Article
Gastroenterology & Hepatology
Rebecca J. Birch, Nicholas Burr, Venkataraman Subramanian, Jim P. Tiernan, Mark A. Hull, Paul Finan, Azmina Rose, Matthew Rutter, Roland Valori, Amy Downing, Eva J. A. Morris
Summary: This study investigated the epidemiology and outcomes of inflammatory bowel disease-associated colorectal cancer (IBD-CRC). It found that IBD patients have a higher risk of developing CRC, are diagnosed at a younger age, and have worse outcomes compared to sporadic CRC. Further research is needed to understand the reasons behind these differences and inform screening, surveillance, and treatment strategies for this high-risk group.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Jordan E. Axelrad, Raymond K. Cross
Summary: Patients with chronic ulcerative and Crohn's colitis have a higher risk of developing colorectal neoplasia (CRN [dysplasia and cancer]) compared to the general population. Risk factors for CRN include the extent of colitis, cumulative inflammatory burden, family history of colorectal cancer, and primary sclerosing cholangitis. Best practices for preventing CRN involve controlling colonic inflammation, conducting high quality surveillance colonoscopy with or without enhanced imaging techniques, removing visible dysplasia if possible, and considering colectomy for patients with unresectable dysplasia, invisible multifocal low-grade dysplasia, or invisible high-grade dysplasia. The decision to stop dysplasia surveillance should be individualized and based on factors such as age, frailty, comorbid conditions, life expectancy, previous surveillance exam results, and risk factors for CRN.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Michelle Temby, Theresa L. Boye, Jacqueline Hoang, Ole H. Nielsen, John Gubatan
Summary: This article reviews the role of kinase signaling pathways in colitis-associated colon cancer, including MAPK, CDK, autophagy-activated kinases, JAK-STAT, and other kinases. It also discusses the involvement of JAK-STAT signaling in the pathogenesis of inflammatory bowel disease (IBD) and the potential use of JAK inhibitors for treating IBD.
Article
Medicine, General & Internal
Writaja Halder, Faidon-Marios Laskaratos, Hanan El-Mileik, Sergio Coda, Stevan Fox, Saswata Banerjee, Owen Epstein
Summary: The COVID-19 pandemic has heavily impacted healthcare services for patients with chronic diseases. This review explores the use of colon capsule endoscopy as a method for assessing and treating inflammatory bowel disease. Despite its limitations, there is increasing evidence to support the use of the second-generation colon capsule.
Article
Gastroenterology & Hepatology
Frederikke S. Troelsen, Henrik T. Sorensen, Seth D. Crockett, Lars Pedersen, Rune Erichsen
Summary: In patients with inflammatory bowel disease (IBD), postcolonoscopy colorectal cancers (PCCRC) account for 50% of cases and have distinct characteristics, while the survival rates are similar to those of colorectal cancer (dCRC) with immediate diagnosis after colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Martin Maronek, Irene Marafini, Roman Gardlik, Rene Link, Edoardo Troncone, Giovanni Monteleone
Summary: Inflammatory bowel diseases (IBD) refer to chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease (CD) and ulcerative colitis (UC). Excessive production of matrix metalloproteinases (MMPs) without sufficient inhibition by tissue inhibitors of metalloproteinases (TIMPs) in inflamed tissue of IBD patients contributes significantly to mucosal degradation in IBD-related pathologies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Anouk M. Wijnands, Michiel E. de Jong, Maurice W. M. D. Lutgens, Frank Hoentjen, Sjoerd G. Elias, Bas Oldenburg
Summary: A systematic review and meta-analysis identified 13 risk factors and 5 protective factors for advanced colorectal neoplasia in IBD patients. These findings could contribute to an improved surveillance based on CRC risk stratification in IBD.
Article
Gastroenterology & Hepatology
Mohammad El-Harakeh, Jessica Saliba, Kawthar Sharaf Aldeen, May Haidar, Layal El Hajjar, Mireille Kallassy Awad, Jana G. Hashash, Margret Shirinian, Marwan El-Sabban
Summary: This study investigated the expression levels of Cx43 and TET-2 under inflammatory conditions both in vitro and in vivo. The results showed that Cx43 and TET-2 expression increased under inflammatory conditions, while 5-hmC levels decreased.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jose Maria Huguet, Luis Ferrer-Barcelo, Patricia Suarez, Eva Sanchez, Jose David Prieto, Victor Garcia, Javier Sempere
Summary: The detection of dysplasia in IBD patients is important and chromoendoscopy with targeted biopsy remains the preferred technique. However, other techniques such as virtual chromoendoscopy are being compared due to their similar results and fewer technical difficulties. New endoscopy techniques and improved devices have the potential to revolutionize the screening and follow-up of dysplasia in IBD patients. Further research is needed to define the optimal follow-up strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Adam Faye, James C. Slaughter, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Colorectal strictures in patients with inflammatory bowel disease (IBD) are not independently associated with the risk of advanced colorectal neoplasia (ACRN) or colectomy, according to a retrospective cohort analysis. Further multicenter, prospective studies are needed to confirm these findings.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Anouk M. Wijnands, Sjoerd G. Elias, Evelien Dekker, Herma H. Fidder, Frank Hoentjen, Joren R. ten Hove, P. W. Jeroen Maljaars, Andrea E. van der Meulen-de Jong, Erik Mooiweer, Renske J. Ouwehand, Bas B. L. Penning de Vries, Cyriel Y. Ponsioen, Fiona D. M. van Schaik, Bas Oldenburg
Summary: This study aimed to clarify the association between smoking and the development of colorectal neoplasia in patients with inflammatory bowel disease (IBD). The results showed that smoking was not associated with the risk of recurrent colorectal neoplasia, but an increasing number of pack-years was associated with a higher risk of recurrence.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Kit Curtius, Misha Kabir, Ibrahim Al Bakir, Chang Ho Ryan Choi, Juanda L. Hartono, Michael Johnson, James E. East, James O. Lindsay, Roser Vega, Siwan Thomas-Gibson, Janindra Warusavitarne, Ana Wilson, Trevor A. Graham, Ailsa Hart
Summary: This study identified that patients with large, unresected, multifocal LGD and recent moderate/severe inflammation are at highest risk of developing advanced neoplasia. Personalised risk prediction provided via the Ulcerative Colitis-Cancer Risk Estimator can support treatment decision-making.
