Article
Immunology
Alison D. Petro, Joseph Dougherty, Bryant R. England, Harlan Sayles, Michael J. Duryee, Carlos D. Hunter, Joel M. Kremer, Dimitrios A. Pappas, William H. Robinson, Jeffrey R. Curtis, Geoffrey M. Thiele, Ted R. Mikuls
Summary: In rheumatoid arthritis patients, the number of positive autoantibodies is dose-dependently associated with treatment response to biologics, with anti-CCP antibody positivity having the strongest impact.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Rheumatology
Francesca Motta, Nicola Bizzaro, Davide Giavarina, Franco Franceschini, Maria Infantino, Boaz Palterer, Gian Domenico Sebastiani, Carlo Selmi
Summary: This study analyzed the role of rheumatoid factor (RF) isotypes in the diagnosis and prognosis of rheumatoid arthritis (RA). The results showed that testing all RF isotypes with latex test or nephelometry provides the highest sensitivity, while determination of IgA isotype provides the highest specificity and positive likelihood ratio. However, RF isotypes do not provide relevant prognostic information due to limited and conflicting data.
Review
Biochemistry & Molecular Biology
Alesandra Florescu, Florin Liviu Gherghina, Anca Emanuela Musetescu, Vlad Padureanu, Anca Rosu, Mirela Marinela Florescu, Cristina Criveanu, Lucian-Mihai Florescu, Anca Bobirca
Summary: This review discusses interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA), including its patterns, molecular mechanisms, and therapeutic challenges. Biomarkers have been found to be useful in identifying high-risk patients and guiding personalized treatment.
Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Francisco Javier Godoy-Navarrete, Jose Manuel Lisbona-Montanez, Rocio Redondo-Rodriguez, Sara Manrique-Arija, Jose Rioja, Arkaitz Mucientes, Patricia Ruiz-Limon, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Begona Oliver-Martos, Laura Cano-Garcia, Antonio Fernandez-Nebro
Summary: This study aimed to identify inflammatory factors and soluble cytokines that act as biomarkers in the diagnosis and prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The study found that patients with RA-ILD had higher inflammatory activity and certain cytokines were associated with both diagnosis and poorer prognosis in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Ketian Li, Wenxiu Mo, Lijun Wu, Xunyao Wu, Cainan Luo, Xinyue Xiao, Xinmiao Jia, Huaxia Yang, Yunyun Fei, Hua Chen, Fengchun Zhang, Yongzhe Li, Lidan Zhao, Xuan Zhang
Summary: This study identified nine novel autoantibodies in ACPA-negative RA, with anti-PTX3 and anti-DUSP11 showing the highest sensitivity. The combination of these two autoantibodies significantly increased the diagnostic sensitivity in ACPA-negative RA. The novel biomarkers provide potential diagnostic value for ACPA-negative RA patients.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Medicine, General & Internal
Ketian Li, Min Wang, Lidan Zhao, Yudong Liu, Xuan Zhang
Summary: This review summarizes the current knowledge about the primary drivers of ACPA(-) RA, focusing on the serological, cellular, and molecular aspects of immune mechanisms. A better understanding of the etiology of ACPA(-) RA will aid in personalized treatment design and improve early treatment and outcomes.
Article
Genetics & Heredity
Rong-zhi Huang, Jie Zheng, Feng-ling Liu, Qing-ling Li, Wen-hui Huang, Dan-meng Zhang, Qiang-chu Wu
Summary: This study aimed to understand the differences in pathogenesis of RA and OA through in-depth studies of autophagy, revealing differences in autophagy levels between the two diseases. A novel autophagy related index (ARI) constructed from CXCR4 and SERPINA showed high disease identification potential and was verified in an independent cohort, indicating great promise for clinical applications.
