Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Nutrition & Dietetics
Sevda Onuk, Nurhayat Tugra Ozer, Merve Ozel, Hilal Sipahioglu, Guven Kahriman, Gulden Baskol, Sahin Temel, Kursat Gundogan, Aynur Akin
Summary: This study evaluated the association between ultrasound-based gastric antrum measurements and serum levels of intestinal fatty acid-binding protein (IFABP) and citrulline with gastrointestinal (GI) dysfunction in critically ill patients. The study found that the cross-sectional area (CSA) of the gastric antrum was associated with GI dysfunction, while serum levels of IFABP and citrulline were not predictive of GI dysfunction.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Byunghyuk Yu, Ryoung-Eun Ko, Keesang Yoo, Eunmi Gil, Kyoung-Jin Choi, Chi-Min Park
Summary: In critically ill patients, a SOFA score >8 upon admission to the ICU, ICU admission for medical problems, and abdominal pain at diagnosis are associated with increased mortality among patients with NOMI.
Article
Microbiology
Maciej Tyszko, Malgorzata Lipinska-Gediga, Anna Lemanska-Perek, Katarzyna Kobylinska, Waldemar Gozdzik, Barbara Adamik
Summary: Gastrointestinal symptoms are common in critically ill COVID-19 patients. Assessing intestinal damage in unconscious or sedated ICU patients is challenging. This study reveals that the levels of I-FABP, a biomarker for enterocyte damage, are significantly higher in COVID-19 patients who eventually died, and it can be a predictor of poor outcome.
Article
Critical Care Medicine
Anhum Konan, Gael Piton, Maxime Ronot, Youness Hassoun, Hadrien Winiszewski, Guillaume Besch, Alexandre Doussot, Eric Delabrousse, Paul Calame
Summary: This study aimed to evaluate whether abdominal atherosclerosis is a risk factor for nonocclusive mesenteric ischemia (NOMI). The study found no significant association between atherosclerosis and NOMI in critically ill patients.
ANNALS OF INTENSIVE CARE
(2022)
Article
Medicine, General & Internal
Pedro Kurtz, Cassia Righy, Monica Gadelha, Fernando A. Bozza, Patricia T. Bozza, Bruno Goncalves, Leonardo S. L. Bastos, Andre M. Vale, Luiza M. Higa, Leda Castilho, Fabio L. Monteiro, Nestor Charris, Fernanda Fialho, Ricardo Turon, Alexandro Guterres, Renan Lyra Miranda, Carlos Henrique de Azeredo Lima, Vanessa de Caro, Marco Aurelio Prazeres, Nina Ventura, Clara Gaspari, Fabio Miranda, Paulo Jose Mata, Margarida Pecego, Sheila Mateos, Maria Esther Lopes, Shirley Castilho, Alvaro Oliveira, Carla Boquimpani, Andrea Rabello, Josiane Lopes, Orlando Conceicao Neto, Orlando da C. Ferreira Jr, Amilcar Tanuri, Paulo Niemeyer Filho, Luiz Amorim
Summary: This study found that convalescent plasma did not lead to clinical improvement or increased 28-day survival in critically ill patients with COVID-19. Biomarker assessment showed reduced inflammatory activity and increased lymphocyte count in convalescent plasma recipients.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Muhammad Z. Mushtaq, Saad B. Z. Mahmood, Aysha Almas, Syed Ather Wasti, Syed Ahsan Ali
Summary: This study examined the response of tocilizumab in COVID-19 patients by analyzing clinical parameters and inflammatory markers. The results showed that tocilizumab can decrease the need for mechanical ventilation and improve inflammatory markers and neutrophil to lymphocyte ratio. However, it is associated with adverse events including bacterial and fungal infections.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hendrik Booke, Otto R. Frey, Anka C. Roehr, Ute Chiriac, Kai Zacharowski, Tomas Holubec, Elisabeth H. Adam
