Article
Immunology
Feyza Guel Oezbay Kurt, Alisa Lepper, Catharina Gerhards, Mathis Roemer, Samantha Lasser, Ihor Arkhypov, Rebekka Bitsch, Peter Bugert, Peter Altevogt, Cecile Gouttefangeas, Michael Neumaier, Jochen Utikal, Viktor Umansky
Summary: A gradual decay in humoral and cellular immune responses may occur over time after SAR1S-CoV-2 vaccination, leading to a lack of protective immunity. However, a third vaccination can enhance antibody and T cell immune responses, and also show reactivity against the Omicron variant. Continuous boosting may be necessary due to the attenuation of immune response over time.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Daryl Geers, Roos S. G. Sablerolles, Debbie van Baarle, Neeltje A. Kootstra, Wim J. R. Rietdijk, Katharina S. Schmitz, Lennert Gommers, Susanne Bogers, Nella J. Nieuwkoop, Laura L. A. van Dijk, Eva van Haren, Melvin Lafeber, Virgil A. S. H. Dalm, Abraham Goorhuis, Douwe F. Postma, Leo G. Visser, Anke L. W. Huckriede, Alessandro Sette, Alba Grifoni, Rik L. de Swart, Marion P. G. Koopmans, P. Hugo M. van der Kuy, Corine H. GeurtsvanKessel, Rory D. de Vries
Summary: The study found that booster vaccinations after Ad26.COV2.S priming, especially heterologous boosters, could significantly increase functional antibodies targeting both ancestral and emerging variants of SARS-CoV-2. Meanwhile, T-cell responses remained similar and cross-reactive towards the variants regardless of homologous or heterologous booster vaccination. Additionally, minimal expansion of SARS-CoV-2-specific T-cell clones and no increase in the breadth of the T-cell repertoire were observed after booster vaccination. These findings suggest that Ad26.COV2.S priming provides a solid immunological foundation for heterologous boosting, enhancing humoral and cellular immune responses against emerging variants of concern.
Article
Multidisciplinary Sciences
Daryl Geers, Ross S. G. Sablerolles, Debbie van Baarle, Neeltje A. Kootstra, Wim J. R. Rietdijk, Katharina S. Schmitz, Lennert Gommers, Susanne Bogers, Nella J. Nieuwkoop, Laura L. A. van Dijk, Eva van Haren, Melvin Lafeber, Virgil A. S. H. Dalm, Abraham Goorhuis, Douwe F. Postma, Leo G. Visser, Anke L. W. Huckriede, Alessandro Sette, Alba Grifoni, Rik L. de Swart, Marion P. G. Koopmans, P. Hugo M. van der Kuy, Corine H. GeurtsvanKessel, Rory D. de Vries, SWITCH Res Grp
Summary: The study investigated the immune response to homologous and heterologous booster vaccinations in individuals primed with Ad26.COV2.S. The findings showed that booster vaccinations increased functional antibodies targeting ancestral and emerging SARS-CoV-2 variants. Heterologous boosters induced higher levels of functional antibodies, while T-cell responses were similar for both types of boosters and maintained cross-reactivity towards variants. The study concluded that Ad26.COV2.S priming provided a strong immunological foundation for heterologous boosting to enhance immune responses against emerging variants.