FRONTIERS IN GENETICS
(2021)
Article
Rheumatology
Eleftheria Pertsinidou, Saedis Saevarsdottir, Vivek Anand Manivel, Lars Klareskog, Lars Alfredsson, Linda Mathsson-Alm, Monika Hansson, Martin Cornillet, Guy Serre, Rikard Holmdahl, Karl Skriner, Per-Johan Jakobsson, Helga Westerlind, Johan Askling, Johan Roennelid
Summary: In early RA patients, ACPA is associated with a lower number of affected joints, while RF is associated with elevated systemic inflammation markers in an ACPA-dependent manner. This finding supports the in vitro models of ACPA and RF in immune complex-induced inflammation. These phenotypic associations are independent of classification criteria.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemical Research Methods
Durgesh Dubey, Sandeep Kumar, Atul Rawat, Anupam Guleria, Reena Kumari, Sakir Ahmed, Rajeev Singh, Ramnath Misra, Dinesh Kumar
Summary: Metabolic changes in synovial fluid may serve as indicative markers for diagnosing reactive arthritis, with certain metabolic features identified as diagnostic biomarkers when compared to other types of arthritis. Additionally, the impact of ReA synovitis on serum metabolic profiles was demonstrated through correlation analysis, showing significant positive correlations for a majority of metabolites.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Medicine, General & Internal
D. Abdelhafiz, T. Baker, D. A. Glascow, Ah Abdelhafiz
Summary: This study systematically explored the role of multiple biomarkers in the diagnosis, treatment, and prognosis of rheumatoid arthritis (RA). The results showed that these biomarkers are helpful tools in clinical practice for RA diagnosis, treatment monitoring, and prognosis prediction. However, further research is needed to investigate novel biomarkers that may be related to patient responsiveness.
POSTGRADUATE MEDICINE
(2023)
Review
Immunology
Yong Jiang, Shuxin Zhong, Shenghua He, Juanling Weng, Lijin Liu, Yufeng Ye, Hanwei Chen
Summary: Given the lack of overt clinical manifestations, early diagnosis and prognosis prediction of rheumatoid arthritis (RA) have always been challenging. Recent studies have focused on using non-coding RNA (ncRNA) as biomarkers for early diagnosis and prognosis prediction of RA. This review provides an overview of the recent advances in mRNA-ncRNA as diagnostic and prognostic biomarkers for RA from the biofluid to the tissue level.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Katerina Chatzidionysiou, Daniela di Giuseppe, Jonas Soderling, Anca Catrina, Johan Askling
Summary: The study found that patients with RA have a significantly increased risk of developing lung cancer, even after adjusting for smoking. Additionally, rheumatoid factor positivity also contributes to an increased incidence of lung cancer.
Article
Rheumatology
Judith Heutz, Pascal Hendrik Pieter de Jong
Summary: Knowledge of RA pathophysiology has improved, leading to new treatment options. Despite RA's heterogeneity, current management adopts a 'one-size-fits-all' approach. Personalised medicine may offer better outcomes by tailoring treatments to individual patients.
Article
Biochemistry & Molecular Biology
Jeneen Panezai, Ambereen Ghaffar, Mohammad Altamash, Mikael Aberg, Thomas E. Van Dyke, Anders Larsson, Per-Erik Engstrom
Summary: Periodontal disease enhances the expression of CVD-related biomarkers in RA patients through shared pathological clusters, concurrently enhancing metabolic and skeletal disease protein interactions, independent of autoimmune status.
