs play a crucial role in regulating bone metabolism and osteoblast proliferation and activation, with Let-7c-5p playing a key role in regulating CyclinD1 in fluoride-induced osteoblast proliferation and activation.
TOXICOLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Xiaodong Lv, Zhixian Fang, Weibo Qi, Yufen Xu, Wenyu Chen
Summary: This study investigates the relationship between the HOXA11-AS/let-7c-5p/IGF2BP1 regulatory axis and lung adenocarcinoma. HOXA11-AS promotes LUAD cell proliferation by targeting let-7c-5p/IGF2BP1, which could be potential molecular targets for LUAD.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Thomas J. Kalantzakos, Luke E. Sebel, James Trussler, Travis B. Sullivan, Eric J. Burks, Carmen D. Sarita-Reyes, David Canes, Alireza Moinzadeh, Kimberly M. Rieger-Christ
Summary: This study found that miRNA dysregulation is involved in the progression of ccRCC, particularly through invasion. The downregulation of let-7c-5p contributes to the aggressiveness of small ccRCC tumors by regulating IGF1R.
Article
Medicine, Research & Experimental
Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He
Summary: The study investigates the pathogenesis and potential molecular markers of glioma by examining the differential expression of miRNA and mRNA. Several miRNAs and mRNAs were identified as having significant impact on glioma cell behavior, with miR-139-5p/GABRA1 axis suggested as a novel therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Yat-Yin Law, Wei-Fang Lee, Chin-Jung Hsu, Yen-You Lin, Chun-Hao Tsai, Chien-Chung Huang, Min-Huan Wu, Chih-Hsin Tang, Ju-Fang Liu
Summary: The research on OA and RA revealed that miR-let-7c-5p and miR-149-5p have inhibitory effects on the transcription of proinflammatory cytokines, suggesting that increasing the expression of these two miRNAs is a novel therapeutic strategy for OA and RA.
Article
Biochemistry & Molecular Biology
Yulong Chong, Chunran Zhu, Wei Hu, Chengrong Jiang, Weibang Liang, Zongjing Zhu
Summary: This study suggests that miR-212-5p plays a suppressive role in glioma development by regulating the expression of SUMO2, thereby affecting the proliferation, migration, and apoptosis of glioma cells. This finding may contribute to the identification of novel therapeutic targets for glioma.
BIOCHEMICAL GENETICS
(2023)
Article
Oncology
Juan Wang, Yixiao Yuan, Lin Tang, Haoqing Zhai, Dahang Zhang, Lincan Duan, Xiulin Jiang, Chen Li
Summary: The study reveals that STRIP2 has a significant role in LUAD development and progression, and its overexpression is associated with poor prognosis and tumor infiltration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wen Li, Juan Liu, Li Ji, Yi Tang, Jianbing Qin, Heyan Zhao, Xiang Cheng, Meiling Tian, Guohua Jin, Hui He
Summary: The study revealed that miR-674-5p may play a crucial role in regulating glioma cell growth by targeting Cul4b, thereby inhibiting cell proliferation and migration.