Article
Immunology
Krystallenia Paniskaki, Moritz Anft, Toni L. Meister, Corinna Marheinecke, Stephanie Pfaender, Sarah Skrzypczyk, Felix S. Seibert, Constantin J. Thieme, Margarethe J. Konik, Sebastian Dolff, Olympia Anastasiou, Bodo Holzer, Ulf Dittmer, Christine Queren, Lutz Fricke, Hana Rohn, Timm H. Westhoff, Oliver Witzke, Ulrik Stervbo, Toralf Roch, Nina Babel
Summary: In this study, the immune response of 8 patients infected with the alpha variant after receiving double mRNA-based vaccines was analyzed. The results showed that these patients had no detectable CD4+ and CD8+ T cell response against the S protein of the alpha variant, but had a strong CD4+ T cell response against the N and M proteins. Furthermore, a delayed CD4+ T cell response against the alpha S protein was observed during disease progression. These patients also had lower neutralizing antibody titers against the alpha variant compared to the vaccinated control group. Therefore, it may be necessary to include VBI patients in alternative vaccination strategies and include additional antigenic targets in next-generation SARS-CoV-2 vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
R. L. Atmar, K. E. Lyke, M. E. Deming, L. A. Jackson, A. R. Branche, H. M. El Sahly, C. A. Rostad, J. M. Martin, C. Johnston, R. E. Rupp, M. J. Mulligan, R. C. Brady, R. W. Frenck, M. Backer, A. C. Kottkamp, T. M. Babu, K. Rajakumar, S. Edupuganti, D. Dobrzynski, R. N. Coler, C. M. Posavad, J. Archer, S. Crandon, S. U. Nayak, D. Szydlo, J. A. Zemanek, C. P. Dominguez Islas, E. R. Brown, M. S. Suthar, M. J. McElrath, A. B. McDermott, D. C. Montefiori, A. Eaton, K. M. Neuzil, D. S. Stephens, P. C. Roberts, J. H. Beigel
Summary: This study investigated the efficacy of homologous and heterologous booster vaccines in adults who had completed a primary Covid-19 vaccine regimen. The results showed that both types of booster vaccines were safe and immunogenic.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David B. Reeg, Valerie Oberhardt, Natascha Roehlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Robert Thimme, Christoph Neumann-Haefelin, Maike Hofmann
Summary: The study demonstrates that COVID-19 mRNA booster vaccination induces a transient T effector cell response while preserving the CD8 memory T cell pool, allowing for reactivation of spike-specific CD8+ T cells during breakthrough infections or 4th vaccination.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Luca Coppeta, Giuseppina Somma, Cristiana Ferrari, Andrea Mazza, Stefano Rizza, Marco Trabucco Aurilio, Stefano Perrone, Andrea Magrini, Antonio Pietroiusti
Summary: The study evaluated the duration of serological protection among healthcare workers three months after vaccination, with 99% of them still having detectable anti-SARS-CoV-2 antibodies after 90 days of receiving the second vaccine shot. Elderly healthcare workers showed significantly lower levels of protective antibodies compared to younger ones, indicating they may lose immunity earlier than other operators.
Article
Immunology
Xun Wang, Xiaoyu Zhao, Jieyu Song, Jing Wu, Yuqi Zhu, Minghui Li, Yuchen Cui, Yanjia Chen, Lulu Yang, Jun Liu, Huanzhang Zhu, Shibo Jiang, Pengfei Wang
Summary: This study found that the Omicron variant is highly resistant to neutralization by sera from convalescents or individuals vaccinated with two doses of inactivated whole-virion vaccines. However, a homologous or heterologous booster significantly increased neutralization titers. Additionally, the Omicron variant resists most monoclonal antibodies targeting distinct epitopes. These findings highlight the importance of pushing forward booster vaccinations to combat emerging SARS-CoV-2 variants.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu
Summary: In individuals vaccinated with either two prior doses of mRNA or inactivated virus vaccine, a booster dose of mRNA vaccine enhances humoral responses against the Omicron variant, providing potentially more effective protection against SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Baoling Ying, Suzanne M. Scheaffer, Bradley Whitener, Chieh-Yu Liang, Oleksandr Dmytrenko, Samantha Mackin, Kai Wu, Diana Lee, Laura E. Avena, Zhenlu Chong, James Brett Case, LingZhi Ma, Thu T. M. Kim, Caralyn E. Sein, Angela Woods, Daniela Montes Berrueta, Gwo-Yu Chang, Guillaume Stewart-Jones, Isabella Renzi, Yen-Ting Lai, Agata Malinowski, Andrea Carfi, Sayda M. Elbashir, Darin K. Edwards, Larissa B. Thackray, Michael S. Diamond
Summary: The study showed that current vaccination can enhance protection against Omicron infections, but different vaccines have varying efficacy, which requires further investigation.