Article
Biochemistry & Molecular Biology
Sandra Pascual-Garcia, Pascual Martinez-Peinado, Ana B. B. Lopez-Jaen, Francisco J. J. Navarro-Blasco, Yoel G. G. Montoyo-Pujol, Enrique Roche, Gloria Peiro, Jose M. Sempere-Ortells
Summary: This study aimed to identify severity biomarkers to predict flare-ups or remission periods in rheumatoid arthritis (RA) patients. The study found that elevated percentages of CD3(+)CD4(-) lymphocytes and granulocytes, as well as a decreased NK/T lymphocyte ratio, can differentiate between flare-up and remission. Therefore, the combined study of leukocyte surface markers could be potential disease severity biomarkers for RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Viktor Molander, Hannah Bower, Thomas Frisell, Benedicte Delcoigne, Daniela Di Giuseppe, Johan Askling
Summary: Patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKi) have a higher incidence of venous thromboembolism (VTE) compared to those treated with other biological disease modifying antirheumatic drugs (bDMARDs), especially in terms of pulmonary embolism (PE).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Mariele Gatto, Sara Bjursten, Charlotte A. Jonsson, Monica Leu Agelii, Caroline Jonell, Sarah McGrath, Erik Loennblom, Outi Sareila, Rikard Holmdahl, Anna Rudin, Max Levin, Inger Gjertsson
Summary: We investigated the correlation between B cell-related immunologic changes and the development of inflammatory arthritis (IA) after treatment with immune checkpoint inhibitors (ICIs). Our results showed that patients with ICI-induced IA had higher proportions of CD19+ B cells and increased levels of transitional B cells compared to patients without immune-related adverse events. Autoantibodies to joint-related proteins were also detected in ICI-IA patients. Monitoring of B cell-driven abnormalities during ICI treatment may help in early recognition of ICI-IA.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Thomas Frisell, Hannah Bower, Matilda Morin, Eva Baecklund, Daniela Di Giuseppe, Benedicte Delcoigne, Nils Feltelius, Helena Forsblad-d'Elia, Elisabet Lindqvist, Ulf Lindstroem, Johan Askling
Summary: The objective of this study was to assess and compare the incidence rates of key safety outcomes for individual targeted synthetic or biological disease-modifying antirheumatic drugs (b/ts DMARDs) in rheumatoid arthritis (RA). The study found that the b/tsDMARDs currently used to treat RA have acceptable and largely similar safety profiles, but differences exist in particular concerning tolerability and specific infection risks.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Taotao Li, Changrong Ge, Alexander Kramer, Outi Sareila, Monica Leu Agelii, Linda Johansson, Kristina Forslind, Erik Lonnblom, Min Yang, Bingze Xu, Qixing Li, Lei Cheng, Goran Bergstrom, Gonzalo Fernandez, Alf Kastbom, Solbritt Rantapaa-Dahlqvist, Inger Gjertsson, Rikard Holmdahl
Summary: In this study, the arthritogenic B cell epitopes of the autoantigen glucose-6-phosphate isomerase (GPI) associated with rheumatoid arthritis (RA) were identified. These epitopes play a crucial role in the development of the disease and joint damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Viking Huss, Hannah Bower, Karin Hellgren, Thomas Frisell, Johan Askling, ARTIS grp
Summary: This study assessed the cancer risks associated with Janus kinase inhibitors (JAKi) compared to biological disease-modifying antirheumatic drugs (bDMARDs) in clinical practice. The results showed that, in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), the short-term risk of cancers other than non-melanoma skin cancer (NMSC) was not higher with JAKi compared to tumor necrosis factor inhibitors (TNFi), but there was evidence of an increased risk for NMSC.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Lina Wirestam, Frida Jonsson, Helena Enocsson, Christina Svensson, Maria Weiner, Jonas Wettero, Helene Zachrisson, Per Eriksson, Christopher Sjowall
Summary: A study examined the association between anti-oxidized low-density lipoprotein (anti-oxLDL) antibodies and subclinical atherosclerosis in patients with different systemic lupus erythematosus (SLE) phenotypes. Anti-oxLDL levels were measured in SLE patients, healthy controls, and subjects with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). The results showed no significant difference in anti-oxLDL levels between SLE patients and healthy controls, but levels were significantly higher in AAV subjects. There was also a significant decrease in anti-oxLDL levels in the SLE group over a 3-year period. The study did not find strong associations between anti-oxLDL antibodies and vascular affection in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Awais Ahmad, Andre Brylid, Charlotte Dahle, Muna Saleh, Orjan Dahlstrom, Helena Enocsson, Christopher Sjowall