NEUROCHEMICAL RESEARCH
(2022)
Article
Environmental Sciences
Li-hua Dong, Jing-jing Huang, Peng Zu, Jing Liu, Xue Gao, Jian-wei Du, Yu-fu Li
Summary: The study revealed that circKDM4C is downregulated in AML patients, and overexpression of circKDM4C in AML cell lines can inhibit proliferation, migration, invasion, and promote ferroptosis. CircKDM4C acts as a sponge of hsa-let-7b-5p to regulate P53 expression in AML. CircKDM4C is negatively correlated with hsa-let-7b-5p, but positively correlated with P53 in AML patients.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Neurosciences
Yongchang Guan, Wenjin Yang, Feng Zhang, Liming Zhang, Liang Wang
Summary: Background: The involvement of certain circular RNAs (circRNAs) in the development of glioma has been revealed. This study validated the positive association of circRNA periostin (circPOSTN) with glioma cell growth and metastasis. The mechanism of circPOSTN in glioma tumorigenesis, specifically its interaction with miR-185-5p/KIF1B axis, was elucidated.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Liang Huang, Kai Lou, Kunyu Wang, Lingxin Liang, Yi Chen, Jichen Zhang
Summary: This study aimed to explore the impact of the let-7c-5p/CDC25A axis on cisplatin resistance in LUAD. The results showed that the downregulation of let-7c-5p and upregulation of CDC25A were associated with the development and cisplatin resistance of LUAD. Upregulation of let-7c-5p could inhibit LUAD cell proliferation, promote cell apoptosis, and arrest the cell cycle, enhancing the sensitivity of LUAD cells to cisplatin.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Song Wu, Tao Tang, Hongchi Zhou, Jing Huang, Xiaoliang Kang, Junli Zhang
Summary: This study reveals that LINC01343 acts as a crucial oncogene in hepatocellular carcinoma (HCC). LINC01343 negatively regulates the expression of miR-526b-5p, which in turn modulates ROBO1 expression, affecting HCC cell proliferation and migration.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Zihang Chen, Huizhi Wang, Zongpu Zhang, Jianye Xu, Yanhua Qi, Hao Xue, Zijie Gao, Rongrong Zhao, Shaobo Wang, Shouji Zhang, Wei Qiu, Xing Guo, Gang Li
Summary: Surface expression of glucose-regulated protein 78 (csGRP78) was found to be preferentially expressed in MES GSCs, and targeting csGRP78 effectively suppressed self-renewal and radioresistance of MES GSCs both in vitro and in vivo by downregulating STAT3, NF-kappa B, and C/EBP beta pathways, potentially through regulation of downstream molecule BACE2. These findings suggest that blocking csGRP78 with a high-specificity antibody could be a promising therapeutic strategy for glioblastoma treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Mingyu Qian, Zihang Chen, Xiaofan Guo, Shaobo Wang, Zongpu Zhang, Wei Qiu, Yanhua Qi, Shouji Zhang, Jianye Xu, Rongrong Zhao, Hao Xue, Gang Li
Summary: This study reveals that hypoxic glioma exosomes promote normoxic glioma migration and invasion by delivering miR-1246 and miR-10b-5p. These microRNAs significantly induce glioma cell motility both in vitro and in vivo by directly targeting different genes. Targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, suggesting a potential for novel anti-tumor therapy development.
LABORATORY INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Ziwen Pan, Rongrong Zhao, Boyan Li, Yanhua Qi, Wei Qiu, Qindong Guo, Shouji Zhang, Shulin Zhao, Hao Xu, Ming Li, Zijie Gao, Yang Fan, Jianye Xu, Huizhi Wang, Shaobo Wang, Jiawei Qiu, Qingtong Wang, Xing Guo, Lin Deng, Ping Zhang, Hao Xue, Gang Li
Summary: This study reveals the significant role of circNEIL3 in promoting gliomagenesis and malignant progression, as well as in driving macrophage infiltration into the tumour microenvironment. CircNEIL3 may serve as a potential prognostic biomarker and therapeutic target for gliomas.
