Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

(2022) Chongbing Liao et al.   Frontiers in Cellular and Infection Microbiology

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors

(2021) Simon Leiris et al.   ACS Medicinal Chemistry Letters

Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model

(2021) Cristina Cigana et al.   Frontiers in Microbiology

Pseudomonas aeruginosa elastase (LasB) as a therapeutic target

(2021) Martin J Everett et al.   DRUG DISCOVERY TODAY

Elastase Activity from Pseudomonas aeruginosa Respiratory Isolates and ICU Mortality

(2021) Jill Zupetic et al.   CHEST

Risk Factors and Relation with Mortality of a New Acquisition and Persistence of Pseudomonas aeruginosa in COPD Patients

(2021) Miguel Ángel Martínez-García et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Pseudomonas aeruginosa in bronchiectasis: infection, inflammation, and therapies

(2021) Celine Vidaillac et al.   Expert Review of Respiratory Medicine

Nasopharyngeal microbiome reveals the prevalence of opportunistic pathogens in SARS-CoV-2 infected individuals and their association with host types

(2021) Abhishek Gupta et al.   MICROBES AND INFECTION

Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose

(2021) Nicholas S. Rhoades et al.   Cell Reports

Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice

(2021) Yajie Zhu et al.   Journal of Inflammation Research

Pseudomonas Aeruginosa Induced Cell Death in Acute Lung Injury and Acute Respiratory Distress Syndrome

(2020) Rushikesh Deshpande et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tolerance and Persistence of Pseudomonas aeruginosa in Biofilms Exposed to Antibiotics: Molecular Mechanisms, Antibiotic Strategies and Therapeutic Perspectives

(2020) Anaïs Soares et al.   Frontiers in Microbiology

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

(2020) Josh Sun et al.   EBioMedicine

Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

(2019) Sankalp Malhotra et al.   CLINICAL MICROBIOLOGY REVIEWS

Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation

(2018) Fabien Bastaert et al.   Frontiers in Immunology

Pseudomonas aeruginosaLasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway

(2017) Vinciane Saint-Criq et al.   THORAX

The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition

(2015) Fiordiligie Casilag et al.   INFECTION AND IMMUNITY

Enhanced annotations and features for comparing thousands ofPseudomonasgenomes in the Pseudomonas genome database

(2015) Geoffrey L. Winsor et al.   NUCLEIC ACIDS RESEARCH

A Drug-Repositioning Screening Identifies Pentetic Acid as a Potential Therapeutic Agent for Suppressing the Elastase-Mediated Virulence of Pseudomonas aeruginosa

(2014) Mia Gi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Flagellar Motility Is a Key Determinant of the Magnitude of the Inflammasome Response to Pseudomonas aeruginosa

(2013) Yash R. Patankar et al.   INFECTION AND IMMUNITY

Novel Inhibitors of the Pseudomonas aeruginosa Virulence Factor LasB: a Potential Therapeutic Approach for the Attenuation of Virulence Mechanisms in Pseudomonal Infection

(2011) George R. A. Cathcart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pseudomonas aeruginosa Elastase Provides an Escape from Phagocytosis by Degrading the Pulmonary Surfactant Protein-A

(2011) Zhizhou Kuang et al.   PLoS One