Article
Immunology
Ida Laake, Siri N. Skodvin, Kristine Blix, Ida Henriette Caspersen, Hakon K. Gjessing, Lene K. Juvet, Per Magnus, Siri Mjaaland, Anna H. Robertson, Jostein Starrfelt, Lill Trogstad, Berit Feiring
Summary: Understanding how booster vaccination can prevent moderate and severe illness without hospitalization is crucial to evaluate the full advantage of mRNA boosters. In this population-based study, mRNA booster vaccination partly prevented moderate and severe COVID-19, but not mild COVID-19. The effectiveness of booster vaccination increased with increasing severity of COVID-19 and decreased with time since booster vaccination. The findings contribute valuable information on the duration of protection and timing of additional booster vaccinations.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Pavinee Assavavongwaikit, Napaporn Chantasrisawad, Orawan Himananto, Chayapa Phasomsap, Pintusorn Klawaja, Sapphire Cartledge, Rachaneekorn Nadsasarn, Thidarat Jupimai, Surinda Kawichai, Suvaporn Anugulruengkitt, Thanyawee Puthanakit
Summary: This study aims to compare the immunogenicity against Omicron before and after booster dose of BNT162b2 in healthy adolescents, and evaluate their attitudes towards booster dose vaccination. The results show that a booster dose of BNT162b2 elicits high immunogenicity against the Omicron variant, and the main motivation for receiving booster doses is to reduce the risk of infection.
Article
Immunology
Ariel Israel, Eugene Merzon, Yotam Shenhar, Ilan Green, Avivit Golan-Cohen, Alejandro A. Schaffer, Eytan Ruppin, Shlomo Vinker, Eli Magen
Summary: A population-based study in Israel found that individuals with chronic kidney disease and anemia had higher rates of COVID-19 infection within 14 days after booster vaccination.
Article
Immunology
Luca Perico, Marta Todeschini, Federica Casiraghi, Marilena Mister, Anna Pezzotta, Tobia Peracchi, Susanna Tomasoni, Piera Trionfini, Ariela Benigni, Giuseppe Remuzzi
Summary: We examined the immune response in individuals previously infected with SARS-CoV2 and those without prior infection after 9 months of primary vaccination and 3 months after receiving a booster dose. Previously infected individuals showed higher levels of residual antibodies and significant neutralizing activity against different variants compared to infection-naive individuals at 9 months after primary vaccination. The higher immune response was associated with higher levels of receptor binding domain (RBD)-specific IgG(+) and IgA(+) memory B cells. The booster dose did not increase neutralizing activity or the frequencies of B and T cells. Conversely, infection-naive individuals required the booster dose to achieve comparable levels of neutralizing antibodies observed in previously infected individuals after primary vaccination. The neutralizing titer correlated with IFN gamma producing T cells specific to the RBD, despite sustained B cell response. Importantly, pre-pandemic samples showed high cross-reactivity to Omicron. These data highlight the significance of the booster dose in reinforcing immunological memory and increasing circulating antibodies in infection-naive individuals.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel Mrak, Daniela Sieghart, Elisabeth Simader, Selma Tobudic, Helga Radner, Peter Mandl, Lisa Goeschl, Maximilian Koblischke, Nikolaus Hommer, Angelika Wagner, Margareta Mayer, Lorenz Schubert, Lukas Hartl, Karin Kozbial, Philipp Hofer, Felix Kartnig, Thomas Hummel, Andreas Kerschbaumer, Thomas Deimel, Antonia Puchner, Venugopal Gudipati, Renate Thalhammer, Petra Munda, Keziban Uyanik-Uenal, Andreas Zuckermann, Gottfried Novacek, Thomas Reiberger, Erika Garner-Spitzer, Roman Reindl-Schwaighofer, Renate Kain, Stefan Winkler, Josef S. Smolen, Karin Stiasny, Gottfried F. Fischer, Thomas Perkmann, Helmuth Haslacher, Markus Zeitlinger, Ursula Wiedermann, Judith H. Aberle, Daniel Aletaha, Leonhard X. Heinz, Michael Bonelli
Summary: Optimizing COVID-19 vaccination strategies for immunosuppressed patients is crucial. In this clinical trial, a homologous mRNA booster vaccine showed higher seroconversion rate compared to a switch to a vector-based vaccine for non-seroconverted immunosuppressed patients. The study highlights the importance of booster vaccination and supports the use of homologous mRNA booster vaccine in this vulnerable group.