Review
Gastroenterology & Hepatology
Nik Sheng Ding, Daniel Tassone, Ibrahim Al Bakir, Kyle Wu, Alexander J. Thompson, William R. Connell, George Malietzis, Phillip Lung, Siddharth Singh, Chang-ho Ryan Choi, Simon Gabe, John T. Jenkins, Ailsa Hart
Summary: This review examines the impact and importance of body composition in inflammatory bowel disease (IBD). The findings suggest that alterations in body composition parameters are common in IBD patients, both during active disease and clinical remission, and are associated with poorer prognoses and treatment outcomes. Further investigation and application of body composition parameters have the potential to improve IBD outcomes in the future.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Multidisciplinary Sciences
Qingli Guo, Eszter Lakatos, Ibrahim Al Bakir, Kit Curtius, Trevor A. Graham, Ville Mustonen
Summary: Clinical archives of patient material are predominantly composed of FFPE blocks. However, sequencing DNA derived from FFPE material is known to have artifacts. In this study, a computational algorithm called FFPEsig is introduced to rectify these artifacts and enable accurate mutational signature analysis.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Medicine, General & Internal
Mohammed Deputy, Ratnakar Devanaboina, Ibrahim Al Bakir, Elaine Burns, Omar Faiz
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Meeting Abstract
Gastroenterology & Hepatology
N. Ding, D. Tassone, I. Al Bakir, K. Wu, W. Connell, A. Thompson, G. Malietzis, P. Lung, S. Singh, C. H. Choi, S. Gabe, J. Jenkins, A. Hart
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
N. Ding, D. Tassone, I. Al Bakir, K. Wu, W. Connell, A. Thompson, G. Malietzis, P. Lung, S. Singh, C. H. Choi, S. Gabe, J. Jenkins, A. Hart
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Yalchin, K. Curtius, S. Nowinski, M. Moorghen, C. Kimberley, K. Smith, A. M. Baker, I. Al-Bakir, M. Mossner, V. Nadhamuni, A. Hart, T. Graham
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Yalchin, K. Curtius, S. Nowinski, M. Moorghen, C. Kimberley, K. Smith, A. M. Baker, I. Al-Bakir, M. Mossner, V. Nadhamuni, A. Hart, T. Graham
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Giannis Ioannidis, Ibrahim Al Bakir, Mario Alexander, Si Emma Chen, Luke Ginnelly, Nikolaos Hadjisavvas, Rajaratnam Rameshshanker
Meeting Abstract
Gastroenterology & Hepatology
Mehmet Yalchin, Kit Curtius, Salpie Nowinski, Morgan Moorghen, Chris Kimberley, Kane Smith, Ann-Marie Baker, Ibrahim Al-Bakir, Ailsa Hart, Trevor Graham
Meeting Abstract
Gastroenterology & Hepatology
Ibrahim Al Bakir, Kathleen Curtius, Kane Smith, Maja Kopczynska, Morgan Moorghen, Ailsa Hart, Trevor Graham
Meeting Abstract
Gastroenterology & Hepatology
I. Al Bakir, K. Curtius, K. Smith, M. Kopczynska, M. Moorghen, A. Hart, T. Graham
JOURNAL OF CROHNS & COLITIS
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Misha Kabir, Kit Curtius, Ibrahim Al-Bakir, Chang-Ho Ryan Choi, Juanda Hartono, Michael Johnson, James E. East, James O. Lindsay, Roser Vega, Siwan Thomas-Gibson, Ailsa Hart, Trevor Graham, Ana Wilson
Meeting Abstract
Gastroenterology & Hepatology
Kit Curtius, Misha Kabir, Ibrahim Al Bakir, Chang-Ho Ryan Choi, Juanda Hartono, Michael Johnson, James E. East, James O. Lindsay, Roser Vega, Siwan Thomas-Gibson, Ana Wilson, Trevor A. Graham, Ailsa Hart