Article
Immunology
Jianye Xu, Zijie Gao, Kaining Liu, Yang Fan, Zongpu Zhang, Hao Xue, Xing Guo, Ping Zhang, Lin Deng, Shaobo Wang, Huizhi Wang, Qingtong Wang, Rongrong Zhao, Gang Li
Summary: This study identified three distinct non-m(6)A RNA modification patterns associated with diverse biological pathways and clinical characteristics. Patients with a high RM score exhibited poor prognosis, enhanced immune infiltration, and MES subtype. Furthermore, the high RM score group had lower tumor mutation burden and weaker response to immunotherapy, but may benefit more from drugs targeting the EGFR and WNT signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yanhua Qi, Chuandi Jin, Wei Qiu, Rongrong Zhao, Shaobo Wang, Boyan Li, Zongpu Zhang, Qindong Guo, Shouji Zhang, Zijie Gao, Shulin Zhao, Ziwen Pan, Yang Fan, Zihang Chen, Huizhi Wang, Jianye Xu, Lin Deng, Shilei Ni, Jian Wang, Hao Xue, Fuzhong Xue, Gang Li
Summary: Clear evidence shows that tumors can use exosomes to secrete microRNAs for modulating the tumor microenvironment. In this study, miRNAs were found to be divided into exosome-enriched miRNAs and intracellular-retained miRNAs, with exosome-enriched miRNAs playing a dual role. Specifically, miR-1298-5p was enriched in CSF exosomes and demonstrated to suppress glioma progression while promoting the immunosuppressive effects of myeloid-derived suppressor cells (MDSCs). Mechanically, miR-1298-5p targeted SETD7 and MSH2 in glioma cells and MDSCs, respectively. These findings provide insights into the selective sorting of miRNAs into exosomes and their role in modulating tumor immunity in glioma.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Shouji Zhang, Shulin Zhao, Yanhua Qi, Boyan Li, Huizhi Wang, Ziwen Pan, Hao Xue, Chuandi Jin, Wei Qiu, Zihang Chen, Qindong Guo, Yang Fan, Jianye Xu, Zijie Gao, Shaobo Wang, Xing Guo, Lin Deng, Shilei Ni, Fuzhong Xue, Jian Wang, Rongrong Zhao, Gang Li
Summary: This study explores the function of FTO, an m(6)A demethylase, in glioblastoma (GBM). The findings suggest that FTO downregulation is associated with higher glioma grades and poorer clinical outcomes. FTO inhibits GBM cell growth and invasion by regulating the m(6)A modification of pri-miR-10a. Additionally, the transcriptional activity of FTO is inhibited by SPI1, and treatment with the SPI1 inhibitor can restore FTO expression and decrease GBM tumor burden.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Immunology
Zijie Gao, Jianye Xu, Zongpu Zhang, Yang Fan, Hao Xue, Xing Guo, Lin Deng, Shaobo Wang, Rongrong Zhao, Ping Zhang, Gang Li
Summary: This study reveals the correlation of METTL1 with tumor immune infiltration and stemness in pan-cancer, highlighting the significance of METTL1 in cancer progression and guiding more effective and generalized therapy strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zijie Gao, Jianye Xu, Yang Fan, Yanhua Qi, Shaobo Wang, Shulin Zhao, Xing Guo, Hao Xue, Lin Deng, Rongrong Zhao, Chong Sun, Ping Zhang, Gang Li
Summary: This study identified a lncRNA, PDIA3P1, that is upregulated in TMZ-resistant GBM cell lines. Overexpression of PDIA3P1 promotes TMZ resistance, while knockdown of PDIA3P1 restores TMZ sensitivity. PDIA3P1 promotes PMT in GBM cells by stabilizing C/EBP beta, reducing their sensitivity to TMZ treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Yang Fan, Zijie Gao, Jianye Xu, Huizhi Wang, Qindong Guo, Hao Xue, Rongrong Zhao, Xing Guo, Gang Li