NATURE COMMUNICATIONS
(2022)
Article
Infectious Diseases
Celine Y. Tan, Calvin J. Chiew, Deanette Pang, Vernon J. Lee, Benjamin Ong, David Chien Lye, Kelvin Bryan Tan
Summary: This study compared the vaccine effectiveness of the primary series and booster against Delta, Omicron BA.1, and BA.2 variants in Singapore. The primary series provided greater protection against Delta infection (45%) compared to Omicron infection (21% for BA.1, 18% for BA.2) within 2 months of vaccination. The booster had similar effectiveness against BA.1 and BA.2 infection (44% and 40% respectively) and provided comparable protection against severe disease as the primary series for Delta (80% for both variants).
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Virology
Angeline Rouers, Nathan Wong, Yun Shan Goh, Anthony Torres-Ruesta, Matthew Zirui Tay, Zi Wei Chang, Siew-Wai Fong, Vanessa Neo, Isaac Kai Jie Kam, Nicholas Kim-Wah Yeo, Yuling Huang, Chiew Yee Loh, Pei Xiang Hor, Joel Xu En Wong, Yong Jie Tan, Paul A. Macary, Xinlei Qian, Wang Bei, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Cheng- Wang, Xuan Ying Poh, Suma Rao, Po Ying Chia, Sean W. X. Ong, Tau Hong Lee, Ray J. H. Lin, Clarissa Lim, Jefanie Teo, Ee Chee Ren, David Chien Lye, Barnaby E. Young, Lisa F. P. Ng, Laurent Renia
Summary: The waning antibody levels against SARS-CoV-2 and the emergence of variants of concern call for booster vaccinations, especially for the elderly population. In this study, the responses to homologous and heterologous mRNA booster vaccines were analyzed. It was found that elderly individuals who received the heterologous vaccine regimen displayed higher levels of neutralizing antibodies and increased immunoglobulin G memory B cells, particularly against the Omicron variant. The T cell responses were also increased in elderly individuals given the heterologous regimen.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Calvin J. Chiew, M. Premikha, Chia Yin Chong, Wycliffe E. Wei, Benjamin Ong, David Chien Lye, Derrick Heng, Vernon J. Lee, Kelvin Bryan Tan
Summary: In Singapore, the effectiveness of the Pfizer-BioNTech vaccine was studied in adolescents aged 12-17. Two doses of the vaccine were found to be effective in preventing infection from the delta and omicron variants, with effectiveness rates of 66% and 25% respectively. The vaccine also showed high effectiveness in preventing hospitalization due to these variants, with rates of 83% and 75%. Additionally, a third booster dose further increased protection against the omicron variant.
LANCET INFECTIOUS DISEASES
(2023)
Review
Virology
Ying Jie Chee, Bingwen Eugene Fan, Barnaby Edward Young, Rinkoo Dalan, David C. C. Lye
Summary: Post-acute sequelae of SARS-CoV-2 infection, also known as long COVID, is an emerging public health concern. This review summarizes published trials and ongoing research on managing long COVID, highlighting the need for standardized diagnostic criteria and outcome measures. Current trials focus on individual symptoms and organ dysfunction, and more research is needed to address the unmet needs of patients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Genetics & Heredity
Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin-Fang Chai, Jimmy Lee, Joseph Jao-Yiu Sung, Tien Yin Wong, Calvin Woon Loong D. Chin, Peter Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee M. Tan, Rob M. Van Dam, Yik Ying Teo, Marie Loh, Paul Eillot, Eng Sing Lee, Joanne Ngeow, Elio Riboli, Rinkoo Dalan, Irfahan Kassam, Lakshmi Narayanan Lakshmanan, Tock Han Lim, Hong Kiat Ng, Theresia Mina, Darwin Tay, Charumathi Sabanayagam, Yih Chung Tham, Tyler Rim, Tin Aung, Miao Ling Chee, Hengtong Li, Miao Li Chee, Khung Keong Yeo, Stuart Alexander Cook, Chee Jian Pua, Chengxi Yang, Yap Seng Chong, Johan Gunnar Eriksson, Kok Hian Tan, Fabian Yap, Chia Wei Lim, Pi Kuang Tsai, Wen Jie Chew, Wey Ching Sim, Li-xian Grace Toh, Clarabelle Bitong Lin, Yee Yen Sia, Tat Hung Koh, Wee Yang Meah, Joanna Hui Juan Tan, Justin Jeyakani, Jack Ow, Shimin Ang, Ashar J. Malik, Dimitar Kenanov, Xueling Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jianjun Liu, Shyam Prabhakar, Sebastian Maurer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C. Chambers, E. Shyong Tai, Patrick Tan
Summary: This article discusses Singapore's efforts to establish a National Precision Medicine Strategy by integrating genomic, clinical, and lifestyle data of up to one million individuals. Precision medicine has the potential to revolutionize healthcare by detecting diseases early, refining diagnoses, and tailoring treatments for groups and individuals. The lack of representation of Asian ancestries in existing genomic-phenotypic databases presents a missed opportunity for new discoveries, especially for diseases relevant to these populations. The Singapore National Precision Medicine initiative aims to generate integrated data from various sources over a 10-year period, including genomic, lifestyle, health, social, and environmental data, in order to promote precision medicine adoption and address social, ethical, legal, and regulatory challenges.
