Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both cell fate within the tumor microenvironment and immune status, which influences the network of antitumor immunity through various pathways. Based on the fact that metal ions influence the fate of cancer cells and participate in both innate and adaptive immunity, they are widely applied in antitumor therapy as immune modulators. Moreover, nanomedicine possesses the advantage of precise delivery and responsive release, which can perfectly remedy the drawbacks of metal ions, such as low target selectivity and systematic toxicity, thus providing an ideal platform for metal ion application in cancer treatment. Emerging evidence has shown that immunotherapy applied with nanometallic materials may significantly enhance therapeutic efficacy. Here, we focus on the physiopathology of metal ions in tumorigenesis and discuss several breakthroughs regarding the use of nanometallic materials in antitumor immunotherapeutics. These findings demonstrate the prominence of metal ion-based nanomedicine in cancer therapy and prophylaxis, providing many new ideas for basic immunity research and clinical application. Consequently, we provide innovative insights into the comprehensive understanding of the application of metal ions combined with nanomedicine in cancer immunotherapy in the past few years.

Automated summary

Even slight changes in the concentrations of metal ions can have amplified effects on signaling cascades that regulate tumor microenvironment and immune status, ultimately influencing the network of antitumor immunity. Metal ions are widely used in antitumor therapy as immune modulators due to their influence on cancer cell fate and participation in innate and adaptive immunity. Nanomedicine, with its precise delivery and responsive release capabilities, provides an ideal platform for the application of metal ions in cancer treatment, overcoming the disadvantages of low target selectivity and systemic toxicity.