Summary: This study evaluated the pharmacokinetics of cefazolin in patients undergoing ECMO treatment and found that cefazolin concentrations varied widely in veno-arterial ECMO patients. Using dosing software would have led to lower but sufficient concentrations of cefazolin.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Gael Piton, Amelie Le Gouge, Julie Boisrame-Helms, Nadia Anguel, Laurent Argaud, Pierre Asfar, Vlad Botoc, Anne Bretagnol, Laurent Brisard, Hoang-Nam Bui, Emmanuel Canet, Delphine Chatelier, Louis Chauvelot, Michael Darmon, Vincent Das, Jerome Devaquet, Michel Djibre, Frederique Ganster, Maite Garrouste-Orgeas, Stephane Gaudry, Olivier Gontier, Samuel Groyer, Bertrand Guidet, Jean-Etienne Herbrecht, Yannick Hourmant, Jean-Claude Lacherade, Philippe Letocart, Frederic Martino, Virginie Maxime, Emmanuelle Mercier, Jean-Paul Mira, Saad Nseir, Jean-Pierre Quenot, Jack Richecoeur, Jean-Philippe Rigaud, Damien Roux, David Schnell, Carole Schwebel, Daniel Silva, Michel Sirodot, Bertrand Souweine, Nathalie Thieulot-Rolin, Francois Tinturier, Patrice Tirot, Didier Thevenin, Guillaume Thiery, Jean-Baptiste Lascarrou, Jean Reignier
Summary: This study retrospectively analyzed 2410 critically ill patients and found that acute mesenteric ischemia was independently associated with enteral nutrition, dobutamine use, SAPS II score greater than or equal to 62, and hemoglobin concentration less than or equal to 10.9 g/dL.
INTENSIVE CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Li-Jing Su, Mei-Jing Chen, Rong Yang, Hong Zou, Ting -Ting Chen, Sai-Lan Li, Yuan Guo, Rong-Fang Hu
Summary: This study aimed to investigate the associations between various plasma biomarkers and delirium. The results showed that 29.2% of postoperative critically ill patients in the intensive care unit experienced delirium. Among the plasma biomarkers, sTNFR-1 level was associated with delirium.
Article
Medicine, General & Internal
Christian Bleilevens, Josefin Soppert, Adrian Hoffmann, Thomas Breuer, Juergen Bernhagen, Lukas Martin, Lara Stiehler, Gernot Marx, Michael Dreher, Christian Stoppe, Tim-Philipp Simon
Summary: Elevated plasma macrophage migration inhibitory factor (MIF) concentrations are significantly associated with aggravated organ function and lower 28-day survival rates in critically ill COVID-19 patients, suggesting a potential role for MIF as a predictive biomarker for disease severity and patient outcomes in ICU management.
Article
Infectious Diseases
Eveline Wallenburg, Rob ter Heine, Dylan W. de Lange, Henk van Leeuwen, Jeroen A. Schouten, Jaap ten Oever, Eva Kolwijck, David M. Burger, Peter Pickkers, Emilie M. Gieling, Monique M. de Maat, Tim Frenzel, Roger J. Bruggemann
Summary: This study aimed to describe the pharmacokinetics of unbound and total flucloxacillin in critically ill patients and define optimal dosing strategies. Results showed that critically ill patients have higher unbound flucloxacillin fractions and concentrations than previously believed, leading to a lower risk of subtherapeutic exposure.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Alexandre Nuzzo, Kevin Guedj, Sonja Curac, Claude Hercend, Claude Bendavid, Nathalie Gault, Alexy Tran-Dinh, Maxime Ronot, Antonino Nicoletti, Yoram Bouhnik, Yves Castier, Olivier Corcos, Katell Peoc'h
Summary: This study aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI, including citrulline, I-FABP, and d-lactate. The results showed that citrulline concentration was significantly lower in AMI patients compared to controls, but it had low accuracy in diagnosing AMI. I-FABP and d-lactate did not show statistical differences between AMI patients and controls, indicating a need for further research to identify new biomarkers.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Jean-Marc Tadie, Clara Locher, Adel Maamar, Jean Reignier, Pierre Asfar, Morgane Commereuc, Mathieu Lesouhaitier, Murielle Gregoire, Estelle Le Pabic, Claude Bendavid, Caroline Moreau, Jean-Luc Diehl, Alain Gey, Eric Tartour, Yves Le Tulzo, Ronan Thibault, Nicolas Terzi, Arnaud Gacouin, Mikael Roussel, Christophe Delclaux, Karin Tarte, Luc Cynober
Summary: Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo.
