Article
Immunology
Isis Ricano-Ponce, Toon Peeters, Vasiliki Matzaraki, Bert Houben, Ruth Achten, Peter Cools, Mihai G. Netea, Inge C. Gyssens, Vinod Kumar
Summary: Genetic variation may be associated with the risk of acute appendicitis, and there may be a shared genetic mechanism between CRP and acute appendicitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Laura Macias-Munoz, Beatriz Frade-Sosa, Jose Iniciarte-Mundo, Susana Hidalgo, Rosa Maria Morla, Yadira Gallegos, Raimon Sanmarti, Josep Maria Auge
Summary: Calprotectin, a calcium-binding protein, can be measured in serum, plasma, and feces. The DiaSorin Liaison (R) fecal Calprotectin assay adapted for serum samples showed good technical performances, and its clinical performances were similar to other assays.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Rheumatology
Michael Gernert, Marc Schmalzing, Hans-Peter Tony, Patrick-Pascal Strunz, Eva Christina Schwaneck, Matthias Froehlich
Summary: Calprotectin in the serum can be a useful inflammation parameter in tocilizumab-treated rheumatoid arthritis patients, with good sensitivity and specificity for detecting disease activity.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Psychiatry
Alessandro Cuomo, Despoina Koukouna, Alessandro Spiti, Giovanni Barilla, Arianna Goracci, Simone Bolognesi, Andrea Fagiolini
Summary: This pilot study evaluated the relationship between C-Reactive-Protein (CRP) and bipolar disorder severity in 61 hospitalized patients. It found a statistically significant decrease in CRP values after 7 days of hospitalization, with positive correlations between CRP and CGI scores at baseline and after 7 days.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Rheumatology
A. E. Thompson, J. E. Pope
Summary: This study demonstrates a relationship between the levels and variability of CRP in patients with RA and disease activity level. Patients in clinical remission have lower and more stable CRP levels compared to those with active disease. The study also found that smokers have higher average CRP readings regardless of clinical status.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Biology
Dandan Zong, Beibei Huang, Young Li, Yichen Lu, Nan Xiang, Chuang Guo, Qian Liu, Qing Sha, Pengcheng Du, Qiaoni Yu, Wen Zhang, Pengfei Cai, Yanping Sun, Jinhui Tao, Xiaomei Li, Shanbao Cai, Kun Qu
Summary: This study revealed a CRP-induced pathogenic chromatin dysregulation signature in monocytes from RA patients, suggesting potential therapeutic targets for the disease.
Review
Immunology
Yixin Zheng, Jianan Zhao, Yu Shan, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation in synovial tissues. Granzymes (Gzms) are serine proteases that enter target cells to induce programmed cell death. Increased levels of Gzms have been found in RA patients and they may contribute to inflammation by degrading extracellular matrix and promoting cytokine release. Although their exact role is yet to be fully understood, Gzms have the potential to be used as biomarkers for RA diagnosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Congqi Hu, Zhao Dai, Jia Xu, Lianyu Zhao, Yanping Xu, Meilin Li, Jiahui Yu, Lu Zhang, Hui Deng, Lijuan Liu, Mingying Zhang, Jiarong Huang, Linping Wu, Guangxing Chen
Summary: This study identified the serum marker ORM1 as a significant differential expression between normal and RA patient samples, positively correlated with disease activity, offering a new perspective for future research on RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yaoting Zhang, Dongsheng Gu
Summary: This study found that pretreatment serum CRP level is associated with prognosis in patients with head and neck squamous cell carcinoma. Patients with high CRP level had worse survival outcomes, and CRP level is correlated with N1-3 stage and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Chaitra Ramavath, Shravan Kumar Katam, Venkateshwarlu Vardhelli, Saikiran Deshabhotla, Tejo Pratap Oleti
Summary: This study aimed to compare the rapid bedside quantitative assessment of C-reactive protein (CRP) in saliva to serum CRP to predict blood culture-positive sepsis in neonates. The study found that salivary CRP had a higher AUC on ROC curve analysis for predicting culture-positive sepsis compared to serum CRP. The correlation between salivary and serum CRP was moderate. Salivary CRP appears to be a promising non-invasive tool for predicting culture-positive sepsis.
Article
Genetics & Heredity
Hosam M. Ahmad, Zaki M. Zaki, Asmaa S. Mohamed, Amr E. Ahmed
Summary: This study compared the association between two polymorphisms of the vitamin D receptor gene and parathyroid hormone and inflammation markers in patients with rheumatoid arthritis. The study found that the FokI gene may play a role in controlling parathyroid hormone levels, but there was no significant correlation between serum parathyroid hormone levels and the severity of rheumatoid arthritis. There were no differences in terms of susceptibility to rheumatoid arthritis for the two gene polymorphisms.
BMC MEDICAL GENOMICS
(2023)
Review
Chemistry, Multidisciplinary
Yan Zhu, Tianjiao Zhao, Min Liu, Shuya Wang, Saili Liu, Yunrong Yang, Yuqi Yang, Yayun Nan, Qiong Huang, Kelong Ai
Summary: Rheumatoid arthritis (RA) is a disease with a significant medical burden and a tumor-like microenvironment. Traditional anti-inflammatory therapies are hindered by the buffer barrier of the RA microenvironment, while nanomaterials offer a potential solution by interfering with multiple pathogenic factors and achieving precise treatment. Recent advances in nanomaterials have greatly improved the therapeutic effect and reduced side effects in RA treatment.
Article
Engineering, Electrical & Electronic
Ahmad Mobed, Sanam Dolati, Seyed Kazem Shakouri, Bina Eftekharsadat, Behzad Izadseresht
Summary: OA and RA are two most frequent types of degenerative joint diseases in adults, with common symptoms but differences in pathological manifestations. Biomarker detection can identify disease development at early stages, benefiting patients with prompt diagnosis.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Rheumatology
D. E. Marsman, N. den Broeder, N. Boers, F. H. J. van den Hoogen, A. A. den Broeder, A. van der Maas
Summary: PMR patients with long-term normal APR appear to be a milder subset of PMR in clinical presentation and prognosis. Additionally, our data suggest there is a subgroup with normal APR who are caught early in the disease. Misdiagnosis does not appear to play a role.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Review
Immunology
Zhuqian Wang, Jie Huang, Duoli Xie, Dongyi He, Aiping Lu, Chao Liang
Summary: Despite significant efforts to overcome treatment failure in rheumatoid arthritis, including identifying biomarkers, exploring reasons for loss of efficacy, developing sequential or combinational DMARD strategies, and approving new DMARDs, specific recommendations for individual patients are still lacking, prompting the potential of precision medicine for personalized disease management using cutting-edge technologies and big data.
FRONTIERS IN IMMUNOLOGY
(2021)