Summary: This study reveals the role of small nucleolar RNA host genes (SNHGs) in glioblastoma (GBM) subtypes, tumor microenvironment (TME) infiltration, and stemness characteristics. By generating the SNHGscore model, it was found that the high SNHGscore group had a poor prognosis, the mesenchymal (MES) subtype, infiltration of suppressive immune cells, and a differentiated phenotype. Furthermore, high SNHGscore was associated with a weaker response to anti-PD-1/L1 immunotherapy and tumor cells with high SNHG scores were more sensitive to drugs targeting the EGFR and ERK-MAPK signaling pathways. Additionally, the universality of SNHG interaction patterns was verified in multiple cancers, highlighting the potential clinical utility for cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zijie Gao, Jianye Xu, Yang Fan, Zongpu Zhang, Huizhi Wang, Mingyu Qian, Ping Zhang, Lin Deng, Jie Shen, Hao Xue, Rongrong Zhao, Teng Zhou, Xing Guo, Gang Li
Summary: ARPC1B is upregulated in MES-GBM/GSCs and correlated with poor prognosis. Knockdown of ARPC1B reduces radiotherapy resistance in GSCs. ARPC1B interacts with IFI16 and HuR to maintain protein stability and activates NF-kappa B and STAT3 pathways, promoting MES phenotype maintenance and radiotherapy resistance. Furthermore, AZD6738, identified based on ARPC1B expression, exhibits excellent anti-GSC activity in combination with radiotherapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shulin Zhao, Boyan Li, Rongrong Zhao, Ziwen Pan, Shouji Zhang, Wei Qiu, Qindong Guo, Yanhua Qi, Zijie Gao, Yang Fan, Hao Xu, Ming Li, Jian Zhang, Huizhi Wang, Jianye Xu, Shaobo Wang, Qingtong Wang, Jiawei Qiu, Lin Deng, Xing Guo, Ping Zhang, Hao Xue, Gang Li
Summary: In this study, a previously unreported circRNA named circADAMTS6 was found to be specifically upregulated in the hypoxic microenvironment of glioblastoma and was closely related to poor prognosis. CircADAMTS6 was shown to promote malignant progression of glioblastoma by enhancing cell proliferation, inhibiting apoptosis, and regulating the NF-kappa B pathway. Targeting circADAMTS6 could be a novel therapeutic strategy for glioblastoma.
Article
Cell Biology
Qindong Guo, Yang Fan, Qingtong Wang, Boyan Li, Wei Qiu, Yanhua Qi, Ziwen Pan, Shouji Zhang, Shulin Zhao, Kehui Yang, Hao Xu, Ming Li, Zijie Gao, Jianye Xu, Huizhi Wang, Shaobo Wang, Qilin Tang, Jiawei Qiu, Xing Guo, Lin Deng, Ping Zhang, Rongrong Zhao, Hao Xue, Chengwei Wang, Gang Li
Summary: This study found that glioma cells can eliminate suppressor miR-204-3p to accelerate angiogenesis under hypoxia by upregulating SUMOylation. hnRNP A2/B1 can accelerate exosome sorting of miR-204-3p by binding a specific sequence. The SUMOylation inhibitor TAK-981 could be a potential drug for glioma by inhibiting the exosome sorting process of miR-204-3p to inhibit tumor growth and angiogenesis.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Guihong Shi, Liang Liu, Yiyao Cao, Guangshuo Ma, Yanlin Zhu, Jianye Xu, Xu Zhang, Tuo Li, Liang Mi, Haoran Jia, Yanfeng Zhang, Xilei Liu, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Baolong Wang, Quanjun Deng, Shu Zhang, Jianning Zhang
Summary: This study found that inhibition of NETs can alleviate neuroinflammation, neuronal apoptosis, and neurological deficits after traumatic brain injury (TBI). This effect is mediated through the STING-dependent IRE1 alpha/ASK1/JNK signaling pathway. The findings suggest that targeting NETs may be a promising therapeutic approach for the early management of TBI.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Yang Fan, Zijie Gao, Jianye Xu, Huizhi Wang, Qindong Guo, Boyan Li, Ming Li, Hao Xu, Yanhua Qi, Shulin Zhao, Wei Qiu, Ziwen Pan, Qingtong Wang, Hao Xue, Rongrong Zhao, Xing Guo, Gang Li
Summary: This study found that targeting SPI1 to block transcription of the MIR222HG cluster helps reduce radioresistance and combat the immunosuppressive microenvironment in GBM. PLX-4720 is a potential GBM drug and radiosensitizer.