Article
Nutrition & Dietetics
P. L. M. Lakenman, J. C. van Schie, B. van der Hoven, S. J. Baart, R. D. Eveleens, J. van Bommel, J. F. Olieman, K. F. M. Joosten
Summary: Gastrointestinal symptoms are not a major barrier to enteral nutrition in critically ill COVID-19 patients during the first 14 days of ICU admission. Nutritional intake is slightly below requirements during this period.
CLINICAL NUTRITION
(2022)
Article
Critical Care Medicine
Marc Pineton de Chambrun, Philippe Cluzel, Isabelle Brocheriou, Nicolas Brechot, Guillaume Hekimian, Mohamed-Wafik Turki, Guillaume Franchineau, Philippe Rouvier, Simon Bourcier, Come Bureau, Ania Nieszkowska, Loic Le Guennec, Alexis Mathian, Zahir Amoura, Matthieu Schmidt, Alain Combes, Charles-Edouard Luyt
CRITICAL CARE MEDICINE
(2019)
Review
Critical Care Medicine
Simon Bourcier, Patrick Hindlet, Bertrand Guidet, Agnes Dechartres
CRITICAL CARE MEDICINE
(2019)
Article
Critical Care Medicine
Simon Bourcier, Maxime Coutrot, Antoine Kimmoun, Romain Sonneville, Etienne de Montmollin, Romain Persichini, David Schnell, Julien Charpentier, Cecile Aubron, Elise Morawiec, Naike Bige, Saad Nseir, Nicolas Terzi, Keyvan Razazi, Elie Azoulay, Alexis Ferre, Yacine Tandjaoui-Lambiotte, Olivier Ellrodt, Sami Hraiech, Clement Delmas, Francois Barbier, Alexandre Lautrette, Nadia Aissaoui, Xavier Repesse, Claire Pichereau, Yoann Zerbib, Jean-Baptiste Lascarrou, Serge Carreira, Danielle Reuter, Aurelien Frerou, Vincent Peigne, Pierre Fillatre, Bruno Megarbane, Guillaume Voiriot, Alain Combes, Matthieu Schmidt
CRITICAL CARE MEDICINE
(2020)
Article
Critical Care Medicine
Juliette Chommeloux, Santiago Montero, Guillaume Franchineau, Nicolas Brechot, Guillaume Hekimian, Guillaume Lebreton, Loic Le Guennec, Simon Bourcier, Ania Nieszkowska, Pascal Leprince, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
CRITICAL CARE MEDICINE
(2020)
Article
Critical Care Medicine
Rene Robert, Amelie Le Gouge, Nancy Kentish-Barnes, Melanie Adda, Juliette Audibert, Francois Barbier, Simon Bourcier, Jeremy Bourenne, Alexandre Boyer, Jerome Devaquet, Guillaume Grillet, Olivier Guisset, Anne-Claire Hyacinthe, Merce Jourdain, Nicolas Lerolle, Olivier Lesieur, Emmanuelle Mercier, Jonathan Messika, Anne Renault, Isabelle Vinatier, Elie Azoulay, Arnaud W. Thille, Jean Reignier, Djillali Annane, Patrick Bardou, Francois Brenas, Vincent Das, Arnaud Desachy, Marc Feissel, Frederique Ganster, Maite Garrouste-Orgeas, Sebastien Jochmans, Alexandre Lautrette, Fabien Lion, Philippe Mateu, Bruno Megarbane, Paul Morin-Longuet, Benedicte Philippon-Jouve, Jean-Pierre Quenot, Xavier Repesse, Jean-Philippe Rigaud, Segolene Robin, Antoine Roquilly, Carole Schwebel, Amelie Seguin, Didier Thevenin, Patrice Tirot
INTENSIVE CARE MEDICINE
(2020)
Article
Critical Care Medicine
Guillaume Franchineau, Nicolas Brechot, Guillaume Hekimian, Guillaume Lebreton, Simon Bourcier, Pierre Demondion, Loic Le Guennec, Ania Nieszkowska, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
ANNALS OF INTENSIVE CARE
(2020)
Letter
Critical Care Medicine
Simon Bourcier, Patricia Villie, Stephanie Nguyen, Guillaume Hekimian, Pierre Demondion, Nicolas Brechot, Charles-Edouard Luyt, Guillaume Lebreton, Alain Combes, Matthieu Schmidt