Summary: The detection of antinuclear antibodies is crucial for diagnosing and predicting the outcome of systemic lupus erythematosus (SLE), primary Sjogren's syndrome (pSS), and mixed connective tissue disease (MCTD). Anti-U1-RNP and anti-RNP70 antibodies were examined in patients with SLE, pSS, and MCTD. The presence of anti-U1-RNP antibodies was associated with a clinical phenotype resembling MCTD and less organ damage in SLE patients. However, subtyping anti-RNP70 in anti-U1-RNP-positive sera did not provide significant clinical value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sandra Lilja, Xinxiu Li, Martin Smelik, Eun Jung Lee, Joseph Loscalzo, Pratheek Bellur Marthanda, Lang Hu, Mattias Magnusson, Oleg Sysoev, Huan Zhang, Yelin Zhao, Christopher Sjowall, Danuta Gawel, Hui Wang, Mikael Benson
Summary: By sequencing the single-cell RNA of a mouse model for immune-mediated inflammatory diseases (IMIDs), we found complex expression changes in all analyzed organs, even if only joints showed inflammation signs. We constructed a multi-organ multicellular disease model that reveals molecular interactions within and between organs, suggesting that inflammation is regulated by the balance of pro- and anti-inflammatory regulators and pathways. Meta-analyses of human IMIDs show a similar on/off switch system, which has the potential to prioritize, diagnose, and treat URs combinations in IMIDs, subgroups, and individual patients. This potential is supported by UR analyses in over 600 sera from systemic lupus erythematosus patients.
CELL REPORTS MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Charlotte Sylwander, Astrid Klopstad Wahl, Maria L. E. Andersson, Emma Haglund, Ingrid Larsson
Summary: This study examined the level of health literacy and its associations with lifestyle habits, health status, chronic pain, and knee osteoarthritis. It also explored the experiences of individuals with knee pain regarding health literacy. The results showed that 71% of participants had sufficient health literacy, and factors such as higher education, healthy lifestyle habits, better general health, and absence of widespread pain were associated with sufficient health literacy. The study also highlighted the importance of health literacy in the decision-making process and emphasized the need for further research on health promotion in individuals with knee pain.
Article
Immunology
Jesper Karlsson, Jonas Wettero, Lawrence A. Potempa, Rafael Fernandez-Botran, Yasmine O'Neill, Lina Wirestam, Fariborz Mobarrez, Christopher Sjowall
Summary: This study found an abundance of both pCRP and mCRP on extracellular vesicles (EVs) in systemic lupus erythematosus (SLE) patients, with elevated mCRP+ EVs in patients with active disease and in anti-CRP positive patients. Additionally, the proportions of mCRP+ EVs were lower in patients with acquired organ damage and displayed an inverse relationship with disease duration in lupus nephritis (LN) and patients with active disease. These findings suggest the relevance of EV-bound mCRP in SLE pathogenesis and its potential role in the development of anti-CRP autoantibodies by stimulating an immune response.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Anna Hedenstedt, Sarah Reid, Ahmed Sayadi, Maija-Leena Eloranta, Elisabeth Skoglund, Karin Bolin, Martina Frodlund, Karoline Lerang, Andreas Joensen, Solbritt Rantapaeae-Dahlqvist, Anders A. Bengtsson, Anna Rudin, Oyvind Molberg, Christopher Sjoewall, Johanna K. Sandling, Dag Leonard
Summary: This study found that the genetic burden related to B cell function is associated with dsDNA antibody development and lupus nephritis in SLE patients.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Elizabeth V. V. Arkema, Muna Saleh, Julia F. F. Simard, Christopher Sjoewall
Summary: This study examined the variations in prevalence and incidence of systemic lupus erythematosus (SLE) in a geographically defined area of central Sweden over a 14-year period. The results showed that the prevalence and incidence of SLE remained constant over this time period, and the disease phenotypes at onset were similar. This study is important for understanding the epidemiology and characteristics of SLE in the region.
ACR OPEN RHEUMATOLOGY
(2023)