Article
Public, Environmental & Occupational Health
Wen Lin Teh, Edimansyah Abdin, P. v. Asharani, Fiona Devi Siva Kumar, Kumarasan Roystonn, Peizhi Wang, Saleha Shafie, Sherilyn Chang, Anitha Jeyagurunathan, Janhavi Ajit Vaingankar, Chee Fang Sum, Eng Sing Lee, Rob M. M. van Dam, Mythily Subramaniam
Summary: Social desirability bias, one of the oldest forms of response bias, is examined in a multicultural Asian context to understand its impact on self-reported lifestyle indicators in epidemiological research. The study reveals unique sociodemographic factors associated with the bias and provides support for data integrity.
Article
Virology
Siew-Wai Fong, Yun Shan Goh, Anthony Torres-Ruesta, Zi Wei Chang, Yi-Hao Chan, Vanessa Kexin Neo, Bernett Lee, Kaibo Duan, Siti Naqiah Amrun, Nicholas Kim-Wah Yeo, Hsiuyi Chen, Matthew Zirui C. Tay, Guillaume Carissimo, Seow Yen Tan, Yee-Sin Leo, David Lye, Laurent Renia, Barnaby Edward Young, Lisa F. P. Ng
Summary: Long-term complications from COVID-19 are concerning, but it is unclear if they are due to prolonged inflammation. Vaccination may reduce these complications. A study on hospitalized patients over 24 months found that post-COVID-19 symptoms persisted for 2 years, but prolonged inflammation resolved after 2 years. Biomarkers associated with persistent inflammation and symptoms were identified, which could help identify high-risk survivors.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Hematology
Samuel Sherng Young Wang, Keefe Chee, Shiun Woei Wong, Guat Bee Tan, Hong Ang, Bernard PuiLam Leung, Chuen Wen Tan, Kollengode Ramanathan, Rinkoo Dalan, Christine Cheung, David Chien Lye, Barnaby Edward Young, Eng Soo Yap, Yew Woon Chia, Bingwen Eugene Fan
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Dermatology
Xiaoli Zhu, Eng Sing Lee, Phoebe X. H. Lim, Yee Chui Chen, Frederick H. F. Chan, Konstadina Griva
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Zhong Wei Jeremy Koh, Sai Zhen Sim, Kaiwei Jeremy Lew, Poay Sian Sabrina Lee, Eng Sing Lee
Summary: This study aimed to evaluate the clinical effectiveness of one-time telephone consultations compared to face-to-face consultations for diabetes management. The results showed that for patients with suboptimally controlled type 2 diabetes, one-time telephone consultations were non-inferior to face-to-face consultations in terms of glycaemic control in the short term. However, for patients with HbA1c >= 9%, telephone consultations were inferior to face-to-face consultations. Further studies are needed to investigate the long-term effects of telephone consultations.
