Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence

Geroconversion: irreversible step to cellular senescence

(2014) Mikhail V Blagosklonny   CELL CYCLE

Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch

(2014) Yoshinori Imai et al.   Cell Reports

Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts

(2014) Helen Pemberton et al.   GENOME BIOLOGY

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion

(2013) Olga V. Leontieva et al.   CELL CYCLE

Stressing the cell cycle in senescence and aging

(2013) Hollie Chandler et al.   CURRENT OPINION IN CELL BIOLOGY

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Contrasting Behavior of the p18INK4c and p16INK4a Tumor Suppressors in Both Replicative and Oncogene-Induced Senescence

(2011) S. Gagrica et al.   CANCER RESEARCH

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

(2009) Nicolas Humbert et al.   EMBO JOURNAL