Journal
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Volume 20, Issue 5, Pages 602-614Publisher
WORLD SCI PUBL CO INC
DOI: 10.1142/S1088424616500413
Keywords
photodynamic therapy; phthalocyanine; N atom number; non-ionic; quaternized; hydrochloride
Categories
Funding
- National Natural Science Foundation of China [21201102, 21571105]
- program of natural science research of Jiangsu higher education institutions of china [13 KJA150003, 14KJD150005, 15KJB150013]
- NSF of Jiangsu Province of China [BK20131394 (213030B3131)]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
- Jiangsu Government Scholarship for Overseas Studies
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Amino group modified phthalocyanines (Pcs) and their derivatives have attracted great attention in the field of photodynamic therapy (PDT) because of their satisfied anticancer activity. The existence of N atoms in these Pcs is very important because they not only provide water solubility of Pcs, but also greatly affect their PDT activity. To clear the influence of N atoms number on PDT activity of amino group modified Pcs and their derivatives, in this manuscript, two series of amine modified Pcs with different N atom number and their water soluble derivatives, hydrochloride and quaternizing derivatives were synthesized. Their photochemical and photobiology properties were studied and compared. The results indicated that with increasing the number on N atom, the reactive oxygen species (ROSs) generation ability, cancer cell uptaken ability and photoinduced anticancer activity were all increased in these ZnPcs.
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