Review
Health Care Sciences & Services
Mauricette Lee, Abu Bakar Shakran Bin Mahmood, Eng Sing Lee, Helen Elizabeth Smith, Lorainne Tudor Car
Summary: This scoping review explores the use of smartphones and mobile apps by physicians in clinical settings. The results show that physicians use smartphones and mobile apps for communication, clinical decision-making, drug compendia, medical education and training, health record maintenance, time management, and patient monitoring. The study highlights the promising benefits of smartphones and mobile apps in clinical practice, but also raises concerns about patient privacy and confidentiality, calling for urgent legislation to protect the liability of healthcare professionals using smartphones.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Immunology
Daniel A. Sweeney, Bonifride Tuyishimire, Neera Ahuja, John H. Beigel, Tatiana Beresnev, Valeria D. Cantos, Jose G. Castro, Stuart H. Cohen, Kaitlyn Cross, Lori E. Dodd, Nathan Erdmann, Monica Fung, Varduhi Ghazaryan, Sarah L. George, Kevin A. Grimes, Noreen A. Hynes, Kathleen G. Julian, Sheetal Kandiah, Hannah Jang Kim, Corri B. Levine, David A. Lindholm, David C. Lye, Ryan C. Maves, Myoung-don Oh, Catharine Paules, Rekha R. Rapaka, Willam R. Short, Kay M. Tomashek, Cameron R. Wolfe, Andre C. Kalil
Summary: We conducted a secondary analysis of the ACTT-2 randomized controlled trial sponsored by the National Institutes of Health and found that baricitinib reduced the risk of secondary infections by 50% after adjusting for baseline and postrandomization patient characteristics. This discovery provides a novel mechanism for the benefits of baricitinib and supports its safety as an immunomodulator for the treatment of COVID-19.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Nicolas Bertin, Maxime Hebrard, Chiea Chuen Khor, Zheng Li, Joanna Hui Juan Tan, Wee Yang Meah, Su Qin Peh, Shi Qi Mok, Kar Seng Sim, Jianjun Liu, Ling Wang, Eleanor Wong, Jingmei Li, Aung Tin, Ching-Yu Cheng, Chew-Kiat Heng, Jian-Min Yuan, Woon-Puay Koh, Seang Mei Saw, Yechiel Friedlander, Xueling Sim, Jin Fang Chai, Yap Seng Chong, Sonia Davila, Liuh Ling Goh, Eng Sing Lee, Tien Yin Wong, Neerja Karnani, Khai Pang Leong, Khung Keong Yeo, John C. Chambers, Su Chi Lim, Rick Siow Mong Goh, Patrick Tan, Rajkumar Dorajoo
Summary: Genomic researchers are increasingly using commercial cloud service providers (CSPs) to manage data and analytics needs. However, without adequate security controls, the risk of unauthorized access to cloud-stored data may be higher. The Research Assets Provisioning and Tracking Online Repository (RAPTOR) by the Genome Institute of Singapore is a cloud-native genomics data repository and analytics platform that implements a five-safes framework to provide security and governance controls to data contributors and users, ensuring compliance with regulations.
Letter
Health Care Sciences & Services
Matthew Zirui Tay, Yun Shan Goh, Siew-Wai Fong, Zi Wei Chang, Angeline Rouers, Nathan Wong, Anthony Torres-Ruesta, Yuling Huang, Sooriya Kannan Selvam, Pei Xiang Hor, Chiew Yee Loh, Bei Wang, Siti Nazihah Mohd Salleh, Eve Zi Xian Ngoh, Raphael Tze Chuen Lee, Vanessa Neo, Isaac Kai Jie Kam, Xuan Ying Poh, Suma Rao, Po Ying Chia, Sean W. X. Ong, Tau Hong Lee, Clarissa Lim, Jefanie Teo, Sebastian NCID Study Grp, Cheng-I PRIBIVAC Cohort Study Grp, Sebastian Maurer-Stroh, Cheng- Wang, Yee-Sin Leo, Raymond Tzer Pin Lin, David C. Lye, Barnaby Edward Young, Lisa F. P. Ng, Laurent Renia
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Endocrinology & Metabolism
Yik Weng Yew, Theresia Mina, Hong Kiat Ng, Benjamin Chih Chiang Lam, Elio Riboli, Eng Sing Lee, Jimmy Lee, Joanne Ngeow, Paul Elliott, Steven Tien Guan Thng, John C. Chambers, Marie Loh
Summary: This study aims to establish the association between obesity and skin physiology measurements and investigates whether obesity may play a possible causal role on skin barrier dysfunction. The results show a strong association between BMI and TEWL and skin pH, with suggestive evidence of a possible causal relationship. It highlights the potential impact of obesity on skin barrier function and the opportunity for prevention.
INTERNATIONAL JOURNAL OF OBESITY
(2023)