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Critical Care Medicine
Marine Paul, Wulfran Bougouin, Ste'phane Legriel, Julien Charpentier, Paul Jaubert, Guillaume Savary, Simon Bourcier, Frederic Pene, Florence Dumas, David Grimaldi, Alain Cariou
Editorial Material
Critical Care Medicine
Laurent Biquet, Herve Quintard, Jerome Pugin, Solange Moll, Sophie De Seigneux, Noemie Suh, Simon Bourcier
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Simon Bourcier, Julian Klug, Lee S. Nguyen
Summary: Acute mesenteric ischemia (AMI) is a severe condition associated with poor prognosis, and non-occlusive mesenteric ischemia (NOMI) is a particular form of AMI prevalent in critically ill patients. Accurate diagnosis is crucial for NOMI management, but the lack of tools for detection has hindered improvement in NOMI prognosis. Artificial intelligence (AI) offers the potential for accurate diagnosis through machine-learning-based algorithms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Critical Care Medicine
Guillaume Franchineau, Juliette Chommeloux, Marc Pineton de Chambrun, Guillaume Lebreton, Nicolas Brechot, Guillaume Hekimian, Simon Bourcier, Loic Le Guennec, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
Summary: This study aims to investigate the impact of bronchoalveolar lavage on regional ventilation in mechanically ventilated patients with acute respiratory distress syndrome, using electrical impedance tomography. It also aims to identify morphologic patterns according to respiratory failure severity.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Simon Bourcier, Cyrielle Desnos, Marina Clement, Guillaume Hekimian, Nicolas Brechot, Fabio Silvio Taccone, Mirko Belliato, Federico Pappalardo, Lars Mikael Broman, Maximilian Valentin Malfertheiner, Dirk Lunz, Matthieu Schmidt, Pascal Leprince, Alain Combes, Guillaume Lebreton, Charles-Edouard Luyt
Summary: This study analyzed the selection criteria and prognosis for in-hospital cardiac arrest patients undergoing ECPR treatment. The results showed that the combination of age, initial rhythm, and low-flow duration can improve patient selection and the survival rate of in-hospital cardiac arrest patients receiving ECPR treatment is low, but the 1-year neurological outcomes for surviving patients are favorable.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Critical Care Medicine
Mikhael Giabicani, Christophe Le Terrier, Antoine Poncet, Bertrand Guidet, Jean-Philippe Rigaud, Jean-Pierre Quenot, Marie-France Mamzer, Jerome Pugin, Emmanuel Weiss, Simon Bourcier
Summary: During the COVID-19 pandemic, limitations on life-sustaining therapies (LST) were frequently implemented in ICUs. This study aimed to investigate the prevalence, timing, and factors associated with LST decisions in critically ill COVID-19 patients. Data from 163 ICUs in France, Belgium, and Switzerland were analyzed, revealing an association between ICU load, age, frailty, and respiratory severity with LST limitations.
Article
Critical Care Medicine
Geoffroy Hariri, Simon Bourcier, Zora Marjanovic, Jeremie Joffre, Jeremie Lemarie, Jean-Remi Lavillegrand, Dominique Charue, Thomas Duflot, Naike Bige, Jean-Luc Baudel, Eric Maury, Mohamad Mohty, Bertrand Guidet, Jeremy Bellien, Olivier Blanc-Brude, Hafid Ait-Oufella