Heterodimeric IL-15 (hetIL-15) reduces circulating tumor cells and metastasis formation improving chemotherapy and surgery in 4T1 mouse model of TNBC

The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells

(2022) Samantha M. Borys et al.   Frontiers in Immunology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

(2021) Siqi Guo et al.   Frontiers in Immunology

Heterodimeric IL-15 in Cancer Immunotherapy

(2021) Cristina Bergamaschi et al.   Cancers

Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

(2021) Kevin Conlon et al.   Journal for ImmunoTherapy of Cancer

Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy

(2020) Xiaoming Zhong et al.   Molecular Cancer

Pembrolizumab for Early Triple-Negative Breast Cancer

(2020) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist

(2020) Karin M Knudson et al.   Journal for ImmunoTherapy of Cancer

Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10

(2020) Cristina Bergamaschi et al.   Journal for ImmunoTherapy of Cancer

IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment

(2020) Mélanie Desbois et al.   Journal for ImmunoTherapy of Cancer

Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells

(2020) Ying Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy

(2019) Karin M. Knudson et al.   Journal for ImmunoTherapy of Cancer

Circulating tumor cells detection in tumor draining vein of breast cancer patients

(2019) Masaya Hattori et al.   Scientific Reports

The potential and promise of IL-15 in immuno-oncogenic therapies

(2017) Tanya O. Robinson et al.   IMMUNOLOGY LETTERS

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

(2017) Maria Ouzounova et al.   Nature Communications

Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion

(2016) Sinnie Sin Man Ng et al.   CLINICAL CANCER RESEARCH

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Improved Efficacy of Neoadjuvant Compared to Adjuvant Immunotherapy to Eradicate Metastatic Disease

(2016) J. Liu et al.   Cancer Discovery

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

(2016) A. Spiegel et al.   Cancer Discovery

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas

(2016) Peter S. Kim et al.   Oncotarget

An overview of triple-negative breast cancer

(2015) Pankaj Kumar et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

KLRG1+ NK Cells Protect T-bet-Deficient Mice from Pulmonary Metastatic Colorectal Carcinoma

(2014) M. Malaise et al.   JOURNAL OF IMMUNOLOGY

The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages

(2014) Amy Gillgrass et al.   JOURNAL OF IMMUNOLOGY

Chemoimmunotherapy: reengineering tumor immunity

(2013) Gang Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer

(2013) D. Alizadeh et al.   CANCER RESEARCH

Characterization and Favorablein VivoProperties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer

(2013) Elena Chertova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets

(2013) J. M. Balko et al.   Cancer Discovery

Neoadjuvant treatments for triple-negative breast cancer (TNBC)

(2012) G. von Minckwitz et al.   ANNALS OF ONCOLOGY

Circulating IL-15 exists as heterodimeric complex with soluble IL-15R  in human and mouse serum

(2012) C. Bergamaschi et al.   BLOOD

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Activity of Recombinant Human Interleukin-15 against Tumor Recurrence and Metastasis in Mice

(2010) Feng Tang et al.   Cellular & Molecular Immunology

Simultaneous Blockade of Multiple Immune System Inhibitory Checkpoints Enhances Antitumor Activity Mediated by Interleukin-15 in a Murine Metastatic Colon Carcinoma Model

(2010) P. Yu et al.   CLINICAL CANCER RESEARCH

Potential differentiation of tumor bearing mouse CD11b+Gr-1+ immature myeloid cells into both suppressor macrophages and immunostimulatory dendritic cells

(2009) Yoshinori Narita et al.   BIOMEDICAL RESEARCH-TOKYO

Secretion and Biological Activity of Short Signal Peptide IL-15 Is Chaperoned by IL-15 Receptor Alpha In Vivo

(2009) C. Bergamaschi et al.   JOURNAL OF IMMUNOLOGY

High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor   fusion protein, in metastatic melanoma and colorectal cancer

(2009) A. Bessard et al.   MOLECULAR CANCER THERAPEUTICS

Twelve immunotherapy drugs that could cure cancers

(2008) Martin A. ‘Mac’ Cheever   IMMUNOLOGICAL REVIEWS

Basal-Like Breast Cancer: A Critical Review

(2008) Emad A. Rakha et al.   JOURNAL OF CLINICAL ONCOLOGY

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

(2008) Surojit Sarkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE