Journal
CELL CYCLE
Volume 14, Issue 9, Pages 1471-1475Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2015.1021520
Keywords
HMGA1P7; miRNA; ceRNA; HMGA1P6; HMGA1
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Funding
- Associazione Italiana per la Ricerca sul Cancro-AIRC [IG 11477]
- P.O.R. Campania FSE Progetto CREMe - CUP [B25B09000050007]
- Progetto di Interesse strategico Invecchiamento (PNR-CNR Aging Program) PNR-CNR [PON01-02782]
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Numerous studies have established that High Mobility Group A (HMGA) proteins play a pivotal role on the onset of human pituitary tumors. They are overexpressed in pituitary tumors, and, consistently, transgenic mice overexpressing either the Hmga1 or the Hmga2 gene develop pituitary tumors. In contrast with HMGA2, HMGA1 overexpression is not related to any rearrangement or amplification of the HMGA1 locus in these tumors. We have recently identified 2 HMGA1 pseudogenes, HMGA1P6 and HMGA1P7, acting as competitive endogenous RNA decoys for HMGA1 and other cancer related genes. Here, we show that HMGA1 pseudogene expression significantly correlates with HMGA1 mRNA levels in growth hormone and nonfunctioning pituitary adenomas likely inhibiting the repression of HMGA1 through microRNAs action. According to our functional studies, these HMGA1 pseudogenes enhance the proliferation and migration of the mouse pituitary tumor cell line, at least in part, through their upregulation. Our results point out that the overexpression of HMGA1P6 and HMGA1P7 could contribute to increase HMGA1 levels in human pituitary tumors, and then to pituitary tumorigenesis.
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